Dysregulation of the Cytokine GM-CSF Induces Spontaneous Phagocyte Invasion and Immunopathology in the Central Nervous System

Immunity

Volumn 46, Issue 2, 2017, Pages 245-260

  Spath, Sabine ^a   Komuczki, Juliana ^a   Hermann, Mario ^a,b,d   Pelczar, Pawel ^a,e   Mair, Florian ^a   Schreiner, Bettina ^a,c   Becher, Burkhard ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^d BIOGEN   (United States)

^e UNIVERSITY OF BASEL   (Switzerland)

Author keywords

brain; CNS inflammation; cytokines; GM CSF; histiocytosis; inflammatory monocytes; moDCs; multiple sclerosis; myeloid cells; phagocytes; reactive oxygen species

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 17; REACTIVE OXYGEN METABOLITE; RETINOID RELATED ORPHAN RECEPTOR GAMMA; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CELL INVASION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; ENCEPHALITIS; GENE EXPRESSION; HELPER CELL; IMMUNOPATHOLOGY; IN VIVO STUDY; KIDNEY; LIVER; LUNG; MACROPHAGE; MICROGLIA; MONOCYTE; MOUSE; NEUROLOGIC DISEASE; NEUTROPHIL; NONHUMAN; PHAGOCYTE; PRIORITY JOURNAL; ANIMAL; ANIMAL MODEL; C57BL MOUSE; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; PATHOLOGY; POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE;

ANIMALS; CENTRAL NERVOUS SYSTEM; FLOW CYTOMETRY; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MODELS, ANIMAL; PHAGOCYTES; POLYMERASE CHAIN REACTION;

EID: 85013979200     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2017.01.007     Document Type: Article

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