Endocrinology of Fetal Development

Williams Textbook of Endocrinology, Twelfth Edition

Volumn , Issue , 2011, Pages 833-867

  Dattani, Mehul T ^a,b   Hindmarsh, Peter C ^a,b,c   Fisher, Delbert A ^d  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

^c GREAT ORMOND STREET HOSPITAL   (United Kingdom)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85041285136     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-1-4377-0324-5.00022-5     Document Type: Chapter

References (334)

1. VE Murphy, R Smith, WB Giles, et al. (2006) Endocrine regulation of human fetal growth: the role of the mother, placenta, and fetus. Endocrine Rev 27 141-169.
2. DA Fisher (2006) Fetal and neonatal endocrinology. LJ DeGroot, JL Jameson,(Eds) Endocrinology 5th ed Philadelphia, PA: Elsevier Saunders 3369-3386.
3. M Palfi and A Selbing (1998) Placental transport of maternal immunoglobulin G. Am J Reprod Immunol 39 24-26.
4. RJ Sodha, M Proegler and H Schneider (1984) Transfer and metabolism of norepinephrine studied from maternal to fetal and fetal to maternal sides in the in vitro perfused human placental life. Am J Obstet Gynecol 148 474-481.
5. R Benediktsson, A Calder, CRW Edwards, et al. (1997) Placental 11β-hydroxysteroid dehydrogenase: a key regulator of fetal glucocorticoid exposure. Clin Endocrinol (Oxf) 46 161-166.
6. BEP Murphy (1979) Cortisol and cortisone in human fetal development. J Steroid Biochem 11 509-513.
7. J Takeyama, H Sasano, T Suzuki, et al. (1998) 17β-Hydroxysteroid dehydrogenase types 1 and 2 in human placenta: an immunohistochemical study with correlation to placental development. J Clin Endocrinol Metab 83 3710-3715.
8. E Krysin, E Brzezinska-Slebodzinska and AB Slebodzinski (1997) Divergent deiodination of thyroid hormones in the separated parts of the fetal and maternal placenta in pigs. J Endocrinol 155 295-303.
9. R Benediktsson, RD Lindsay, J Noble, et al. (1993) Glucocorticoid exposure in utero: new model for adult hypertension. [Erratum in Lancet. 1993;341572.]. Lancet 341 339-341.
10. JL Yau, T Olsson, RG Morris, et al. (1995) Glucocorticoids, hippocampal corticosteroid receptor gene expression and antidepressant treatment: relationship with spatial learning in young and aged rats. Neuroscience 66 571-581.
11. Roberts D, Dalziel SR. Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst Rev. 2006;(3):CD004454.
12. E Roti, A Gnudi and LE Braverman (1983) The placental transport, synthesis and metabolism of hormones and drugs which affect thyroid function. Endocr Rev 4 131-149.
13. VJ Pop, EP Brouwers, HL Vader, et al. (2003) Maternal hypothyroxinaemia during early pregnancy and subsequent child development: a 3-year follow-up study. Clin Endocrinol (Oxf) 59 282-288.
14. JE Haddow, GE Palomaki, WC Allan, et al. (1999) Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. N Engl J Med 341 549-555.
15. E Iisalo and O Castren (1967) The enzymatic inactivation of noradrenaline in human placental tissue. Ann Med Exp Biol Fenn 45 253-257.
16. S Mesiano and RB Jaffe (2004) Neuroendocrine-metabolic regulation of pregnancy. JF Strauss, III,RL Barbieri,(Eds) Reproductive Endocrinology 5th ed Philadelphia, PA: WB Saunders 327-366.
17. PC Goldsmith, WG McGregor, WJ Raymoure, et al. (1983) Cellular localization of chorionic gonadotropin in human fetal liver and kidney. J Clin Endocrinol Metab 57 654-661.
18. LP Kapcala (1985) Immunoassayable adrenocorticotropin in peripheral organs: concentrations during early development. Life Sci 37 2283-2290.
19. E Martino, A Lernmark, H Seo, et al. (1978) High concentration of thyrotropin releasing hormone in pancreatic islets. Proc Natl Acad Sci U S A 75 4265-4267.
20. AE Pekary, NV Meyer, C Vaillant, et al. (1980) Thyrotropin releasing hormone and a homologous peptide in the male rat reproductive system. Biochem Biophys Res Commun 95 993-1000.
21. T Suda, N Tomori, F Tozawa, et al. (1984) Distribution and characterization of immunoreactive corticotropin-releasing factor in human tissues. J Clin Endocrinol Metab 59 861-866.
22. RC Thompson, AF Seasholtz and E Herbert (1987) Rat corticotropin releasing hormone gene: sequence and tissue specific expression. Mol Endocrinol 1 363-370.
23. T Shibaski, Y Kiyosawa, A Masuda, et al. (1984) Distribution of growth hormone releasing hormone-like immunoreactivity in human tissue extracts. J Clin Endocrinol Metab 59 263-268.
24. P Wu and IMD Jackson (1988) Identification, characterization and localization of thyrotropin releasing hormone precursor peptides in perinatal rat pancreas. Regul Pept 22 347-360.
25. T Koshimizu (1983) The development of pancreatic and gastrointestinal somatostatin-like immunoreactivity and its relationship to feeding in neonatal rats. Endocrinology 112 911-916.
26. DH Polk, AL Reviczky, RW Lam, et al. (1991) Thyrotropin releasing hormone in the ovine fetus: ontogeny and effect of thyroid hormone. Am J Physiol 23 E53-E58.
27. J Rahier, J Wallon and JC Henquin (1980) Abundance of somatostatin cells in the human neonatal pancreas. Diabetologia 18 251-254.
28. P Leduque, S Aratan-Spire, P Czernichow, et al. (1986) Ontogenesis of thyrotropin-releasing hormone in the human fetal pancreas. J Clin Invest 78 1028-1034.
29. H Saito, S Saito, T Sano, et al. (1983) Fetal and maternal plasma levels of immunoreactive somatostatin at delivery: evidence for its increase in the umbilical artery and its arteriovenous gradient in the fetoplacental circulation. J Clin Endocrinol Metab 56 567-571.
30. T Koshimizu, Y Ohyama, Y Yokota, et al. (1985) Peripheral plasma concentrations of somatostatin-like immunoreactivity in newborns and infants. J Clin Endocrinol Metab 61 78-82.
31. D Kelberman, K Rizzoti, R Lovell-Badge, et al. (2009) Genetic Regulation of pituitary gland development in human and mouse. Endocr Rev 30 790-829.
32. JS Dasen and MG Rosenfeld (2001) Signaling and transcriptional mechanisms in pituitary development. Annu Rev Neurosci 24 327-355.
33. MM Grumbach and PD Gluckman (1994) The human fetal hypothalamus and pituitary gland: the maturation of neuroendocrine mechanisms controlling secretion of fetal pituitary growth hormone, prolactin, gonadotropins, adrenocorticotropin-related peptides, and thyrotropin. D Tulchinsky, AB Little,(Eds) Maternal Fetal Endocrinology 2nd ed Philadelphia, PA: WB Saunders 193-261.
34. LE Cohen and S Radovik (2002) Molecular basis of combined pituitary hormone deficiencies. Endocr Rev 23 431-442.
35. X Zhu, J Zhang, J Tollkuhn, et al. (2006) Sustained Notch signaling in progenitors is required for sequential emergence of distinct cell lineages during organogenesis. Genes Dev 20 2739-2753.
36. E Roessler, E Belloni, K Gaudenz, et al. (1996) Mutations in the human Sonic Hedgehog gene cause holoprosencephaly. Nat Genet 14 357-360.
37. SA Brown, D Warburton, LY Brown, et al. (1998) Holoprosencephaly due to mutation in ZIC1, a homologue of Drosophila odd-paired. Nat Genet 20 180-183.
38. E Roessler and M Muenke (2010) The molecular genetics of holoprosencephaly. Am J Med Genet C Semin Med Genet 154C(1), 52-61.
39. MT Dattani, JP Martinez-Barbera, PQ Thomas, et al. (1998) Mutations in the homeobox gene HESX1/Hesx1 associated with septo-optic dysplasia in human and mouse. Nat Genet 19 125-133.
40. D Kelberman, K Rizzoti, A Avilion, et al. (2006) Mutations within Sox2/SOX2 are associated with abnormalities in the hypothalamo-pituitary-gonadal axis in mice and humans. J Clin Invest 116 2442-2455.
41. D Kelberman, SC de Castro, S Huang, et al. (2008) SOX2 plays a critical role in the pituitary, forebrain and eye during human embryonic development. J Clin Endocrinol Metab 93 1865-1873.
42. T Tajima, A Ohtake, M Hoshino, et al. (2008) OTX2 loss of function mutation causes anophthalmia and combined pituitary hormone deficiency with a small anterior and ectopic posterior pituitary. J Clin Endocrinol Metab 94 314-319.
43. S Dateki, M Fukami, N Sato, et al. (2008) OTX2 mutation in a patient with anophthalmia, short stature, and partial growth hormone deficiency: functional studies using the IRBP, HESX1, and POU1F1 promoters. J Clin Endocrinol Metab 93 3697-3702.
44. D Diaczok, C Romero, J Zunich, et al. (2008) A novel dominant negative mutation of OTX2 associated with combined pituitary hormone deficiency. J Clin Endocrinol Metab 93 4351-4359.
45. KS Woods, M Cundall, J Turton, et al. (2005) Over- and underdosage of SOX3 is associated with infundibular hypoplasia and hypopituitarism. Am J Hum Genet 76 833-849.
46. I Netchine, ML Sobrier, H Krude, et al. (2000) Mutations in LHX3 result in a new syndrome revealed by combined pituitary hormone deficiency. Nat Genet 25 182-186.
47. A Rajab, D Kelberman, SC de Castro, et al. (2008) Novel mutations in LHX3 are associated with hypopituitarism and sensorineural hearing loss. Hum Mol Genet 17 2150-2159.
48. K Machinis, J Pantel, I Netchine, et al. (2001) Syndromic short stature in patients with a germline mutation in the LIM homeobox LHX4. Am J Hum Genet 69 961-968.
49. W Wu, JD Cogan, RW Pfaffle, et al. (1998) Mutations in PROP1 cause familial combined pituitary hormone deficiency. Nat Genet 18 147-149.
50. S Radovick, M Nations, Y Du, et al. (1992) A mutation in the POU-homeodomain of Pit-1 responsible for combined pituitary hormone deficiency. Science 257 1115-1118.
51. K Ohta, Y Nobukuni, H Mitsubuchi, et al. (1992) Mutations in the Pit-1 gene in children with combined pituitary hormone deficiency. Biochem Biophys Res Commun 189 851-855.
52. AM Pulichino, S Vallette-Kasic, C Couture, et al. (2003) Human and mouse TPIT gene mutations cause early onset pituitary ACTH deficiency. Genes Dev 17 711-716.
53. JJ Mulchahey, AM DiBlasio, MC Martin, et al. (1987) Hormone production and peptide regulation of the human fetal pituitary gland. Endocr Rev 8 406-425.
54. N Suganuma, H Seo, N Yamamoto, et al. (1989) The ontogeny of growth hormone in the human fetal pituitary. Am J Obstet Gynecol 160 729-733.
55. CG Goodyear, JM Sellen, M Fuks, et al. (1987) Regulation of growth hormone secretion from human fetal pituitaries, interactions between growth hormone releasing factor and somatostatin. Reprod Nutr Dev 27 461-470.
56. DD DeLeon, P Cohen and LEL Katz (2004) Growth factor regulation of fetal growth. RA Polin, WW Fox, SH Abman,(Eds) Fetal and Neonatal Physiology 3rd ed Philadelphia, PA: WB Saunders 1880-1890.
57. KL Kind, JA Owens, JS Robinson, et al. (1995) Effect of restriction of placental growth on expression of IGFs in fetal sheep: relationship to fetal growth, circulating IGFs and binding proteins. J Endocrinol 146 23-34.
58. PD Gluckman and CS Pinal (2004) Growth hormone and prolactin. RA Polin, WW Fox, SH Abman,(Eds) Fetal and Neonatal Physiology 3rd ed Philadelphia, PA: WB Saunders 1891-1895.
59. P Clement-Lacroix, C Ormandy, L Lepescheux, et al. (1999) Osteoblasts are a new target for prolactin analysis of bone formation in prolactin receptor knockout mice. Endocrinology 140 3404-3410.
60. JSD Winter (2004) Fetal and neonatal adrenocortical physiology. RA Polin, WW Fox, SH Abman,(Eds) Fetal and Neonatal Physiology Philadelphia, PA: WB Saunders 1915-1925.
61. DH Geller and WL Miller (2004) Molecular development of the adrenal gland. OH Pescovitz, EA Eugster,(Eds) Pediatric Endocrinology Philadelphia, PA: Lippincott Williams & Wilkins 548-567.
62. Y Ikeda, A Swain, TH Weber, et al. (1996) Steroidogenic factor 1 and DAX-1 localize in multiple cell lineages: potential links in endocrine development. Mol Endocrinol 10 1261-1272.
63. GD Hammer, KL Parker and BP Schimmer (2005) Minireview: transcriptional regulation of adrenocortical development. Endocrinology 146 1018-1024.
64. K Fujieda and T Tajima (2005) Molecular basis of adrenal insufficiency. Pediatric Res 57 62R-69R.
65. WL Miller (1998) Steroid hormone biosynthesis and actions in the materno-feto-placental unit. Clin Perinatal 25 799-817.
66. BY Baker, L Lin, CJ Kim, et al. (2006) Nonclassic congenital lipoid adrenal hyperplasia: a new disorder of the steroidogenic acute regulatory protein with very late presentation and normal male genitalia. J Clin Endocrinol Metab 91 4781-4785.
67. M Goto, K Piper Hanley, J Marcos, et al. (2006) In humans, early cortisol biosynthesis provides a mechanism to safeguard female sexual development. J Clin Invest 116 953-960.
68. MG Leavitt, EO Albrecht and GJ Pepe (1999) Development of the baboon fetal adrenal gland: regulation of the ontogenesis of the definitive and transitional zones by adrenocorticotropin. J Clin Endocrinol Metab 84 3831-3835.
69. DA Dotzler, JJ Digeronimo, BA Yoder, et al. (2004) Distribution of corticotrophin releasing hormone in the fetus, newborn, juvenile and adult baboon. Pediatr Res 55 120-125.
70. TJ Cole, JA Blendy, AD Monaghan, et al. (1995) Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin development and severely retards lung maturation. Genes Dev 9 1608-1625.
71. M Thompson and R Smith (1989) The action of hypothalamic and placental corticotrophin releasing factor on the corticotrope. Mol Cell Endocrinol 62 1-12.
72. RS Goland, SL Wardlow, M Blum, et al. (1988) Biologically active corticotropin-releasing hormone in maternal and fetal plasma during pregnancy. Am J Obstet Gynecol 159 884-890.
73. C Rivier and W Vale (1985) Neuroendocrine interactions between corticotrophin releasing factor and vasopressin on adrenocorticotropic hormone secretion in the rat. WW Schrier,(Eds) Vasopressin New York, NY: Raven 181-188.
74. ED Albrecht, GW Aberdeen and GJ Pepe (2005) Estrogen elicits cortical zone specific effects on development of the primate fetal adrenal gland. Endocrinology 146 1737-1744.
75. JC Rose, CS Turner, R. DeW Ray, et al. (1988) Evidence that cortisol inhibits basal adrenocorticotropin secretion in the sheep fetus by 0.70 gestation. Endocrinology 123 1307-1313.
76. K Yang, SA Jones and JRG Challis (1990) Changes in glucocorticoid receptor number in the hypothalamus of the sheep fetus with gestational age and after adrenocorticotropin treatment. Endocrinology 126 11-17.
77. NT McKenna and DD Moore (2006) Nuclear receptors: structure, function and cofactors. LJ DeGroot, JL Jameson,(Eds) Endocrinology 5th ed Philadelphia, PA: Elsevier Saunders 277-287.
78. A Pavlik and M Buresova (1984) The neonatal cerebellum: the highest level of glucocorticoid receptors in the brain. Dev Brain Res 12 13-20.
79. JW Johnson, W Mitzner, JC Beck, et al. (1981) Long term effects of betamethasone in fetal development. Am J Obstet Gynecol 141 1053-1064.
80. GC Liggins (1994) The role of cortisol in preparing the fetus for birth. Reprod Fertil Dev 6 141-150.
81. IZ Beitins, GG Graham, A Kowarski, et al. (1974) Adrenal function in normal infants and in marasmus and kwashiorkor: plasma aldosterone concentration and aldosterone secretion rate. J Pediatr 84 444-451.
82. FH Katz, P Beck and EL Makowski (1974) The renin-aldosterone system in mother and fetus at term. Am J Obstet Gynecol 118 51-55.
83. SR Siegel and DA Fisher (1980) Ontogeny of the renin-angiotensin-aldosterone system in the fetal and newborn lamb. Pediatr Res 14 99-102.
84. ER Lumbers (1995) Functions of the renin-angiotensin system during development. Clin Exp Pharmacol Physiol 22 499-505.
85. S Berger, M Bleich, N Schmid, et al. (1998) Mineralocorticoid receptor knockout mice: pathophysiology of Na + metabolism. Proc Natl Acad Sci U S A 95 9424-9429.
86. G Hirasawa, H Sasano, T Suzuki, et al. (1999) 11β-Hydroxysteroid dehydrogenase type 2 and mineralocorticoid receptor in human fetal development. J Clin Endocrinol Metab 84 1453-1458.
87. JE Robillard, WV Page, MS Matthews, et al. (1995) Differential gene expression and regulation of renal angiotensin II receptor subtypes (AT1 and AT2) during fetal life in sheep. Pediatr Res 38 896-904.
88. K Chen, LC Carey, J Liu, et al. (2005) The effect of hypothalamo-pituitary disconnection on the renin-angiotensin system in the late gestation sheep. Am J Physiol Regul Integr Comp Physiol 288 R1279-R1287.
89. T Walther, HP Schultheiss, C Tschope, et al. (2002) Natriuretic peptide system in fetal heart and circulation. J Hypertens 20 785-791.
90. AJ Clark, LF Chan, TT Chung, et al. (2009) The genetics of familial glucocorticoid deficiency. Best Pract Res Clin Endocrinol Metab 23 159-165.
91. SN Cooray, L Chan, L Metherell, et al. (2008) Adrenocorticotropin resistance syndromes. Endocr Devel 13 99-116.
92. B Ferraz-de-Souza and JC Achermann (2008) Disorders of adrenal development. Endocr Devel 13 19-32.
93. AC Kim, FM Barlaskar, JH Heaton, et al. (2009) In search of adrenocortical stem and progenitor cells. Endocr Rev 30 241-263.
94. B Kohler, L Lin, B Ferraz-de-Souza, et al. (2008) Five novel mutations in steroidogenic factor 1 (SF1/Ad4BP, NR5A1) are associated with 46XY disorders of sex development with normal adrenal function. Human Mutation 29 59-64.
95. D Lourenco, R Brauner, L Lin, et al. (2009) Mutations in NR5A1 associated with ovarian insufficiency. N Engl J Med 360 1200-1210.
96. P Santisteban (2005) Development and anatomy of the hypothalamic-pituitary axis. LE Braverman, RD Utiger,(Eds) The Thyroid 9th ed Philadelphia, PA: JB Lippincott 8-25.
97. RS Brown, SA Huang and DA Fisher (2005) The maturation of thyroid function in the perinatal period and during childhood. LE Braverman, RD Utiger,(Eds) The Thyroid 9th ed Philadelphia, PA: JB Lippincott 1013-1028.
98. B Alt, OA Elsalini, P Schrumpf, et al. (2006) Arteries define the position of the thyroid gland during its developmental relocalization. Development 133 3797-3804.
99. H Fagman, J Liao, J Westerlund, et al. (2007) The 22q11 deletion syndrome candidate gene Tbx1 determines thyroid size and positioning. Hum Mol Genet 16 276-285.
100. R O’Rahilly (1983) The timing and sequence of events in the development of the human endocrine system during the embryonic period proper. Anat Embryol (Berlin) 166 439-451.
101. GM Sprinzl, J Koebke, J Wimmers-Klick, et al. (2000) Morphology of the human thyroglossal tract: a histologic and macroscopic study in infants and children. Ann Otol Rhinol Laryngol 109(12 Pt 1), 1135-1139.
102. P Macchia (2000) Recent advances in understanding the molecular basis of primary congenital hypothyroidism. Mol Med Today 6 36-42.
103. G Szinnai, L Lacroix, A Carre, et al. (2007) Sodium/iodide symporter (NIS) gene expression is the limiting step for the onset of thyroid function in the human fetus. J Clin Endocrinol Metab 92 70-76.
104. R Parlato, A Rosica, A Rodriguez-Mallon, et al. (2004) An integrated regulatory network controlling survival and migration in thyroid organogenesis. Dev Biol 276 464-475.
105. SS Trueba, J Auge, G Mattei, et al. (2005) PAX8, TITF1 and FOXE1 gene expression patterns during human development: new insights into human thyroid development and thyroid dysgenesis-associated malformations. J Clin Endocrinol Metab 90 455-462.
106. M De Felice and R Di Lauro (2004) Thyroid development and its disorders: genetics and molecular mechanisms. Endocr Rev 25 722-746.
107. M Dentice, V Cordeddu, A Rosica, et al. (2006) Missense mutation in the transcription factor NKX2-5: a novel molecular event in the pathogenesis of thyroid dysgenesis. J Clin Endocrinol Metab 91 1428-1433.
108. O Chisaka and MR Capecchi (1991) Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5. Nature 350 473-479.
109. GN Burrow, DA Fisher and PR Larsen (1994) Maternal and fetal thyroid function. N Engl J Med 331 1072-1078.
110. E Roti (1988) Regulation of thyroid stimulating hormone (TSH) secretion in the fetus and neonate. J Endocrinol Invest 11 145-158.
111. DA Fisher, JC Nelson, EI Carlton, et al. (2000) Maturation of human hypothalamic-pituitary-thyroid function and control. Thyroid 10 229-234.
112. N Murphy, R Home, H vanToor, et al. (2004) The hypothalamic-pituitary-thyroid axis in preterm infants: changes in the first 24 hours of postnatal life. J Clin Endocrinol Metab 89 2824-2831.
113. FLR Williams, J Simpson, C Delahunty, et al. (2004) Developmental trends in cord and postpartum serum thyroid hormones in preterm infants. J Clin Endocr Metab 89 5314-5320.
114. PHK Eng, GR Cardona, SL Fang, et al. (1999) Escape from the acute Wolff-Chaikoff effect is associated with a decrease in thyroid sodium/iodide symporter messenger ribonucleic acid and protein. Endocrinology 140 3404-3410.
115. JR Sherwin (1982) Development of regulatory mechanisms in the thyroid: failure of iodide to suppress iodide transport activity. Proc Soc Exp Biol Med 169 458-462.
116. DL St. Germain, A Hernandez, MJ Schneider, et al. (2005) Insights into the role of deiodinases from studies of genetically modified animals. Thyroid 15 905-916.
117. R Hume, J Simpson, C Delahunty, et al. (2004) Human fetal and cord serum thyroid hormones: developmental trends and interrelationships. J Clin Endocrinol Metab 89 4097-4103.
118. DH Polk, A Reviczky, SY Wu, et al. (1994) Metabolism of sulfoconjugated thyroid hormone derivatives in developing sheep. Am J Physiol 266 E892-E896.
119. R Kerry, R Hume, E Kaptein, et al. (2001) Sulfation of thyroid hormone and dopamine during human development: ontogeny of phenol sulfotransferases and arylsulfatase in liver, lung, and brain. J Clin Endocrinol Metab 86 2734-2742.
120. K Richard, R Hume, E Kaptein, et al. (1998) Ontogeny of iodothyronine deiodinases in human liver. J Clin Endocrinol Metab 83 2868-2874.
121. DH Polk, WY Wu, C Wright, et al. (1988) Ontogeny of thyroid hormone effect on tissue 5′-monodeiodinase activity in fetal sheep. Am J Physiol 254 E337-E341.
122. J Jansen, ECH Friesema, C Milici, et al. (2005) Thyroid hormone transporters in health and disease. Thyroid 15 757-768.
123. H Heuer, ML Maier, S Iden, et al. (2005) The monocarboxylate transporter 8 linked to human psychomotor retardation is highly expressed in thyroid hormone-sensitive neuron populations. Endocrinology 146 1701-1706.
124. AM Dumitrescu, XH Liao, TB Best, et al. (2004) A novel syndrome combining thyroid and neurological abnormalities is associated with mutations in a monocarboxylate transporter gene. Am J Hum Genet 74 168-175.
125. JJ Bergh, HY Lin, L Lansing, et al. (2005) Integrin αVβ3 contains a cell surface receptor site for thyroid hormone that is linked to activation of mitogen-activated protein kinase and induction of angiogenesis. Endocrinology 146 2864-2871.
126. P Yen (2005) Genomic and nongenomic actions of thyroid hormones. LE Braverman, RD Utiger,(Eds) The Thyroid 9th ed Philadelphia, PA: Lippincott Williams and Wilkins 135-150.
127. F Flamant and J Samarut (2005) Thyroid hormone receptors: lessons from knockout and knockin mutant mice. Trends Endocrinol Metab 14 85-90.
128. G Morreale de Escobar, MJ Obregon and F Escobar del Rey (2004) Role of thyroid hormone during early brain development. Eur J Endocrinol 151 U25-U37.
129. MD Kilby, N Giltoes, C McCabe, et al. (2000) Expression of thyroid receptor isoforms in the human fetal central nervous system and the effects of intrauterine growth retardation. Clin Endocrinol (Oxf) 53 469-477.
130. J Iskaros, M Pickard, I Evans, et al. (2000) Thyroid hormone receptor gene expression in first trimester human fetal brain. J Clin Endocrinol Metab 85 2620-2623.
131. P Rajatapiti, MHA Kester, RR de Krijger, et al. (2005) Expression of glucocorticoid, retinoid, and thyroid hormone receptors during human lung development. J Clin Endocrinol Metab 90 4309-4314.
132. B Contempre, E Jauniaux, R Calvo, et al. (1993) Detection of thyroid hormones in human embryonic cavities during the first trimester of pregnancy. J Clin Endocrinol Metab 77 1719-1722.
133. T Vulsma, MH Gons and JJ de Vijlder (1989) Maternal-fetal transfer of thyroxine in congenital hypothyroidism due to a total organification defect or thyroid agenesis. N Engl J Med 321 13-16.
134. G Morreale De Escobar, R Calvo, MJ Obregon, et al. (1990) Contribution of maternal thyroxine to fetal thyroxine pools in normal rats near term. Endocrinology 126 2765-2767.
135. PM Sadow, O Chassande, EK Koo, et al. (2003) Regulation of expression of thyroid hormone receptor isoforms and coactivators in liver and heart by thyroid hormone. Mol Cell Endocrinol 203 65-75.
136. L Quignodon, C Legrand, N Allioli, et al. (2004) Thyroid hormone signaling is highly heterogeneous during pre- and postnatal brain development. J Molec Endocrinol 33 467-476.
137. M Plateroti, K Gauthier, C Domon-Dell, et al. (2001) Functional interference between thyroid hormone receptor α (TRα) and natural truncated TRΔα isoforms in the control of intestinal development. Mol Cell Biol 21 4761-4772.
138. W Mai, MF Janier, N Allioli, et al. (2004) Thyroid hormone receptor α is a molecular switch of cardiac function between fetal and postnatal life. Proc Natl Acad Sci U S A 101 10332-10337.
139. CB Harvey, PJ O'Shea, AJ Scott, et al. (2002) Molecular mechanisms of thyroid hormone effects on bone growth and function. Mol Gen Metab 75 17-30.
140. H Marrit, A Schifman, Z Stepanyan, et al. (2004) Temperature homeostasis in transgenic mice lacking thyroid receptor α gene products. Endocrinology 146 2872-2884.
141. C Angelin-Duclos, C Domenget, A Kolbus, et al. (2005) Thyroid hormone T3 acting through the thyroid hormone α receptor is necessary for implementation of erythropoiesis in the neonatal spleen environment in the mouse. Development 132 925-934.
142. G Morreale de Escobar, MJ Obregon and F Escobar del Rey (2000) Is neuropsychological development related to maternal hypothyroidism or to maternal hypothyroxinemia? J Clin Endocrinol Metab 85 3975-3987.
143. RP Erickson and SR Blecher (2004) Genetics of sex determination and differentiation. RA Polin, WW Fox, SH Abman,(Eds) Fetal and Neonatal Physiology 3rd ed Philadelphia, PA: WB Saunders 1935-1941.
144. MM Lee (2004) Molecular genetic control of sex differentiation. OH Pescovitz, EA Eugster,(Eds) Pediatric Endocrinology Philadelphia, PA: Lippincott Williams & Wilkins 231-242.
145. VR Harley, MJ Clarkson and A Argentaro (2003) The molecular action and regulation of the testis-determining factors, SRY (sex determining region of the Y chromosome) and SOX9 (SRY-related high-mobility group [HMG] Box 9). Endocr Rev 24 466-487.
146. SY Park and JL Jameson (2005) Minireview: transcriptional regulation of gonadal development and differentiation. Endocrinology 146 1035-1042.
147. R Sekido and R Lovell-Badge (2008) Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer. Nature 453 930-934.
148. FP Zang, M Poutanen, J Wilbertz, et al. (2001) Normal prenatal but arrested postnatal sexual development of luteinizing hormone receptor knockout (LURKO) mice. Mol Endocrinol 15 172-183.
149. P Philibert, D Zenaty, L Lin, et al. (2007) Mutational analysis of steroidogenic factor 1 (NR5a1) in 24 boys with bilateral anorchia: a French collaborative study. Hum Reprod 22 3255-3261.
150. AR Aslan, BA Kogan and B Gondos (2004) Testicular development. RA Polin, WW Fox, SH Abmans,(Eds) Fetal and Neonatal Physiology 3rd ed Philadelphia, PA: WB Saunders 1950-1955.
151. S Nef and LF Parada (1999) Cryptorchidism in mice mutant for Insl3. Nat Genet 22 295-299.
152. AG Byskov and LG Westergaard (2004) Differentiation of the ovary. RA Polin, WW Fox, SH Abman,(Eds) Fetal and Neonatal Physiology 3rd ed Philadelphila, PA: WB Saunders 1941-1949.
153. N Fulton, SJM da Silva, RAL Bayne, et al. (2005) Germ cell proliferation and apoptosis in the developing human ovary. J Clin Endocrinol Metab 90 4664-4670.
154. Y Sajjad, S Quenby, P Nickson, et al. (2004) Immunohistochemical localization of androgen receptors in the urogenital tracts of human embryos. Reproduction 128 331-339.
155. S Tomaselli, F Megiorni, C De Bernardo, et al. (2008) Syndromic true hermaphroditism due to an R-spondin 1 (RSPO1) homozygous mutation. Hum Mutation 29 220-226.
156. P Parma, O Radi, V Vidal, et al. (2006) R-spondin 1 is essential in sex determination, skin differentiation and malignancy. Nat Genet 38 1304-1309.
157. N Josso, C Belville and JY Dicard (2003) Mutations in AMH and its receptors. Endocrinology 13 247-251.
158. V Roviller Fabre, S Carmona, A Abou Merhi, et al. (1998) Effect of anti-müllerian hormone on Sertoli and Leydig cell functions in fetal and immature rats. Endocrinology 139 1213-1220.
159. AW Brandenberger, MK Tee, JY Lee, et al. (1997) Tissue distribution of estrogen receptors alpha (ERα) and beta (ERβ) mRNA in the midgestation human fetus. J Clin Endocrinol Metab 82 3509-3512.
160. JF Couse and KS Korach (1999) Estrogen receptor null mice: what have we learned and where will they lead us? Endocrine Rev 20 358-417.
161. AG Falgueras, H Pinos, P Collado, et al. (2005) The role of the androgen receptor in CNS masculinization. Brain Res 1035 13-23.
162. F Naftolin and JB Brawer (1978) The effect of estrogens on hypothalamic structure and function. Am J Obstet Gynecol 132 758-765.
163. SA Sholl, RW Goy and KL Kim (1989) 5α-Reductase, aromatase, and androgen receptor levels in the monkey brain during fetal development. Endocrinology 124 627-634.
164. M Visser and DF Swaab (1979) Life span changes in the presence of alpha-melanocyte-stimulating-hormone-containing cells in the human pituitary. J Dev Physiol 1 161-178.
165. RA Perry, HM Mulvogue, IC McMillen, et al. (1985) Immunohistochemical localization of ACTH in the adult and fetal sheep pituitary. J Dev Physiol 7 397-404.
166. RE Silman, T Holland, T Chard, et al. (1978) The ACTH family tree of the rhesus monkey changes with development. Nature 276 526-528.
167. MA Charles, H Suh, TA Hjalt, et al. (2005) PITX genes are required for cell survival and Lhx3 activation. Mol Endocrinol 19 1893-1903.
168. JA Glickman, GD Carson and JRG Challis (1979) Differential effects of synthetic adrenocorticotropin and melanocyte stimulating hormone on adrenal formation in human and sheep fetus. Endocrinology 104 34-39.
169. DF Swaab and JT Martin (1981) Functions of alpha melanotropin and other opiomelanocortin peptides in labour, intrauterine growth and brain development. Ciba Found Symp 81 196-217.
170. F Facchinetti, AR Storchi, F Petraglia, et al. (1987) Ontogeny of pituitary β-endorphin and related peptides in the human embryo and fetus. Am J Obstet Gynecol 156 735-739.
171. RD Leake and DA Fisher (1985) Ontogeny of vasopressin in man. P Czernichow, AG Robinson,(Eds) Diabetes Insipidus in Man: Frontiers in Hormone Research vol 13 Basel: S Karger 42-51.
172. RD Leake (1998) The fetal-maternal neurohypophysial system. RA Polin, WW Fox,(Eds) Fetal and Neonatal Physiology 2nd ed Philadelphia, PA: WB Saunders 2442-2446.
173. MG Ervin, RD Leake, MG Ross, et al. (1985) Arginine vasotocin in ovine maternal and fetal blood, fetal urine, and amniotic fluid. J Clin Invest 75 1696-1701.
174. M Morris, M Castro and JC Rose (1992) Alterations in prohormone processing during early development in the fetal sheep. Am J Physiol 263 R738-R740.
175. X Zhao, MJM Nijland, G Ervin, et al. (1998) Regulation of hypothalamic arginine vasopressin content in fetal sheep: effect of acute tonicity alterations and fetal maturation. Am J Obstet Gynecol 179 899-905.
176. GW DeVane and JC Porter (1980) An apparent stress-induced release of arginine vasopressin by human neonates. J Clin Endocrinol Metab 51 1412-1416.
177. SG Matthews and JRG Challis (1995) Regulation of CRH and AVP mRNA in the developing ovine hypothalamus: effects of stress and glucocorticoids. Am J Physiol 268 E1096-E1107.
178. AN Brooks and A White (1990) Activation of pituitary adrenal function in fetal sheep by corticotrophin-releasing factor and arginine vasopressin. J Endocrinol 124 27-35.
179. MT Benedetto, F DeCicco, F Rossiello, et al. (1990) Oxytocin receptor in human fetal membranes at term and during labor. J Steroid Biochem 35 205-208.
180. E Tribollet, S Charpak, A Schmidt, et al. (1989) Appearance and transient expression of oxytocin receptors in fetal, infant and peripubertal rat brain studied by autoradiography and electrophysiology. J Neurosci 9 1764-1773.
181. MG Ervin, SJ Miller, LJ Ramseyer, et al. (1990) Renal arginine vasopressin receptors in newborn and adult sheep. Clin Res 38 170A.
182. O Devuyst, CR Burrow, BL Smithe, et al. (1996) Expression of aquaporins 1 and 2 during nephrogenesis and in autosomal dominant polycystic kidney disease. Am J Physiol 271 F169-F183.
183. MA Baum, MK Ruddy, CA Hosselet, et al. (1998) The perinatal expression of aquaporin-2 and aquaporin-3 in developing kidney. Pediatr Res 43 783-790.
184. K Cryns, TA Sivakumaran, JM Van den Ouweland, et al. (2003) Mutational spectrum of the WFS1 gene in Wolfram syndrome, nonsyndromic hearing impairment, diabetes mellitus and psychiatric disease. Hum Mutation 22 275-287.
185. JF Padbury (1989) Functional maturation of the adrenal medulla and peripheral sympathetic nervous system. Baillieres Clin Endocrinol Metab 33 689-705.
186. K Huber, N Karch, U Ernsberger, et al. (2005) The role of PHOX2B in chromaffin cell development. Dev Biol 279 501-508.
187. C Gaultier, H Trang, S Dauger, et al. (2005) Pediatric disorders with autoimmune dysfunction: What role for PHOX2B? Pediatr Res 58 1-6.
188. L Aloe and R Levi-Montalcini (1979) Nerve growth factor-induced transformation of immature chromaffin cells in vivo into sympathetic neurons: effect of antiserum to nerve growth factor. Proc Natl Acad Sci U S A 76 1246-1250.
189. TA Slotkin and FJ Seidler (1988) Adrenomedullary catecholamine release in the fetus and newborn: secretory mechanisms and their role in stress and survival. J Dev Physiol 10 1-16.
190. BS Stonestreet, GJ Piasecki, JB Susa, et al. (1989) Effects of insulin infusion on catecholamine concentration in fetal sheep. Am J Obstet Gynecol 160 740-745.
191. WR Cohen, GJ Piasecki, HE Cohn, et al. (1987) Plasma catecholamines in the hypoxaemic fetal rhesus monkey. J Dev Physiol 9 507-515.
192. O Pryds, NJ Christensen and B Friis-Hansen (1990) Increased cerebral blood flow and plasma epinephrine in hypoglycemic, preterm neonates. Pediatrics 85 172-176.
193. SM Palmer, GK Oakes, RW Lam, et al. (1984) Catecholamine physiology in the ovine fetus. I: Gestational age variation in basal plasma concentrations. Am J Obstet Gynecol 149 420-425.
194. SM Palmer, GK Oakes, RW Lam, et al. (1984) Catecholamine physiology in the ovine fetus. II: Metabolic clearance rate of epinephrine. Am J Physiol 246 E350-E355.
195. SM Palmer, GK Oakes, JA Champion, et al. (1984) Catecholamine physiology in the ovine fetus. III: Maternal and fetal response to acute maternal exercise. Am J Obstet Gynecol 149 426-434.
196. QY Zhou, CJ Ouaife and RD Palmiter (1995) Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development. Nature 374 640-643.
197. SA Thomas, AM Matsumoto and RD Palmiter (1995) Noradrenaline is essential for mouse fetal development. Nature 374 643-646.
198. Z. Hochberg Ze'ev and D Tiosano (2004) Disorders of mineral metabolism. OH Pescovitz, EA Eugster,(Eds) Pediatric Endocrinology Philadelphia, PA: Lippincott Williams & Wilkins 614-640.
199. D Miao, B He, C Karaplis, et al. (2002) Parathyroid hormone is essential for normal fetal bone formation. J Clin Invest 109 1173-1182.
200. MR Bowl, MA Nesbit, B Harding, et al. (2005) An interstitial deletion/insertion involving chromosomes 2p25.3 and Xq27.1 near SOX3 causes X-linked recessive hypoparathyroidism. J Clin Invest 115 2822-2831.
201. JA Prada (1998) Calcium-regulating hormones. RA Polin, WW Fox,(Eds) Fetal and Neonatal Physiology 2nd ed Philadelphia, PA: WB Saunders 2287-2296.
202. CS Kovaks and HM Kronenberg (1997) Maternal-fetal calcium and bone metabolism during pregnancy, puerperium and lactation. Endocr Rev 18 832-872.
203. AD Care, SK Abbas, DW Pickard, et al. (1990) Stimulation of ovine placental transport of calcium and magnesium by mid-molecule fragments of human parathyroid hormone-related protein. J Exp Physiol 75 605-608.
204. CS Kovacs, B Lanske, JL Hunzelman, et al. (1996) Parathyroid hormone-related peptide (PTHrP) regulates fetal-placental calcium transport through a receptor distinct from the PTH/PTHrP receptor. Proc Natl Acad Sci U S A 93 15233-15238.
205. AC Karaplis, A Luz, J Glowacki, et al. (1994) Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related protein gene. Genes Dev 8 277-289.
206. R Ross, K Halbert and RC Tsang (1989) Determination of the production and metabolic clearance rates of 1,25-dihydroxyvitamin D 3 in the pregnant sheep and its chronically catheterized fetus by primed infusion technique. Pediatr Res 26 633-638.
207. JF Habener, DM Kemp and MJ Thomas (2005) Mini review: transcriptional regulation in pancreatic development. Endocrinology 146 1025-1034.
208. FX Jiang and LC Harrison (2005) Laminin-1 and epidermal growth factor family members co-stimulate fetal pancreas cell proliferation and colony formation. Differentiation 73 45-49.
209. B Formby, A Ullrich, L Coussens, et al. (1988) Growth hormone stimulates insulin gene expression in cultured human fetal pancreatic islets. J Clin Endocrinol Metab 66 1075-1079.
210. H Edlund (2002) Pancreatic organogenesis: developmental mechanisms and implications for therapy. Nat Rev Genet 3 524-532.
211. MA Sperling (1994) Carbohydrate metabolism: insulin and glucagons. D Tulchinsky, AB Little,(Eds) Maternal-Fetal Endocrinology 2nd ed Philadelphia, PA: WB Saunders 380-400.
212. J Girard (1989) Control of fetal and neonatal glucose metabolism by pancreatic hormones. Baillieres Clin Endocrinol Metab 3 817-836.
213. HP Ammon, C Glocker, RG Waldner, et al. (1989) Insulin release from pancreatic islets of fetal rats mediated by leucine, b-BCH, tolbutamide, glibenclamide, arginine, potassium chloride, and theophylline does not require stimulation of Ca 2+ net uptake. Cell Calcium 10 441-450.
214. JJ Meier, AE Butler, Y Saisho, et al. (2008) Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans. Diabetes 57 1584-1594.
215. GJ Pepe and ED Albrecht (1995) Actions of placental and fetal adrenal steroid hormones in primate pregnancy. Endocr Rev 16 608-648.
216. C Ruiz de Ona, MJ Obregon, F Escobar del Rey, et al. (1988) Developmental changes in rat brain 5′-deiodinase and thyroid hormones during the fetal period: the effects of fetal hypothyroidism and maternal thyroid hormones. Pediatr Res 24 588-594.
217. DH Polk, D Cheromcha, A Reviczky, et al. (1989) Nuclear thyroid hormone receptors: ontogeny and thyroid hormone effects in sheep. Am J Physiol 256 E543-E549.
218. P Coulombe, J Ruel and JH Dussault (1980) Effects of neonatal hypo- and hyperthyroidism on pituitary growth hormone content in the rat. Endocrinology 107 2027-2033.
219. J Lakshmanan, J Perheentupa, T Macaso, et al. (1985) Acquisition of urine, kidney and submandibular gland epidermal growth factor responsiveness to thyroxine administration in neonatal mice. Acta Endocrinol 109 511-516.
220. J Alm, SM Scott and DA Fisher (1986) Epidermal growth factor receptor ontogeny in mice with congenital hypothyroidism. J Dev Physiol 8 377-385.
221. SB Hoath, J Lakshmanan and DA Fisher (1984) Thyroid hormone effects on skin and hepatic epidermal growth factor concentrations in neonatal and adult mice. Biol Neonate 45 49-52.
222. SB Hoath, J Lakshmanan and DA Fisher (1985) Epidermal growth factor binding to neonatal mouse skin explants and membrane preparations: effect of triiodothyronine. Pediatr Res 19 277-280.
223. A Perez Castillo, J Bernal, B Ferriero, et al. (1985) The early ontogenesis of thyroid hormone receptor in the rat fetus. Endocrinology 117 2457-2461.
224. A Mehta, PC Hindmarsh, RG Stanhope, et al. (2005) The role of growth hormone in determining birth size and early postnatal growth, using congenital growth hormone deficiency (GHD) as a model. Clin Endocrinol (Oxf) 63 223-231.
225. JF Padbury, RW Lam, JP Newnham, et al. (1985) Neonatal adaptation: greater neurosympathetic system activity in preterm than full term sheep at birth. Am J Physiol 248 E443-E449.
226. JR Pasqualini, C Sumida, C Gelly, et al. (1976) Progesterone receptors in the fetal uterus and ovary of the guinea pig: evolution during fetal development and induction and stimulation in estradiol-primed animals. J Steroid Biochem 7 1031-1038.
227. S Yamashita, RR Newbold, JA McLachlan, et al. (1989) Developmental pattern of estrogen receptor expression in female mouse genital tracts. Endocrinology 125 2888-2896.
228. FA Simmen, RCM Simmon, LR Letcher, et al. (1989) IGFs in pregnancy: developmental expression in uterus and mammary gland and paracrine actions during embryonic and neonatal growth. D LeRoith, MK Raizada,(Eds) Molecular and Cellular Biology of Insulin-Like Growth Factors and Their Receptors New York, NY: Plenum 195-208.
229. R Spaventi, M Antica and K Pavelic (1990) Insulin and insulin-like growth factor I (IGF I) in early mouse embryogenesis. Development 108 491-495.
230. CP Sibley, PM Coan, AC Ferguson-Smith, et al. (2004) Placental-specific insulin-like growth factor 2 (Igf2) regulates the diffusional exchange characteristics of the mouse placenta. Proc Natl Acad Sci U S A 101 8204-8208.
231. M Constancia, E Angiolini, I Sandovici, et al. (2005) Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems. Proc Natl Acad Sci U S A 102 19219-19224.
232. KA Woods, C Camacho-Huebner, MO Savage, et al. (1996) Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor 1 gene. N Engl J Med 335 1383-1387.
233. MJ Abuzzahab, A Schneider, A Goddard, et al. (2003) IGF-1 receptor mutations resulting in intrauterine and postnatal growth retardation. N Engl J Med 349 2211-2222.
234. C Gicquel, S Rossignol, S Cabrol, et al. (2005) Epimutation of the telomeric imprinting center region on chromosome 11p15 in Silver-Russell syndrome. Nat Genet 37 1003-1007.
235. Q Qiu, A Basak, M Mbikay, et al. (2005) Role of pro-IGF-11 processing by proprotein convertase 4 in human placental development. Proc Natl Acad Sci U S A 102 11047-11052.
236. R Murphy, J Baptista, J Holly, et al. (2008) Severe intrauterine growth retardation and atypical diabetes associated with a translocation breakpoint disrupting regulation of the insulin-like growth factor 2 gene. J Clin Endocrinol Metab 93 4373-4380.
237. A Sparago, F Cerrato, M Vernucci, et al. (2004) Microdeletions in the human H19 DMR result in loss of IGF2 imprinting and Beckwith-Wiedemann syndrome. Nat Genet 36 958-960.
238. CS Watson, P Bialek, M Arizo, et al. (2006) Elevated circulating insulin-like growth factor-binding protein-1 is sufficient to cause fetal growth restriction. Endocrinology 147 1175-1186.
239. N Ben Lagha, D Seurin, Y Le Bouc, et al. (2006) Insulin-like growth factor-binding protein (IGFBP-1) involvement in intrauterine growth retardation: study on IGFBP-1 overexpressing transgenic mice. Endocrinology 147 4730-4737.
240. AJ Forhead, J Li, RS Gilmour, et al. (2002) Thyroid hormone and the mRNA of the GH receptor and IGFs in skeletal muscle of fetal sheep. Am J Physiol Endocrinol Metab 282 E80-E86.
241. K Ong, J Kratzsch, W Kiess, et al. (2000) Size at birth and cord blood levels of insulin, insulin-like growth factor (IGF-I), IGF-II, IGF binding protein-1 (IGFBP-1), IGFBP-3 and the soluble IGF-II/mannose-6-phosphate receptor in term human infants. J Clin Endocrinol Metab 85 4266-4269.
242. SJ Pilistine, AC Moses and HN Munro (1984) Placental lactogen administration reverses the effect of low protein diet on maternal and fetal somatomedin levels in the pregnant rat. Proc Natl Acad Sci U S A 81 5853-5857.
243. BC Gohlke, H Fahnenstich, C Dame, et al. (2004) Longitudinal data for intrauterine levels of fetal IGF-I and IGF-II. Horm Res 61 200-204.
244. D Accili, J Drago, EJ Lee, et al. (1996) Early neonatal death in mice homozygous for a null allele of the insulin receptor gene. Nat Genet 12 106-109.
245. DA Fisher and J Lakshmanan (1990) Metabolism and effects of EGF and related growth factors in mammals. Endocr Rev 11 418-442.
246. P Rotwein (2006) Peptide growth factors other than insulin-like growth factors or cytokines. LJ DeGroot, JL Jameson,(Eds) Endocrinology 5th ed Philadelphia, PA: Elsevier Saunders 675-695.
247. PJ Meittinen, JE Berger, J Menesses, et al. (1995) Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature 376 337-341.
248. PI Brown, R Lam, J Lakshmanan, et al. (1990) Transforming growth factor alpha in developing rats. Am J Physiol 259 E256-E260.
249. R Hemmings, J Langlais, T Falcone, et al. (1992) Human embryos produce transforming growth factor α activity and insulin-like growth factor II. Fertil Steril 58 101-104.
250. IE Mazzoni and RL Kenigsberg (1992) Effects of epidermal growth factor in the mammalian central nervous system. Drug Dev Res 26 111-128.
251. DL Kitchens, EY Snyder and DI Gottlieb (1990) FGF and EGF are mitogens for immortalized neural progenitors. J Neurobiol 21 356-375.
252. J Santa-Olalla and L Covarrubias (1995) Epidermal growth factor, transforming growth factor-α, and fibroblast growth factor differentially influence neural precursor cells of mouse embryonic mesencephalon. J Neurosci Res 42 172-183.
253. KF Lee, H Simon, C Chen, et al. (1995) Requirement for neuregulin receptor erbB2 in neural and cardiac development. Nature 378 394-398.
254. Y Kamei, O Tsutsumi, Y Kuwabara, et al. (1993) Intrauterine growth retardation and fetal losses are caused by epidermal growth factor deficiency in mice. Am J Physiol 264 R597-R600.
255. Q Yan, J Elliott and WD Snider (1992) Brain derived neurotrophic factor rescues spinal motor neurons from axotomy-induced cell death. Nature 360 753-755.
256. D Gospodarowicz (1981) Epidermal and nerve growth factors in mammalian development. Annu Rev Physiol 43 251-263.
257. JF Padbury, RW Lam, DH Polk, et al. (1986) Autoimmune sympathectomy in fetal rabbits. J Dev Physiol 8 369-376.
258. RH Tarris, ME Weichsel Jr and DA Fisher (1986) Synthesis and secretion of a nerve growth stimulating factor by neonatal mouse astrocyte cells in vitro. Pediatr Res 20 367-372.
259. T Giordano, JB Pan, D Casuto, et al. (1992) Thyroid hormone regulation of NGF, NT3 and BDNF RNA in the adult rat brain. Mol Brain Res 16 239-245.
260. GB Lim, M Dodic, L Earnest, et al. (1996) Regulation of erythropoietin gene expression in fetal sheep by glucocorticoids. Endocrinology 137 1658-1663.
261. KM Moritz, GB Lim and EM Wintour (1997) Developmental regulation of erythropoietin and erythropoiesis. Am J Physiol 273 R1829-R1844.
262. C Betsholtz (2000) Functions of platelet-derived growth factor and its receptors deduced from gene inactivation in mice. J Clin Ligand Assay 23 206-213.
263. M Lewandoski, X Sun and GR Martin (2000) Fgf8 signalling from the AER is essential for normal limb development. Nat Genet 26 460-463.
264. AM Oberbauer, TA Linkhart, S Mohan, et al. (1988) Fibroblast growth factor enhances human chorionic gonadotropin synthesis independent of mitogenic stimulation in Jar choriocarcinoma cells. Endocrinology 123 2696-2700.
265. N Alfaidy, W Li, T Macintosh, et al. (2003) Late gestation increase in 11beta-hydroxysteroid dehydrogenase 1 expression in human fetal membranes: a novel intrauterine source of cortisol. J Clin Endocrinol Metab 88 5033-5038.
266. MJ Wallace, SB Hooper and R Harding (1995) Effects of elevated fetal cortisol concentrations on the volume, secretion, and reabsorption of lung liquid. Am J Physiol 269 R881-R887.
267. L Muglia, L Jacobson, P Dikkes, et al. (1995) Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need. Nature 373 427-432.
268. TJ Cole, JA Blendy, P Monaghan, et al. (1995) Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation. Genes Dev 9 1608-1621.
269. DH Polk (1988) Thyroid hormone effects on neonatal thermogenesis. Semin Perinatol 12 151-156.
270. TR Gunn and PD Gluckman (1995) Perinatal thermogenesis. Early Hum Dev 42 169-183.
271. MJ Obregon, R Pitamber, A Jacobsson, et al. (1987) Euthyroid status is essential for the perinatal increase in thermogenin mRNA in brown adipose tissue of rat pups. Biochem Biophys Res Commun 148 9-14.
272. DH Polk, JF Padbury, CC Callegari, et al. (1987) Effect of fetal thyroidectomy on newborn thermogenesis in lambs. Pediatr Res 21 453-457.
273. JL Longhead, F Minouni and RC Tsang (1988) Serum ionized calcium concentrations in normal neonates. Am J Dis Child 142 516-518.
274. PS Venkataraman, RC Tsang, IW Chen, et al. (1987) Pathogenesis of early neonatal hypocalcemia: studies of serum calcitonin, gastrin and plasma glucagon. J Pediatr 110 599-603.
275. F Mimoumi and RC Tsang (1994) Perinatal mineral metabolism. D Tulchinsky, AB Little,(Eds) Maternal-Fetal Endocrinology 2nd ed Philadelphia, PA: WB Saunders 402-417.
276. MD Wheeler and DM Styne (1990) Longitudinal changes in growth hormone response to growth hormone-releasing hormone in neonatal rhesus monkeys. Pediatr Res 28 15-18.
277. R Penny, AF Parlow and SD Frasier (1979) Testosterone and estradiol concentrations in paired maternal and cord sera and their correlation with the concentration of chorionic gonadotropin. Pediatrics 64 604-608.
278. DR Mann, KG Gould, DC Collins, et al. (1989) Blockade of neonatal activation of the pituitary-testicular axis: effect on peripubertal luteinizing hormone and testosterone secretion and on testicular development in male monkeys. J Clin Endocrinol Metab 68 600-607.
279. KD Dohler (1986) The special case of hormonal imprinting: the neonatal influence on sex. Experientia 42 759-769.
280. JA Resko and CE Roselli (1997) Prenatal hormones organize sex differences in the neuroendocrine reproductive system: observations on guinea pigs and nonhuman primates. Cell Mol Neurobiol 17 627-648.
281. SS Kosut, RI Wood, C Herbosa-Encaracion, et al. (1997) Prenatal androgens time neuroendocrine puberty in the sheep: effect of testosterone dose. Endocrinology 138 1072-1077.
282. CA Grocock, HM Charlton and MC Pike (1988) Role of fetal pituitary in cryptorchidism induced by exogenous maternal oestrogen during pregnancy in mice. J Reprod Fertil 83 295-300.
283. SM Martin and GP Moberg (1981) Effects of early neonatal thyroxine treatment on development of the thyroid and adrenal axes in rats. Life Sci 29 1683-1688.
284. P Walker and F Courtin (1985) Transient neonatal hyperthyroidism results in hypothyroidism in the adult rat. Endocrinology 116 2246-2250.
285. G Csaba, A Inczefi-Gonda and O Dobozy (1984) Hereditary transmission in the F 1 generation of hormonal imprinting (receptor memory) induced in rats by neonatal exposure to insulin. Acta Physiol Hung 63 93-99.
286. G Csaba, A Ronai, V Laszlo, et al. (1980) Amplification of hormone receptors by neonatal oxytocin and vasopressin treatment. Horm Metab Res 12 28-31.
287. R Benediktsson, RD Lindsay, J Noble, et al. (1993) Glucocorticoid exposure in utero: new model for adult hypertension. Lancet 341 339-341.
288. AJ Drake, BR Walker and JR Seckl (2005) Intergenerational consequences of fetal programming by in utero exposure to glucocorticoids in rats. Am J Physiol Regul Integr Comp Physiol 288 R34-R38.
289. DR Lackland (2004) Fetal and early life determinants of hypertension in adults: implications for study. Hypertension 44 811-812.
290. DJP Barker (2002) Fetal programming of coronary heart disease. Trends Endocrinol Metab 13 364-368.
291. DJP Barker (2004) The developmental origins of chronic adult disease. Acta Paediatr Suppl 336 26-33.
292. SE Ozanne and CN Hales (2002) Early programming of glucose-insulin metabolism. Trends Endocrinol Metab 13 368-373.
293. SG Matthews (2002) Early programming of the hypothalamo-pituitary-adrenal axis. Trends Endocrinol Metab 13 373-380.
294. BS Young (2002) Programming of sympatho-adrenal function. Trends Endocrinol Metab 13 381-385.
295. MJ Davies and RJ Norman (2002) Programming and reproductive function. Trends Endocrinol Metab 13 386-392.
296. RIG Holt (2002) Fetal programming of the growth hormone–insulin-like growth factor axis. Trends Endocrinol Metab 13 392-402.
297. M Dodic, K Moritz, I Koukoulas, et al. (2002) Programmed hypertension: kidney, brain or both. Trends Endocrinol Metab 13 403-408.
298. W Reik, M Constancia, A Fowdey, et al. (2003) Regulation of supply and demand for maternal nutrients in mammals by imprinted genes. J Physiol 547 35-44.
299. L Ibanez, K Ong, N Potau, et al. (2001) Insulin gene variable number of tandem repeat genotype and the low birth weight, precocious pubarche, and hyperinsulinism sequence. J Clin Endocrinol Metab 86 5788-5793.
300. RG Ijzerman, CDA Stehouwer, EJ de Geus, et al. (2003) Low birth weight is associated with increased sympathetic activity: dependence on genetic factors. Circulation 108 566-571.
301. AL Fowden and AJ Forhead (2004) Endocrine mechanisms of intrauterine programming. Reproduction 127 515-526.
302. J Slone-Wilcoxon and EE Redei (2004) Maternal-fetal glucocorticoid milieu programs hypothalamic-pituitary-thyroid function of adult offspring. Endocrinology 145 4068-4072.
303. L Lavcola, S Perrini, G Belsanti, et al. (2005) Intrauterine growth restriction in humans is associated with abnormalities in placental insulin-like growth factor signaling. Endocrinology 146 1498-1505.
304. RA Waterland and RL Jirtle (2004) Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases. Nutrition 20 63-68.
305. S McMullen and SC Langley-Evans (2005) Maternal low-protein diet in rat pregnancy programs blood pressure through sex-specific mechanisms. Am J Physiol Regul Integr Physiol 288 R85-R90.
306. JC Bunt, PA Tataranni and AD Salbe (2005) Intrauterine exposure to diabetes is a determinant of hemoglobin A(1)c and systolic blood pressure in Pima Indian children. J Clin Endocrinol Metab 90 3225-3229.
307. X Zheng and WJ Hendry III (1997) Neonatal stilbestrol treatment alters the estrogen-related expression of both cell proliferation and apoptosis-related proto-oncogene (c-jun, dfos, cmyc, bax, bcl-2 and bcl-x) in the hamster uterus. Cell Growth Diff 8 425-434.
308. WW Huang, Y Yin, Q Bi, et al. (2005) Developmental diethylstilbestrol exposure alters genetic pathways of uterine cytodifferentiation. Mol Endocrinol 19 669-682.
309. G Csaba (1986) Receptor ontogeny and hormonal imprinting. Experientia 42 750-759.
310. SM Sato, MI Mains, MS Adzick, et al. (1988) Plasticity in the adrenocorticotropin-related peptides produced by primary cultures of neonatal rat pituitary. Endocrinology 122 68-77.
311. MH Vickers, PD Gluckman, HH Coveny, et al. (2005) Neonatal leptin treatment reverses developmental programming. Endocrinology 146 4211-4216.
312. AW Flake (1999) Fetal therapy: medical and surgical approaches. RK Creasy, R Resnik,(Eds) Maternal-Fetal Medicine 4th ed Philadelphia, PA: WB Saunders 365-377.
313. CR Harman (2004) Assessment of fetal health. RK Creasy, R Resnik,(Eds) Maternal-Fetal Medicine 5th ed Philadelphia, PA: WB Saunders 357-401.
314. R Resnick and RK Creasy (2004) Intrauterine growth restriction. RK Creasy, R Resnick,(Eds) Maternal Fetal Medicine 5th ed Philadelphia, PA: WB Saunders 495-512.
315. DW Bianchi (2002) Prenatal exclusion of recessively inherited disorders: should maternal plasma analysis precede invasive techniques. Clin Chem 48 689-690.
316. FA Manning (2004) General principles and applications of ultrasonography. RK Creasy, R Resnik,(Eds) Maternal-Fetal Medicine 5th ed Philadelphia, PA: WB Saunders 315-355.
317. DA Fisher (1997) Fetal thyroid function: diagnosis and management of fetal thyroid disorders. Clin Obstet Gynecol 40 16-31.
318. MI New, A Carlton, J Obeid, et al. (2003) Update: prenatal diagnosis for congenital adrenal hyperplasia in 595 pregnancies. Endocrinologist 13 233-239.
319. V Charlton and M Johengen (1987) Fetal intravenous nutritional supplementation ameliorates the development of embolization-induced growth retardation in sheep. Pediatr Res 22 55-61.
320. AW Flake and ED Zanjani (1997) In utero hematopoietic stem cell transplantation. JAMA 278 932-937.
321. RY Lin, A Kubo, GM Keller, et al. (2003) Committing embryonic stem cells to differentiate into thyrocyte-like cells in vitro. Endocrinology 144 2644-2649.
322. SN Waddington, NL Kennea, SMK Buckley, et al. (2004) Fetal and neonatal gene therapy: benefits and pitfalls. Gene Therapy 11 592-597.
323. A Bennett, DM Wilson, R Liu, et al. (1983) Levels of insulin-like growth factors I and II in human cord blood. J Clin Endocrinol Metab 57 609-612.
324. SL Kaplan, MM Grumbach and ML Aubert (1976) The ontogenesis of pituitary hormones and hypothalamic factors in the human fetus: maturation of central nervous system regulation of anterior pituitary function. Recent Prog Horm Res 32 161-243.
325. RM Bala, J Lopatka, A Leung, et al. (1981) Serum immunoreactive somatomedin levels in normal adults, pregnant women at term, children at various ages, and children with constitutionally delayed growth. J Clin Endocrinol Metab 52 508-512.
326. AJ Winters, C Oliver, C Colston, et al. (1974) Plasma ATH levels in the human fetus and neonate as related to age and parturition. J Clin Endocrinol Metab 39 269-273.
327. BEP Murphy (1982) Human fetal serum cortisol levels related to gestational age: evidence of a midgestational fall and a steep late gestational rise, independent of sex or mode of delivery. Am J Obstet Gynecol 144 276-282.
328. IZ Beitins, F Bayard, FIG Ances, et al. (1973) The metabolic clearance rate, blood production, interconversion and transplacental passage of cortisol and cortisone in pregnancy near term. Pediatr Res 7 509-513.
329. DA Fisher and AH Klein (1981) Thyroid development and disorders of thyroid function in the newborn. N Engl J Med 304 702-712.
330. F Santini, L Chiovato, P Ghirri, et al. (1999) Serum iodothyronines in the human fetus and the newborn: evidence for an important role of placenta in fetal thyroid hormone homeostasis. J Clin Endocrinol Metab 84 493-498.
331. FI Reyes, RS Boroditsky, JS Winter, et al. (1974) Studies on human sexual development: II. Fetal and maternal serum gonadotropin and sex steroid concentrations. J Clin Endocrinol Metab 38 612-617.
332. SL Kaplan, MM Grumbach and ML Aubert (1976) The ontogenesis of pituitary hormones and hypothalamic factors in the human fetus: maturation of central nervous system regulation of anterior pituitary function. Recent Prog Horm Res 32 161-243.
333. JS Winter, C Faiman, WC Hobson, et al. (1975) Pituitary-gonadal relations in infancy: I. Patterns of serum gonadotropin concentrations from birth to four years of age in man and chimpanzee. J Clin Endocrinol Metab 40 545-551.
334. MG Forest and AM Cathiard (1975) Pattern of plasma testosterone and delta4-androstenedione in normal newborns; evidence for testicular activity at birth. J Clin Endocrinol Metab 41 977-980.