Metabolomic analysis of cerebrospinal fluid indicates iron deficiency compromises cerebral energy metabolism in the infant monkey

Neurochemical Research

Volumn 38, Issue 3, 2013, Pages 573-580

  Rao, Raghavendra ^a,b   Ennis, Kathleen ^a   Oz, Gulin ^a   Lubach, Gabriele R ^c   Georgieff, Michael K ^a,b   Coe, Christopher L ^c  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Anemia; Cerebrospinal fluid; Infancy; Iron deficiency; Metabolomics; Primate

Indexed keywords

CITRIC ACID; GLUTAMINE; IRON; LACTIC ACID; PYRUVIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN METABOLISM; CENTRAL NERVOUS SYSTEM DISEASE; CEREBROSPINAL FLUID ANALYSIS; CONTROLLED STUDY; ENERGY METABOLISM; INFANCY; IRON DEFICIENCY ANEMIA; IRON INTAKE; IRON THERAPY; METABOLOMICS; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY; THERAPY EFFECT;

ANEMIA, IRON-DEFICIENCY; ANIMALS; BRAIN; CITRIC ACID; ENERGY METABOLISM; FEMALE; GLUTAMINE; IRON; LACTIC ACID; MACACA MULATTA; MAGNETIC RESONANCE IMAGING; METABOLOMICS; PYRUVIC ACID;

PRIMATES;

EID: 84876407703     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-012-0950-7     Document Type: Article

References (52)

1. Lozoff B, Beard J, Connor J, Barbara F, Georgieff M, Schallert T (2006) Long-lasting neural and behavioral effects of iron deficiency in infancy. Nutr Rev 64(5 Pt 2):S34-S43
2. Georgieff MK (2011) Long-term brain and behavioral consequences of early iron deficiency. Nutr Rev 69(Suppl 1):S43-S48
3. Beard JL, Felt B, Schallert T, Burhans M, Connor JR, Georgieff MK (2006) Moderate iron deficiency in infancy: biology and behavior in young rats. Behav Brain Res 170(2):224-232
4. Dallman PR (1986) Biochemical basis for the manifestations of iron deficiency. Ann Rev Nutr 6:13-40
5. Lai JC, White BK, Buerstatte CR, Haddad GG, Novotny EJ Jr, Behar KL (2003) Chronic hypoxia in development selectively alters the activities of key enzymes of glucose oxidative metabolism in brain regions. Neurochem Res 28(6):933-940
6. Raman L, Tkac I, Ennis K, Georgieff MK, Gruetter R, Rao R (2005) In vivo effect of chronic hypoxia on the neurochemical profile of the developing rat hippocampus. Brain Res Dev Brain Res 156(2):202-209
7. Unger EL, Hurst AR, Georgieff MK, Schallert T, Rao R, Connor JR, Kaciroti N, Lozoff B, Felt B (2012) Behavior and monoamine deficits in prenatal and perinatal iron deficiency are not corrected by early postnatal moderate-iron or high-iron diets in rats. J Nutr 142:2040-2049
8. Lukowski AF, Koss M, Burden MJ, Jonides J, Nelson CA, Kaciroti N, Jimenez E, Lozoff B (2010) Iron deficiency in infancy and neurocognitive functioning at 19 years: evidence of long-term deficits in executive function and recognition memory. Nutr Neurosci 13(2):54-70
9. Beard JL, Unger EL, Bianco LE, Paul T, Rundle SE, Jones BC (2007) Early postnatal iron repletion overcomes lasting effects of gestational iron deficiency in rats. J Nutr 137(5):1176-1182
10. Petry CD, Eaton MA, Wobken JD, Mills MM, Johnson DE, Georgieff MK (1992) Iron deficiency of liver, heart, and brain in newborn infants of diabetic mothers. J Pediatr 121(1):109-114
11. Guiang SF, Georgieff MK, Lambert DJ, Schmidt RL, Widness JA (1997) Intravenous iron supplementation effect on tissue iron and hemoproteins in chronically phlebotomized lambs. Am J Physiol 273(6 Pt 2):R2124-R2131
12. Nagashima H, Morio Y, Meshitsuka S, Yamane K, Nanjo Y, Teshima R (2010) High-resolution nuclear magnetic resonance spectroscopic study of metabolites in the cerebrospinal fluid of patients with cervical myelopathy and lumbar radiculopathy. Eur Spine J 19(8):1363-1368
13. Locasale JW, Melman T, Song S, Yang X, Swanson KD, Cantley LC, Wong ET, Asara JM (2012) Metabolomics of human cerebrospinal fluid identifies signatures of malignant glioma. Mol Cell Proteomics 11(6):M111 014688
14. Sinclair AJ, Viant MR, Ball AK, Burdon MA, Walker EA, Stewart PM, Rauz S, Young SP (2010) NMR-based metabolomic analysis of cerebrospinal fluid and serum in neurological diseases - a diagnostic tool? NMR Biomed 23(2):123-132
15. Noga MJ, Dane A, Shi S, Attali A, van Aken H, Suidgeest E, Tuinstra T, Muilwijk B, Coulier L, Luider T, Reijmers TH, Vreeken RJ, Hankemeier T (2012) Metabolomics of cerebrospinal fluid reveals changes in the central nervous system metabolism in a rat model of multiple sclerosis. Metabolomics 8(2):253-263
16. Verwaest KA, Vu TN, Laukens K, Clemens LE, Nguyen HP, Van Gasse B, Martins JC, Van Der Linden A, Dommisse R (2011) (1)H NMR based metabolomics of CSF and blood serum: a metabolic profile for a transgenic rat model of Huntington disease. Biochim Biophys Acta 1812(11):1371-1379
17. Rao R, Tkac I, Townsend EL, Gruetter R, Georgieff MK (2003) Perinatal iron deficiency alters the neurochemical profile of the developing rat hippocampus. J Nutr 133(10):3215-3221
18. Rao R, Tkac I, Schmidt AT, Georgieff MK (2011) Fetal and neonatal iron deficiency causes volume loss and alters the neurochemical profile of the adult rat hippocampus. Nutr Neurosci 14(2):59-65
19. Carlson ES, Fretham SJB, Unger E, O'Connor M, Petryk A, Schallert T, Rao R, Tkac I, Georgieff MK (2010) Hippocampus specific iron deficiency alters competition and cooperation between developing memory systems. J Neurodev Disord 2:133-143
20. Ward KL, Tkac I, Jing Y, Felt B, Beard J, Connor J, Schallert T, Georgieff MK, Rao R (2007) Gestational and lactational iron deficiency alters the developing striatal metabolome and associated behaviors in young rats. J Nutr 137(4):1043-1049
21. Rao R, Tkac I, Unger EL, Ennis K, Hurst A, Schallert T, Connor J, Felt B, Georgieff MK (2012) The iron supplementation dose for perinatal iron deficiency differentially alters the neurochemistry of frontal cortex and hippocampus in adult rats Pediatr Res. doi: 10.1038/pr.2012.143
22. Lubach GR, Coe CL (2006) Preconception maternal iron status is a risk factor for iron deficiency in infant rhesus monkeys (Macaca mulatta). J Nutr 136(9):2345-2349
23. Coe CL, Lubach GR, Busbridge M, Chapman R (2012) Optimal iron fortification of maternal diet during pregnancy and nursing for investigating and preventing iron deficiency in young rhesus monkey. Res Vet Sci. doi: 10.1016/j.rvsc.2012.11.017
24. Thorsdottir I, Gunnarsson BS, Atladottir H, Michaelsen KF, Palsson G (2003) Iron status at 12 months of age - effects of body size, growth and diet in a population with high birth weight. Eur J Clin Nutr 57(4):505-513
25. Georgieff MK, Wewerka SW, Nelson CA, Deregnier RA (2002) Iron status at 9 months of infants with low iron stores at birth. J Pediatr 141(3):405-409
26. Geguchadze RN, Coe CL, Lubach GR, Clardy TW, Beard JL, Connor JR (2008) CSF proteomic analysis reveals persistent iron deficiency-induced alterations in non-human primate infants. J Neurochem 105(1):127-136
27. Coe CL, Lubach GR, Bianco L, Beard JL (2009) A history of iron deficiency anemia during infancy alters brain monoamine activity later in juvenile monkeys. Dev Psychobiol 51(3):301-309
28. Patton SM, Coe CL, Lubach GR, Connor JR (2012) Quantitative proteomic analyses of cerebrospinal fluid using iTRAQ in a primate model of iron deficiency anemia. Dev Neurosci 34:354-365
29. Bicknese EJ, George JW, Hird DW, Paul-Murphy J, Anderson JA, Roberts JR (1993) Prevalence and risk factors for iron deficiency anemia in weanling rhesus macaques. Lab Anim Sci 43(5):434-438
30. Kreite MF, Champoux M, Suomi S (1995) Development of iron deficiency anemia in infant rhesus monkeys. Lab Animal Sci 45:15-21
31. Wevers RA, Engelke U, Wendel U, de Jong JG, Gabreels FJ, Heerschap A (1995) Standardized method for high-resolution 1H-NMR of cerebrospinal fluid. Clin Chem 41(5):744-751
32. Provencher SW (1993) Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med 30(6):672-679
33. Oz G, Tkac I, Charnas LR, Choi IY, Bjoraker KJ, Shapiro EG, Gruetter R (2005) Assessment of adrenoleukodystrophy lesions by high field MRS in non-sedated pediatric patients. Neurology 64(3):434-441
34. Henry PG, Oz G, Provencher S, Gruetter R (2003) Toward dynamic isotopomer analysis in the rat brain in vivo: automatic quantitation of 13C NMR spectra using LCModel. NMR Biomed 16(6-7):400-412
35. Govindaraju V, Young K, Maudsley AA (2000) Proton NMR chemical shifts and coupling constants for brain metabolites. NMR Biomed 13(3):129-153
36. Baker RD, Greer FR (2010) Diagnosis and prevention of iron deficiency and iron-deficiency anemia in infants and young children (0-3 years of age). Pediatrics 126(5):1040-1050
37. Rao R, Tkac I, Townsend EL, Ennis K, Gruetter R, Georgieff MK (2007) Perinatal iron deficiency predisposes the developing rat hippocampus to greater injury from mild to moderate hypoxia-ischemia. J Cereb Blood Flow Metab 27(4):729-740
38. Carlson ES, Tkac I, Magid R, O'Connor MB, Andrews NC, Schallert T, Gunshin H, Georgieff MK, Petryk A (2009) Iron is essential for neuron development and memory function in mouse hippocampus. J Nutr 139(4):672-679
39. deUngria M, Rao R, Wobken JD, Luciana M, Nelson CA, Georgieff MK (2000) Perinatal iron deficiency decreases cytochrome c oxidase (CytOx) activity in selected regions of neonatal rat brain. Pediatr Res 48(2):169-176
40. Vigani G (2012) Does a similar metabolic reprogramming occur in fe-deficient plant cells and animal tumor cells? Front Plant Sci 3:47
41. Rellan-Alvarez R, Andaluz S, Rodriguez-Celma J, Wohlgemuth G, Zocchi G, Alvarez-Fernandez A, Fiehn O, Lopez-Millan AF, Abadia J (2010) Changes in the proteomic and metabolic profiles of Beta vulgaris root tips in response to iron deficiency and resupply. BMC Plant Biol 10:120
42. Henderson SA, Dallman PR, Brooks GA (1986) Glucose turnover and oxidation are increased in the iron-deficient anemic rat. Am J Physiol 250(4 Pt 1):E414-E421
43. Brooks GA, Henderson SA, Dallman PR (1987) Increased glucose dependence in resting, iron-deficient rats. Am J Physiol 253(4 Pt 1):E461-E466
44. Oexle H, Gnaiger E, Weiss G (1999) Iron-dependent changes in cellular energy metabolism: influence on citric acid cycle and oxidative phosphorylation. Biochim Biophys Acta 1413(3):99-107
45. Taneja V, Mishra K, Agarwal KN (1986) Effect of early iron deficiency in rat on the gamma-aminobutyric acid shunt in brain. J Neurochem 46:1670-1674
46. Tanaka M, Kariya F, Kaihatsu K, Nakamura K, Asakura T, Kuroda Y, Ohira Y (1995) Effects of chronic iron deficiency anemia on brain metabolism. Jpn J Physiol 45:257-263
47. Mackler B, Person R, Miller LR, Inamdar AR, FInch CA (1978) Iron deficiency in the rat: biochemical studies of brain metabolism. Pediat Res 12:217-220
48. Sibson NR, Dhankhar A, Mason GF, Rothman DL, Behar KL, Shulman RG (1998) Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity. Proc Nat Acad Sci 95:316-321
49. Ohira Y, Chen CS, Hegenauer J, Saltman P (1983) Adaptations of lactate metabolism in iron-deficient rats. Proc Soc Exp Biol Med 173(2):213-216
50. Ben-Shachar D, Yehuda S, Finberg JP, Spanier I, Youdim MB (1988) Selective alteration in blood-brain barrier and insulin transport in iron-deficient rats. J Neurochem 50(5):1434-1437
51. Burdo JR, Connor JR (2003) Brain iron uptake and homeostatic mechanisms: an overview. Biometals 16(1):63-75
52. van Ommen B (2004) Nutrigenomics: exploiting systems biology in the nutrition and health arenas. Nutrition 20(1):4-8