NETosis markers: Quest for specific, objective, and quantitative markers

Clinica Chimica Acta

Volumn 459, Issue , 2016, Pages 89-93

  Masuda, Sakiko ^a   Nakazawa, Daigo ^b   Shida, Haruki ^b   Miyoshi, Arina ^b   Kusunoki, Yoshihiro ^b   Tomaru, Utano ^b   Ishizu, Akihiro ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Citrullinated histone; Flow cytometry; MPO DNA complex; Neutrophil extracellular trap; Peptidylarginine deiminase 4

Indexed keywords

CYCLIC CITRULLINATED PEPTIDE ANTIBODY; LEUKOCYTE ELASTASE; MYELOBLASTIN; MYELOPEROXIDASE; NEUTROPHIL CYTOPLASMIC ANTIBODY; PROTEIN ARGININE DEIMINASE; BIOLOGICAL MARKER;

CELL DEATH; CELL FUNCTION; CELL NUCLEUS MEMBRANE; CYTOLOGY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR TRAP; FLOW CYTOMETRY; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOHISTOLOGY; INNATE IMMUNITY; MOLECULAR IMAGING; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; REVIEW; SENSITIVITY AND SPECIFICITY; CHEMISTRY; IMMUNOLOGY;

BIOMARKERS; EXTRACELLULAR TRAPS; FLOW CYTOMETRY; HUMANS; NEUTROPHILS;

EID: 84973161088     PISSN: 00098981     EISSN: 18733492     Source Type: Journal    
DOI: 10.1016/j.cca.2016.05.029     Document Type: Review

References (46)

1. Brinkmann V., Reichard U., Goosmann C., Fauler B., Uhlemann Y., Weiss D.S., Weinrauch Y., Zychlinsky A. Neutrophil extracellular traps kill bacteria. Science 2004, 303:1532-1535.
2. Bianchi M., Hakkim A., Brinkmann V., Siler U., Seger R.A., Zychlinsky A., Reichenbach J. Restoration of NET formation by gene therapy in CGD controls aspergillosis. Blood 2009, 114:2619-2622.
3. Papayannopoulos V., Zychlinsky A. NETs: a new strategy for using old weapons. Trends Immunol. 2009, 30:513-521.
4. Fuchs T.A., Abed U., Goosmann C., Hurwitz R., Schulze I., Wahn V., Weinrauch Y., Brinkmann V., Zychlinsky A. Novel cell death program leads to neutrophil extracellular traps. J. Cell Biol. 2007, 176:231-241.
5. Steinberg B.E., Grinstein S. Unconventional roles of the NADPH oxidase: signaling, ion homeostasis, and cell death. Sci. STKE 2007, 2007:pe11.
6. Clark S.R., Ma A.C., Tavener S.A., McDonald B., Goodarzi Z., Kelly M.M., Patel K.D., Chakrabarti S., McAvoy E., Sinclair G.D., Keys E.M., Allen-Vercoe E., Devinney R., Doig C.J., Green F.H., Kubes P. Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood. Nat. Med. 2007, 13:463-469.
7. Pilsczek F.H., Salina D., Poon K.K., Fahey C., Yipp B.G., Sibley C.D., Robbins S.M., Green F.H., Surette M.G., Sugai M., Bowden M.G., Hussain M., Zhang K., Kubes P. A novel mechanism of rapid nuclear neutrophil extracellular trap formation in response to Staphylococcus aureus. J. Immunol. 2010, 185:7413-7425.
8. Yipp B.G., Petri B., Salina D., Jenne C.N., Scott B.N., Zbytnuik L.D., Pittman K., Asaduzzaman M., Wu K., Meijndert H.C., Malawista S.E., de Boisfleury Chevance A., Zhang K., Conly J., Kubes P. Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo. Nat. Med. 2012, 18:1386-1393.
9. Yipp B.G., Kubes P. NETosis: how vital is it?. Blood 2013, 122:2784-2794.
10. Hakkim A., Fuchs T.A., Martinez N.E., Hess S., Prinz H., Zychlinsky A., Waldmann H. Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation. Nat. Chem. Biol. 2011, 7:75-77.
11. Desai J., Kumar S.V., Mulay S.R., Konrad L., Romoli S., Schauer C., Herrmann M., Bilyy R., Muller S., Popper B., Nakazawa D., Weidenbusch M., Thomasova D., Krautwald S., Linkermann A., Anders H.J. PMA and crystal-induced neutrophil extracellular trap formation involves RIPK1-RIPK3-MLKL signaling. Eur. J. Immunol. 2016, 46:223-229.
12. Li P., Li M., Lindberg M.R., Kennett M.J., Xiong N., Wang Y. PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps. J. Exp. Med. 2010, 207:1853-1862.
13. Rochael N.C., Guimaraes-Costa A.B., Nascimento M.T., DeSouza-Vieira T.S., Oliveira M.P., Souza L.F.G.e., Oliveira M.F., Saraiva E.M. Classical ROS-dependent and early/rapid ROS-independent release of neutrophil extracellular traps triggered by Leishmania parasites. Sci Rep 2015, 5:18302.
14. Desai J., Mulay S.R., Nakazawa D., Anders H.J. Matters of life and death. How neutrophils die or survive along NET release and is "NETosis" = necroptosis?. Cell. Mol. Life Sci. 2016, 10.1007/s00018-016-2195-0.
15. Xu J., Zhang X., Pelayo R., Monestier M., Ammollo C.T., Semeraro F., Taylor F.B., Esmon N.L., Lupu F., Esmon C.T. Extracellular histones are major mediators of death in sepsis. Nat. Med. 2009, 15:1318-13121.
16. Doring Y., Weber C., Soehnlein O. Footprints of neutrophil extracellular traps as predictors of cardiovascular risk. Arterioscler. Thromb. Vasc. Biol. 2013, 33:1735-1736.
17. Fuchs T.A., Brill A., Duerschmied D., Schatzberg D., Monestier M., Myers D.D., Wrobleski S.K., Wakefield T.W., Hartwig J.H., Wagner D.D. Extracellular DNA traps promote thrombosis. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:15880-15885.
18. Fuchs T.A., Brill A., Wagner D.D. Neutrophil extracellular trap (NET) impact on deep vein thrombosis. Arterioscler. Thromb. Vasc. Biol. 2012, 32:1777-1783.
19. Wong S.L., Demers M., Martinod K., Gallant M., Wang Y., Goldfine A.B., Kahn C.R., Wagner D.D. Diabetes primes neutrophils to undergo NETosis, which impairs wound healing. Nat. Med. 2015, 21:815-819.
20. Fadini G.P., Menegazzo L., Rigato M., Scattolini V., Poncina N., Bruttocao A., Ciciliot S., Mammano F., Ciubotaru C.D., Brocco E., Marescotti M.C., Cappellari R., Arrigoni G., Millioni R., Vigili de Kreutzenberg S., Albiero M., Avogaro A. NETosis delays diabetic wound healing in mice and humans. Diabetes 2016, (pii: db150863).
21. Hakkim A., Furnrohr B.G., Amann K., Laube B., Abed U.A., Brinkmann V., Herrmann M., Voll R.E., Zychlinsky A. Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:9813-9818.
22. Nakazawa D., Tomaru U., Suzuki A., Masuda S., Hasegawa R., Kobayashi T., Nishio S., Kasahara M., Ishizu A. Abnormal conformation and impaired degradation of propylthiouracil-induced neutrophil extracellular traps: implications of disordered neutrophil extracellular traps in a rat model of myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheum. 2012, 64:3779-3787.
23. Kessenbrock K., Krumbholz M., Schonermarck U., Back W., Gross W.L., Werb Z., Grone H.J., Brinkmann V., Jenne D.E. Netting neutrophils in autoimmune small-vessel vasculitis. Nat. Med. 2009, 15:623-625.
24. Nakazawa D., Shida H., Tomaru U., Yoshida M., Nishio S., Atsumi T., Ishizu A. Enhanced formation and disordered regulation of NETs in myeloperoxidase-ANCA-associated microscopic polyangiitis. J. Am. Soc. Nephrol. 2014, 25:990-997.
25. Nakazawa D., Shida H., Kusunoki Y., Miyoshi A., Nishio S., Tomaru U., Atsumi T., Ishizu A. The responses of macrophages in interaction with neutrophils that undergo NETosis. J. Autoimmun. 2015, 67:19-28.
26. Nakazawa D., Tomaru U., Yamamoto C., Jodo S., Ishizu A. Abundant neutrophil extracellular traps in thrombus of patient with microscopic polyangiitis. Front. Immunol. 2012, 3:333.
27. Yoshida M., Sasaki M., Sugisaki K., Yamaguchi Y., Yamada M. Neutrophil extracellular trap components in fibrinoid necrosis of the kidney with myeloperoxidase-ANCA-associated vasculitis. Clin. Kidney J. 2013, 6:308-312.
28. Leshner M., Wang S., Lewis C., Zheng H., Chen X.A., Santy L., Wang Y. PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures. Front. Immunol. 2012, 3:307.
29. Rohrbach A.S., Slade D.J., Thompson P.R., Mowen K.A. Activation of PAD4 in NET formation. Front. Immunol. 2012, 3:360.
30. Wang S., Wang Y. Peptidylarginine deiminases in citrullination, gene regulation, health and pathogenesis. Biochim. Biophys. Acta 2013, 1829:1126-1135.
31. Nakashima K., Hagiwara T., Yamada M. Nuclear localization of peptidylarginine deiminase V and histone deimination in granulocytes. J. Biol. Chem. 2002, 277:49562-49568.
32. Remijsen Q., Kuijpers T.W., Wirawan E., Lippens S., Vandenabeele P., Vanden Berghe T. Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality. Cell Death Differ. 2011, 18:581-588.
33. Wang Y., Li M., Stadler S., Correll S., Li P., Wang D., Hayama R., Leonelli L., Han H., Grigoryev S.A., Allis C.D., Coonrod S.A. Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation. J. Cell Biol. 2009, 184:205-213.
34. Knight J.S., Zhao W., Luo W., Subramanian V., O'Dell A.A., Yalavarthi S., Hodgin J.B., Eitzman D.T., Thompson P.R., Kaplan M.J. Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus. J. Clin. Invest. 2013, 123:2981-2993.
35. Willis V.C., Gizinski A.M., Banda N.K., Causey C.P., Knuckley B., Cordova K.N., Luo Y., Levitt B., Glogowska M., Chandra P., Kulik L., Robinson W.H., Arend W.P., Thompson P.R., Holers V.M. N-alpha-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritis. J. Immunol. 2011, 186:4396-4404.
36. Chumanevich A.A., Causey C.P., Knuckley B.A., Jones J.E., Poudyal D., Chumanevich A.P., Davis T., Matesic L.E., Thompson P.R., Hofseth L.J. Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor. Am. J. Physiol. Gastrointest. Liver Physiol. 2011, 300:G929-G938.
37. Imamoto T., Nakazawa D., Shida H., Suzuki A., Otsuka N., Tomaru U., Ishizu A. Possible linkage between microscopic polyangiitis and thrombosis via neutrophil extracellular traps. Clin. Exp. Rheumatol. 2014, 32:149-150.
38. Hemmers S., Teijaro J.R., Arandjelovic S., Mowen K.A. PAD4-mediated neutrophil extracellular trap formation is not required for immunity against influenza infection. PLoS One 2011, 6.
39. Zhang S., Lu X., Shu X., Tian X., Yang H., Yang W., Zhang Y., Wang G. Elevated plasma cfDNA may be associated with active lupus nephritis and partially attributed to abnormal regulation of neutrophil extracellular traps (NETs) in patients with systemic lupus erythematosus. Intern. Med. 2014, 53:2763-2771.
40. Ma Y.H., Ma T.T., Wang C., Wang H., Chang D.Y., Chen M., Zhao M.H. High-mobility group box 1 potentiates antineutrophil cytoplasmic antibody-inducing neutrophil extracellular traps formation. Arthritis Res. Ther. 2016, 18:2.
41. Bronkhorst A.J., Aucamp J., Pretorius P.J. Cell-free DNA: preanalytical variables. Clin. Chim. Acta 2015, 450:243-253.
42. Soderberg D., Kurz T., Motamedi A., Hellmark T., Eriksson P., Segelmark M. Increased levels of neutrophil extracellular trap remnants in the circulation of patients with small vessel vasculitis, but an inverse correlation to anti-neutrophil cytoplasmic antibodies during remission. Rheumatology (Oxford) 2015, 54:2085-2094.
43. Miyoshi A., Yamada M., Shida H., Nakazawa D., Kusunoki Y., Nakamura A., Miyoshi H., Tomaru U., Atsumi T., Ishizu A. Circulating neutrophil extracellular trap levels in well-controlled type 2 diabetes and pathway involved in their formation induced by high-dose glucose. Pathobiology 2016, 83:243-251.
44. Zhao W., Fogg D.K., Kaplan M.J. A novel image-based quantitative method for the characterization of NETosis. J. Immunol. Methods 2015, 423:104-110.
45. Gavillet M., Martinod K., Renella R., Harris C., Shapiro N.I., Wagner D.D., Williams D.A. Flow cytometric assay for direct quantification of neutrophil extracellular traps in blood samples. Am. J. Hematol. 2015, 90:1155-1158.
46. Langsrud S., Sundheim G. Flow cytometry for rapid assessment of viability after exposure to a quaternary ammonium compound. J. Appl. Bacteriol. 1996, 81:411-418.