-
1
-
-
84874424895
-
Sepsis definitions: time for change
-
Vincent JL, Opal SM, Marshall JC, Tracey KJ Sepsis definitions: time for change. Lancet 2013, 381:774-775.
-
(2013)
Lancet
, vol.381
, pp. 774-775
-
-
Vincent, J.L.1
Opal, S.M.2
Marshall, J.C.3
Tracey, K.J.4
-
2
-
-
84897377065
-
Why have clinical trials in sepsis failed?
-
Marshall JC Why have clinical trials in sepsis failed?. Trends Mol Med 2014, 20:195-203.
-
(2014)
Trends Mol Med
, vol.20
, pp. 195-203
-
-
Marshall, J.C.1
-
4
-
-
84888325490
-
Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy
-
Hotchkiss RS, Monneret G, Payen D Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat Rev Immunol 2013, 13:862-874.
-
(2013)
Nat Rev Immunol
, vol.13
, pp. 862-874
-
-
Hotchkiss, R.S.1
Monneret, G.2
Payen, D.3
-
5
-
-
84857190262
-
Human genetic susceptibility to infectious disease
-
Chapman SJ, Hill AV Human genetic susceptibility to infectious disease. Nat Rev Genet 2012, 13:175-188.
-
(2012)
Nat Rev Genet
, vol.13
, pp. 175-188
-
-
Chapman, S.J.1
Hill, A.V.2
-
6
-
-
84920376264
-
Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study
-
Rautanen A, Mills TC, Gordon AC, et al. Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study. Lancet Respir Med 2015, 3:53-60.
-
(2015)
Lancet Respir Med
, vol.3
, pp. 53-60
-
-
Rautanen, A.1
Mills, T.C.2
Gordon, A.C.3
-
7
-
-
84929001104
-
The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans
-
The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans. Science 2015, 348:648-660. GTEx Consortium.
-
(2015)
Science
, vol.348
, pp. 648-660
-
-
-
8
-
-
84896742056
-
Innate immune activity conditions the effect of regulatory variants upon monocyte gene expression
-
Fairfax BP, Humburg P, Makino S, et al. Innate immune activity conditions the effect of regulatory variants upon monocyte gene expression. Science 2014, 343:1246949.
-
(2014)
Science
, vol.343
, pp. 1246949
-
-
Fairfax, B.P.1
Humburg, P.2
Makino, S.3
-
9
-
-
0022256529
-
APACHE II: a severity of disease classification system
-
Knaus WA, Draper EA, Wagner DP, Zimmerman JE APACHE II: a severity of disease classification system. Crit Care Med 1985, 13:818-829.
-
(1985)
Crit Care Med
, vol.13
, pp. 818-829
-
-
Knaus, W.A.1
Draper, E.A.2
Wagner, D.P.3
Zimmerman, J.E.4
-
10
-
-
0030015661
-
The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine
-
Vincent JL, Moreno R, Takala J, et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 1996, 22:707-710.
-
(1996)
Intensive Care Med
, vol.22
, pp. 707-710
-
-
Vincent, J.L.1
Moreno, R.2
Takala, J.3
-
11
-
-
44249109682
-
A general approach to simultaneous model fitting and variable elimination in response models for biological data with many more variables than observations
-
Kiiveri HT A general approach to simultaneous model fitting and variable elimination in response models for biological data with many more variables than observations. BMC Bioinformatics 2008, 9:195.
-
(2008)
BMC Bioinformatics
, vol.9
, pp. 195
-
-
Kiiveri, H.T.1
-
12
-
-
77956649096
-
A survey of cross-validation procedures for model selection
-
Arlot S, Celisse A A survey of cross-validation procedures for model selection. Stat Surv 2010, 4:40-79.
-
(2010)
Stat Surv
, vol.4
, pp. 40-79
-
-
Arlot, S.1
Celisse, A.2
-
13
-
-
77952395705
-
Potent phagocytic activity with impaired antigen presentation identifying lipopolysaccharide-tolerant human monocytes: demonstration in isolated monocytes from cystic fibrosis patients
-
del Fresno C, Garcia-Rio F, Gomez-Pina V, et al. Potent phagocytic activity with impaired antigen presentation identifying lipopolysaccharide-tolerant human monocytes: demonstration in isolated monocytes from cystic fibrosis patients. J Immunol 2009, 182:6494-6507.
-
(2009)
J Immunol
, vol.182
, pp. 6494-6507
-
-
del Fresno, C.1
Garcia-Rio, F.2
Gomez-Pina, V.3
-
14
-
-
79959558906
-
Endotoxin tolerance represents a distinctive state of alternative polarization (M2) in human mononuclear cells
-
Pena OM, Pistolic J, Raj D, Fjell CD, Hancock RE Endotoxin tolerance represents a distinctive state of alternative polarization (M2) in human mononuclear cells. J Immunol 2011, 186:7243-7254.
-
(2011)
J Immunol
, vol.186
, pp. 7243-7254
-
-
Pena, O.M.1
Pistolic, J.2
Raj, D.3
Fjell, C.D.4
Hancock, R.E.5
-
15
-
-
77955889132
-
ROAST: rotation gene set tests for complex microarray experiments
-
Wu D, Lim E, Vaillant F, Asselin-Labat ML, Visvader JE, Smyth GK ROAST: rotation gene set tests for complex microarray experiments. Bioinformatics 2010, 26:2176-2182.
-
(2010)
Bioinformatics
, vol.26
, pp. 2176-2182
-
-
Wu, D.1
Lim, E.2
Vaillant, F.3
Asselin-Labat, M.L.4
Visvader, J.E.5
Smyth, G.K.6
-
16
-
-
45249095384
-
Mapping gene expression quantitative trait loci by singular value decomposition and independent component analysis
-
Biswas S, Storey JD, Akey JM Mapping gene expression quantitative trait loci by singular value decomposition and independent component analysis. BMC Bioinformatics 2008, 9:244.
-
(2008)
BMC Bioinformatics
, vol.9
, pp. 244
-
-
Biswas, S.1
Storey, J.D.2
Akey, J.M.3
-
17
-
-
84885018609
-
Systematic identification of trans eQTLs as putative drivers of known disease associations
-
Westra HJ, Peters MJ, Esko T, et al. Systematic identification of trans eQTLs as putative drivers of known disease associations. Nat Genet 2013, 45:1238-1243.
-
(2013)
Nat Genet
, vol.45
, pp. 1238-1243
-
-
Westra, H.J.1
Peters, M.J.2
Esko, T.3
-
18
-
-
84907483941
-
Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity
-
Saeed S, Quintin J, Kerstens HH, et al. Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity. Science 2014, 345:1251086.
-
(2014)
Science
, vol.345
, pp. 1251086
-
-
Saeed, S.1
Quintin, J.2
Kerstens, H.H.3
-
19
-
-
84860317030
-
Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles
-
Fairfax BP, Makino S, Radhakrishnan J, et al. Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles. Nat Genet 2012, 44:502-510.
-
(2012)
Nat Genet
, vol.44
, pp. 502-510
-
-
Fairfax, B.P.1
Makino, S.2
Radhakrishnan, J.3
-
20
-
-
84905484562
-
Cis and trans effects of human genomic variants on gene expression
-
Bryois J, Buil A, Evans DM, et al. Cis and trans effects of human genomic variants on gene expression. PLoS Genet 2014, 10:e1004461.
-
(2014)
PLoS Genet
, vol.10
, pp. e1004461
-
-
Bryois, J.1
Buil, A.2
Evans, D.M.3
-
21
-
-
69949176863
-
Common regulatory variation impacts gene expression in a cell type-dependent manner
-
Dimas AS, Deutsch S, Stranger BE, et al. Common regulatory variation impacts gene expression in a cell type-dependent manner. Science 2009, 325:1246-1250.
-
(2009)
Science
, vol.325
, pp. 1246-1250
-
-
Dimas, A.S.1
Deutsch, S.2
Stranger, B.E.3
-
22
-
-
84897378109
-
The new normal: immunomodulatory agents against sepsis immune suppression
-
Hutchins NA, Unsinger J, Hotchkiss RS, Ayala A The new normal: immunomodulatory agents against sepsis immune suppression. Trends Mol Med 2014, 20:224-233.
-
(2014)
Trends Mol Med
, vol.20
, pp. 224-233
-
-
Hutchins, N.A.1
Unsinger, J.2
Hotchkiss, R.S.3
Ayala, A.4
-
23
-
-
33746345574
-
Systemic transcriptional analysis in survivor and non-survivor septic shock patients: a preliminary study
-
Pachot A, Lepape A, Vey S, Bienvenu J, Mougin B, Monneret G Systemic transcriptional analysis in survivor and non-survivor septic shock patients: a preliminary study. Immunol Lett 2006, 106:63-71.
-
(2006)
Immunol Lett
, vol.106
, pp. 63-71
-
-
Pachot, A.1
Lepape, A.2
Vey, S.3
Bienvenu, J.4
Mougin, B.5
Monneret, G.6
-
24
-
-
78650624395
-
Genome-wide transcription profiling of human sepsis: a systematic review
-
Tang BM, Huang SJ, McLean AS Genome-wide transcription profiling of human sepsis: a systematic review. Crit Care 2010, 14:R237.
-
(2010)
Crit Care
, vol.14
, pp. R237
-
-
Tang, B.M.1
Huang, S.J.2
McLean, A.S.3
-
25
-
-
70349559403
-
Endotoxin tolerance: new mechanisms, molecules and clinical significance
-
Biswas SK, Lopez-Collazo E Endotoxin tolerance: new mechanisms, molecules and clinical significance. Trends Immunol 2009, 30:475-487.
-
(2009)
Trends Immunol
, vol.30
, pp. 475-487
-
-
Biswas, S.K.1
Lopez-Collazo, E.2
-
26
-
-
84921987242
-
An Endotoxin Tolerance Signature Predicts Sepsis and Organ Dysfunction at Initial Clinical Presentation
-
Pena OM, Hancock DG, Lyle NH, et al. An Endotoxin Tolerance Signature Predicts Sepsis and Organ Dysfunction at Initial Clinical Presentation. EBioMedicine 2014, 1:64-71.
-
(2014)
EBioMedicine
, vol.1
, pp. 64-71
-
-
Pena, O.M.1
Hancock, D.G.2
Lyle, N.H.3
-
27
-
-
12244283722
-
Messenger RNA expression of major histocompatibility complex class II genes in whole blood from septic shock patients
-
Pachot A, Monneret G, Brion A, et al. Messenger RNA expression of major histocompatibility complex class II genes in whole blood from septic shock patients. Crit Care Med 2005, 33:31-38.
-
(2005)
Crit Care Med
, vol.33
, pp. 31-38
-
-
Pachot, A.1
Monneret, G.2
Brion, A.3
-
28
-
-
84255194001
-
Immunosuppression in patients who die of sepsis and multiple organ failure
-
Boomer JS, To K, Chang KC, et al. Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA 2011, 306:2594-2605.
-
(2011)
JAMA
, vol.306
, pp. 2594-2605
-
-
Boomer, J.S.1
To, K.2
Chang, K.C.3
-
29
-
-
42149191249
-
Transglutaminase type II is involved in the pathogenesis of endotoxic shock
-
Falasca L, Farrace MG, Rinaldi A, Tuosto L, Melino G, Piacentini M Transglutaminase type II is involved in the pathogenesis of endotoxic shock. J Immunol 2008, 180:2616-2624.
-
(2008)
J Immunol
, vol.180
, pp. 2616-2624
-
-
Falasca, L.1
Farrace, M.G.2
Rinaldi, A.3
Tuosto, L.4
Melino, G.5
Piacentini, M.6
-
30
-
-
33750465872
-
SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes
-
Cai S, Lee CC, Kohwi-Shigematsu T SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes. Nat Genet 2006, 38:1278-1288.
-
(2006)
Nat Genet
, vol.38
, pp. 1278-1288
-
-
Cai, S.1
Lee, C.C.2
Kohwi-Shigematsu, T.3
-
31
-
-
84930336482
-
Host genetic variation influences gene expression response to rhinovirus infection
-
Caliskan M, Baker SW, Gilad Y, Ober C Host genetic variation influences gene expression response to rhinovirus infection. PLoS Genet 2015, 11:e1005111.
-
(2015)
PLoS Genet
, vol.11
, pp. e1005111
-
-
Caliskan, M.1
Baker, S.W.2
Gilad, Y.3
Ober, C.4
-
32
-
-
85027203102
-
Peripheral blood RNA gene expression profiling in patients with bacterial meningitis
-
Lill M, Koks S, Soomets U, et al. Peripheral blood RNA gene expression profiling in patients with bacterial meningitis. Front Neurosci 2013, 7:33.
-
(2013)
Front Neurosci
, vol.7
, pp. 33
-
-
Lill, M.1
Koks, S.2
Soomets, U.3
-
33
-
-
84893525976
-
Simultaneous targeting of IL-1 and IL-18 is required for protection against inflammatory and septic shock
-
Vanden Berghe T, Demon D, Bogaert P, et al. Simultaneous targeting of IL-1 and IL-18 is required for protection against inflammatory and septic shock. Am J Respir Crit Care Med 2014, 189:282-291.
-
(2014)
Am J Respir Crit Care Med
, vol.189
, pp. 282-291
-
-
Vanden Berghe, T.1
Demon, D.2
Bogaert, P.3
-
34
-
-
84873091770
-
Genome-wide association analysis identifies new susceptibility loci for Behcet's disease and epistasis between HLA-B*51 and ERAP1
-
Kirino Y, Bertsias G, Ishigatsubo Y, et al. Genome-wide association analysis identifies new susceptibility loci for Behcet's disease and epistasis between HLA-B*51 and ERAP1. Nat Genet 2013, 45:202-207.
-
(2013)
Nat Genet
, vol.45
, pp. 202-207
-
-
Kirino, Y.1
Bertsias, G.2
Ishigatsubo, Y.3
-
35
-
-
34147158763
-
Treatment with BX471, a CC chemokine receptor 1 antagonist, attenuates systemic inflammatory response during sepsis
-
He M, Horuk R, Moochhala SM, Bhatia M Treatment with BX471, a CC chemokine receptor 1 antagonist, attenuates systemic inflammatory response during sepsis. Am J Physiol Gastrointest Liver Physiol 2007, 292:G1173-G1180.
-
(2007)
Am J Physiol Gastrointest Liver Physiol
, vol.292
, pp. G1173-G1180
-
-
He, M.1
Horuk, R.2
Moochhala, S.M.3
Bhatia, M.4
-
36
-
-
7044272272
-
The Th2 response as monitored by CRTH2 or CCR3 expression is severely decreased during septic shock
-
Venet F, Lepape A, Debard AL, Bienvenu J, Bohe J, Monneret G The Th2 response as monitored by CRTH2 or CCR3 expression is severely decreased during septic shock. Clin Immunol 2004, 113:278-284.
-
(2004)
Clin Immunol
, vol.113
, pp. 278-284
-
-
Venet, F.1
Lepape, A.2
Debard, A.L.3
Bienvenu, J.4
Bohe, J.5
Monneret, G.6
-
37
-
-
79955485454
-
Role of the immediate early response 3 (IER3) gene in cellular stress response, inflammation and tumorigenesis
-
Arlt A, Schafer H Role of the immediate early response 3 (IER3) gene in cellular stress response, inflammation and tumorigenesis. Eur J Cell Biol 2011, 90:545-552.
-
(2011)
Eur J Cell Biol
, vol.90
, pp. 545-552
-
-
Arlt, A.1
Schafer, H.2
-
38
-
-
0033587689
-
Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo
-
Pham CT, Ley TJ Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo. Proc Natl Acad Sci USA 1999, 96:8627-8632.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 8627-8632
-
-
Pham, C.T.1
Ley, T.J.2
-
39
-
-
1542287347
-
Neutrophil extracellular traps kill bacteria
-
Brinkmann V, Reichard U, Goosmann C, et al. Neutrophil extracellular traps kill bacteria. Science 2004, 303:1532-1535.
-
(2004)
Science
, vol.303
, pp. 1532-1535
-
-
Brinkmann, V.1
Reichard, U.2
Goosmann, C.3
-
40
-
-
84924952897
-
Human monocytes undergo functional re-programming during sepsis mediated by hypoxia-inducible Factor-1α
-
Shalova IN, Lim JY, Chittezhath M, et al. Human monocytes undergo functional re-programming during sepsis mediated by hypoxia-inducible Factor-1α. Immunity 2015, 42:484-498.
-
(2015)
Immunity
, vol.42
, pp. 484-498
-
-
Shalova, I.N.1
Lim, J.Y.2
Chittezhath, M.3
-
41
-
-
84907543940
-
MTOR- and HIF-1alpha-mediated aerobic glycolysis as metabolic basis for trained immunity
-
Cheng SC, Quintin J, Cramer RA, et al. mTOR- and HIF-1alpha-mediated aerobic glycolysis as metabolic basis for trained immunity. Science 2014, 345:1250684.
-
(2014)
Science
, vol.345
, pp. 1250684
-
-
Cheng, S.C.1
Quintin, J.2
Cramer, R.A.3
-
42
-
-
0030024779
-
Serial blood lactate levels can predict the development of multiple organ failure following septic shock
-
Bakker J, Gris P, Coffernils M, Kahn RJ, Vincent JL Serial blood lactate levels can predict the development of multiple organ failure following septic shock. Am J Surg 1996, 171:221-226.
-
(1996)
Am J Surg
, vol.171
, pp. 221-226
-
-
Bakker, J.1
Gris, P.2
Coffernils, M.3
Kahn, R.J.4
Vincent, J.L.5
-
43
-
-
84902198047
-
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) prevents lipopolysaccharide (LPS)-induced, sepsis-related severe acute lung injury in mice
-
Takaoka Y, Goto S, Nakano T, et al. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) prevents lipopolysaccharide (LPS)-induced, sepsis-related severe acute lung injury in mice. Sci Rep 2014, 4:5204.
-
(2014)
Sci Rep
, vol.4
, pp. 5204
-
-
Takaoka, Y.1
Goto, S.2
Nakano, T.3
-
44
-
-
84920528079
-
Sequential actions of SIRT1-RELB-SIRT3 coordinate nuclear-mitochondrial communication during immunometabolic adaptation to acute inflammation and sepsis
-
Liu TF, Vachharajani V, Millet P, Bharadwaj MS, Molina AJ, McCall CE Sequential actions of SIRT1-RELB-SIRT3 coordinate nuclear-mitochondrial communication during immunometabolic adaptation to acute inflammation and sepsis. J Biol Chem 2015, 290:396-408.
-
(2015)
J Biol Chem
, vol.290
, pp. 396-408
-
-
Liu, T.F.1
Vachharajani, V.2
Millet, P.3
Bharadwaj, M.S.4
Molina, A.J.5
McCall, C.E.6
-
45
-
-
0028357297
-
Induction of the heat shock response reduces mortality rate and organ damage in a sepsis-induced acute lung injury model
-
Villar J, Ribeiro SP, Mullen JB, Kuliszewski M, Post M, Slutsky AS Induction of the heat shock response reduces mortality rate and organ damage in a sepsis-induced acute lung injury model. Crit Care Med 1994, 22:914-921.
-
(1994)
Crit Care Med
, vol.22
, pp. 914-921
-
-
Villar, J.1
Ribeiro, S.P.2
Mullen, J.B.3
Kuliszewski, M.4
Post, M.5
Slutsky, A.S.6
-
46
-
-
84896512664
-
Rab8 binding to immune cell-specific adaptor LAX facilitates formation of trans-Golgi network-proximal CTLA-4 vesicles for surface expression
-
Banton MC, Inder KL, Valk E, Rudd CE, Schneider H Rab8 binding to immune cell-specific adaptor LAX facilitates formation of trans-Golgi network-proximal CTLA-4 vesicles for surface expression. Mol Cell Biol 2014, 34:1486-1499.
-
(2014)
Mol Cell Biol
, vol.34
, pp. 1486-1499
-
-
Banton, M.C.1
Inder, K.L.2
Valk, E.3
Rudd, C.E.4
Schneider, H.5
-
47
-
-
84875468205
-
Novel function of Trim44 promotes an antiviral response by stabilizing VISA
-
Yang B, Wang J, Wang Y, et al. Novel function of Trim44 promotes an antiviral response by stabilizing VISA. J Immunol 2013, 190:3613-3619.
-
(2013)
J Immunol
, vol.190
, pp. 3613-3619
-
-
Yang, B.1
Wang, J.2
Wang, Y.3
-
48
-
-
84887280855
-
DDX24 negatively regulates cytosolic RNA-mediated innate immune signaling
-
Ma Z, Moore R, Xu X, Barber GN DDX24 negatively regulates cytosolic RNA-mediated innate immune signaling. PLoS Pathog 2013, 9:e1003721.
-
(2013)
PLoS Pathog
, vol.9
, pp. e1003721
-
-
Ma, Z.1
Moore, R.2
Xu, X.3
Barber, G.N.4
-
49
-
-
84943279884
-
A molecular biomarker to diagnose community-acquired pneumonia on intensive care unit admission
-
Scicluna BP, Klein Klouwenberg PM, van Vught LA, et al. A molecular biomarker to diagnose community-acquired pneumonia on intensive care unit admission. Am J Respir Crit Care Med 2015, 192:826-835.
-
(2015)
Am J Respir Crit Care Med
, vol.192
, pp. 826-835
-
-
Scicluna, B.P.1
Klein Klouwenberg, P.M.2
van Vught, L.A.3
-
50
-
-
84922311029
-
Developing a clinically feasible personalized medicine approach to pediatric septic shock
-
Wong HR, Cvijanovich NZ, Anas N, et al. Developing a clinically feasible personalized medicine approach to pediatric septic shock. Am J Respir Crit Care Med 2015, 191:309-315.
-
(2015)
Am J Respir Crit Care Med
, vol.191
, pp. 309-315
-
-
Wong, H.R.1
Cvijanovich, N.Z.2
Anas, N.3
|