Assessment of antioxidant, anti-inflammatory, anti-cholinesterase and cytotoxic activities of pomegranate (Punica granatum) leaves

Food and Chemical Toxicology

Volumn 55, Issue , 2013, Pages 470-475

  Bekir, Jalila ^a,b   Mars, Mohamed ^b   Souchard, Jean Pierre ^a   Bouajila, Jalloul ^a  

^a Université Paul Sabatier   (France)

^b UNIVERSITY OF GABES   (Tunisia)

Author keywords

Anti inflammatory; Antioxidant; Cholinesterase; Cytotoxic; Extraction; Punica granatum

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; 2,2' AZINOBIS(3 ETHYLBENZOTHIAZOLINE 6 SULFONIC ACID); ACETYLCHOLINESTERASE; ANTHOCYANIN; ARACHIDONATE 5 LIPOXYGENASE; CHOLINESTERASE; CYANIDIN 3 GLUCOSIDE; FLAVANOID; GALLIC ACID; PHENOL; POMEGRANATE EXTRACT; QUERCETIN; TANNIN DERIVATIVE;

ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CELL STRAIN MCF 7; CHOLINESTERASE INHIBITION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG SCREENING; DRY WEIGHT; ENZYME INHIBITION; HUMAN; HUMAN CELL; PHYTOCHEMISTRY; PLANT LEAF;

ANTHOCYANINS; ANTI-INFLAMMATORY AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTIOXIDANTS; CELL LINE, TUMOR; CHOLINESTERASE INHIBITORS; FLAVONOIDS; HUMANS; PHENOLS; PLANT EXTRACTS; PLANT LEAVES; PUNICACEAE; TANNINS;

EID: 84874404614     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.01.036     Document Type: Article

References (34)

1. Akkol E.K., Orhan I.E., Yeşilada E. Anticholinesterase and antioxidant effects of the ethanol extract, ethanol fractions and isolated flavonoids from Cistus laurifolius L. leaves. Food Chem. 2012, 131:626-631.
2. Al-Muammar M.N., Fozia Khan F. Obesity: the preventive role of the pomegranate (Punica granatum). Nutrition 2012, 28:595-604.
3. Arancibia-Avila P., Namiesnik J., Toledo F., Werner E., Martinez-Ayala A.L., Rocha-Guzmán N.E., Gallegos-Infante J.A., Gorinstein S. The influence of different time durations of thermal processing on berries quality. Food Cont. 2012, 26(2):587-593.
4. Arvouet-Grand A., Vennat B., Pourrat A., Legret P. Standardization of a propolis extract and identification of the main constituents. J. Pharm. Belg. 1994, 49:462-468.
5. Baravalia Y., Kaneria M., Vaghasiya Y., Parekh J., Chanda S. Antioxidant and antibacterial activity of Diospyros ebenum Roxb. leaf extracts. Turk. J. Biol. 2009, 33:159-164.
6. Blois M.S. Antioxidant determinations by the use of a stable free radical. Nature 1958, 181:1199-1200.
7. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 2001, 414:813-820.
8. Bylac S., Racine P. Inhibition of 5-lipoxygenase by essential oils and other natural fragrant extracts. Int. J. Aromather. 2003, 13:138-142.
9. Cheng G.W., Breen P.J. Activity of phenylalanine ammonialyase (PAL) and concentrations of anthocyanins and phenolics in developing strawberry fruit. J. Am. Soc. Hortic. Sci. 1991, 117:946-950.
10. Christen Y. Oxidative stress and Alzheimer disease. Am. J. Clin. Nutr. 2000, 71:621-629.
11. Dorman H.J.D., Bachmayer O., Kosar M., Hiltunen R. Antioxidant properties of aqueous extracts from selected Lamiaceae species grown in Turkey. J. Agric. Food Chem. 2004, 52:762-770.
12. Egharevba H.O., Kunle O.F., Iliya I., Orji P.N., Abdullahi M.S., Okwute S.K., Okogun J.I. Phytochemical analysis and antimicrobial activity of Punica granatum L. (fruit bark and leaves). N. Y. Sci. J. 2010, 3:91-98.
13. Elfalleh W., Hannachi H., Tlili N., Yahia Y., Nasri N., Ferchichi A. Total phenolic contents and antioxidant activities of pomegranate peel, seed, leaf and flower. J. Med. Plants Res. 2012, 6:4724-4730.
14. El-Shennawy A., Ali E., El-Komy W., Fahmy Z., El-Wakel E. Evaluation of ponytail antiparasitic activity of pomegranate juice, peels and leaves against Giardia lamblia. Int. J. Infect. Dis. 2010, 14:S84.
15. Georgé S., Brat P., Alter P., Amiot M.J. Rapid Determination of polyphenols and vitamin C in plant-derived products. J. Agric. Food Chem. 2005, 53:1370-1373.
16. Heo B.G., Jang H.G., Cho J.Y., Namiesnik J., Jastrzebski Z., Vearasilp K., Gonzalez-Aguilar G., Martinez-Ayala A.L., Suhaj M., Gorinstein S. Partial characterization of indigo (Polygonum tinctorium Ait.) plant seeds and leaves. Ind. Crop. Prod. 2013, 42:429-439.
17. Kaneria M.J., Bapodara M.B., Chanda S.V. Effect of extraction techniques and solvents on antioxidant activity of pomegranate (Punica granatum L.) leaf and stem. Food Anal. Methods 2012, 5:396-404.
18. Lan J.Q., Lei F., Hua L., Wang Y.G., Xing D.M., Du L.J. Transport behavior of ellagic acid of pomegranate leaf tannins and its correlation with total cholesterol alteration in HepG2 cells. Biomed. Chromatogr. 2009, 23:531-536.
19. Lansky E.P., Newman R.A. Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer. Rev. J. Ethnopharmacol. 2007, 109:177-206.
20. Lei F., Zhang X.N., Wang W., Xing D.M., Xie W.D., Su H., Du L.J. Evidence of anti-obesity effects of the pomegranate leaf extract in high-fat diet induced obese mice. Int. J. Obes. 2007, 31:1023-1029.
21. Mars M., Marrakchi M. Diversity of pomegranate (Punica granatum L.) germplasm in Tunisia. Genetic Resour. Crop Ev. 1999, 46:461-467.
22. McCall D.O., McGartland C.P., McKinley M.C., Sharpe P., McCance D.R., Young I.S., Woodside J.V. The effect of increased dietary fruit and vegetable consumption on endothelial activation, inflammation and oxidative stress in hypertensive volunteers. Nutr. Metab. Cardiovas. Dis. 2011, 21:658-664.
23. Min B., Chen M.H., Green B.W. Antioxidant activities of purple rice bran extract and its effect on the quality of low-NaCl, phosphate-free patties made from channel catfish (Ictalurus punctatus) belly flap meat. J. Food Sci. 2009, 74(3):C268-C277.
24. Naczk M., Amarowicz R., Pink D., Shahidi F. Insoluble condensed tannins of canola/rapeseed. J. Agric. Food Chem. 2000, 48:1758-1762.
25. Natarajan N., Thamaraiselvan R., Lingaiah H., Srinivasan P., Balasubramanian Maruthaiveeran Periyasamy B.M. Effect of flavonone hesperidin on the apoptosis of human mammary carcinoma cell line MCF-7. Biomed. Prev. Nutr. 2011, 1:207-215.
26. Prakash M.V.D., Premkumar K. Phytochemical screening, free radical scavenging and cytotoxic studies on Punica granatum L. leaf extracts. Int. J. Med. Res. 2012, 1(6):333-337.
27. Prasad N.S., Raghavendra R., Lokesh B.R., Naidu K.A. Spice phenolics inhibit human PMNL 5-lipoxygenase. Prostag. Leukotr. Ess. 2004, 70:521-528.
28. Re R., Pellegrini N., Proteggente A., Pannala A., Yang M., Rice-Evans C. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free. Radical. Biol. Med. 1999, 26:1231-1237.
29. Reuter S., Gupta S.C., Chaturvedi M.M., Aggarwal B.B. Oxidative stress, inflammation, and cancer: how are they linked?. Free Radic. Biol. Med. 2010, 49:1603-1616.
30. Toullec A., Gerald D., Despouy G., Bourachot B., Cardon M., Lefort S., Richardson M., Rigaill G., Parrini M.C., Lucchesi C., Bellanger D., Stern M.H., Dubois T., Sastre-Garau X., Delattre O., Vincent-Salomon A., Mechta-Grigoriou F. Oxidative stress promotes myofibroblast differentiation and tumour spreading. EMBO Mol. Med. 2010, 2:211-230.
31. Voss C., Sepulveda-Boza S., Zilliken F.W. New isoflavonoids as inhibitors of porcine 5-lipoxygenase. Biochem. Pharmacol. 1992, 44:157-162.
32. Wang C., Shi L., Fan L., Ding Y., Zhao S., Liu Y., Chao Ma.C. Optimization of extraction and enrichment of phenolics from pomegranate (Punica granatum L.) leaves. Ind. Crop. Prod. 2013, 42:587-594.
33. Zhang L., Gao Y., Zhang Y., Liu J., Yu J. Changes in bioactive compounds and antioxidant activities in pomegranate leaves. Sci. Hortic. 2010, 123:543-546.
34. Zhang L., Yang X., Zhang Y., Wang L., Zhang R. In vitro antioxidant properties of different parts of pomegranate flowers. Food Bioprod. Process. 2011, 89:234-240.