Eye-blinking rates are slower in infants with iron-deficiency anemia than in nonanemic iron-deficient or iron-sufficient infants

Journal of Nutrition

Volumn 140, Issue 5, 2010, Pages 1057-1061

  Lozoff, Betsy ^a   Armony Sivan, Rinat ^b   Kaciroti, Niko ^a   Jing, Yuezhou ^a   Golub, Mari ^c   Jacobson, Sandra W ^d  

^a UNIVERSITY OF MICHIGAN   (United States)

^b ASHKELON ACADEMIC COLLEGE   (Israel)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE; IRON;

ARTICLE; BIRTH WEIGHT; BODY HEIGHT; CLINICAL ASSESSMENT; CONTROLLED STUDY; CORNEA REFLEX; FEMALE; GESTATIONAL AGE; HUMAN; INFANT; IRON DEFICIENCY ANEMIA; MAJOR CLINICAL STUDY; MALE; PROTEIN FUNCTION;

ANEMIA, IRON-DEFICIENCY; BLINKING; DOPAMINE; HUMANS; INFANT; IRON; MICHIGAN; POISSON DISTRIBUTION; REFERENCE VALUES; TIME FACTORS; TRACE ELEMENTS;

RODENTIA;

EID: 77951427157     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.110.120964     Document Type: Article

References (37)

1. Stoltzfus RJ, Mullany L, Black RE. Iron deficiency anaemia. In: Ezzati M, Lopez AD, Rodgers A, Murray CJL, editors. Comparative Quantification of health risks: global and regional burden of disease attributable to selected major risk factors. 1st vol. Geneva: WHO; 2004. p. 163-209.
2. McLean E, Cogswell M, Egli I, Wojdyla D, de Benoist B. Worldwide prevalence of anaemia, WHO Vitamin and Mineral Nutrition Information System, 1993-2005. Public Health Nutr. 2009;12:444-454
3. Brotanek JM, Halterman J, Auinger P, Flores G, Weitzman M. Iron deficiency, prolonged bottle-feeding, and racial/ethnic disparities in young children. Arch Pediatr Adolesc Med. 2005;159:1038-1042 (Pubitemid 41633363)
4. Brotanek JM, Gosz J, Weitzman M, Flores G. Secular trends in the prevalence of iron deficiency among US toddlers, 1976-2002. Arch Pediatr Adolesc Med. 2008;162:374-381
5. Beard JL, Felt B, Schallert T, Burhans M, Connor JR, Georgieff MK. Moderate iron deficiency in infancy: biology and behavior in young rats. Behav Brain Res. 2006;170:224-232
6. Burhans MS, Dailey C, Beard Z, Wiesinger J, Murray-Kolb L, Jones BC, Beard JL. Iron deficiency: differential effects on monoamine transporters. Nutr Neurosci. 2005;8:31-38 (Pubitemid 40637245)
7. Connor JR, Wang XS, Neely EB, Ponnuru P, Morita H, Beard J. Comparative study of the influence of Thy1 deficiency and dietary iron deficiency on dopaminergic profiles in the mouse striatum. J Neurosci Res. 2008;86:3194-3202
8. Beard JL, Connor JR. Iron status and neural functioning. Annu Rev Nutr. 2003;23:41-58.
9. Lozoff B, Beard J, Connor J, Felt B, Georgieff M, Schallert T. Long-lasting neural and behavioral effects of iron deficiency in infancy. Nutr Rev. 2006;64:S34-43. (Pubitemid 44606856)
10. Tsubota K. Tear dynamics and dry eye. Prog Retin Eye Res. 1998;17:565-596
11. Bacher LF, Smotherman WP. Spontaneous eye blinking in human infants: a review. Dev Psychobiol. 2004;44:95-102.
12. Pivik RT, Dykman RA. Endogenous eye blinks in preadolescents: relationship to information processing and performance. Biol Psychol. 2004;66:191-219.
13. Colzato LS, van Wouwe NC, Hommel B. Spontaneous eyeblink rate predicts the strength of visuomotor binding. Neuropsychologia. 2007;45:2387-2392 (Pubitemid 46678112)
14. Bacher LF, Smotherman WP. Systematic temporal variation in the rate of spontaneous eye blinking in human infants. Dev Psychobiol. 2004;44:140-145
15. Dreisbach G, Muller J, Goschke T, Strobel A, Schulze K, Lesch KP, Brocke B. Dopamine and cognitive control: the influence of spontaneous eyeblink rate and dopamine gene polymorphisms on perseveration and distractibility. Behav Neurosci. 2005;119:483-490 (Pubitemid 40547953)
16. Muller J, Dreisbach G, Brocke B, Lesch KP, Strobel A, Goschke T. Dopamine and cognitive control: the influence of spontaneous eyeblink rate, DRD4 exon III polymorphism and gender on flexibility in set-shifting. Brain Res. 2007;1131:155-162
17. Karson CN. Spontaneous eye-blink rates and dopaminergic systems. Brain. 1983;106:643-653
18. Lawrence MS, Redmond DE Jr. MPTP lesions and dopaminergic drugs alter eye blink rate in African green monkey. Pharmacol Biochem Behav. 1991;38:869-874
19. Elsworth JD, Lawrence MS, Roth RH, Taylor JR, Mailman RB, Nichols DE, Lewis MH, Redmond DE. D1 and D2 dopamine receptors independently regulate spontaneous blink rate in the vervet monkey. JPET. 1991;259:595-600.
20. Kleven MS, Koek W. Differential effects of direct and indirect dopamine agonists on eye blink rate in cynomolgus monkeys. JPET. 1996;279:1211-1219 (Pubitemid 27166767)
21. Karson CN, Staub RA, Kleinman JE, Wyatt RJ. Drug effects on blink rates in rhesus monkeys: preliminary studies. Biol Psychiatry. 1981;16:249-254
22. Karson CN. Physiology of normal and abnormal blinking. Adv Neurol. 1988;49:25-37.
23. Zametkin AJ, Stevens JR, Pittman R. Ontogeny of spontaneous blinking and of habituation of the blink reflex. Ann Neurol. 1979;5:453-457 (Pubitemid 9150138)
24. Doughty MJ. Further assessment of gender- and blink pattern-related differences in the spontaneous eyeblink activity in primary gaze in young adult humans. Optom Vis Sci. 2002;79:439-447
25. Zaman ML, Doughty MJ. Some methodological issues in the assessment of the spontaneous eyeblink frequency in man. Ophthalmic Physiol Opt. 1997;17:421-432
26. Lozoff B, Clark KM, Jing Y, Armony-Sivan R, Angelilli ML, Jacobson SW. Dose-response relationships between iron deficiency with or without anemia and infant social-emotional behavior. J Pediatr. 2008;152:696-702. (Pubitemid 351503532)
27. CDC. Recommendations to prevent and control iron deficiency in the United States. MMWR Rcomm Rep. 1998;47:1-29.
28. CDC. Healthy People: 2000 National Health Promotion and Disease Prevention objectives final review. Hyattsville (MD): Department of Health and Human Services; 2001.
29. Looker AC, Dallman P, Carroll MD, Gunter EW, Johnson CL. Prevalence of iron deficiency in the United States. JAMA. 1997;277:973-976 (Pubitemid 27142364)
30. Life Sciences Research Office. Assessment of the iron nutrition status of the U.S. population based on data collected in the Second National Health and Nutrition Survey, 1976-1980. Bethesda (MD): Federation of American Societies for Experimental Biology; 1984.
31. Dawson G, Klinger LG, Panagiotides H, Hill D, Spieker S. Frontal lobe activity and affective behavior of infants of mothers with depressive symptoms. Child Dev. 1992;63:725-737
32. Jones NA, Field T, Fox NA, Davalos M, Gomez C. EEG during different emotions in 10-month-old infants of depressed mothers. J Reprod Infant Psychol. 2001;19:295-312. (Pubitemid 34030585)
33. McCullagh P, Nelder JA. Generalized linear models. 2nd ed. London: Chapman and Hall; 1989.
34. Konrad K, Gauggel S, Schurek J. Catecholamine functioning in children with traumatic brain injuries and children with attention-deficit/hyperactivity disorder. Brain Res Cogn Brain Res. 2003;16:425-433 (Pubitemid 36423338)
35. Barbato G, Ficca G, Muscettola G, Fichele M, Beatrice M, Rinaldi F. Diurnal variation in spontaneous eye-blink rate. Psychiatry Res. 2000;93:145-151 (Pubitemid 30139481)
36. Lavezzo MM, Schellini SA, Padovani CR, Hirai FE. Eye blink in newborn and preschool-age children. Acta Ophthalmol. 2008;86:275-278
37. Bannon MJ, Michelhaugh SK, Wang J, Sacchetti P. The human dopamine transporter gene: gene organization, transcriptional regulation, and potential involvement in neuropsychiatric disorders. Eur Neuropsychopharmacol. 2001;11:449-455 (Pubitemid 33026519)