Forsythin inhibits lipopolysaccharide-induced inflammation by suppressing JAK-STAT and p38 MAPK signalings and ROS production

Inflammation Research

Volumn 63, Issue 7, 2014, Pages 597-608

  Pan, Xiaolong ^a   Cao, Xiang ^a   Li, Na ^a   Xu, Yimiao ^a   Wu, Qiuyue ^a   Bai, Jing ^a   Yin, Zhimin ^a,c   Luo, Lan ^b,c   Lan, Lei ^a,c  

^a NANJING NORMAL UNIVERSITY   (China)

^b NANJING UNIVERSITY   (China)

^c Collaborative Innovation Center of Biomedicine for Public Hygiene Emergency and Critical Care Jiangsu Life Sciences and Technology Innovation Park ^*  (China)

Author keywords

Forsythin; JAK STATs; p38 MAPKs; RAW264.7 cells; ROS

Indexed keywords

ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 2; FORSYTHIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; JANUS KINASE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE SYNTHASE; PROSTAGLANDIN E2; REACTIVE OXYGEN METABOLITE; STAT PROTEIN; STAT1 PROTEIN; STAT3 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CYTOKINE; FORSYTHENIN; FURAN DERIVATIVE; FUSED HETEROCYCLIC RINGS; INDUCIBLE NITRIC OXIDE SYNTHASE; NOS2 PROTEIN, MOUSE; PTGS2 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; ENZYME REPRESSION; INFLAMMATION; LIPOPOLYSACCHARIDE-INDUCED INFLAMMATION; MACROPHAGE; NONHUMAN; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; DRUG EFFECTS; GENETICS; METABOLISM; MOUSE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BICYCLO COMPOUNDS, HETEROCYCLIC; CELL LINE; CYCLOOXYGENASE 2; CYTOKINES; FURANS; JANUS KINASES; LIPOPOLYSACCHARIDES; MICE; NITRIC OXIDE SYNTHASE TYPE II; P38 MITOGEN-ACTIVATED PROTEIN KINASES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; STAT TRANSCRIPTION FACTORS;

EID: 84902654627     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-014-0731-7     Document Type: Article

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