Maternal iron deficiency and the risk of schizophrenia in offspring

Archives of General Psychiatry

Volumn 65, Issue 10, 2008, Pages 1136-1144

  Insel, Beverly J ^a,b   Schaefer, Catherine A ^d,e,f   McKeague, Ian W ^b   Susser, Ezra S ^a,b,c   Brown, Alan S ^a,b,c  

^a NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^b Mailman School of Public Health ^*

^c College of Physicians and Surgeons ^*

^d Och Spine at New York Presbyterian Hospitals   (United States)

^e Division of Research

^f Unit 23 ^*

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN;

ADULT; ANEMIA; ARTICLE; BLOOD ANALYSIS; COHORT ANALYSIS; DISEASE PREDISPOSITION; EDUCATIONAL STATUS; ETHNICITY; FEMALE; HEMOGLOBIN BLOOD LEVEL; HEMOGLOBIN DETERMINATION; HUMAN; IRON DEFICIENCY; LABORATORY TEST; MAJOR CLINICAL STUDY; MATERNAL DISEASE; PREGNANCY; PROGENY; SCHIZOPHRENIA;

ADULT; ANEMIA, IRON-DEFICIENCY; BODY MASS INDEX; COHORT STUDIES; COMORBIDITY; CROSS-SECTIONAL STUDIES; FEMALE; HEMOGLOBINOMETRY; HUMANS; INFANT, LOW BIRTH WEIGHT; INFANT, NEWBORN; INFANT, PREMATURE, DISEASES; INFANT, SMALL FOR GESTATIONAL AGE; MALE; PREGNANCY; PREGNANCY COMPLICATIONS; PRENATAL EXPOSURE DELAYED EFFECTS; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; RETROSPECTIVE STUDIES; RISK FACTORS; SCHIZOPHRENIA;

EID: 53849141514     PISSN: 0003990X     EISSN: 15383636     Source Type: Journal    
DOI: 10.1001/archpsyc.65.10.1136     Document Type: Article

References (51)

1. Susser E, Matte TD. Early antecedents of adult health. J Urban Health. 1998;75(2):236-241.
2. Scholl TO, Reilly T. Anemia, iron and pregnancy outcome. J Nutr. 2000;130(2S suppl):443S-447S.
3. Cannon M, Jones PB, Murray RM. Obstetric complications and schizophrenia: historical and meta-analytic review. Am J Psychiatry. 2002;159(7):1080-1092.
4. Dalman C, Thomas HV, David AS, Gentz J, Lewis G, Allebeck P. Signs of asphyxia at birth and risk of schizophrenia: population-based case-control study. Br J Psychiatry. 2001;179:403-408.
5. Zornberg GL, Buka SL, Tsuang MT. Hypoxic-ischemia-related fetal/neonatal complications and risk of schizophrenia and other nonaffective psychoses: a 19-year longitudinal study. Am J Psychiatry. 2000;157(2):196-202.
6. McNeil TF, Cantor-Graae E, Ismail B. Obstetric complications and congenital malformation in schizophrenia. Brain Res Brain Res Rev. 2000;31(2-3):166-178.
7. Buka SL, Tsuang MT, Lipsitt LP. Pregnancy/delivery complications and psychiatric diagnosis: a prospective study. Arch Gen Psychiatry. 1993;50(2):151-156.
8. Cannon TD, Rosso IM, Hollister JM, Bearden CE, Sanchez LE, Hadley T. A prospective cohort study of genetic and perinatal influences in the etiology of schizophrenia. Schizophr Bull. 2000;26(2):351-366.
9. Susser E, Neugebauer R, Hoek HW, Brown AS, Lin S, Labovitz D, Gorman JM. Schizophrenia after prenatal famine: further evidence. Arch Gen Psychiatry. 1996; 53(1):25-31.
10. St Clair D, Xu M, Wang P, Yu Y, Fang Y, Zhang F, Zheng X, Gu N, Feng G, Sham P, He L. Rates of adult schizophrenia following prenatal exposure to the Chinese famine of 1959-1961. JAMA. 2005;294(5):557-562.
11. Viteri FE. The consequences of iron deficiency and anemia in pregnancy. Adv Exp Med Biol. 1994;352:127-139.
12. Kunugi H, Nanko S, Murray RM. Obstetric complications and schizophrenia: prenatal underdevelopment and subsequent neurodevelopmental impairment. Br J Psychiatry Suppl. 2001;40:s25-s29.
13. Rao R, de Ungria M, Sullivan D, Wu P, Wobken JD, Nelson CA, Georgieff MK. Perinatal brain iron deficiency increases the vulnerability of rat hippocampus to hypoxic ischemic insult. J Nutr. 1999;129(1):199-206.
14. Lozoff B, Beard J, Connor J, Barbara F, Georgieff M, Schallert T. Long-lasting neural and behavioral effects of iron deficiency in infancy. Nutr Rev. 2006; 64(5, pt 2):S34-S43.
15. Davis KL, Stewart DG, Friedman JI, Buchsbaum M, Harvey PD, Hof PR, Buxbaum J, Haroutunian V. White matter changes in schizophrenia: evidence for myelin-related dysfunction. Arch Gen Psychiatry. 2003;60(5):443-456.
16. Beard JL, Connor JR. Iron status and neural functioning. Annu Rev Nutr. 2003; 23:41-58.
17. Isohanni M, Murray GK, Jokelainen J, Croudace T, Jones PB. The persistence of developmental markers in childhood and adolescence and risk for schizophrenic psychoses in adult life: a 34-year follow-up of the Northern Finland 1966 birth cohort. Schizophr Res. 2004;71(2-3):213-225.
18. Erlenmeyer-Kimling L. Neurobehavioral deficits in offspring of schizophrenic parents: liability indicators and predictors of illness. Am J Med Genet. 2000;97(1):65-71.
19. Jones PB, Tarrant CJ. Specificity of developmental precursors to schizophrenia and affective disorders. Schizophr Res. 1999;39(2):121-125.
20. Done DJ, Crow TJ, Johnstone EC, Sacker A. Childhood antecedents of schizophrenia and affective illness: social adjustment at ages 7 and 11. BMJ. 1994; 309(6956):699-703.
21. Tamura T, Goldenberg RL, Hou J, Johnston KE, Cliver SP, Ramey SL, Nelson KG. Cord serum ferritin concentrations and mental and psychomotor development of children at five years of age. J Pediatr. 2002;140(2):165-170.
22. Perez EM, Hendricks MK, Beard JL, Murray-Kolb LE, Berg A, Tomlinson M, Irlam J, Isaacs W, Njengele T, Sive A, Vernon-Feagans L. Mother-infant interactions and infant development are altered by maternal iron deficiency anemia. J Nutr. 2005;135(4):850-855.
23. Susser ES, Schaefer CA, Brown AS, Begg MD, Wyatt RJ. The design of the prenatal determinants of schizophrenia study. Schizophr Bull. 2000;26(2):257-273.
24. van den Berg BJ. The California Child Health and Development Studies: twenty years of research. World Health Stat Q. 1979;32(4):269-286.
25. van den Berg BJ, Christianson RE, Oechsli FW. The California Child Health and Development Studies of the School of Public Health, University of California at Berkeley. Paediatr Perinat Epidemiol. 1988;2(3):265-282.
26. Kendler KS, Neale MC, Walsh D. Evaluating the spectrum concept of schizophrenia in the Roscommon Family Study. Am J Psychiatry. 1995;152(5):749-754.
27. Nurnberger JI Jr, Blehar MC, Kaufmann CA, York-Cooler C, Simpson SG, Harkavy-Friedman J, Severe JB, Malaspina D, Reich T. Diagnostic interview for genetic studies: rationale, unique features, and training; NIMH Genetics Initiative. Arch Gen Psychiatry. 1994;51(11):849-859.
28. Dallman PR. Iron deficiency anemia: a synthesis of current scientific knowledge and U.S. recommendations for prevention and treatment. In: Earl R, Woteki CE, eds. Iron Deficiency Anemia: Recommended Guidelines for the Prevention, Detection, and Management Among U.S. Children and Women of Childbearing Age. Washington, DC: National Academies Press; 1993:41-98.
29. Tam KF, Lao TT. Hemoglobin and red cell indices correlated with serum ferritin concentration in late pregnancy. Obstet Gynecol. 1999;93(3):427-431.
30. Cox DR, Oakes D. Analysis of Survival Data. London, England: Chapman & Hall Ltd; 1984.
31. Bresnahan M, Begg MD, Brown A, Schaefer C, Sohler N, Insel B, Vella L, Susser E. Race and risk of schizophrenia in a US birth cohort: another example of health disparity? Int J Epidemiol. 2007;36(4):751-758.
32. Schaefer CA, Brown AS, Wyatt RJ, Kline J, Begg MD, Bresnahan MA, Susser ES. Maternal prepregnant body mass and risk of schizophrenia in adult offspring. Schizophr Bull. 2000;26(2):275-286.
33. Naeye RL, Peters EC. Antenatal hypoxia and low IQ values. Am J Dis Child. 1987; 141(1):50-54.
34. Seidman LJ, Buka SL, Goldstein JM, Horton NJ, Rieder RO, Tsuang MT. The relationship of prenatal and perinatal complications to cognitive functioning at age 7 in the New England Cohorts of the National Collaborative Perinatal Project. Schizophr Bull. 2000;26(2):309-321.
35. Cleves M, Gould WW, Gutierrez R. Postestimation commands for parametric models. In: An Introduction to Survival Analysis Using Stata. Revised edition. College Station, Texas: Stata Press; 2004:279-292.
36. Greenland S. Modeling and variable selection in epidemiologic analysis. Am J Public Health. 1989;79(3):340-349.
37. Jones PB, Rantakallio P, Hartikainen AL, Isohanni M, Sipila P. Schizophrenia as a long-term outcome of pregnancy, delivery, and perinatal complications: a 28-year follow-up of the 1966 north Finland general population birth cohort. Am J Psychiatry. 1998;155(3):355-364.
38. McCreadie R, Macdonald E, Blacklock C, Tilak-Singh D, Wiles D, Halliday J, Paterson J. Dietary intake of schizophrenic patients in Nithsdale, Scotland: case-control study. BMJ. 1998;317(7161):784-785.
39. Schmidt AT, Waldow KJ, Grove WM, Salinas JA, Georgieff MK. Dissociating the long-term effects of fetal/neonatal iron deficiency on three types of learning in the rat. Behav Neurosci. 2007;121(3):475-482.
40. Kwik-Uribe CL, Golub MS, Keen CL. Chronic marginal iron intakes during early development in mice alter brain iron concentrations and behavior despite postnatal iron supplementation. J Nutr. 2000;130(8):2040-2048.
41. Ortiz E, Pasquini JM, Thompson K, Felt B, Butkus G, Beard J, Connor JR. Effect of manipulation of iron storage, transport, or availability on myelin composition and brain iron content in three different animal models. J Neurosci Res. 2004; 77(5):681-689.
42. Carlson ES, Stead JD, Neal CR, Petryk A, Georgieff MK. Perinatal iron deficiency results in altered developmental expression of genes mediating energy metabolism and neuronal morphogenesis in hippocampus. Hippocampus. 2007;17(8):679-691.
43. Goldstein JM. Sex differences in schizophrenia: epidemiology, genetics, and the brain. Int Rev Psychiatry. 1997;9(4):399-408.
44. Cerghet M, Skoff RP, Bessert D, Zhang Z, Mullins C, Ghandour MS. Proliferation and death of oligodendrocytes and myelin proteins are differentially regulated in male and female rodents. J Neurosci. 2006;26(5):1439-1447.
45. Byne W, Dracheva S, Chin B, Schmeidler JM, Davis KL, Haroutunian V. Schizophrenia and sex associated differences in the expression of neuronal and oligodendrocyte-specific genes in individual thalamic nuclei. Schizophr Res. 2008; 98(1-3):118-128.
46. Choi JW, Kim CS, Pai SH. Erythropoietic activity and soluble transferrin receptor level in neonates and maternal blood. Acta Paediatr. 2000;89(6):675-679.
47. Kumar A, Rai AK, Basu S, Dash D, Singh JS. Cord blood and breast milk iron status in maternal anemia. Pediatrics. 2008;121(3):e673-e677. doi:10.1542/peds.2007-1986.
48. Rusia U, Madan N, Agarwal N, Sikka M, Sood S. Effect of maternal iron deficiency anaemia on foetal outcome. Indian J Pathol Microbiol. 1995;38(3):273-279.
49. Colomer J, Colomer C, Gutierrez D, Jubert A, Nolasco A, Donat J, Fernandez-Delgado R, Donat F, Alvarez-Dardet C. Anaemia during pregnancy as a risk factor for infant iron deficiency: report from the Valencia Infant Anaemia Cohort (VIAC) study. Paediatr Perinat Epidemiol. 1990;4(2):196-204.
50. Kilbride J, Baker TG, Parapia LA, Khoury SA, Shuqaidef SW, Jerwood D. Anaemia during pregnancy as a risk factor for iron-deficiency anaemia in infancy: a case-control study in Jordan. Int J Epidemiol. 1999;28(3):461-468.
51. Strauss MB. Anemia of infancy from maternal iron deficiency in pregnancy. J Clin Invest. 1933;12(2):345-353.