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Volumn 9, Issue 1, 2018, Pages

A community approach to mortality prediction in sepsis via gene expression analysis

(26)  Sweeney, Timothy E a,w   Perumal, Thanneer M b   Henao, Ricardo c,d   Nichols, Marshall c   Howrylak, Judith A e   Choi, Augustine M f   Bermejo Martin, Jesús F g   Almansa, Raquel g   Tamayo, Eduardo g   Davenport, Emma E h,i,j   Burnham, Katie L k   Hinds, Charles J l   Knight, Julian C k   Woods, Christopher W c,m   Kingsmore, Stephen F n   Ginsburg, Geoffrey S c   Wong, Hector R o,p   Parnell, Grant P q   Tang, Benjamin q,r,s,t   Moldawer, Lyle L u   more..


Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; COHORT ANALYSIS; DISEASE; GENE EXPRESSION; GENETIC ANALYSIS; IMMUNE RESPONSE; MODEL; MORTALITY; PERFORMANCE ASSESSMENT; PREDICTION; RISK ASSESSMENT;

EID: 85042210696     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/s41467-018-03078-2     Document Type: Article
Times cited : (154)

References (69)
  • 1
    • 84959273475 scopus 로고    scopus 로고
    • The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
    • Singer, M. et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA 315, 801 (2016).
    • (2016) JAMA , vol.315 , pp. 801
    • Singer, M.1
  • 3
    • 84903614329 scopus 로고    scopus 로고
    • Hospital deaths in patients with sepsis from 2 independent cohorts
    • Liu, V. et al. Hospital deaths in patients with sepsis from 2 independent cohorts. JAMA, https://doi.org/10.1001/jama.2014.5804 (2014).
    • (2014) JAMA
    • Liu, V.1
  • 4
    • 84928485055 scopus 로고    scopus 로고
    • Systemic inflammatory response syndrome criteria in defining severe sepsis
    • Kaukonen, K. M., Bailey, M., Pilcher, D., Cooper, D. J. & Bellomo, R. Systemic inflammatory response syndrome criteria in defining severe sepsis. N. Engl. J. Med. 372, 1629-1638 (2015).
    • (2015) N. Engl. J. Med , vol.372 , pp. 1629-1638
    • Kaukonen, K.M.1    Bailey, M.2    Pilcher, D.3    Cooper, D.J.4    Bellomo, R.5
  • 5
    • 84902511727 scopus 로고    scopus 로고
    • The next generation of sepsis clinical trial designs: What is next after the demise of recombinant human activated protein C?
    • Opal, S. M., Dellinger, R. P., Vincent, J. L., Masur, H. & Angus, D. C. The next generation of sepsis clinical trial designs: what is next after the demise of recombinant human activated protein C?. Crit. Care. Med. 42, 1714-1721 (2014).
    • (2014) Crit. Care. Med , vol.42 , pp. 1714-1721
    • Opal, S.M.1    Dellinger, R.P.2    Vincent, J.L.3    Masur, H.4    Angus, D.C.5
  • 6
    • 84928156751 scopus 로고    scopus 로고
    • Sepsis: A roadmap for future research
    • Cohen, J. et al. Sepsis: a roadmap for future research. Lancet Infect. Dis. 15, 581-614 (2015).
    • (2015) Lancet Infect. Dis , vol.15 , pp. 581-614
    • Cohen, J.1
  • 7
    • 84959308793 scopus 로고    scopus 로고
    • Developing a new definition and assessing new clinical criteria for septic shock: For the third international consensus definitions for sepsis and septic shock (Sepsis-3)
    • Shankar-Hari, M. et al. Developing a new definition and assessing new clinical criteria for septic shock: for the third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 315, 775-787 (2016).
    • (2016) JAMA , vol.315 , pp. 775-787
    • Shankar-Hari, M.1
  • 8
    • 85007329661 scopus 로고    scopus 로고
    • The TRIAGE-ProADM score for an early risk stratification of medical patients in the emergency department - Development based on a multi-national, prospective, observational study
    • Kutz, A. et al. The TRIAGE-ProADM score for an early risk stratification of medical patients in the emergency department - development based on a multi-national, prospective, observational study. PLoS ONE 11, e0168076 (2016).
    • (2016) PLoS ONE , vol.11 , pp. e0168076
    • Kutz, A.1
  • 9
    • 84978607474 scopus 로고    scopus 로고
    • Clinical scores and blood biomarkers for early risk assessment of patients presenting to the emergency department
    • Rast, A., Mueller, B. & Schuetz, P. Clinical scores and blood biomarkers for early risk assessment of patients presenting to the emergency department. OA Emerg. Med. 1, 2 (2014).
    • (2014) OA Emerg. Med , vol.1 , pp. 2
    • Rast, A.1    Mueller, B.2    Schuetz, P.3
  • 10
    • 84959267157 scopus 로고    scopus 로고
    • New definitions for sepsis and septic shock: Continuing evolution but with much still to be done
    • Abraham, E. New definitions for sepsis and septic shock: continuing evolution but with much still to be done. JAMA 315, 757-759 (2016).
    • (2016) JAMA , vol.315 , pp. 757-759
    • Abraham, E.1
  • 11
    • 85011591501 scopus 로고    scopus 로고
    • Characterising Systemic Immune Dysfunction Syndrome (SIDS) to fill in the gaps of SEPSIS-2 and SEPSIS-3 definitions
    • Bermejo-Martin, J. F., Tamayo, E., Andaluz-Ojeda, D., Fernández, M. M. & Almansa, R. Characterising Systemic Immune Dysfunction Syndrome (SIDS) to fill in the gaps of SEPSIS-2 and SEPSIS-3 definitions. CHEST 151, 518-519 (2017).
    • (2017) CHEST , vol.151 , pp. 518-519
    • Bermejo-Martin, J.F.1    Tamayo, E.2    Andaluz-Ojeda, D.3    Fernández, M.M.4    Almansa, R.5
  • 12
    • 84959898939 scopus 로고    scopus 로고
    • Risk stratification and prognosis in sepsis: What have we learned from microarrays?
    • Sweeney, T. E. & Wong, H. R. Risk stratification and prognosis in sepsis: what have we learned from microarrays? Clin. Chest. Med. 37, 209-218 (2016).
    • (2016) Clin. Chest. Med , vol.37 , pp. 209-218
    • Sweeney, T.E.1    Wong, H.R.2
  • 13
    • 84927006065 scopus 로고    scopus 로고
    • Transcriptomic correlates of organ failure extent in sepsis
    • Almansa, R. et al. Transcriptomic correlates of organ failure extent in sepsis. J. Infect. 70, 445-456 (2015).
    • (2015) J. Infect , vol.70 , pp. 445-456
    • Almansa, R.1
  • 14
    • 84922311029 scopus 로고    scopus 로고
    • Developing a clinically feasible personalized medicine approach to pediatric septic shock
    • Wong, H. R. et al. Developing a clinically feasible personalized medicine approach to pediatric septic shock. Am. J. Respir. Crit. Care. Med. 191, 309-315 (2015).
    • (2015) Am. J. Respir. Crit. Care. Med , vol.191 , pp. 309-315
    • Wong, H.R.1
  • 15
    • 84963568655 scopus 로고    scopus 로고
    • Genomic landscape of the individual host response and outcomes in sepsis: A prospective cohort study
    • Davenport, E. E. et al. Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study. Lancet Respir. Med. https://doi.org/10.1016/S2213-2600(16)00046-1 (2016).
    • (2016) Lancet Respir. Med
    • Davenport, E.E.1
  • 16
    • 79952395259 scopus 로고    scopus 로고
    • Aberrant cell cycle and apoptotic changes characterise severe influenza A infection - A meta-analysis of genomic signatures in circulating leukocytes
    • Parnell, G. et al. Aberrant cell cycle and apoptotic changes characterise severe influenza A infection - a meta-analysis of genomic signatures in circulating leukocytes. PLoS ONE 6, e17186 (2011).
    • (2011) PLoS ONE , vol.6 , pp. e17186
    • Parnell, G.1
  • 17
    • 84883303075 scopus 로고    scopus 로고
    • Identifying key regulatory genes in the whole blood of septic patients to monitor underlying immune dysfunctions
    • Parnell, G. P. et al. Identifying key regulatory genes in the whole blood of septic patients to monitor underlying immune dysfunctions. Shock 40, 166-174 (2013).
    • (2013) Shock , vol.40 , pp. 166-174
    • Parnell, G.P.1
  • 18
    • 34547470882 scopus 로고    scopus 로고
    • Genome-level expression profiles in pediatric septic shock indicate a role for altered zinc homeostasis in poor outcome
    • Wong, H. R. et al. Genome-level expression profiles in pediatric septic shock indicate a role for altered zinc homeostasis in poor outcome. Physiol. Genom. 30, 146-155 (2007).
    • (2007) Physiol. Genom , vol.30 , pp. 146-155
    • Wong, H.R.1
  • 19
    • 84928005646 scopus 로고    scopus 로고
    • An integrated transcriptome and expressed variant analysis of sepsis survival and death
    • Tsalik, E. L. et al. An integrated transcriptome and expressed variant analysis of sepsis survival and death. Genome Med. 6, 111 (2014).
    • (2014) Genome Med , vol.6 , pp. 111
    • Tsalik, E.L.1
  • 20
    • 84871882852 scopus 로고    scopus 로고
    • Prognostic models in the clinical arena
    • Bolignano, D. et al. Prognostic models in the clinical arena. Aging Clin. Exp. Res. 24, 300-304 (2012).
    • (2012) Aging Clin. Exp. Res , vol.24 , pp. 300-304
    • Bolignano, D.1
  • 21
    • 84984705713 scopus 로고    scopus 로고
    • Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis
    • Sieberts, S. K. et al. Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis. Nat. Commun. 7, 12460 (2016).
    • (2016) Nat. Commun , vol.7
    • Sieberts, S.K.1
  • 22
    • 84966539175 scopus 로고    scopus 로고
    • Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease
    • Allen, G. I. et al. Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease. Alzheimers Dement. 12, 645-653 (2016).
    • (2016) Alzheimers Dement , vol.12 , pp. 645-653
    • Allen, G.I.1
  • 23
    • 85006765760 scopus 로고    scopus 로고
    • Prediction of overall survival for patients with metastatic castration-resistant prostate cancer: Development of a prognostic model through a crowdsourced challenge with open clinical trial data
    • Guinney, J. et al. Prediction of overall survival for patients with metastatic castration-resistant prostate cancer: development of a prognostic model through a crowdsourced challenge with open clinical trial data. Lancet Oncol. https://doi.org/10.1016/S1470-2045(16)30560-5 (2016).
    • (2016) Lancet Oncol
    • Guinney, J.1
  • 24
    • 84978888838 scopus 로고    scopus 로고
    • A crowdsourcing approach to developing and assessing prediction algorithms for AML prognosis
    • Noren, D. P. et al. A crowdsourcing approach to developing and assessing prediction algorithms for AML prognosis. PLoS Comput. Biol. 12, e1004890 (2016).
    • (2016) PLoS Comput. Biol , vol.12 , pp. e1004890
    • Noren, D.P.1
  • 25
    • 84978541160 scopus 로고    scopus 로고
    • Crowdsourcing biomedical research: Leveraging communities as innovation engines
    • Saez-Rodriguez, J. et al. Crowdsourcing biomedical research: leveraging communities as innovation engines. Nat. Rev. Genet. 17, 470-486 (2016).
    • (2016) Nat. Rev. Genet , vol.17 , pp. 470-486
    • Saez-Rodriguez, J.1
  • 26
    • 77950537175 scopus 로고    scopus 로고
    • Regularization paths for generalized linear models via coordinate descent
    • Friedman, J., Hastie, T. & Tibshirani, R. Regularization paths for generalized linear models via coordinate descent. J. Stat. Softw. 33, 1-22 (2010).
    • (2010) J. Stat. Softw , vol.33 , pp. 1-22
    • Friedman, J.1    Hastie, T.2    Tibshirani, R.3
  • 29
    • 33746345574 scopus 로고    scopus 로고
    • Systemic transcriptional analysis in survivor and non-survivor septic shock patients: A preliminary study
    • Pachot, A. et al. Systemic transcriptional analysis in survivor and non-survivor septic shock patients: a preliminary study. Immunol. Lett. 106, 63-71 (2006).
    • (2006) Immunol. Lett , vol.106 , pp. 63-71
    • Pachot, A.1
  • 30
    • 84954392490 scopus 로고    scopus 로고
    • Diagnostic accuracy and clinical relevance of an inflammatory biomarker panel for sepsis in adult critically ill patients
    • Bauer, P. R. et al. Diagnostic accuracy and clinical relevance of an inflammatory biomarker panel for sepsis in adult critically ill patients. Diagn. Microbiol. Infect. Dis. 84, 175-180 (2016).
    • (2016) Diagn. Microbiol. Infect. Dis , vol.84 , pp. 175-180
    • Bauer, P.R.1
  • 31
    • 84928911070 scopus 로고    scopus 로고
    • The precision-recall plot is more informative than the ROC plot when evaluating binary classifiers on imbalanced datasets
    • Saito, T. & Rehmsmeier, M. The precision-recall plot is more informative than the ROC plot when evaluating binary classifiers on imbalanced datasets. PLoS ONE 10, e0118432 (2015).
    • (2015) PLoS ONE , vol.10 , pp. e0118432
    • Saito, T.1    Rehmsmeier, M.2
  • 32
    • 84966339558 scopus 로고    scopus 로고
    • Human myeloid-derived suppressor cells are associated with chronic immune suppression after severe sepsis/septic shock
    • Mathias, B. et al. Human myeloid-derived suppressor cells are associated with chronic immune suppression after severe sepsis/septic shock. Ann. Surg. https://doi.org/10.1097/SLA.0000000000001783 (2016).
    • (2016) Ann. Surg
    • Mathias, B.1
  • 33
    • 33745559712 scopus 로고    scopus 로고
    • Neutrophil serine proteases: Specific regulators of inflammation
    • Pham, C. T. N. Neutrophil serine proteases: specific regulators of inflammation. Nat. Rev. Immunol. 6, 541-550 (2006).
    • (2006) Nat. Rev. Immunol , vol.6 , pp. 541-550
    • Pham, C.T.N.1
  • 34
    • 84905643663 scopus 로고    scopus 로고
    • Instructive influences of phagocytic clearance of dying cells on neutrophil extracellular trap generation
    • Manfredi, A. A., Covino, C., Rovere-Querini, P. & Maugeri, N. Instructive influences of phagocytic clearance of dying cells on neutrophil extracellular trap generation. Clin. Exp. Immunol. 179, 24-29 (2015).
    • (2015) Clin. Exp. Immunol , vol.179 , pp. 24-29
    • Manfredi, A.A.1    Covino, C.2    Rovere-Querini, P.3    Maugeri, N.4
  • 35
    • 84973161088 scopus 로고    scopus 로고
    • NETosis markers: Quest for specific, objective, and quantitative markers
    • Masuda, S. et al. NETosis markers: quest for specific, objective, and quantitative markers. Clin. Chim. Acta 459, 89-93 (2016).
    • (2016) Clin. Chim. Acta , vol.459 , pp. 89-93
    • Masuda, S.1
  • 36
    • 85017189474 scopus 로고    scopus 로고
    • Transcriptional reprogramming of metabolic pathways in critically ill patients
    • Nalos, M. et al. Transcriptional reprogramming of metabolic pathways in critically ill patients. Intensive Care Med. Exp. 4, 21 (2016).
    • (2016) Intensive Care Med. Exp , vol.4 , pp. 21
    • Nalos, M.1
  • 37
    • 84904489275 scopus 로고    scopus 로고
    • PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis
    • Yang, L. et al. PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis. Nat. Commun. 5, 4436 (2014).
    • (2014) Nat. Commun , vol.5
    • Yang, L.1
  • 38
    • 84907543940 scopus 로고    scopus 로고
    • MTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity
    • Cheng, S.-C. et al. mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity. Science 345, 1250684 (2014).
    • (2014) Science , vol.345 , pp. 1250684
    • Cheng, S.C.1
  • 39
    • 84865504765 scopus 로고    scopus 로고
    • Fueling the flame: Bioenergy couples metabolism and inflammation
    • Liu, T. F. et al. Fueling the flame: bioenergy couples metabolism and inflammation. J. Leukoc. Biol. 92, 499-507 (2012).
    • (2012) J. Leukoc. Biol , vol.92 , pp. 499-507
    • Liu, T.F.1
  • 40
    • 79955040218 scopus 로고    scopus 로고
    • Regression shrinkage and selection via the lasso: A retrospective
    • Tibshirani, R. Regression shrinkage and selection via the lasso: a retrospective. J. R. Stat. Soc. Ser. B Stat. Methodol. 73, 273-282 (2011).
    • (2011) J. R. Stat. Soc. Ser. B Stat. Methodol , vol.73 , pp. 273-282
    • Tibshirani, R.1
  • 41
    • 84975511473 scopus 로고    scopus 로고
    • A global, neutral platform for sharing trial data
    • Bierer, B. E., Li, R., Barnes, M. & Sim, I. A global, neutral platform for sharing trial data. N. Engl. J. Med. 374, 2411-2413 (2016).
    • (2016) N. Engl. J. Med , vol.374 , pp. 2411-2413
    • Bierer, B.E.1    Li, R.2    Barnes, M.3    Sim, I.4
  • 42
    • 85016160000 scopus 로고    scopus 로고
    • Methods to increase reproducibility in differential gene expression via meta-analysis
    • Sweeney, T. E., Haynes, W. A., Vallania, F., Ioannidis, J. P. & Khatri, P. Methods to increase reproducibility in differential gene expression via meta-analysis. Nucleic Acids Res. 45, e1 (2017).
    • (2017) Nucleic Acids Res , vol.45 , pp. e1
    • Sweeney, T.E.1    Haynes, W.A.2    Vallania, F.3    Ioannidis, J.P.4    Khatri, P.5
  • 43
    • 43249104003 scopus 로고    scopus 로고
    • Validation of virulence and epidemiology DNA microarray for identification and characterization of staphylococcus aureus isolates
    • Spence, R. P. et al. Validation of virulence and epidemiology DNA microarray for identification and characterization of staphylococcus aureus isolates. J. Clin. Microbiol. 46, 1620-1627 (2008).
    • (2008) J. Clin. Microbiol , vol.46 , pp. 1620-1627
    • Spence, R.P.1
  • 44
    • 66149092331 scopus 로고    scopus 로고
    • Discovery of the gene signature for acute lung injury in patients with sepsis
    • Howrylak, J. A. et al. Discovery of the gene signature for acute lung injury in patients with sepsis. Physiol. Genom. 37, 133-139 (2009).
    • (2009) Physiol. Genom , vol.37 , pp. 133-139
    • Howrylak, J.A.1
  • 45
    • 76249091272 scopus 로고    scopus 로고
    • Genomic transcriptional profiling identifies a candidate blood biomarker signature for the diagnosis of septicemic melioidosis
    • Pankla, R. et al. Genomic transcriptional profiling identifies a candidate blood biomarker signature for the diagnosis of septicemic melioidosis. Genome Biol. 10, R127 (2009).
    • (2009) Genome Biol , vol.10 , pp. R127
    • Pankla, R.1
  • 46
    • 80052957457 scopus 로고    scopus 로고
    • Excessive innate immune response and mutant D222G/N in severe A (H1N1) pandemic influenza
    • Berdal, J. E. et al. Excessive innate immune response and mutant D222G/N in severe A (H1N1) pandemic influenza. J. Infect. 63, 308-316 (2011).
    • (2011) J. Infect , vol.63 , pp. 308-316
    • Berdal, J.E.1
  • 47
    • 84861785677 scopus 로고    scopus 로고
    • Inflammasome-regulated cytokines are critical mediators of acute lung injury
    • Dolinay, T. et al. Inflammasome-regulated cytokines are critical mediators of acute lung injury. Am. J. Respir. Crit. Care. Med. 185, 1225-1234 (2012).
    • (2012) Am. J. Respir. Crit. Care. Med , vol.185 , pp. 1225-1234
    • Dolinay, T.1
  • 48
    • 85027203102 scopus 로고    scopus 로고
    • Peripheral blood RNA gene expression profiling in patients with bacterial meningitis
    • Lill, M. et al. Peripheral blood RNA gene expression profiling in patients with bacterial meningitis. Front. Neurosci. 7, 33 (2013).
    • (2013) Front. Neurosci , vol.7 , pp. 33
    • Lill, M.1
  • 49
    • 84930842760 scopus 로고    scopus 로고
    • Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS
    • Kangelaris, K. N. et al. Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS. Am. J. Physiol. Lung Cell. Mol. Physiol. 308, L1102-L1113 (2015).
    • (2015) Am. J. Physiol. Lung Cell. Mol. Physiol , vol.308 , pp. L1102-L1113
    • Kangelaris, K.N.1
  • 50
    • 77956486528 scopus 로고    scopus 로고
    • Host adaptive immunity deficiency in severe pandemic influenza
    • Bermejo-Martin, J. F. et al. Host adaptive immunity deficiency in severe pandemic influenza. Crit. Care 14, R167 (2010).
    • (2010) Crit. Care , vol.14 , pp. R167
    • Bermejo-Martin, J.F.1
  • 51
    • 84872175208 scopus 로고    scopus 로고
    • Gene expression-based classifiers identify Staphylococcus aureus infection in mice and humans
    • Ahn, S. H. et al. Gene expression-based classifiers identify Staphylococcus aureus infection in mice and humans. PLoS ONE 8, e48979 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e48979
    • Ahn, S.H.1
  • 52
    • 84955579105 scopus 로고    scopus 로고
    • Host gene expression classifiers diagnose acute respiratory illness etiology
    • Tsalik, E. L. et al. Host gene expression classifiers diagnose acute respiratory illness etiology. Sci. Transl. Med. 8, 322ra11 (2016).
    • (2016) Sci. Transl. Med , vol.8 , pp. 322ra11
    • Tsalik, E.L.1
  • 53
    • 84860500036 scopus 로고    scopus 로고
    • Novel biomarker combination improves the diagnosis of serious bacterial infections in Malawian children
    • Irwin, A. D. et al. Novel biomarker combination improves the diagnosis of serious bacterial infections in Malawian children. BMC Med. Genom. 5, 13 (2012).
    • (2012) BMC Med. Genom , vol.5
    • Irwin, A.D.1
  • 54
    • 84875455649 scopus 로고    scopus 로고
    • Transcriptional instability during evolving sepsis may limit biomarker based risk stratification
    • Kwan, A., Hubank, M., Rashid, A., Klein, N. & Peters, M. J. Transcriptional instability during evolving sepsis may limit biomarker based risk stratification. PLoS ONE 8, e60501 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e60501
    • Kwan, A.1    Hubank, M.2    Rashid, A.3    Klein, N.4    Peters, M.J.5
  • 55
    • 84937813440 scopus 로고    scopus 로고
    • Oxidative phosphorylation gene expression falls at onset and throughout the development of meningococcal sepsis-induced multi-organ failure in children
    • Raman, S. et al. Oxidative phosphorylation gene expression falls at onset and throughout the development of meningococcal sepsis-induced multi-organ failure in children. Intensive Care Med. 41, 1489-1490 (2015).
    • (2015) Intensive Care Med , vol.41 , pp. 1489-1490
    • Raman, S.1
  • 56
    • 84929629371 scopus 로고    scopus 로고
    • A comprehensive time-course-based multicohort analysis of sepsis and sterile inflammation reveals a robust diagnostic gene set
    • Sweeney, T. E., Shidham, A., Wong, H. R. & Khatri, P. A comprehensive time-course-based multicohort analysis of sepsis and sterile inflammation reveals a robust diagnostic gene set. Sci. Transl. Med. 7, 287ra71 (2015).
    • (2015) Sci. Transl. Med , vol.7 , pp. 287ra71
    • Sweeney, T.E.1    Shidham, A.2    Wong, H.R.3    Khatri, P.4
  • 57
    • 84896717668 scopus 로고    scopus 로고
    • Transcriptomic evidence of impaired immunoglobulin G production in fatal septic shock
    • Almansa, R. et al. Transcriptomic evidence of impaired immunoglobulin G production in fatal septic shock. J. Crit. Care 29, 307-309 (2014).
    • (2014) J. Crit. Care , vol.29 , pp. 307-309
    • Almansa, R.1
  • 58
    • 33845432928 scopus 로고    scopus 로고
    • Adjusting batch effects in microarray expression data using empirical Bayes methods
    • Johnson, W. E., Li, C. & Rabinovic, A. Adjusting batch effects in microarray expression data using empirical Bayes methods. Biostatistics 8, 118-127 (2006).
    • (2006) Biostatistics , vol.8 , pp. 118-127
    • Johnson, W.E.1    Li, C.2    Rabinovic, A.3
  • 59
    • 84874457770 scopus 로고    scopus 로고
    • Genomic responses in mouse models poorly mimic human inflammatory diseases
    • Seok, J. et al. Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc. Natl. Acad. Sci. USA 110, 3507-3512 (2013).
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 3507-3512
    • Seok, J.1
  • 60
    • 1342288026 scopus 로고    scopus 로고
    • Affy - Analysis of Affymetrix GeneChip data at the probe level
    • Gautier, L., Cope, L., Bolstad, B. M. & IrizarryR. A. affy - analysis of Affymetrix GeneChip data at the probe level. Bioinformatics 20, 307-315 (2004).
    • (2004) Bioinformatics , vol.20 , pp. 307-315
    • Gautier, L.1    Cope, L.2    Bolstad, B.M.3    Irizarry, R.A.4
  • 61
    • 84926507971 scopus 로고    scopus 로고
    • Limma powers differential expression analyses for RNA-sequencing and microarray studies
    • Ritchie, M. E. et al. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43, e47-e47 (2015).
    • (2015) Nucleic Acids Res , vol.43 , pp. e47-e47
    • Ritchie, M.E.1
  • 62
    • 84896735766 scopus 로고    scopus 로고
    • Voom: Precision weights unlock linear model analysis tools for RNA-seq read counts
    • Law, C. W., Yunshun, C., Wei, S. & Smyth, G. K. Voom: precision weights unlock linear model analysis tools for RNA-seq read counts. Genome Biol. 15, R29 (2014).
    • (2014) Genome Biol , vol.15 , pp. R29
    • Law, C.W.1    Yunshun, C.2    Wei, S.3    Smyth, G.K.4
  • 63
    • 78649477601 scopus 로고    scopus 로고
    • Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers
    • Pencina, M. J., D'Agostino, R. B. Sr & Steyerberg, E. W. Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers. Stat. Med. 30, 11-21 (2011).
    • (2011) Stat. Med , vol.30 , pp. 11-21
    • Pencina, M.J.1    D'Agostino, R.B.2    Steyerberg, E.W.3
  • 64
    • 84959505947 scopus 로고    scopus 로고
    • Genome-wide expression for diagnosis of pulmonary tuberculosis: A multicohort analysis
    • Sweeney, T. E., Braviak, L., Tato, C. M. & Khatri, P. Genome-wide expression for diagnosis of pulmonary tuberculosis: a multicohort analysis. Lancet Respir. Med 4, 213-224 (2016).
    • (2016) Lancet Respir. Med , vol.4 , pp. 213-224
    • Sweeney, T.E.1    Braviak, L.2    Tato, C.M.3    Khatri, P.4
  • 65
    • 84946735654 scopus 로고    scopus 로고
    • Gene Ontology Consortium: Going forward
    • The Gene Ontology Consortium
    • The Gene Ontology Consortium. Gene Ontology Consortium: going forward. Nucleic Acids Res. 43, D1049-D1056 (2014).
    • (2014) Nucleic Acids Res , vol.43 , pp. D1049-D1056
  • 66
    • 84976870113 scopus 로고    scopus 로고
    • The Reactome pathway knowledgebase
    • Fabregat, A. et al. The Reactome pathway knowledgebase. Nucleic Acids Res. 44, D481-D487 (2016).
    • (2016) Nucleic Acids Res , vol.44 , pp. D481-D487
    • Fabregat, A.1
  • 68
    • 84872202078 scopus 로고    scopus 로고
    • GSVA: Gene set variation analysis for microarray and RNA-seq data
    • Hänzelmann, S., Castelo, R. & Guinney, J. GSVA: gene set variation analysis for microarray and RNA-seq data. BMC Bioinformatics 14, 7 (2013).
    • (2013) BMC Bioinformatics , vol.14 , pp. 7
    • Hänzelmann, S.1    Castelo, R.2    Guinney, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.