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Volumn 288, Issue 38, 2013, Pages 27299-27306

Glycerol-3-phosphate acyltransferase (GPAT)-1, but not GPAT4, incorporates newly synthesized fatty acids into triacylglycerol and diminishes fatty acid oxidation

Author keywords

[No Author keywords available]

Indexed keywords

ACYLCARNITINE; ACYLCARNITINES; ACYLTRANSFERASE; FATTY ACID OXIDATION; GLYCEROLIPID SYNTHESIS; HEPATOCYTES; HIGH-SUCROSE DIETS; TRIACYLGLYCEROLS;

EID: 84884562454     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.485219     Document Type: Article
Times cited : (71)

References (32)
  • 1
    • 80054057662 scopus 로고    scopus 로고
    • Mammalian triacylglycerol metabolism: Synthesis, lipolysis, and signaling
    • Coleman, R. A., and Mashek, D. G. (2011) Mammalian triacylglycerol metabolism: Synthesis, lipolysis, and signaling. Chem. Rev. 111, 6359-6386
    • (2011) Chem. Rev. , vol.111 , pp. 6359-6386
    • Coleman, R.A.1    Mashek, D.G.2
  • 2
    • 0036889152 scopus 로고    scopus 로고
    • Mitochondrial glycerol-3-phosphate acyltransferase-deficient mice have reduced weight and liver triacylglycerol content and altered glycerolipid fatty acid composition
    • Hammond, L. E., Gallagher, P. A., Wang, S., Hiller, S., Kluckman, K. D., Posey-Marcos, E. L., Maeda, N., and Coleman, R. A. (2002) Mitochondrial glycerol-3-phosphate acyltransferase-deficient mice have reduced weight and liver triacylglycerol content and altered glycerolipid fatty acid composition. Mol. Cell. Biol. 22, 8204-8214
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 8204-8214
    • Hammond, L.E.1    Gallagher, P.A.2    Wang, S.3    Hiller, S.4    Kluckman, K.D.5    Posey-Marcos, E.L.6    Maeda, N.7    Coleman, R.A.8
  • 6
    • 33845941190 scopus 로고    scopus 로고
    • Molecular identification of microsomal acyl-CoA: Glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis
    • Cao, J., Li, J. L., Li, D., Tobin, J. F., and Gimeno, R. E. (2006) Molecular identification of microsomal acyl-CoA: glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis. Proc. Natl. Acad. Sci. U. S. A. 103, 19695-19700
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 19695-19700
    • Cao, J.1    Li, J.L.2    Li, D.3    Tobin, J.F.4    Gimeno, R.E.5
  • 7
    • 0345171460 scopus 로고    scopus 로고
    • Enzymes of triacylglycerol synthesis and their regulation
    • Coleman, R. A., and Lee, D. P. (2004) Enzymes of triacylglycerol synthesis and their regulation. Prog. Lipid Res. 43, 134-176
    • (2004) Prog. Lipid Res. , vol.43 , pp. 134-176
    • Coleman, R.A.1    Lee, D.P.2
  • 8
    • 34250015897 scopus 로고    scopus 로고
    • Mitochondrial glycerol-3-P acyltransferase 1 is most active in outer mitochondrial membrane but not in mitochondrial associated vesicles (MAV)
    • Pellon-Maison, M., Montanaro, M. A., Coleman, R. A., and Gonzalez-Baró, M. R. (2007) Mitochondrial glycerol-3-P acyltransferase 1 is most active in outer mitochondrial membrane but not in mitochondrial associated vesicles (MAV). Biochim. Biophys. Acta 1771, 830-838
    • (2007) Biochim. Biophys. Acta , vol.1771 , pp. 830-838
    • Pellon-Maison, M.1    Montanaro, M.A.2    Coleman, R.A.3    Gonzalez-Baró, M.R.4
  • 9
    • 0036251153 scopus 로고    scopus 로고
    • SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver
    • Horton, J. D., Goldstein, J. L., and Brown, M. S. (2002) SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J. Clin. Invest. 109, 1125-1131
    • (2002) J. Clin. Invest. , vol.109 , pp. 1125-1131
    • Horton, J.D.1    Goldstein, J.L.2    Brown, M.S.3
  • 10
    • 77953190989 scopus 로고    scopus 로고
    • Glycerol-3-phosphate acyltransferase 1 deficiency in ob/ob mice diminishes hepatic steatosis but does not protect against insulin resistance or obesity
    • Wendel, A. A., Li, L. O., Li, Y., Cline, G. W., Shulman, G. I., and Coleman, R. A. (2010) Glycerol-3-phosphate acyltransferase 1 deficiency in ob/ob mice diminishes hepatic steatosis but does not protect against insulin resistance or obesity. Diabetes 59, 1321-1329
    • (2010) Diabetes , vol.59 , pp. 1321-1329
    • Wendel, A.A.1    Li, L.O.2    Li, Y.3    Cline, G.W.4    Shulman, G.I.5    Coleman, R.A.6
  • 16
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipides from animal tissues
    • Folch, J., Lees, M., and Sloane Stanley, G. H. (1957) A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem. 226, 497-509
    • (1957) J. Biol. Chem. , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Sloane Stanley, G.H.3
  • 18
    • 0035186931 scopus 로고    scopus 로고
    • De novo lipogenesis during controlled overfeeding with sucrose or glucose in lean and obese women
    • McDevitt, R. M., Bott, S. J., Harding, M., Coward, W. A., Bluck, L. J., and Prentice, A. M. (2001) De novo lipogenesis during controlled overfeeding with sucrose or glucose in lean and obese women. Am. J. Clin. Nutr. 74, 737-746
    • (2001) Am. J. Clin. Nutr. , vol.74 , pp. 737-746
    • McDevitt, R.M.1    Bott, S.J.2    Harding, M.3    Coward, W.A.4    Bluck, L.J.5    Prentice, A.M.6
  • 20
    • 78149317974 scopus 로고    scopus 로고
    • Expression and regulation of GPAT isoforms in cultured human keratinocytes and rodent epidermis
    • Lu, B., Jiang, Y. J., Kim, P., Moser, A., Elias, P. M., Grunfeld, C., and Feingold, K. R. (2010) Expression and regulation of GPAT isoforms in cultured human keratinocytes and rodent epidermis. J. Lipid Res. 51, 3207-3216
    • (2010) J. Lipid Res. , vol.51 , pp. 3207-3216
    • Lu, B.1    Jiang, Y.J.2    Kim, P.3    Moser, A.4    Elias, P.M.5    Grunfeld, C.6    Feingold, K.R.7
  • 21
    • 0017074839 scopus 로고
    • The glycerolphosphate acyltransferases and their function in the metabolism of fatty acids
    • Bremer, J., Bjerve, K. S., Borrebaek, B., and Christiansen, R. (1976) The glycerolphosphate acyltransferases and their function in the metabolism of fatty acids. Mol. Cell Biochem. 12, 113-125
    • (1976) Mol. Cell Biochem. , vol.12 , pp. 113-125
    • Bremer, J.1    Bjerve, K.S.2    Borrebaek, B.3    Christiansen, R.4
  • 22
    • 0018801024 scopus 로고
    • Phospholipid requirement of acyl coenzyme A: Sn-glycerol-3-phosphate acyltransferase from rat liver mitochondria
    • Kelker, H. C., and Pullman, M. E. (1979) Phospholipid requirement of acyl coenzyme A: sn-glycerol-3-phosphate acyltransferase from rat liver mitochondria. J. Biol. Chem. 254, 5364-5371
    • (1979) J. Biol. Chem. , vol.254 , pp. 5364-5371
    • Kelker, H.C.1    Pullman, M.E.2
  • 23
    • 0015935405 scopus 로고
    • Partial purification and properties of an acyl coenzyme A: Sn-glycerol 3-phosphate acyltransferase from rat liver mitochondria
    • Monroy, G., Kelker, H. C., and Pullman, M. E. (1973) Partial purification and properties of an acyl coenzyme A: sn-glycerol 3-phosphate acyltransferase from rat liver mitochondria. J. Biol. Chem. 248, 2845-2852
    • (1973) J. Biol. Chem. , vol.248 , pp. 2845-2852
    • Monroy, G.1    Kelker, H.C.2    Pullman, M.E.3
  • 24
    • 0029079129 scopus 로고
    • Purification and reconstitution of murine mitochondrial glycerol-3-phosphate acyltransferase. Functional expression in baculovirus-infected insect cells
    • Yet, S.-F., Moon, Y. K., and Sul, H. S. (1995) Purification and reconstitution of murine mitochondrial glycerol-3-phosphate acyltransferase. Functional expression in baculovirus-infected insect cells. Biochemistry 34, 7303-7310
    • (1995) Biochemistry , vol.34 , pp. 7303-7310
    • Yet, S.-F.1    Moon, Y.K.2    Sul, H.S.3
  • 25
    • 33947726025 scopus 로고    scopus 로고
    • Increased oxidative stress is associated with balanced increases in hepatocyte apoptosis and proliferation in glycerol-3-phosphate acyltransferase-1 deficient mice
    • Hammond, L. E., Albright, C. D., He, L., Rusyn, I., Watkins, S. M., Doughman, S. D., Lemasters, J. J., and Coleman, R. A. (2007) Increased oxidative stress is associated with balanced increases in hepatocyte apoptosis and proliferation in glycerol-3-phosphate acyltransferase-1 deficient mice. Exp. Mol. Pathol. 82, 210-219
    • (2007) Exp. Mol. Pathol. , vol.82 , pp. 210-219
    • Hammond, L.E.1    Albright, C.D.2    He, L.3    Rusyn, I.4    Watkins, S.M.5    Doughman, S.D.6    Lemasters, J.J.7    Coleman, R.A.8
  • 26
    • 0033559856 scopus 로고    scopus 로고
    • AMPactivated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: Evidence that sn-glycerol-3-phosphate acyltransferase is a novel target
    • Muoio, D. M., Seefeld, K., Witters, L. A., and Coleman, R. A. (1999) AMPactivated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target. Biochem. J. 338, 783-791
    • (1999) Biochem. J. , vol.338 , pp. 783-791
    • Muoio, D.M.1    Seefeld, K.2    Witters, L.A.3    Coleman, R.A.4
  • 28
    • 24144475456 scopus 로고    scopus 로고
    • Increased dietary substrate delivery alters hepatic fatty acid recycling in healthy men
    • Timlin, M. T., Barrows, B. R., and Parks, E. J. (2005) Increased dietary substrate delivery alters hepatic fatty acid recycling in healthy men. Diabetes 54, 2694-2701
    • (2005) Diabetes , vol.54 , pp. 2694-2701
    • Timlin, M.T.1    Barrows, B.R.2    Parks, E.J.3
  • 29
    • 44449096155 scopus 로고    scopus 로고
    • Dietary sugars stimulate fatty acid synthesis in adults
    • Parks, E. J., Skokan, L. E., Timlin, M. T., and Dingfelder, C. S. (2008) Dietary sugars stimulate fatty acid synthesis in adults. J. Nutr. 138, 1039-1046
    • (2008) J. Nutr. , vol.138 , pp. 1039-1046
    • Parks, E.J.1    Skokan, L.E.2    Timlin, M.T.3    Dingfelder, C.S.4
  • 30
    • 50949096938 scopus 로고    scopus 로고
    • Mice deficient in mitochondrial glycerol-3-phosphate acyltransferase-1 have diminished myocardial triacylglycerol accumulation during lipogenic diet and altered phospholipid fatty acid composition
    • Lewin, T. M., De Jong, H., Schwerbrock, N. J., Hammond, L. E., Watkins, S. M., Combs, T. P., and Coleman, R. A. (2008) Mice deficient in mitochondrial glycerol-3-phosphate acyltransferase-1 have diminished myocardial triacylglycerol accumulation during lipogenic diet and altered phospholipid fatty acid composition. Biochim. Biophys. Acta 1781, 352-358
    • (2008) Biochim. Biophys. Acta , vol.1781 , pp. 352-358
    • Lewin, T.M.1    De Jong, H.2    Schwerbrock, N.J.3    Hammond, L.E.4    Watkins, S.M.5    Combs, T.P.6    Coleman, R.A.7
  • 31


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.