-
1
-
-
64649104158
-
Banting Lecture. from the triumvirate to the ominous octet: A new paradigm for the treatment of type 2 diabetes mellitus
-
Defronzo, R. A. Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes. 58, 773-795 (2009).
-
(2009)
Diabetes
, vol.58
, pp. 773-795
-
-
Defronzo R. ., A.1
-
2
-
-
33744515637
-
FoxO1 regulates multiple metabolic pathways in the liver: Effects on gluconeogenic, glycolytic, and lipogenic gene expression
-
Zhang, W. et al. FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression. J. Biol. Chem. 281, 10105-10117 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 10105-10117
-
-
Zhang, W.1
-
3
-
-
84862909028
-
Hepatic suppression of Foxo1 and Foxo3 causes hypoglycemia and hyperlipidemia in mice
-
Zhang, K. et al. Hepatic suppression of Foxo1 and Foxo3 causes hypoglycemia and hyperlipidemia in mice. Endocrinology 153, 631-646 (2012).
-
(2012)
Endocrinology
, vol.153
, pp. 631-646
-
-
Zhang, K.1
-
4
-
-
78149272381
-
FoxOs function synergistically to promote glucose production
-
Haeusler, R. A., Kaestner, K. H. & Accili, D. FoxOs function synergistically to promote glucose production. J. Biol. Chem. 285, 35245-35248 (2010).
-
(2010)
J. Biol. Chem
, vol.285
, pp. 35245-35248
-
-
Haeusler, R.A.1
Kaestner, K.H.2
Accili, D.3
-
5
-
-
84883205274
-
Deletion of hepatic FoxO1/3/4 genes in mice significantly impacts on glucose metabolism through downregulation of gluconeogenesis and upregulation of glycolysis
-
Xiong, X., Tao, R., DePinho, R. A. & Dong, X. C. Deletion of hepatic FoxO1/3/4 genes in mice significantly impacts on glucose metabolism through downregulation of gluconeogenesis and upregulation of glycolysis. PloS ONE 8, e74340 (2013).
-
(2013)
PloS ONE
, vol.8
, pp. e74340
-
-
Xiong, X.1
Tao, R.2
Depinho, R.A.3
Dong, X.C.4
-
6
-
-
0033582929
-
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
-
Brunet, A. et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96, 857-868 (1999).
-
(1999)
Cell
, vol.96
, pp. 857-868
-
-
Brunet, A.1
-
7
-
-
0034680839
-
Regulation of glucose-6-phosphatase gene expression by protein kinase Balpha and the forkhead transcription factor FKHR. Evidence for insulin response unit-dependent and -independent effects of insulin on promoter activity
-
Schmoll, D. et al. Regulation of glucose-6-phosphatase gene expression by protein kinase Balpha and the forkhead transcription factor FKHR. Evidence for insulin response unit-dependent and -independent effects of insulin on promoter activity. J. Biol. Chem. 275, 36324-36333 (2000).
-
(2000)
J. Biol. Chem
, vol.275
, pp. 36324-36333
-
-
Schmoll, D.1
-
8
-
-
0034730660
-
Regulation of phosphoenolpyruvate carboxykinase and insulinlike growth factor-binding protein-1 gene expression by insulin. The role of winged helix/forkhead proteins
-
Hall, R. K. et al. Regulation of phosphoenolpyruvate carboxykinase and insulinlike growth factor-binding protein-1 gene expression by insulin. The role of winged helix/forkhead proteins. J. Biol. Chem. 275, 30169-30175 (2000).
-
(2000)
J. Biol. Chem
, vol.275
, pp. 30169-30175
-
-
Hall, R.K.1
-
9
-
-
0038187621
-
Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction
-
Puigserver, P. et al. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature 423, 550-555 (2003).
-
(2003)
Nature
, vol.423
, pp. 550-555
-
-
Puigserver, P.1
-
10
-
-
33748312093
-
Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism
-
Matsumoto, M., Han, S., Kitamura, T. & Accili, D. Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism. J. Clin. Invest. 116, 2464-2472 (2006).
-
(2006)
J. Clin. Invest
, vol.116
, pp. 2464-2472
-
-
Matsumoto, M.1
Han, S.2
Kitamura, T.3
Accili, D.4
-
11
-
-
45549090182
-
Inactivation of hepatic Foxo1 by insulin signalling is required for adaptive nutrient homeostasis and endocrine growth regulation
-
Dong, X. C. et al. Inactivation of hepatic Foxo1 by insulin signalling is required for adaptive nutrient homeostasis and endocrine growth regulation. Cell Metab. 8, 65-76 (2008).
-
(2008)
Cell Metab
, vol.8
, pp. 65-76
-
-
Dong, X.C.1
-
12
-
-
84857934301
-
Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1
-
Lu, M. et al. Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1. Nat. Med. 18, 388-395 (2012).
-
(2012)
Nat. Med
, vol.18
, pp. 388-395
-
-
Lu, M.1
-
13
-
-
84857986993
-
The AKTion in non-canonical insulin signalling
-
Cheng, Z. &White, M. F. The AKTion in non-canonical insulin signalling. Nat. Med. 18, 351-353 (2012).
-
(2012)
Nat. Med
, vol.18
, pp. 351-353
-
-
Cheng, Z.1
White, M.F.2
-
14
-
-
70449122132
-
Foxo1 integrates insulin signalling with mitochondrial function in the liver
-
Cheng, Z. et al. Foxo1 integrates insulin signalling with mitochondrial function in the liver. Nat. Med. 15, 1307-1311 (2009).
-
(2009)
Nat. Med
, vol.15
, pp. 1307-1311
-
-
Cheng, Z.1
-
15
-
-
33847221165
-
Mechanisms of disease: Metabolic effects of growth hormone and insulin-like growth factor 1
-
LeRoith, D. & Yakar, S. Mechanisms of disease: metabolic effects of growth hormone and insulin-like growth factor 1. Nature clinical practice. Endocrinol. Metab. 3, 302-310 (2007).
-
(2007)
Nature Clinical Practice. Endocrinol. Metab
, vol.3
, pp. 302-310
-
-
Leroith, D.1
Yakar, S.2
-
16
-
-
0033636523
-
Loss of insulin signalling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction
-
Michael, M. D. et al. Loss of insulin signalling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol. Cell 6, 87-97 (2000).
-
(2000)
Mol. Cell
, vol.6
, pp. 87-97
-
-
Michael, M.D.1
-
17
-
-
52949099133
-
A novel high-affinity peptide antagonist to the insulin receptor
-
Schaffer, L. et al. A novel high-affinity peptide antagonist to the insulin receptor. Biochem. Biophys. Res. Commun. 376, 380-383 (2008).
-
(2008)
Biochem. Biophys. Res. Commun
, vol.376
, pp. 380-383
-
-
Schaffer, L.1
-
18
-
-
0037088683
-
Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c
-
Liang, G. et al. Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c. J. Biol. Chem. 277, 9520-9528 (2002).
-
(2002)
J. Biol. Chem
, vol.277
, pp. 9520-9528
-
-
Liang, G.1
-
19
-
-
0034282947
-
Starvation increases the amount of pyruvate dehydrogenase kinase in several mammalian tissues
-
Wu, P. et al. Starvation increases the amount of pyruvate dehydrogenase kinase in several mammalian tissues. Arch. Biochem. Biophys. 381, 1-7 (2000).
-
(2000)
Arch. Biochem. Biophys
, vol.381
, pp. 1-7
-
-
Wu, P.1
-
20
-
-
1842475551
-
Protein kinase B-alpha inhibits human pyruvate dehydrogenase kinase-4 gene induction by dexamethasone through inactivation of FOXO transcription factors
-
Kwon, H. S., Huang, B., Unterman, T. G. & Harris, R. A. Protein kinase B-alpha inhibits human pyruvate dehydrogenase kinase-4 gene induction by dexamethasone through inactivation of FOXO transcription factors. Diabetes 53, 899-910 (2004).
-
(2004)
Diabetes
, vol.53
, pp. 899-910
-
-
Kwon, H.S.1
Huang, B.2
Unterman, T.G.3
Harris, R.A.4
-
21
-
-
84929148324
-
Hepatic insulin signaling is dispensable for suppression of glucose output by insulin in vivo
-
Titchenell, P.M., Chu, Q., Monks, B.R. & Birnbaum, M.J. Hepatic insulin signaling is dispensable for suppression of glucose output by insulin in vivo. Nat. Commun. (2015) doi:10.1038/ncomms8078.
-
(2015)
Nat. Commun
-
-
Titchenell, P.M.1
Chu, Q.2
Monks, B.R.3
Birnbaum, M.J.4
-
22
-
-
0031467268
-
Indirect effect of insulin to suppress endogenous glucose production is dominant, even with hyperglucagonemia
-
Mittelman, S. D., Fu, Y. Y., Rebrin, K., Steil, G. & Bergman, R. N. Indirect effect of insulin to suppress endogenous glucose production is dominant, even with hyperglucagonemia. J. Clin. Invest. 100, 3121-3130 (1997).
-
(1997)
J. Clin. Invest
, vol.100
, pp. 3121-3130
-
-
Mittelman, S.D.1
Fu, Y.Y.2
Rebrin, K.3
Steil, G.4
Bergman, R.N.5
-
23
-
-
84860435420
-
Evidence against a physiologic role for acute changes in CNS insulin action in the rapid regulation of hepatic glucose production
-
Ramnanan, C. J., Edgerton, D. S. & Cherrington, A. D. Evidence against a physiologic role for acute changes in CNS insulin action in the rapid regulation of hepatic glucose production. Cell Metab. 15, 656-664 (2012).
-
(2012)
Cell Metab
, vol.15
, pp. 656-664
-
-
Ramnanan, C.J.1
Edgerton, D.S.2
Cherrington, A.D.3
-
24
-
-
84922754155
-
Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors
-
Haeusler, R. A. et al. Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors. Nat. Commun. 5, 5190 (2014).
-
(2014)
Nat. Commun
, vol.5
, pp. 5190
-
-
Haeusler, R.A.1
-
25
-
-
0028825129
-
Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin
-
Rebrin, K., Steil, G. M., Getty, L. & Bergman, R. N. Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin. Diabetes 44, 1038-1045 (1995).
-
(1995)
Diabetes
, vol.44
, pp. 1038-1045
-
-
Rebrin, K.1
Steil, G.M.2
Getty, L.3
Bergman, R.N.4
-
26
-
-
0030975131
-
Fatty acids mediate the acute extrahepatic effects of insulin on hepatic glucose production in humans
-
Lewis, G. F., Vranic, M., Harley, P. & Giacca, A. Fatty acids mediate the acute extrahepatic effects of insulin on hepatic glucose production in humans. Diabetes 46, 1111-1119 (1997).
-
(1997)
Diabetes
, vol.46
, pp. 1111-1119
-
-
Lewis, G.F.1
Vranic, M.2
Harley, P.3
Giacca, A.4
-
27
-
-
84874241199
-
Liver-derived systemic factors drive beta cell hyperplasia in insulin-resistant states
-
El Ouaamari, A. et al. Liver-derived systemic factors drive beta cell hyperplasia in insulin-resistant states. Cell Rep. 3, 401-410 (2013).
-
(2013)
Cell Rep
, vol.3
, pp. 401-410
-
-
El Ouaamari, A.1
-
28
-
-
33846295218
-
FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis
-
Paik, J. H. et al. FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell 128, 309-323 (2007).
-
(2007)
Cell
, vol.128
, pp. 309-323
-
-
Paik, J.H.1
-
29
-
-
33644778829
-
Considerations in the design of hyperinsulinemic-euglycemic clamps in the conscious mouse
-
Ayala, J. E., Bracy, D. P., McGuinness, O. P. & Wasserman, D. H. Considerations in the design of hyperinsulinemic-euglycemic clamps in the conscious mouse. Diabetes 55, 390-397 (2006).
-
(2006)
Diabetes
, vol.55
, pp. 390-397
-
-
Ayala, J.E.1
Bracy, D.P.2
McGuinness, O.P.3
Wasserman, D.H.4
-
30
-
-
48249100979
-
Glucose metabolism in vivo in four commonly used inbred mouse strains
-
Berglund, E. D. et al. Glucose metabolism in vivo in four commonly used inbred mouse strains. Diabetes 57, 1790-1799 (2008).
-
(2008)
Diabetes
, vol.57
, pp. 1790-1799
-
-
Berglund, E.D.1
-
31
-
-
79551595824
-
Diet-induced muscle insulin resistance is associated with extracellular matrix remodeling and interaction with integrin alpha2beta1 in mice
-
Kang, L. et al. Diet-induced muscle insulin resistance is associated with extracellular matrix remodeling and interaction with integrin alpha2beta1 in mice. Diabetes 60, 416-426 (2011).
-
(2011)
Diabetes
, vol.60
, pp. 416-426
-
-
Kang, L.1
-
32
-
-
0031973056
-
Starvation and diabetes increase the amount of pyruvate dehydrogenase kinase isoenzyme 4 in rat heart
-
Wu, P. et al. Starvation and diabetes increase the amount of pyruvate dehydrogenase kinase isoenzyme 4 in rat heart. Biochem. J. 329(Pt 1): 197-201 (1998).
-
(1998)
Biochem. J.
, vol.329
, pp. 197-201
-
-
Wu, P.1
|