메뉴 건너뛰기




Volumn 10, Issue 2, 2018, Pages

Approaches for reducing the risk of early-life iron deficiency-induced brain dysfunction in children

Author keywords

Brain dysfunction; Children; Infants; Iron; Iron deficiency; Iron supplementation; Neurodevelopment

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; FERRITIN; FERROPORTIN; HEPCIDIN; IRON BINDING PROTEIN; PROTOPORPHYRIN; REACTIVE OXYGEN METABOLITE; TRACE ELEMENT; TRANSFERRIN RECEPTOR; IRON;

EID: 85042320096     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu10020227     Document Type: Review
Times cited : (63)

References (92)
  • 1
  • 2
    • 85042264018 scopus 로고    scopus 로고
    • Assessment, Prevention, and Control
    • accessed on 5 October
    • World Health Organization. Iron Deficiency Anaemia. Assessment, Prevention, and Control. A Guide for Programme Managers. Available online: http://www.who.int/nutrition/publications/en/ida_assessment_prevention_control.pdf (accessed on 5 October 2017).
    • (2017) A Guide for Programme Managers
  • 3
    • 77951137209 scopus 로고    scopus 로고
    • Iron deficiency in infancy and neurocognitive functioning at 19 years: Evidence of long-term deficits in executive function and recognition memory
    • Lukowski, A.F.; Koss, M.; Burden, M.J.; Jonides, J.; Nelson, C.A.; Kaciroti, N.; Jimenez, E.; Lozoff, B. Iron deficiency in infancy and neurocognitive functioning at 19 years: Evidence of long-term deficits in executive function and recognition memory. Nutr. Neurosci. 2010, 13, 54–70.
    • (2010) Nutr. Neurosci. , vol.13 , pp. 54-70
    • Lukowski, A.F.1    Koss, M.2    Burden, M.J.3    Jonides, J.4    Nelson, C.A.5    Kaciroti, N.6    Jimenez, E.7    Lozoff, B.8
  • 4
    • 79953314689 scopus 로고    scopus 로고
    • Iron-deficiency anemia in infancy and social emotional development in preschool-aged Chinese children
    • Chang, S.; Wang, L.; Wang, Y.; Brouwer, I.D.; Kok, F.J.; Lozoff, B.; Chen, C. Iron-deficiency anemia in infancy and social emotional development in preschool-aged Chinese children. Pediatrics 2011, 127, e927– e933.
    • (2011) Pediatrics , vol.127 , pp. e927-e933
    • Chang, S.1    Wang, L.2    Wang, Y.3    Brouwer, I.D.4    Kok, F.J.5    Lozoff, B.6    Chen, C.7
  • 5
    • 78650523557 scopus 로고    scopus 로고
    • Exercise as a mediator of hepcidin activity in athletes
    • Peeling, P. Exercise as a mediator of hepcidin activity in athletes. Eur. J. Appl. Physiol. 2010, 110, 877–883.
    • (2010) Eur. J. Appl. Physiol. , vol.110 , pp. 877-883
    • Peeling, P.1
  • 6
    • 33847781430 scopus 로고    scopus 로고
    • Iron treatment normalizes cognitive functioning in young women
    • Murray-Kolb, L.E.; Beard, J.L. Iron treatment normalizes cognitive functioning in young women. Am. J. Clin. Nutr. 2007, 85, 778–787.
    • (2007) Am. J. Clin. Nutr. , vol.85 , pp. 778-787
    • Murray-Kolb, L.E.1    Beard, J.L.2
  • 7
    • 0016227179 scopus 로고
    • Trace elements in foetal and early postnatal development
    • Widdowson, E.M. Trace elements in foetal and early postnatal development. Proc. Nutr. Soc. 1974, 33, 275–284.
    • (1974) Proc. Nutr. Soc. , vol.33 , pp. 275-284
    • Widdowson, E.M.1
  • 9
    • 0031423574 scopus 로고    scopus 로고
    • Intravenous iron supplementation effect on tissue iron and hemoproteins in chronically phlebotomized lambs
    • Guiang, S.F., III; Georgieff, M.K.; Lambert, D.J.; Schmidt, R.L.; Widness, J.A. Intravenous iron supplementation effect on tissue iron and hemoproteins in chronically phlebotomized lambs. Am. J. Physiol. 1997, 273, R2124–R2131.
    • (1997) Am. J. Physiol , vol.273 , pp. R2124-R2131
    • Guiang, S.F.1    Georgieff, M.K.2    Lambert, D.J.3    Schmidt, R.L.4    Widness, J.A.5
  • 10
    • 0029162767 scopus 로고
    • Reduced neonatal liver iron concentrations after uteroplacental insufficiency
    • Georgieff, M.K.; MM, M.I.; Gordon, K.; Wobken, J.D. Reduced neonatal liver iron concentrations after uteroplacental insufficiency. J. Pediatr. 1995, 127, 308–304.
    • (1995) J. Pediatr. , vol.127 , pp. 308-304
    • Georgieff, M.K.1    Mm, M.I.2    Gordon, K.3    Wobken, J.D.4
  • 11
    • 0016742687 scopus 로고
    • Brain iron: Persistent deficiency following short-term iron deprivation in the young rat
    • Dallman, P.R.; Siimes, M.A.; Manies, E.C. Brain iron: Persistent deficiency following short-term iron deprivation in the young rat. Br. J. Haematol. 1975, 31, 209–215.
    • (1975) Br. J. Haematol. , vol.31 , pp. 209-215
    • Dallman, P.R.1    Siimes, M.A.2    Manies, E.C.3
  • 13
    • 41149144581 scopus 로고    scopus 로고
    • Csf proteomic analysis reveals persistent iron deficiency-induced alterations in non-human primate infants
    • Geguchadze, R.N.; Coe, C.L.; Lubach, G.R.; Clardy, T.W.; Beard, J.L.; Connor, J.R. Csf proteomic analysis reveals persistent iron deficiency-induced alterations in non-human primate infants. J. Neurochem. 2008, 105, 127–136.
    • (2008) J. Neurochem. , vol.105 , pp. 127-136
    • Geguchadze, R.N.1    Coe, C.L.2    Lubach, G.R.3    Clardy, T.W.4    Beard, J.L.5    Connor, J.R.6
  • 14
    • 0026580959 scopus 로고
    • Fetal iron and cytochrome c status after intrauterine hypoxemia and erythropoietin administration
    • Georgieff, M.K.; Schmidt, R.L.; Mills, M.M.; Radmer, W.J.; Widness, J.A. Fetal iron and cytochrome c status after intrauterine hypoxemia and erythropoietin administration. Am. J. Physiol. 1992, 262, R485– R491.
    • (1992) Am. J. Physiol. , vol.262 , pp. R485-R491
    • Georgieff, M.K.1    Schmidt, R.L.2    Mills, M.M.3    Radmer, W.J.4    Widness, J.A.5
  • 15
    • 0141639898 scopus 로고    scopus 로고
    • Perinatal iron deficiency alters the neurochemical profile of the developing rat hippocampus
    • Rao, R.; Tkac, I.; Townsend, E.L.; Gruetter, R.; Georgieff, M.K. Perinatal iron deficiency alters the neurochemical profile of the developing rat hippocampus. J. Nutr. 2003, 133, 3215–3221.
    • (2003) J. Nutr. , vol.133 , pp. 3215-3221
    • Rao, R.1    Tkac, I.2    Townsend, E.L.3    Gruetter, R.4    Georgieff, M.K.5
  • 16
    • 0037097199 scopus 로고    scopus 로고
    • Developmental changes in the expression of iron regulatory proteins and iron transport proteins in the perinatal rat brain
    • Siddappa, A.J.; Rao, R.B.; Wobken, J.D.; Leibold, E.A.; Connor, J.R.; Georgieff, M.K. Developmental changes in the expression of iron regulatory proteins and iron transport proteins in the perinatal rat brain. J. Neurosci. Res. 2002, 68, 761–775.
    • (2002) J. Neurosci. Res. , vol.68 , pp. 761-775
    • Siddappa, A.J.1    Rao, R.B.2    Wobken, J.D.3    Leibold, E.A.4    Connor, J.R.5    Georgieff, M.K.6
  • 17
    • 84863784294 scopus 로고    scopus 로고
    • Temporal manipulation of transferrin-receptor-1-dependent iron uptake identifies a sensitive period in mouse hippocampal neurodevelopment
    • Fretham, S.J.; Carlson, E.S.; Wobken, J.; Tran, P.V.; Petryk, A.; Georgieff, M.K. Temporal manipulation of transferrin-receptor-1-dependent iron uptake identifies a sensitive period in mouse hippocampal neurodevelopment. Hippocampus 2012, 22, 1691–1702.
    • (2012) Hippocampus , vol.22 , pp. 1691-1702
    • Fretham, S.J.1    Carlson, E.S.2    Wobken, J.3    Tran, P.V.4    Petryk, A.5    Georgieff, M.K.6
  • 18
    • 80155160039 scopus 로고    scopus 로고
    • Long-term brain and behavioral consequences of early iron deficiency
    • Georgieff, M.K. Long-term brain and behavioral consequences of early iron deficiency. Nutr. Rev. 2011, 69 (Suppl. 1), S43–S48.
    • (2011) Nutr. Rev , vol.69 , pp. S43-S48
    • Georgieff, M.K.1
  • 19
    • 16444380593 scopus 로고    scopus 로고
    • Relation of neonatal iron status to individual variability in neonatal temperament
    • Wachs, T.D.; Pollitt, E.; Cueto, S.; Jacoby, E.; Creed-Kanashiro, H. Relation of neonatal iron status to individual variability in neonatal temperament. Dev. Psychobiol. 2005, 46, 141–153.
    • (2005) Dev. Psychobiol. , vol.46 , pp. 141-153
    • Wachs, T.D.1    Pollitt, E.2    Cueto, S.3    Jacoby, E.4    Creed-Kanashiro, H.5
  • 20
  • 21
    • 85015161891 scopus 로고    scopus 로고
    • Impact of fetal-neonatal iron deficiency on recognition memory at 2 months of age
    • Geng, F.; Mai, X.; Zhan, J.; Xu, L.; Zhao, Z.; Georgieff, M.; Shao, J.; Lozoff, B. Impact of fetal-neonatal iron deficiency on recognition memory at 2 months of age. J. Pediatr. 2015, 167, 1226–1232.
    • (2015) J. Pediatr. , vol.167 , pp. 1226-1232
    • Geng, F.1    Mai, X.2    Zhan, J.3    Xu, L.4    Zhao, Z.5    Georgieff, M.6    Shao, J.7    Lozoff, B.8
  • 22
    • 0036184842 scopus 로고    scopus 로고
    • Cord serum ferritin concentrations and mental and psychomotor development of children at five years of age
    • Tamura, T.; Goldenberg, R.L.; Hou, J.; Johnston, K.E.; Cliver, S.P.; Ramey, S.L.; Nelson, K.G. Cord serum ferritin concentrations and mental and psychomotor development of children at five years of age. J. Pediatr. 2002, 140, 165–170.
    • (2002) J. Pediatr. , vol.140 , pp. 165-170
    • Tamura, T.1    Goldenberg, R.L.2    Hou, J.3    Johnston, K.E.4    Cliver, S.P.5    Ramey, S.L.6    Nelson, K.G.7
  • 24
    • 76749147280 scopus 로고    scopus 로고
    • In utero iron status and auditory neural maturation in premature infants as evaluated by auditory brainstem response
    • Amin, S.B.; Orlando, M.; Eddins, A.; MacDonald, M.; Monczynski, C.; Wang, H. In utero iron status and auditory neural maturation in premature infants as evaluated by auditory brainstem response. J. Pediatr. 2010, 156, 377–381.
    • (2010) J. Pediatr. , vol.156 , pp. 377-381
    • Amin, S.B.1    Orlando, M.2    Eddins, A.3    Macdonald, M.4    Monczynski, C.5    Wang, H.6
  • 26
    • 33745502924 scopus 로고    scopus 로고
    • Long-lasting neural and behavioral effects of iron deficiency in infancy
    • Lozoff, B.; Beard, J.; Connor, J.; Barbara, F.; Georgieff, M.; Schallert, T. Long-lasting neural and behavioral effects of iron deficiency in infancy. Nutr. Rev. 2006, 64, S34–S91.
    • (2006) Nutr. Rev , vol.64 , pp. S34-S91
    • Lozoff, B.1    Beard, J.2    Connor, J.3    Barbara, F.4    Georgieff, M.5    Schallert, T.6
  • 27
    • 84886724011 scopus 로고    scopus 로고
    • Functional significance of early-life iron deficiency: Outcomes at 25 years
    • Lozoff, B.; Smith, J.B.; Kaciroti, N.; Clark, K.M.; Guevara, S.; Jimenez, E. Functional significance of early-life iron deficiency: Outcomes at 25 years. J. Pediatr. 2013, 163, 1260–1266.
    • (2013) J. Pediatr. , vol.163 , pp. 1260-1266
    • Lozoff, B.1    Smith, J.B.2    Kaciroti, N.3    Clark, K.M.4    Guevara, S.5    Jimenez, E.6
  • 28
    • 84876407703 scopus 로고    scopus 로고
    • Metabolomic analysis of cerebrospinal fluid indicates iron deficiency compromises cerebral energy metabolism in the infant monkey
    • Rao, R.; Ennis, K.; Oz, G.; Lubach, G.R.; Georgieff, M.K.; Coe, C.L. Metabolomic analysis of cerebrospinal fluid indicates iron deficiency compromises cerebral energy metabolism in the infant monkey. Neurochem. Res. 2013, 38, 573–580.
    • (2013) Neurochem. Res. , vol.38 , pp. 573-580
    • Rao, R.1    Ennis, K.2    Oz, G.3    Lubach, G.R.4    Georgieff, M.K.5    Coe, C.L.6
  • 29
    • 34247102590 scopus 로고    scopus 로고
    • Gestational and lactational iron deficiency alters the developing striatal metabolome and associated behaviors in young rats
    • Ward, K.L.; Tkac, I.; Jing, Y.; Felt, B.; Beard, J.; Connor, J.; Schallert, T.; Georgieff, M.K.; Rao, R. Gestational and lactational iron deficiency alters the developing striatal metabolome and associated behaviors in young rats. J. Nutr. 2007, 137, 1043–1049.
    • (2007) J. Nutr. , vol.137 , pp. 1043-1049
    • Ward, K.L.1    Tkac, I.2    Jing, Y.3    Felt, B.4    Beard, J.5    Connor, J.6    Schallert, T.7    Georgieff, M.K.8    Rao, R.9
  • 31
    • 77955097786 scopus 로고    scopus 로고
    • Gestational and neonatal iron deficiency alters apical dendrite structure of ca1 pyramidal neurons in adult rat hippocampus
    • Brunette, K.E.; Tran, P.V.; Wobken, J.D.; Carlson, E.S.; Georgieff, M.K. Gestational and neonatal iron deficiency alters apical dendrite structure of ca1 pyramidal neurons in adult rat hippocampus. Dev. Neurosci. 2010, 32, 238–248.
    • (2010) Dev. Neurosci. , vol.32 , pp. 238-248
    • Brunette, K.E.1    Tran, P.V.2    Wobken, J.D.3    Carlson, E.S.4    Georgieff, M.K.5
  • 32
    • 57349165847 scopus 로고    scopus 로고
    • Early-life iron deficiency anemia alters neurotrophic factor expression and hippocampal neuron differentiation in male rats
    • Tran, P.V.; Carlson, E.S.; Fretham, S.J.; Georgieff, M.K. Early-life iron deficiency anemia alters neurotrophic factor expression and hippocampal neuron differentiation in male rats. J. Nutr. 2008, 138, 2495–2501.
    • (2008) J. Nutr. , vol.138 , pp. 2495-2501
    • Tran, P.V.1    Carlson, E.S.2    Fretham, S.J.3    Georgieff, M.K.4
  • 33
    • 84856199026 scopus 로고    scopus 로고
    • Gestational-neonatal iron deficiency suppresses and iron treatment reactivates IGF signaling in developing rat hippocampus
    • Tran, P.V.; Fretham, S.J.; Wobken, J.; Miller, B.S.; Georgieff, M.K. Gestational-neonatal iron deficiency suppresses and iron treatment reactivates IGF signaling in developing rat hippocampus. Am. J. Physiol. Endocrinol. Metab. 2012, 302, E316–E324.
    • (2012) Am. J. Physiol. Endocrinol. Metab. , vol.302 , pp. E316-E324
    • Tran, P.V.1    Fretham, S.J.2    Wobken, J.3    Miller, B.S.4    Georgieff, M.K.5
  • 34
    • 84867993283 scopus 로고    scopus 로고
    • Quantitative proteomic analyses of cerebrospinal fluid using iTRAQ in a primate model of iron deficiency anemia
    • Patton, S.M.; Coe, C.L.; Lubach, G.R.; Connor, J.R. Quantitative proteomic analyses of cerebrospinal fluid using iTRAQ in a primate model of iron deficiency anemia. Dev. Neurosci. 2012, 34, 354–365.
    • (2012) Dev. Neurosci , vol.34 , pp. 354-365
    • Patton, S.M.1    Coe, C.L.2    Lubach, G.R.3    Connor, J.R.4
  • 35
    • 34247857387 scopus 로고    scopus 로고
    • Early postnatal iron repletion overcomes lasting effects of gestational iron deficiency in rats
    • Beard, J.L.; Unger, E.L.; Bianco, L.E.; Paul, T.; Rundle, S.E.; Jones, B.C. Early postnatal iron repletion overcomes lasting effects of gestational iron deficiency in rats. J. Nutr. 2007, 137, 1176–1182.
    • (2007) J. Nutr. , vol.137 , pp. 1176-1182
    • Beard, J.L.1    Unger, E.L.2    Bianco, L.E.3    Paul, T.4    Rundle, S.E.5    Jones, B.C.6
  • 36
    • 84869121627 scopus 로고    scopus 로고
    • Behavior and monoamine deficits in prenatal and perinatal iron deficiency are not corrected by early postnatal moderate-iron or high-iron diets in rats
    • Unger, E.L.; Hurst, A.R.; Georgieff, M.K.; Schallert, T.; Rao, R.; Connor, J.R.; Kaciroti, N.; Lozoff, B.; Felt, B. Behavior and monoamine deficits in prenatal and perinatal iron deficiency are not corrected by early postnatal moderate-iron or high-iron diets in rats. J. Nutr. 2012, 142, 2040–2049.
    • (2012) J. Nutr. , vol.142 , pp. 2040-2049
    • Unger, E.L.1    Hurst, A.R.2    Georgieff, M.K.3    Schallert, T.4    Rao, R.5    Connor, J.R.6    Kaciroti, N.7    Lozoff, B.8    Felt, B.9
  • 37
    • 84872056251 scopus 로고    scopus 로고
    • Iron supplementation dose for perinatal iron deficiency differentially alters the neurochemistry of the frontal cortex and hippocampus in adult rats
    • Rao, R.; Tkac, I.; Unger, E.L.; Ennis, K.; Hurst, A.; Schallert, T.; Connor, J.; Felt, B.; Georgieff, M.K. Iron supplementation dose for perinatal iron deficiency differentially alters the neurochemistry of the frontal cortex and hippocampus in adult rats. Pediatr. Res. 2013, 73, 31–37.
    • (2013) Pediatr. Res. , vol.73 , pp. 31-37
    • Rao, R.1    Tkac, I.2    Unger, E.L.3    Ennis, K.4    Hurst, A.5    Schallert, T.6    Connor, J.7    Felt, B.8    Georgieff, M.K.9
  • 38
    • 78049422747 scopus 로고    scopus 로고
    • Committee on Nutrition American Academy of Pediatrics. Diagnosis and prevention of iron deficiency and iron-deficiency anemia in infants and young children (0–3 years of age)
    • Baker, R.D.; Greer, F.R.; Committee on Nutrition American Academy of Pediatrics. Diagnosis and prevention of iron deficiency and iron-deficiency anemia in infants and young children (0–3 years of age). Pediatrics 2010, 126, 1040–1050.
    • (2010) Pediatrics , vol.126 , pp. 1040-1050
    • Baker, R.D.1    Greer, F.R.2
  • 40
    • 84976417299 scopus 로고    scopus 로고
    • Iron is prioritized to red blood cells over the brain in phlebotomized anemic newborn lambs
    • Zamora, T.G.; Guiang, S.F., III; Georgieff, M.K.; Widness, J.A. Iron is prioritized to red blood cells over the brain in phlebotomized anemic newborn lambs. Pediatr. Res. 2016, 79, 922–928.
    • (2016) Pediatr. Res. , vol.79 , pp. 922-928
    • Zamora, T.G.1    Guiang, S.F.2    Georgieff, M.K.3    Widness, J.A.4
  • 42
    • 84927749455 scopus 로고    scopus 로고
    • Screening and routine supplementation for iron deficiency anemia: A systematic review
    • McDonagh, M.S.; Blazina, I.; Dana, T.; Cantor, A.; Bougatsos, C. Screening and routine supplementation for iron deficiency anemia: A systematic review. Pediatrics 2015, 135, 723–733.
    • (2015) Pediatrics , vol.135 , pp. 723-733
    • McDonagh, M.S.1    Blazina, I.2    Dana, T.3    Cantor, A.4    Bougatsos, C.5
  • 43
    • 77951427157 scopus 로고    scopus 로고
    • Eye-blinking rates are slower in infants with iron-deficiency anemia than in nonanemic iron-deficient or iron-sufficient infants
    • Lozoff, B.; Armony-Sivan, R.; Kaciroti, N.; Jing, Y.; Golub, M.; Jacobson, S.W. Eye-blinking rates are slower in infants with iron-deficiency anemia than in nonanemic iron-deficient or iron-sufficient infants. J. Nutr. 2010, 140, 1057–1061.
    • (2010) J. Nutr. , vol.140 , pp. 1057-1061
    • Lozoff, B.1    Armony-Sivan, R.2    Kaciroti, N.3    Jing, Y.4    Golub, M.5    Jacobson, S.W.6
  • 44
    • 85042304557 scopus 로고    scopus 로고
    • Metabolomic analysis of CSF indicates brain metabolic impairment precedes hematological indices of anemia in the iron-deficient infant monkey
    • Rao, R.; Ennis, K.; Lubach, G.R.; Lock, E.F.; Georgieff, M.K.; Coe, C.L. Metabolomic analysis of CSF indicates brain metabolic impairment precedes hematological indices of anemia in the iron-deficient infant monkey. Nutr. Neurosci. 2018, 38, 573–580.
    • (2018) Nutr. Neurosci. , vol.38 , pp. 573-580
    • Rao, R.1    Ennis, K.2    Lubach, G.R.3    Lock, E.F.4    Georgieff, M.K.5    Coe, C.L.6
  • 45
    • 0030378241 scopus 로고    scopus 로고
    • Iron-deficiency anemia and infant development: Effects of extended oral iron therapy
    • Lozoff, B.; Wolf, A.W.; Jimenez, E. Iron-deficiency anemia and infant development: Effects of extended oral iron therapy. J. Pediatr. 1996, 129, 382–389.
    • (1996) J. Pediatr. , vol.129 , pp. 382-389
    • Lozoff, B.1    Wolf, A.W.2    Jimenez, E.3
  • 46
    • 84886724116 scopus 로고    scopus 로고
    • Latent iron deficiency in utero is associated with abnormal auditory neural myelination in ≥35 weeks gestational age infants
    • Amin, S.B.; Orlando, M.; Wang, H. Latent iron deficiency in utero is associated with abnormal auditory neural myelination in ≥35 weeks gestational age infants. J. Pediatr. 2013, 163, 1267–1271.
    • (2013) J. Pediatr. , vol.163 , pp. 1267-1271
    • Amin, S.B.1    Orlando, M.2    Wang, H.3
  • 47
    • 0033575131 scopus 로고    scopus 로고
    • Reticulocyte hemoglobin content to diagnose iron deficiency in children
    • Brugnara, C.; Zurakowski, D.; DiCanzio, J.; Boyd, T.; Platt, O. Reticulocyte hemoglobin content to diagnose iron deficiency in children. JAMA 1999, 281, 2225–2230.
    • (1999) JAMA , vol.281 , pp. 2225-2230
    • Brugnara, C.1    Zurakowski, D.2    Dicanzio, J.3    Boyd, T.4    Platt, O.5
  • 48
    • 84964911794 scopus 로고    scopus 로고
    • Absolute reticulocyte count and reticulocyte hemoglobin content as predictors of early response to exclusive oral iron in children with iron deficiency anemia
    • Parodi, E.; Giraudo, M.T.; Ricceri, F.; Aurucci, M.L.; Mazzone, R.; Ramenghi, U. Absolute reticulocyte count and reticulocyte hemoglobin content as predictors of early response to exclusive oral iron in children with iron deficiency anemia. Anemia 2016, 2016, 7345835, doi:10.1155/2016/7345835.
    • (2016) Anemia , vol.2016
    • Parodi, E.1    Giraudo, M.T.2    Ricceri, F.3    Aurucci, M.L.4    Mazzone, R.5    Ramenghi, U.6
  • 49
    • 84887595383 scopus 로고    scopus 로고
    • Effect of daily iron supplementation on health in children aged 4–23 months: A systematic review and meta-analysis of randomised controlled trials
    • Pasricha, S.R.; Hayes, E.; Kalumba, K.; Biggs, B.A. Effect of daily iron supplementation on health in children aged 4–23 months: A systematic review and meta-analysis of randomised controlled trials. Lancet Glob. Health 2013, 1, e77–e86.
    • (2013) Lancet Glob. Health , vol.1
    • Pasricha, S.R.1    Hayes, E.2    Kalumba, K.3    Biggs, B.A.4
  • 50
    • 84942849018 scopus 로고    scopus 로고
    • Screening for iron deficiency anemia in young children: Uspstf recommendation statement
    • Siu, A.L.; Force, U.S.P.S.T. Screening for iron deficiency anemia in young children: Uspstf recommendation statement. Pediatrics 2015, 136, 746–752.
    • (2015) Pediatrics , vol.136 , pp. 746-752
    • Siu, A.L.1
  • 51
    • 0027987099 scopus 로고
    • Prevention of iron deficiency and psychomotor decline in high-risk infants through use of iron-fortified infant formula: A randomized clinical trial
    • Moffatt, M.E.; Longstaffe, S.; Besant, J.; Dureski, C. Prevention of iron deficiency and psychomotor decline in high-risk infants through use of iron-fortified infant formula: A randomized clinical trial. J. Pediatr. 1994, 125, 527–534.
    • (1994) J. Pediatr. , vol.125 , pp. 527-534
    • Moffatt, M.E.1    Longstaffe, S.2    Besant, J.3    Dureski, C.4
  • 52
    • 0344276474 scopus 로고    scopus 로고
    • A double-masked, randomized control trial of iron supplementation in early infancy in healthy term breast-fed infants
    • Friel, J.K.; Aziz, K.; Andrews, W.L.; Harding, S.V.; Courage, M.L.; Adams, R.J. A double-masked, randomized control trial of iron supplementation in early infancy in healthy term breast-fed infants. J. Pediatr. 2003, 143, 582–586.
    • (2003) J. Pediatr. , vol.143 , pp. 582-586
    • Friel, J.K.1    Aziz, K.2    Andrews, W.L.3    Harding, S.V.4    Courage, M.L.5    Adams, R.J.6
  • 53
    • 84901365706 scopus 로고    scopus 로고
    • Iron stores of breastfed infants during the first year of life
    • Ziegler, E.E.; Nelson, S.E.; Jeter, J.M. Iron stores of breastfed infants during the first year of life. Nutrients 2014, 6, 2023–2034.
    • (2014) Nutrients , vol.6 , pp. 2023-2034
    • Ziegler, E.E.1    Nelson, S.E.2    Jeter, J.M.3
  • 54
    • 0347273033 scopus 로고    scopus 로고
    • Iron. In Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc
    • Washington, DC, USA
    • Institue of Medicine. Iron. In Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc; National Academy Press: Washington, DC, USA, 2001; pp. 290–393.
    • (2001) National Academy Press , pp. 290-393
  • 57
    • 84901020592 scopus 로고    scopus 로고
    • Prevalence of anemia in pregnant women and its effect on neonatal outcomes in northeast India
    • Bora, R.; Sable, C.; Wolfson, J.; Boro, K.; Rao, R. Prevalence of anemia in pregnant women and its effect on neonatal outcomes in northeast India. J. Matern. Fetal Neonatal Med. 2014, 27, 887–891.
    • (2014) J. Matern. Fetal Neonatal Med. , vol.27 , pp. 887-891
    • Bora, R.1    Sable, C.2    Wolfson, J.3    Boro, K.4    Rao, R.5
  • 58
    • 84888859334 scopus 로고    scopus 로고
    • Effect of timing of umbilical cord clamping of term infants on maternal and neonatal outcomes
    • CD004074
    • McDonald, S.J.; Middleton, P.; Dowswell, T.; Morris, P.S. Effect of timing of umbilical cord clamping of term infants on maternal and neonatal outcomes. Cochrane Database Syst. Rev. 2013, CD004074, doi:10.1002/14651858.CD004074.pub3.
    • (2013) Cochrane Database Syst. Rev
    • McDonald, S.J.1    Middleton, P.2    Dowswell, T.3    Morris, P.S.4
  • 59
    • 84942983981 scopus 로고    scopus 로고
    • Effect of 40-cm segment umbilical cord milking on hemoglobin and serum ferritin at 6 months of age in full-term infants of anemic and non-anemic mothers
    • Bora, R.; Akhtar, S.S.; Venkatasubramaniam, A.; Wolfson, J.; Rao, R. Effect of 40-cm segment umbilical cord milking on hemoglobin and serum ferritin at 6 months of age in full-term infants of anemic and non-anemic mothers. J. Perinatol. 2015, 35, 832–836.
    • (2015) J. Perinatol. , vol.35 , pp. 832-836
    • Bora, R.1    Akhtar, S.S.2    Venkatasubramaniam, A.3    Wolfson, J.4    Rao, R.5
  • 61
    • 59649126243 scopus 로고    scopus 로고
    • Iron supplementation of breastfed infants from an early age
    • Ziegler, E.E.; Nelson, S.E.; Jeter, J.M. Iron supplementation of breastfed infants from an early age. Am. J. Clin. Nutr. 2009, 89, 525–532.
    • (2009) Am. J. Clin. Nutr. , vol.89 , pp. 525-532
    • Ziegler, E.E.1    Nelson, S.E.2    Jeter, J.M.3
  • 62
    • 30444459334 scopus 로고    scopus 로고
    • Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: Community-based, randomised, placebo-controlled trial
    • Sazawal, S.; Black, R.E.; Ramsan, M.; Chwaya, H.M.; Stoltzfus, R.J.; Dutta, A.; Dhingra, U.; Kabole, I.; Deb, S.; Othman, M.K.; et al. Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: Community-based, randomised, placebo-controlled trial. Lancet 2006, 367, 133–143.
    • (2006) Lancet , vol.367 , pp. 133-143
    • Sazawal, S.1    Black, R.E.2    Ramsan, M.3    Chwaya, H.M.4    Stoltzfus, R.J.5    Dutta, A.6    Dhingra, U.7    Kabole, I.8    Deb, S.9    Othman, M.K.10
  • 65
    • 84879888176 scopus 로고    scopus 로고
    • Effect of provision of daily zinc and iron with several micronutrients on growth and morbidity among young children in Pakistan: A cluster-randomised trial
    • Soofi, S.; Cousens, S.; Iqbal, S.P.; Akhund, T.; Khan, J.; Ahmed, I.; Zaidi, A.K.; Bhutta, Z.A. Effect of provision of daily zinc and iron with several micronutrients on growth and morbidity among young children in Pakistan: A cluster-randomised trial. Lancet 2013, 382, 29–40.
    • (2013) Lancet , vol.382 , pp. 29-40
    • Soofi, S.1    Cousens, S.2    Iqbal, S.P.3    Akhund, T.4    Khan, J.5    Ahmed, I.6    Zaidi, A.K.7    Bhutta, Z.A.8
  • 67
    • 34147196258 scopus 로고    scopus 로고
    • Effect of iron supplementation on haemoglobin response in children: Systematic review of randomised controlled trials
    • Gera, T.; Sachdev, H.P.; Nestel, P.; Sachdev, S.S. Effect of iron supplementation on haemoglobin response in children: Systematic review of randomised controlled trials. J. Pediatr. Gastroenterol. Nutr. 2007, 44, 468– 486.
    • (2007) J. Pediatr. Gastroenterol. Nutr. , vol.44 , pp. 468-486
    • Gera, T.1    Sachdev, H.P.2    Nestel, P.3    Sachdev, S.S.4
  • 68
    • 0038662619 scopus 로고    scopus 로고
    • Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
    • Nemeth, E.; Valore, E.V.; Territo, M.; Schiller, G.; Lichtenstein, A.; Ganz, T. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 2003, 101, 2461–2463.
    • (2003) Blood , vol.101 , pp. 2461-2463
    • Nemeth, E.1    Valore, E.V.2    Territo, M.3    Schiller, G.4    Lichtenstein, A.5    Ganz, T.6
  • 69
    • 84901443702 scopus 로고    scopus 로고
    • Combinatorial effects of malaria season, iron deficiency, and inflammation determine plasma hepcidin concentration in African children
    • Atkinson, S.H.; Armitage, A.E.; Khandwala, S.; Mwangi, T.W.; Uyoga, S.; Bejon, P.A.; Williams, T.N.; Prentice, A.M.; Drakesmith, H. Combinatorial effects of malaria season, iron deficiency, and inflammation determine plasma hepcidin concentration in African children. Blood 2014, 123, 3221–3229.
    • (2014) Blood , vol.123 , pp. 3221-3229
    • Atkinson, S.H.1    Armitage, A.E.2    Khandwala, S.3    Mwangi, T.W.4    Uyoga, S.5    Bejon, P.A.6    Williams, T.N.7    Prentice, A.M.8    Drakesmith, H.9
  • 73
    • 84988354654 scopus 로고    scopus 로고
    • Delaying iron therapy until 28 days after antimalarial treatment is associated with greater iron incorporation and equivalent hematologic recovery after 56 days in children: A randomized controlled trial
    • Cusick, S.E.; Opoka, R.O.; Abrams, S.A.; John, C.C.; Georgieff, M.K.; Mupere, E. Delaying iron therapy until 28 days after antimalarial treatment is associated with greater iron incorporation and equivalent hematologic recovery after 56 days in children: A randomized controlled trial. J. Nutr. 2016, 146, 1769– 1774.
    • (2016) J. Nutr. , vol.146 , pp. 1769-1774
    • Cusick, S.E.1    Opoka, R.O.2    Abrams, S.A.3    John, C.C.4    Georgieff, M.K.5    Mupere, E.6
  • 74
    • 85028680714 scopus 로고    scopus 로고
    • Delaying the start of iron until 28 days after antimalarial treatment is associated with lower incidence of subsequent illness in children with malaria and iron deficiency
    • Jaramillo, E.G.; Mupere, E.; Opoka, R.O.; Hodges, J.S.; Lund, T.C.; Georgieff, M.K.; John, C.C.; Cusick, S.E. Delaying the start of iron until 28 days after antimalarial treatment is associated with lower incidence of subsequent illness in children with malaria and iron deficiency. PLoS One 2017, 12, e0183977, doi:10.1371/journal.pone.0183977.
    • (2017) Plos One , vol.12
    • Jaramillo, E.G.1    Mupere, E.2    Opoka, R.O.3    Hodges, J.S.4    Lund, T.C.5    Georgieff, M.K.6    John, C.C.7    Cusick, S.E.8
  • 76
    • 84928881926 scopus 로고    scopus 로고
    • Iron fortification adversely affects the gut microbiome, increases pathogen abundance and induces intestinal inflammation in Kenyan infants
    • Jaeggi, T.; Kortman, G.A.; Moretti, D.; Chassard, C.; Holding, P.; Dostal, A.; Boekhorst, J.; Timmerman, H.M.; Swinkels, D.W.; Tjalsma, H.; et al. Iron fortification adversely affects the gut microbiome, increases pathogen abundance and induces intestinal inflammation in Kenyan infants. Gut 2015, 64, 731–742.
    • (2015) Gut , vol.64 , pp. 731-742
    • Jaeggi, T.1    Kortman, G.A.2    Moretti, D.3    Chassard, C.4    Holding, P.5    Dostal, A.6    Boekhorst, J.7    Timmerman, H.M.8    Swinkels, D.W.9    Tjalsma, H.10
  • 78
    • 85030999991 scopus 로고    scopus 로고
    • Prebiotic galacto-oligosaccharides mitigate the adverse effects of iron fortification on the gut microbiome: A randomised controlled study in Kenyan infants
    • Paganini, D.; Uyoga, M.A.; Kortman, G.A.M.; Cercamondi, C.I.; Moretti, D.; Barth-Jaeggi, T.; Schwab, C.; Boekhorst, J.; Timmerman, H.M.; Lacroix, C. et al. Prebiotic galacto-oligosaccharides mitigate the adverse effects of iron fortification on the gut microbiome: A randomised controlled study in Kenyan infants. Gut 2017, 66, 1956–1967.
    • (2017) Gut , vol.66 , pp. 1956-1967
    • Paganini, D.1    Uyoga, M.A.2    Kortman, G.A.M.3    Cercamondi, C.I.4    Moretti, D.5    Barth-Jaeggi, T.6    Schwab, C.7    Boekhorst, J.8    Timmerman, H.M.9    Lacroix, C.10
  • 80
    • 85003874497 scopus 로고    scopus 로고
    • Anemia offers stronger protection than sickle cell trait against the erythrocytic stage of falciparum malaria and this protection is reversed by iron supplementation
    • Goheen, M.M.; Wegmuller, R.; Bah, A.; Darboe, B.; Danso, E.; Affara, M.; Gardner, D.; Patel, J.C.; Prentice, A.M.; Cerami, C. Anemia offers stronger protection than sickle cell trait against the erythrocytic stage of falciparum malaria and this protection is reversed by iron supplementation. EBioMedicine 2016, 14, 123– 130.
    • (2016) Ebiomedicine , vol.14 , pp. 123-130
    • Goheen, M.M.1    Wegmuller, R.2    Bah, A.3    Darboe, B.4    Danso, E.5    Affara, M.6    Gardner, D.7    Patel, J.C.8    Prentice, A.M.9    Cerami, C.10
  • 82
    • 85037658552 scopus 로고    scopus 로고
    • Iron status of toddlers, nonpregnant females, and pregnant females in the United States
    • Gupta, P.M.; Hamner, H.C.; Suchdev, P.S.; Flores-Ayala, R.; Mei, Z. Iron status of toddlers, nonpregnant females, and pregnant females in the United States. Am. J. Clin. Nutr. 2017, 106, 1640S–1646S.
    • (2017) Am. J. Clin. Nutr. , vol.106 , pp. 1640S-1646S
    • Gupta, P.M.1    Hamner, H.C.2    Suchdev, P.S.3    Flores-Ayala, R.4    Mei, Z.5
  • 83
    • 85037624363 scopus 로고    scopus 로고
    • Excess iron intake as a factor in growth, infections, and development of infants and young children
    • Lonnerdal, B. Excess iron intake as a factor in growth, infections, and development of infants and young children. Am. J. Clin. Nutr. 2017, 106, 1681S–1687S.
    • (2017) Am. J. Clin. Nutr. , vol.106 , pp. 1681S-1687S
    • Lonnerdal, B.1
  • 84
    • 84941350242 scopus 로고    scopus 로고
    • Balancing benefits and risks of iron fortification in resource-rich countries
    • Krebs, N.F.; Domellof, M.; Ziegler, E. Balancing benefits and risks of iron fortification in resource-rich countries. J. Pediatr. 2015, 167, S20–S25.
    • (2015) J. Pediatr. , vol.167 , pp. S20-S25
    • Krebs, N.F.1    Domellof, M.2    Ziegler, E.3
  • 85
    • 84907321312 scopus 로고    scopus 로고
    • Circulating non-transferrin-bound iron after oral administration of supplemental and fortification doses of iron to healthy women: A randomized study
    • Brittenham, G.M.; Andersson, M.; Egli, I.; Foman, J.T.; Zeder, C.; Westerman, M.E.; Hurrell, R.F. Circulating non-transferrin-bound iron after oral administration of supplemental and fortification doses of iron to healthy women: A randomized study. Am. J. Clin. Nutr. 2014, 100, 813–820.
    • (2014) Am. J. Clin. Nutr. , vol.100 , pp. 813-820
    • Brittenham, G.M.1    Andersson, M.2    Egli, I.3    Foman, J.T.4    Zeder, C.5    Westerman, M.E.6    Hurrell, R.F.7
  • 86
    • 34250670302 scopus 로고    scopus 로고
    • Oxidative stress markers and antioxidant status after oral iron supplementation to very low birth weight infants
    • Braekke, K.; Bechensteen, A.G.; Halvorsen, B.L.; Blomhoff, R.; Haaland, K.; Staff, A.C. Oxidative stress markers and antioxidant status after oral iron supplementation to very low birth weight infants. J. Pediatr. 2007, 151, 23–28.
    • (2007) J. Pediatr. , vol.151 , pp. 23-28
    • Braekke, K.1    Bechensteen, A.G.2    Halvorsen, B.L.3    Blomhoff, R.4    Haaland, K.5    Staff, A.C.6
  • 87
    • 84863229124 scopus 로고    scopus 로고
    • Iron-fortified vs. Low-iron infant formula: Developmental outcome at 10 years
    • Lozoff, B.; Castillo, M.; Clark, K.M.; Smith, J.B. Iron-fortified vs. low-iron infant formula: Developmental outcome at 10 years. Arch. Pediatr. Adolesc. Med. 2012, 166, 208–215.
    • (2012) Arch. Pediatr. Adolesc. Med. , vol.166 , pp. 208-215
    • Lozoff, B.1    Castillo, M.2    Clark, K.M.3    Smith, J.B.4
  • 89
    • 0031083624 scopus 로고    scopus 로고
    • Risk of diarrhea related to iron content of infant formula: Lack of evidence to support the use of low-iron formula as a supplement for breastfed infants
    • Scariati, P.D.; Grummer-Strawn, L.M.; Fein, S.B.; Yip, R. Risk of diarrhea related to iron content of infant formula: Lack of evidence to support the use of low-iron formula as a supplement for breastfed infants. Pediatrics 1997, 99, E2, doi:10.1542/peds.99.3.e2.
    • (1997) Pediatrics , vol.99
    • Scariati, P.D.1    Grummer-Strawn, L.M.2    Fein, S.B.3    Yip, R.4
  • 90
    • 85037618740 scopus 로고    scopus 로고
    • The effects of iron fortification and supplementation on the gut microbiome and diarrhea in infants and children: A review
    • Paganini, D.; Zimmermann, M.B. The effects of iron fortification and supplementation on the gut microbiome and diarrhea in infants and children: A review. Am. J. Clin. Nutr. 2017, 106, 1688S–1693S.
    • (2017) Am. J. Clin. Nutr. , vol.106 , pp. 1688S-1693S
    • Paganini, D.1    Zimmermann, M.B.2
  • 91
    • 84941337137 scopus 로고    scopus 로고
    • Developmental physiology of iron absorption, homeostasis, and metabolism in the healthy term infant
    • Lonnerdal, B.; Georgieff, M.K.; Hernell, O. Developmental physiology of iron absorption, homeostasis, and metabolism in the healthy term infant. J. Pediatr. 2015, 167, S8–S14.
    • (2015) J. Pediatr. , vol.167 , pp. SS8-S14
    • Lonnerdal, B.1    Georgieff, M.K.2    Hernell, O.3
  • 92
    • 34547753552 scopus 로고    scopus 로고
    • The assessment of newborn iron stores at birth: A review of the literature and standards for ferritin concentrations
    • Siddappa, A.M.; Rao, R.; Long, J.D.; Widness, J.A.; Georgieff, M.K. The assessment of newborn iron stores at birth: A review of the literature and standards for ferritin concentrations. Neonatology 2007, 92, 73–82.
    • (2007) Neonatology , vol.92 , pp. 73-82
    • Siddappa, A.M.1    Rao, R.2    Long, J.D.3    Widness, J.A.4    Georgieff, M.K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.