Iron-deficiency anemia in infancy and social emotional development in preschool-aged Chinese children

Pediatrics

Volumn 127, Issue 4, 2011, Pages

  Chang, Suying ^a,b,e   Wang, Li ^c   Wang, Yuying ^a   Brouwer, Inge D ^b   Kok, Frans J ^b   Lozoff, Betsy ^d   Chen, Chunming ^a  

^a Chinese Center for Diseases Control and Prevention   (China)

^b WAGENINGEN UNIVERSITY   (Netherlands)

^c PEKING UNIVERSITY   (China)

^d UNIVERSITY OF MICHIGAN   (United States)

^e UNICEF   (United States)

Author keywords

Infants; Iron deficiency anemia; Preschool aged children; Social emotional developmental

Indexed keywords

CALCIUM; CYANOMETHEMOGLOBIN; HEMOGLOBIN; IRON; PROTEIN; RIBOFLAVIN; UNCLASSIFIED DRUG; VITAMIN D; ZINC;

AFFECT; ARTICLE; BLOOD SAMPLING; CHILD; CHILD BEHAVIOR; CHINESE; CLINICAL ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DISEASE DURATION; EMOTION; FEMALE; FRUSTRATION; HUMAN; INFANT; IRON DEFICIENCY ANEMIA; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; SOCIAL EVOLUTION;

ADAPTATION, PSYCHOLOGICAL; AFFECTIVE SYMPTOMS; ANEMIA, IRON-DEFICIENCY; CHILD BEHAVIOR DISORDERS; CHILD, PRESCHOOL; CHINA; CHRONIC DISEASE; CROSS-SECTIONAL STUDIES; DEVELOPING COUNTRIES; DIETARY SUPPLEMENTS; FEMALE; FRUSTRATION; HUMANS; IMPULSIVE BEHAVIOR; INCIDENCE; INFANT; INHIBITION (PSYCHOLOGY); IRON, DIETARY; LONGITUDINAL STUDIES; MALE; PERSONALITY ASSESSMENT; PSYCHOMETRICS; REFERENCE VALUES; RISK FACTORS; SELF STIMULATION; SOCIAL ADJUSTMENT; SOCIAL BEHAVIOR; SOCIAL ENVIRONMENT;

EID: 79953314689     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2010-1659     Document Type: Article

References (36)

1. Leung AK, Chan KW. Iron deficiency anemia. Adv Pediatr. 2001;48:385-408
2. Zhu Y, Liao Q. Prevalence of iron deficiency in children aged 7 months to 7 years in China. Zhonghua Er ke Za Zhi. 2004;42(12):886-891
3. Lozoff B. Iron deficiency and child development. Food Nutr Bull. 2007;28(4 suppl):S560-S571 (Pubitemid 351149506)
4. Lozoff B, Brittenham GM, Wolf AW, et al. Iron deficiency anemia and iron therapy effects on infant developmental test performance. Pediatrics. 1987;79(6):981-995 (Pubitemid 17079015)
5. Lozoff B, Wolf AW, Jimenez E. Iron-deficiency anemia and infant development: effects of extended oral iron therapy. J Pediatr. 1996;129(3):382-389 (Pubitemid 27484144)
6. Hokama T, Gushi Ken M, Nosoko N. Iron deficiency anaemia and child development. Asia Pac J Public Health. 2005;17(1):19-21 (Pubitemid 40994877)
7. Walter T, Kovalskys J, Stekel A. Effect of mild iron deficiency on infant mental development scores. J Pediatr. 1983;102(4):519-522 (Pubitemid 13114855)
8. Lozoff B, Brittenham GM, Viteri FE, Wolf AW, Urrutia JJ. The effects of short-term oral iron therapy on developmental deficits in iron-deficient anemic infants. J Pediatr. 1982;100(3):351-357 (Pubitemid 12179993)
9. Lozoff B, Beard J, Connor J, Barbara F, Georgieff M, Schallert T. Long-lasting neural and behavioral effects of iron deficiency in infancy. Nutr Rev. 2006;64(5 pt 2):S34-S43; discussion S72-S91
10. Lozoff B, Jimenez E, Hagen J, Mollen E, Wolf AW. Poorer behavioral and developmental outcome more than 10 years after treatment for iron deficiency in infancy. Pediatrics. 2000;105(4). Available at: www. pediatrics.org/cgi/content/ full/105/4/e51
11. Stoltzfus RJ, Mullany L, Black RE. Iron deficiency anemia. In: Ezzati M, Lopez AD, Rodgers A, Murray C, eds. Comparative Quantification of Health Risks: Global and Regional Burden of Disease Attributable to Selected Major Risk Factors. Geneva, Switzerland: World Health Organization; 2004
12. Levitsky DA. Malnutrition and hunger to learn. In: Levitsky DA, eds. Malnutrition, Environment, and Behavior. Ithaca, NY: Cornell University; 1979:161-179
13. Brown JL, Pollitt E. Malnutrition, poverty and intellectual development. Sci Am. 1996;274(2):38-43
14. Grantham-McGregor S, Ani C. A review of studies on the effect of iron deficiency on cognitive development in children. J Nutr. 2001;131(2S-2):649-668
15. De Andraca I, Walter T, Castillo M. Iron deficiency anemia and its effects upon psychological development at preschool age: a longitudinal study. In: Nestle Foundation Nutrition Annual Report (1990). Vevey, Switzerland: Nestec Ltd; 1991:53-62
16. Dommergues JP, Archambeaud MP, Ducot B, et al. Iron deficiency and psychomotor development tests: longitudinal study between 10 months and 4 years of age [in French]. Arch Fr Pediatr. 1989;46(7):487-490 (Pubitemid 19247157)
17. Palti H, Pevsner B, Adler B. Does anemia in infancy affect achievement on developmental and intelligence tests? Hum Biol. 1983;55(1):183-194
18. Lozoff B, Jimenez E, Wolf AW. Long-term developmental outcome of infants with iron deficiency. N Engl J Med. 1991;325(10):687-694
19. Tamura T, Goldenberg RL, Hou J, et al. Cord serum ferritin concentrations and mental and psychomotor development of children at five years of age. J Pediatr. 2002;140(2):165-170 (Pubitemid 34187621)
20. Corapci F, Radan AE, Lozoff B. Iron deficiency in infancy and mother-child interaction at 5 years. J Dev Behav Pediatr. 2006;27(5):371-378 (Pubitemid 44581125)
21. Chen C, Wang Y, Chang S. Effect of in-home fortification of complementary feeding on intellectual development of Chinese children. Biomed Environ Sci. 2010;23(2):83-91
22. Lozoff B, Corapci F, Burden MJ, et al. Preschool-aged children with iron deficiency anemia show altered affect and behavior. J Nutr. 2007;137(3):683-689 (Pubitemid 46397503)
23. Chen X, Hastings PD, Rubbin KH, Chen H, Cen G, Stewart SL. Child-rearing attitudes and behavioral inhibition in Chinese and Canadian toddlers: a cross-cultural study. Dev Psychol. 1998;34(4):677-686
24. World Health Organization. Iron Deficiency Anemia: Assessment, Prevention, and Control. A Guide for Programme Managers. Geneva, Switzerland: World Health Organization; 2001.Available at: www.who. int/nutrition/ publications/micronutrients/ anaemia-iron-deficiency/WHO-NHD-01.3/ en/index.html. Accessed February 2, 2011
25. Mischel W, Shoda Y, Rodriguez ML. Delay of gratification in children. Science. 1989; 244(4907):933-938
26. Rubin KH, Hastings PD, Stewart SL, Henderson HA, Chen XY. The consistency and concomitants of inhibition: Some of the children, all of the time. Child Dev. 1997;68(3):467-483 (Pubitemid 127456030)
27. Caspi A, Henry B, McGee RO, Moffitt TE, Silva PA. Temperamental origins of child and adolescent behavior problems: from age 3 to age 15. Child Dev. 1995;66(1):55-68
28. Lozoff B, Klein NK, Nelson EC, McClish DK, Manuel M, Chacon ME. Behavior of infants with iron-deficiency anemia. Child Dev. 1998;69(1):24-36 (Pubitemid 128453689)
29. Angulo-Kinzler RM, Peirano P, Lin E, Algarin C, Garrido M, Lozoff B. Twenty-four-hour motor activity in human infants with and without iron deficiency anemia. Early Hum Dev. 2002;70(1-2):85-101 (Pubitemid 35351307)
30. Lozoff B, Clark KM, Jing Y, Armony-Sivan R, Angelilli MR, Jacobson SW. Dose-response relationships between iron deficiency with or without anemia and infant social-emotional behavior. J Pediatr. 2008;152(5):696-702
31. Beard J, Felt B, Schallert T, Burhans M, Connor J, Georgieff M. Moderate iron deficiency in infancy: biology and behavior in young rats. Behav Brain Res. 2006;170(2):224-232
32. Beard J, Chen Q, Connor J, Jones B. Altered monoamine metabolism in caudate-putamen of iron-deficient rat. Pharmacol Biochem Behav. 1994;3(48):621-624 (Pubitemid 24216999)
33. Beard JL, Connor JR. Iron status and neural functioning. Annu Rev Nutr. 2003(23):41-58 (Pubitemid 37059715)
34. Zimmermann MB, Hurrell RF. Nutritional iron deficiency. Lancet. 2007;370(9586):511-520 (Pubitemid 47214636)
35. Wang Y, Chen C, Jia M, Fang J. Effect of complementary food supplements on anemia in infant and young children. Wei Sheng Yan Jiu. 2004;33(3):334-336
36. Dallman PR, Reeves JD, Driggers DA, Lo EY. Diagnosis of iron deficiency: the limitations of laboratory tests in predicting response to iron treatment in 1-year-old infants. J Pediatr. 1981;99(3):376-381 (Pubitemid 11029928)