Iron supplementation of breastfed infants from an early age

American Journal of Clinical Nutrition

Volumn 89, Issue 2, 2009, Pages 525-532

  Ziegler, Ekhard E ^a   Nelson, Steven E ^a   Jeter, Janice M ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; FERRITIN; FERROUS SULFATE; HEMOGLOBIN; IRON; MULTIVITAMIN; PLACEBO; RETINOL; TRANSFERRIN RECEPTOR; TRI VI SOL; UNCLASSIFIED DRUG; VITAMIN D;

ARTICLE; BLOOD ANALYSIS; BREAST FEEDING; CHILD; CLINICAL TRIAL; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG TOLERABILITY; EARLY INTERVENTION; FECES ANALYSIS; FECES COLOR; FEEDING BEHAVIOR; FEMALE; FERRITIN BLOOD LEVEL; GROWTH DISORDER; GROWTH REGULATION; HEMOGLOBIN BLOOD LEVEL; HUMAN; INFANCY; INFANT; INFANT DISEASE; IRON BLOOD LEVEL; IRON DEFICIENCY ANEMIA; IRON STORAGE; IRON THERAPY; LOOSE FECES; MAJOR CLINICAL STUDY; MALE; MEAN CORPUSCULAR VOLUME; OUTCOME ASSESSMENT; PATIENT MONITORING; PRESCHOOL CHILD; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; TREATMENT OUTCOME; VOMITING;

AGE FACTORS; ANEMIA, IRON-DEFICIENCY; BIOLOGICAL AVAILABILITY; BREAST FEEDING; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INFANT; INFANT FOOD; INFANT NUTRITIONAL PHYSIOLOGICAL PHENOMENA; INFANT, NEWBORN; IRON; MALE; MILK, HUMAN; NUTRITIONAL STATUS; PROSPECTIVE STUDIES; TREATMENT OUTCOME; WEANING;

EID: 59649126243     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.3945/ajcn.2008.26591     Document Type: Article

References (28)

1. Saarinen UM, Siimes MA, Dallman PR. Iron absorption in infants: high bioavailability of breast milk iron as indicated by the extrinsic tag method of iron absorption and by the concentration of serum ferritin. J Pediatr 1977;91:36-9.
2. Hicks PD, Zavaleta N, Chen Z, Absrams SA, Lönnerdal B. Iron deficiency, but not anemia, upregulates iron absorption in breast-fed Peruvian infants. J Nutr 2006;136:2435-8.
3. Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium and zinc. Washington, DC: National Academy Press, 2000.
4. Georgieff MK, Landon MB, Mills MM, et al. Abnormal iron distribution in infants of diabetic mothers: spectrum and maternal antecedents. J Pediatr 1990;117:455-61.
5. Georgieff MK, Wewerka SW, Nelson CA, de Regnier R-A. Iron status at 9 months of infants with low iron stores at birth. J Pediatr 2002;141:405-9.
6. Tamura T, Goldenberg RL, Hou J, et al. Cord serum ferritin concentrations and mental psychomotor development of children at five years of age. J Pediatr 2002;140:165-70.
7. Makrides M, Leeson R, Gibson RA, Simmer K. A randomized controlled clinical trial of increased dietary iron in breast-fed infants. J Pediatr 1998;133:559-62.
8. Domellöf M, Cohen RJ, Dewey KG, Hernell O, Rivera LL, Lönnerdal B. Iron supplementation of breast-fed Honduran and Swedish infants from 4 to 9 months of age. J Pediatr 2001;138:679-87.
9. Lind T, Lönnerdal B, Persson L-A, Stenlund H, Tennefors K, Hernell O. Effects of weaning cereals with different phytate contents on hemoglobin, iron stores, and zinc: a randomized intervention in infants from 6 to 12 mo of age. Am J Clin Nutr 2003;78:168-75.
10. Hay G, Sandstad B, Whitelaw A, Borch-Iohnsen B. Iron status in a group of Norwegian children aged 6-24 months. Acta Paediatr 2004;93:592-8.
11. Lozoff B, De Andraca I, Castillo M, Smith JB, Walter T, Pino P. Behavioral and developmental effects of preventing iron-deficiency anemia in healthy full-term infants. Pediatrics 2003;112:846-54.
12. Michaelsen KF, Milman N, Samuelson G. A longitudinal study of iron status in healthy Danish infants: effects of early iron status, growth velocity, and dietary factors. Acta Paediatr 1995;84:1035-44.
13. Lozoff B, Beard J, Connor J, Felt B, Georgieff M, Schallert T. Long-lasting neural and behavioral effects of iron deficiency in infancy. Nutr Rev 2006;64:S34-43.
14. Idjradinata P, Watkins WE, Pollitt E. Adverse effect of iron supplementation on weight gain of iron-replete young children. Lancet 1994;343:1252-4.
15. Dewey KG, Dommellöf M, Cohen RJ, Rivera LL, Hernell O, Lönnerdal B. Iron supplementation affects growth and morbidity of breast-fed infants: results of a randomized trial in Sweden and Honduras. J Nutr 2002;132:3249-55.
16. Majumdar I, Paul P, Talib H, Ranga S. The effect of iron therapy on the growth of iron-replete and iron-deplete children. J Trop Pediatr 2003;49:84-8.
17. Lind T, Seswandhana R, Persson L-A, Lönnerdal B. Iron supplementation of iron-replete Indonesian infants is associated with reduced weight-for-age. Acta Paediatr 2008;97:770-5.
18. Ziegler EE, Jiang T, Romero E, Vinco A, Frantz JA, Nelson SE. Cow's milk and intestinal blood loss in late infancy. J Pediatr 1999;135:720-6.
19. 58Fe-labeled supplement. Pediatr Res 1995;38:373-8.
20. Fomon SJ, Nelson SE. Size and growth. In: Fomon SJ, ed. Nutrition of normal infants. St Louis, MO: Mosby, 1993:36-84.
21. Domellof M, Dewey KG, Lönnerdal B, Cohen RJ, Hernell O. The diagnostic criteria for iron deficiency should be reevaluated. J Nutr 2002;132:3680-6.
22. Beard JL, Murray-Kolb LE, Rosales FJ, Solomons NW, Angelilli ML. Interpretation of serum ferritin concentrations as indicators of total-body iron stores in survey populations: the role of biomarkers for the acute-phase response. Am J Clin Nutr 2006;84:1498-505.
23. Feelders RA, Vreugdenhil G, Eggermont AMM, Kuiper-Kramer PA, van Eijk HG, Swaak AJG. Regulation of iron metabolism in the acute-phase response: interferon γ and tumour necrosis factor α induce hypo-ferraemia, ferritin production, and a decrease in circulating transferrin receptors in cancer patients. Eur J Clin Invest 1998;28:520-7.
24. Ogden CL, Kuczmarski RJ, Flegal KM, et al. Centers for Disease Control and Prevention 2000 growth charts for the United States: improvements to the 1977 National Center for Health Statistics version. Pediatrics 2002;109:45-60.
25. Friel JK, Aziz K, Andrews WL, Harding SV, Courage ML, Adams RJ. A double-blind, randomized control trial of iron supplementation in early infancy in healthy term breast-fed infants. J Pediatr 2003;143:582-6.
26. Dijkhuizen MA, Wieringa FT, West CE, Martuti S, Muhilal. Effects of iron and zinc supplementation in Indonesian infants on micronutrient status and growth. J Nutr 2001;131:2860-5.
27. Hernell O, Lönnerdal B. Iron status of infants fed low-iron formula: no effect of added bovine lactoferrin or nucleotides. Am J Clin Nutr 2002;76:858-64.
28. DomellöfM, Lönnerdal B, Dewey KB, Cohen RJ, Rivera LL, Hernell O. Sex differences in iron status during infancy. Pediatrics 2002;110: 545-52.