CSF proteomic analysis reveals persistent iron deficiency-induced alterations in non-human primate infants

Journal of Neurochemistry

Volumn 105, Issue 1, 2008, Pages 127-136

  Geguchadze, Ramaz N ^a   Coe, Christopher L ^b   Lubach, Gabriele R ^b   Clardy, Thomas W ^a   Beard, John L ^c   Connor, James R ^a,d  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c PENNSYLVANIA STATE UNIVERSITY   (United States)

^d PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

CSF; Iron deficiency; Proteomics; Subhuman primates

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; PROSTAGLANDIN D SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR DISORDER; CEREBROSPINAL FLUID ANALYSIS; CONTROLLED STUDY; DIET SUPPLEMENTATION; HEMATOLOGICAL PARAMETERS; IRON DEFICIENCY ANEMIA; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MYELINATION; NONHUMAN; NUCLEOTIDE SEQUENCE; OLFACTORY RECEPTOR; PRIMATE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SLEEP DISORDER;

AGE FACTORS; ANEMIA, IRON-DEFICIENCY; ANIMALS; ANIMALS, NEWBORN; BODY WEIGHT; CEREBROSPINAL FLUID; DISEASE MODELS, ANIMAL; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; GLIAL FIBRILLARY ACIDIC PROTEIN; INTRAMOLECULAR OXIDOREDUCTASES; LIPOCALINS; MACACA MULATTA; PROTEIN ARRAY ANALYSIS; PROTEOMICS; RANDOM ALLOCATION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

ANIMALIA; PRIMATES;

EID: 41149144581     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2007.05113.x     Document Type: Article

References (43)

1. Albrechtsen M., Sorensen P. S., Gjerris F. Bock E. (1985) High cerebrospinal fluid concentration of glial fibrillary acidic protein (GFAP) in patients with normal pressure hydrocephalus. J. Neurol. Sci. 70, 269 274.
2. Allen R. P., Barker P. B., Wehrl F., Song H. K. Earley C. J. (2001) MRI measurement of brain iron in patients with restless legs syndrome. Neurology 56, 263 265.
3. Beard J., Finch C. A. Green W. L. (1982) Interactions of iron deficiency, anemia, and thyroid hormone levels in response of rats to cold exposure. Life Sci. 30, 691 697.
4. Beard J., Tobin B. Green W. (1989) Evidence for thyroid hormone deficiency in iron-deficient anemic rats. J. Nutr. 119, 772 778.
5. Borel M. J., Smith S. M., Derr J. Beard J. L. (1991) Day-to-day variation in iron-status indices in healthy men and women. Am. J. Clin. Nutr. 54, 729 735.
6. Burdo J. R., Menzies S. L., Simpson I. A., Garrick L. M., Garrick M. D., Dolan K. G., Haile D. J., Beard J. L. Conner J. R. (2001) Distribution of divalent metal transporter 1 and metal transport protein 1 in the normal and Belgrade rat. J. Neurosci. Res. 66, 1198 1207.
7. Clardy S. L., Earley C. J., Allen R. P., Beard J. L. Connor J. R. (2006a) Ferritin subunits in CSF are decreased in restless legs syndrome. J. Lab. Clin. Med. 147, 67 73.
8. Clardy S. L., Wang X., Zhao W., Liu W., Chase G. A., Beard J. L., Felt B. T. Connor J. R. (2006b) Acute and chronic affects of developmental iron deficiency on mRNA expression patterns in the brain. J. Neural Trans. Suppl. 71, 173 196.
9. Coe C. L., Lubach G. R. Shirtcliff E. A. (2007) Maternal stress during pregnancy predisposes for iron deficiency in infant monkeys impacting innate immunity. Pediatr. Res. 61, 520 524.
10. Der Perng M., Su M., Wen S. F., Li R., Gibbon T., Prescott A. R., Brenner M. Quinlan R. A. (2006) The Alexander disease-causing glial fibrillary acidic protein mutant, R416W, accumulates into Rosenthal fibers by a pathway that involves filament aggregation and the association of alpha B-crystallin and HSP27. Am. J. Hum. Genet. 79, 197 213.
11. Fisher J., Devraj K., Ingram J., Slagle-Webb B., Madhankumar A. B., Klinger M., Simpson I. A. Connor J. R. (2007) Ferritin: a novel mechanism for delivery of iron to the brain and other organs. Am. J. Physiol. Cell Physiol. 293, C641 C649.
12. Golub M. S., Hogrefe C. E., Germann S. L., Capitanio J. P. Lozoff B. (2006) Behavioral consequences of developmental iron deficiency in infant rhesus monkeys. Neurotoxicol. Teratol. 28, 3 17.
13. Gunshin H., Mackenzie B., Berger U. V., Gunshin Y., Romero M. F., Boron W. F., Nussberger S., Gollan J. L. Hediger M. A. (1997) Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388, 482 488.
14. Guyatt G. H., Oxman A. D., Ali M., Willan A., McIlroy W. Patterson C. (1992) Laboratory diagnosis of iron-deficiency anemia: an overview. J. Gen. Intern. Med. 7, 145 153.
15. Ho L., Luterman J. D., Aisen P. S., Pasinetti G. M., Montine T. J. Morrow J. D. (2000). Elevated CSF prostaglandin E2 levels in patients with probable AD. Neurology 55 (2 323.
16. Jensen B. M., Sando S. H., Grandjean P., Wiggers P. Dalhoj J. (1990) Screening with zinc protoporphyrin for iron deficiency in non-anemic female blood donors. Clin. Chem. 36, 846 848.
17. Joosten E. (2004) Strategies for the laboratory diagnosis of some common causes of anaemia in elderly patients. Gerontology 50, 49 56.
18. Kohgo Y., Niitsu Y., Kondo H., Kato J., Tsushima N., Sasaki K. et al. (1987) Serum transferrin receptor as a new index of erythropoiesis. Blood 70, 1955 1958.
19. Kovacs T. (2004) Mechanisms of olfactory dysfunction in aging and neurodegenerative disorders. Ageing Res Rev 3, 215 232.
20. Lau K. Y., Chan Y. L., Lam W. W., Li C. K. Metreweli C. (1998) Magnetic resonance imaging evaluation of the pituitary gland and hypothalamus in thalassaemic children with elevated serum ferritin levels. J. Paediatr. Child Health 34, 463 466.
21. Lozoff B., Beard J., Connor J., Barbara F., Georgieff M. Schallert T. (2006) Long-lasting neural and behavioral effects of iron deficiency in infancy. Nutr. Rev. 64, S34 S43.
22. Lubach G. R. Coe C. L. (2006) Preconception maternal iron status is a risk factor for iron deficiency in infant rhesus monkeys (Macaca mulatta). J. Nutr. 136, 2345 2349.
23. Lynch S. R. (2005) The impact of iron fortification on nutritional anemia. Best Pract. Res. Clin. Haematol. 18, 333 346.
24. Malmestrom C., Haghighi S., Rosengren L., Andersen O. Lycke J. (2003) Neurofilament light protein and glial fibrillary acidic protein as biological markers in MS. Neurology 61, 1720 1725.
25. McArthur J., Hill J., Paech M. J., Dodd P. H., Bennett E. J. Holden J. (2005) Cerebrospinal fluid and serum concentrations of beta-trace protein during pregnancy. Anaesthesia 60, 163 167.
26. Murphy C., Schubert C. R., Cruickshanks K. J., Klein B. E., Klein R. Nondahl D. M. (2002) Prevalence of olfactory impairment in older adults. JAMA 288, 2307 2312.
27. Ortiz E., Pasquini J. M., Thompson K., Felt B., Butkus G., Beard J. Connor J. R. (2004) Effect of manipulation of iron storage, transport, or availability on myelin composition and brain iron content in three different animal models. J. Neurosci. Res. 77, 681 689.
28. Prigge S. T., Boyington J. C., Faig M., Doctor K. S., Gaffney B. J. Amzel L. M. (1997) Structure and mechanism of lipoxygenases. Biochimie 79, 629 636.
29. Rao R. Georgieff M. K. (2001) Neonatal iron nutrition. Semin. Neonatol. 6, 425 435.
30. Rao R. Georgieff M. K. (2002) Perinatal aspects of iron metabolism. Acta Paediatr. Suppl. 91, 124 129.
31. Rohlff C. (2000) Proteomics in molecular medicine: applications in central nervous systems disorders. Electrophoresis 21, 1227 1234.
32. Roncagliolo M., Garrido M., Walter T., Peirano P. Lozoff B. (1998) Evidence of altered central nervous system development in infants with iron deficiency anemia at 6 mo: delayed maturation of auditory brainstem responses. Am. J. Clin. Nutr. 68, 683 690.
33. Sancho D., Gomez M. Sanchez-Madrid F. (2005) CD69 is an immunoregulatory molecule induced following activation. Trends Immunol. 26, 136 140.
34. Simakajornboon N., Gozal D., Vlasic V., Mack C., Sharon D. McGinley B. M. (2003) Periodic limb movements in sleep and iron status in children. Sleep 26, 735 738.
35. Szarfarc S. C. de Souza S. B. (1997) Prevalence and risk factors in iron deficiency and anemia. Arch. Latinoam. Nutr. 47, 35 38.
36. Tamachi T., Maezawa Y., Ikeda K., Iwamoto I. Nakajima H. (2006) Interleukin 25 in allergic airway inflammation. Int. Arch. Allergy Immunol. 140 (Suppl 1 59 62.
37. Tarasiuk A., Abdul-Hai A., Moser A., Freidman B., Tal A. Kapelushnik J. (2003) Sleep disruption and objective sleepiness in children with beta-thalassemia and congenital dyserythropoietic anemia. Arch. Pediatr. Adolesc. Med. 157, 463 468.
38. Thompson E. J. (2004) Cerebrospinal Fluid: CSF Proteins and Their Relevance in Research, Diagnostics and Treatment. Elsevier Academic Press, London
39. Ueno R., Honda K., Inoue S. Hayaishi O. (1983) Prostaglandin D2, a cerebral sleep-inducing substance in rats. Proc. Natl Acad. Sci. USA 80, 1735 1737.
40. Wilson R. S., Arnold S. E., Schneider J. A., Tang Y. Bennett D. A. (2007) The relationship between cerebral Alzheimer's disease pathology and odour identification in old age. J. Neurol Neurosurg. Psych. 78, 30 35.
41. Yuan X., Russell T., Wood G. Desiderio D. M. (2002) Analysis of the human lumbar cerebrospinal fluid proteome. Electrophoresis 23, 1185 1196.
42. Zappone E., Bellotti V., Cazzola M., Ceroni M., Meloni F., Pedrazzoli P. et al. (1986) Cerebrospinal fluid ferritin in human disease. Haematologica 71, 103 107.
43. Zecca L., Youdim M. B. H., Riederer P., Connor J. R. Crichton R. R. (2004) Iron, brain aging and neurodegenerative disorders. Nat. Rev. Neurosci. 5, 863 873.