Selective Inhibition of FOXO1 Activator/Repressor Balance Modulates Hepatic Glucose Handling

Cell

Volumn 171, Issue 4, 2017, Pages 824-835.e18

  Langlet, Fanny ^a,b   Haeusler, Rebecca A ^a   Lindén, Daniel ^c   Ericson, Elke ^c   Norris, Tyrrell ^c   Johansson, Anders ^c   Cook, Joshua R ^a,b   Aizawa, Kumiko ^a,b   Wang, Ling ^d   Buettner, Christoph ^d   Accili, Domenico ^a,b  

^a Department of Medicine   (United States)

^b Innovative Medicines and Early Development Biotech Unit ^*  (United States)

^c ASTRAZENECA R AND D   (Sweden)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

diabetes; drug therapy; hepatic glucose production; hepatosteatosis; insulin resistance; insulin sensitizers; lipogenesis; selective modulators; small molecule inhibitor; transcription repressor

Indexed keywords

GLUCOCORTICOID; GLUCOKINASE; HISTONE DEACETYLASE; INSULIN; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR SIN3A; FOXO1 PROTEIN, MOUSE; GLUCOSE; GLUCOSE 6 PHOSPHATASE; REPRESSOR PROTEIN; SIN3A TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME REPRESSION; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HUMAN; HUMAN CELL; INSULIN SENSITIVITY; LIVER CELL; LIVER METABOLISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ACETYLATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; ACETYLATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; GENETICS; HEK293 CELL LINE; INSULIN RESISTANCE; KNOCKOUT MOUSE; LIPOGENESIS; METABOLISM; PHOSPHORYLATION;

ACETYLATION; ANIMALS; CELLS, CULTURED; FORKHEAD BOX PROTEIN O1; GLUCOKINASE; GLUCOSE; GLUCOSE-6-PHOSPHATASE; HEK293 CELLS; HEPATOCYTES; HISTONE DEACETYLASES; HUMANS; INSULIN RESISTANCE; LIPOGENESIS; MICE; MICE, KNOCKOUT; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; REPRESSOR PROTEINS;

EID: 85031770271     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2017.09.045     Document Type: Article

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