Protective effect and mechanism of Ginkgo biloba extract-EGb 761 on STZ-induced diabetic cardiomyopathy in rats

Pharmacognosy Magazine

Volumn 10, Issue 38, 2014, Pages 172-178

  Saini, Arminder Singh ^a   Taliyan, Rajeev ^b   Sharma, Pyare Lal ^a  

^a ISF COLLEGE OF PHARMACY   (India)

^b BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

Author keywords

Cardioprotective; diabetes mellitus; EGb 761; mPTP channel; oxidative stress

Indexed keywords

ATRACTYLOSIDE; COLLAGEN; GINKGO BILOBA EXTRACT; GLUCOSE; GLUTATHIONE; LACTATE DEHYDROGENASE; LISINOPRIL; NITRITE; STREPTOZOCIN; SUPEROXIDE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; HYDROXYPROLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIABETES CONTROL; DIABETIC CARDIOMYOPATHY; DRUG EFFECT; DRUG MECHANISM; DRUG MEGADOSE; ETHNOPHARMACOLOGY; GLUCOSE BLOOD LEVEL; HEART LEFT VENTRICLE FUNCTION; HEART PROTECTION; HEART WEIGHT; LACTATE DEHYDROGENASE BLOOD LEVEL; MULTIPLE CYCLE TREATMENT; NITROSATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; PROTEIN CONTENT; RAT; STREPTOZOCIN INDUCED DIABETIC CARDIOMYOPATHY; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; GINKGO BILOBA; HEART LEFT VENTRICLE; HEART MUSCLE; LIPID PEROXIDATION; MITOCHONDRIAL MEMBRANE POTENTIAL; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS;

EID: 84899455321     PISSN: 09731296     EISSN: 09764062     Source Type: Journal    
DOI: 10.4103/0973-1296.131031     Document Type: Article

References (41)

1. Marwick TH the diabetic myocardium. Curr Diab Rep 2006;6:36-41.
2. Parchwani ND, Upadhyah AA. Diabetic nephropathy: Progression and pathophysiology. Int J Med Sci Public Health 2012;1:59-70.
3. Chauhan N, Taliyan R, Sharma PL. Effect of dipyrone and thalidomide alone and in combination on STZ-induced diabetic neuropathic pain. Naunyn Schmiedebergs Arch Pharmacol 2012;385:527-38.
4. Jay D, Hitomi H, Griendling KK. Oxidative stress and diabetic cardiovascular complications. Free Radic Biol Med 2006;40:183-92.
5. Opie LH. Cardiomyopathies and heart failure. Heart Metab 2010;46:17-24.
6. Spitaler MM, Graier WF. Vascular targets of redox signalling in diabetes mellitus. Diabetologia 2102;45:476-94.
7. Pacher P, Schulz R, Liaudet L, Szabo, C. Nitrosative stress and pharmacological modulation of heart failure. Trends Pharmacol Sci 2005;26:302-10.
8. Mariappan N, Elks CM, Sriramula S, Guggilam A, Liu Z, Borkhsenious O, et al. NF-kB-induced oxidative stress contributes to mitochondrial and cardiac dysfunction in type II diabetes. Cardiovasc Res 2010;85:473-83.
9. Zorov DB, Filburn CR, Klotz LO, Zweier JL, Sollott SJ. Reactive oxygen species (ROS)-induced ROS release: A new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes. J Exp Med 2010;192:1001-4.
10. Halestrap AP. Calcium, mitochondria and reperfusion injury: A pore way to die. Biochem Soc Trans 2006;34:232-7.
11. Green DR, Kroemer G the pathophysiology of mitochondrial cell death. Science 2004;5:626-9.
12. Drieu K. Preparation and definition of Ginkgo biloba extract. In: Funfgeld EW, editor. Rokan (Ginkgo biloba) Recent results in pharmacology and clinic. Berlin: Springer-Verlag; 1988. p. 32-6.
13. Pietri S, Maurelli E, Drieu K, Culcasi M. Cardioprotective and anti-oxidant effects of the terpenoid constituents of Ginkgo biloba extract (EGb 761). J Mol Cell Cardiol 1997;29:733-42.
14. Smith JV, Burdick AJ, Golik P, Khan I, Wallace D, Luo Y. Anti-apoptotic properties of Ginkgo biloba extract EGb 761 in differentiated PC12 cells. Cell Mol Biol 2002;48:699-707.
15. Eckert A, Keil U, Kressmann S, Schindowski K, Leutner S, Leutz S, et al. Effects of EGb 761 Ginkgo biloba extract on mitochondrial function and oxidative stress. Pharmacopsychiatry 2003;36:S15-23.
16. Zhou LJ, Zhu XZ. Reactive oxygen species-induced apoptosis in PC12 cells and protective effect of bilobalide. J Pharmacol Exp Ther 2000;293:982-8.
17. Abdel-Kader R, Hauptmann S, Keil U, Scherping I, Leuner K, Eckert A, et al. Stabilization of mitochondrial function by Ginkgo biloba extract (EGb 761). Pharmacol Res 2007;56:493-502.
18. Zhu XX, Zhou XP, Zhong XL, Zhong CS, Yu YF. Streptozotocin induced cardiomyopathy in diabetic rats. Chin Med J (Engl) 1993;106:463-6.
19. Taliyan R, Sharma PL. Protective effect and potential mechanism of Ginkogo-biloba extract-EGb-761 on STZ-induced neuropathic pain behavior in rats. Pytother Res 2012;26:1823-9.
20. Trinder P. Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor. Ann Clin Biochem 1969;6:24.
21. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with folin-phenol reagent. J Biol Chem 1951;193:265-75.
22. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979;95:351-8.
23. Beutler E, Duron O, Kelly BM. Improved method for the determination of blood glutathione. J Lab Clin Med 1963;61:882-8.
24. McAnulty RJ. Methods for measuring hydroxyproline and estimating in vivo rates of collagen synthesis and degradation. Methods Mol Med 2005;117:189-207.
25. Wang HD, Pagano PJ, Du Y, Cayatte AJ, Quinn MT, Brecher P, et al. Superoxide anion from the adventitia of the rat thoracic aorta inactivates nitric oxide. Circ Res 1998;82:810-8.
26. Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR. Analysis of nitrate, nitrite and [15 N] nitrate in biological fluids. Anal Biochem 1982;126:131-8.
27. Lum G, Gambino SR. A comparison of serum versus heparinised plasma for routine chemistry tests. Am J Clin Pathol 1974;61:108.
28. Eizirik DL, Pipeleers DG, Ling Z, Welsh N, Hellerstrom C, Andersson A. Major species differences between humans and rodents in the susceptibility to pancreatic beta-cell injury. Proc Natl Acad Sci USA 1994;91:9253-6.
29. Ma H, Li SY, Xu P, Babcock SA, Dolence EK, Brownlee M, et al. Advanced glycation endproduct (AGE) accumulation and AGE receptor (RAGE) up-regulation contribute to the onset of diabetic cardiomyopathy. J Cell Mol Med 2009;13:1751-64.
30. Taliyan R, Sharma PL. Possible mechanism of protective effect of thalidomide in STZ-induced-neuropathic pain behavior in rats. Inflammopharmacology 2012;20:89-97.
31. Touyz RM. Reactive oxygen species and angiotensin II signaling in vascular cells-implications in cardiovascular disease. Braz J Med Biol Res 2004;37:1263-73.
32. Marijianowski MM, Teeling P, Mann J, Becker A. Dilated cardiomyopathy is associated with an increase in the type I/type III collagen ratio: A quantitative assessment. J Am Coll Cardiol 1995;25:1263-72.
33. Geraldes P, King GL. Activation of protein Kinase C Isoforms and its impact on diabetic complications. Circ Res 2010;106:1319-31.
34. Chiu J, Farhangkhoee H, Xu BY, Chen S, George B, Chakrabarti S. PARP mediates structural alterations in diabetic cardiomyopathy. J Mol Cell Cardiol 2008;45:385-93.
35. Nakagawa T, Shimizu S, Watanabe T, Yamaguchi O, Otsu K, Yamagata H, et al. Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death. Nature 2005;434:652-8.
36. Javadov S, Karmazyn M, Escobales N. Mitochondrial permeability transition pore opening as a promising therapeutic target in cardiac diseases. J Pharmacol Exp Ther 2009;330:670-8.
37. Nakayama H, Chen X, Baines CP, Klevitsky R, Zhang X, Zhang H, et al. Ca2-and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure. J Clin Invest 2007;117:2431-44.
38. Oliveira PJ, Seiça R, Coxito PM, Rolo AP, Palmeira CM, Santos MS, et al. Enhanced permeability transition explains the reduced calcium uptake in cardiac mitochondria from streptozotocin-induced diabetic rats. FEBS Lett 2003;554:511-4.
39. Shen J, Wang J, Zhao B, Hou J, Gao T, Xin W. Effects of EGb 761 on nitric oxide and oxygen free radicals, myocardial damage and arrhythmia in ischemia-reperfusion injury in vivo. Biochim Biophys Acta 1998;1406:228-36.
40. Shen J, Lee W, Gu Y, Tong Y, Fung P, Tong L. Ginkgo biloba extract (EGb761) inhibits mitochondria-dependent caspase pathway and prevents apoptosis in hypoxia-reoxygenated cardiomyocytes. Chin Med 2011;6:1-8.
41. Yeh YC, Liu TJ, Wang LC, Lee HW, Ting CT, Lee WL, et al. A standardized extract of Ginkgo biloba suppresses doxorubicin-induced oxidative stress and p53-mediated mitochondrial apoptosis in rat testes. Br J Pharmacol 2009;156:48-61.