High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease

Immunity

Volumn 48, Issue 2, 2018, Pages 380-395.e6

  Mrdjen, Dunja ^a   Pavlovic, Anto ^a   Hartmann, Felix J ^a   Schreiner, Bettina ^a   Utz, Sebastian G ^a   Leung, Brian P ^a   Lelios, Iva ^a   Heppner, Frank L ^b   Kipnis, Jonathan ^c   Merkler, Doron ^d   Greter, Melanie ^a   Becher, Burkhard ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c UNIVERSITY OF VIRGINIA   (United States)

^d UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

aging; Alzheimer's disease; central nervous system; experimental autoimmune encephalomyelitis; high dimensional; macrophages; mass cytometry; microglia; multiple sclerosis; neurodegeneration

Indexed keywords

BIOLOGICAL MARKER;

AGING; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CELL INVASION; CELL POPULATION; CENTRAL NERVOUS SYSTEM; CYTOMETRY; DEGENERATIVE DISEASE; DENDRITIC CELL; DISEASE COURSE; FLUORESCENCE; GENE MAPPING; HEALTH STATUS; IMMUNOCOMPETENT CELL; LEUKOCYTE; MACROPHAGE; MICROENVIRONMENT; MICROGLIA; MOUSE; MULTIPLE SCLEROSIS; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; SINGLE CELL ANALYSIS; STEADY STATE; ANIMAL; C57BL MOUSE; IMMUNOLOGY;

AGING; ANIMALS; CENTRAL NERVOUS SYSTEM; DENDRITIC CELLS; LEUKOCYTES; MACROPHAGES; MICE; MICE, INBRED C57BL; MICROGLIA; NEURODEGENERATIVE DISEASES; SINGLE-CELL ANALYSIS;

EID: 85042778066     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2018.01.011     Document Type: Article

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