Signaling and transcriptional mechanisms in pituitary development

Annual Review of Neuroscience

Volumn 24, Issue , 2001, Pages 327-355

  Dasen, J S ^a   Rosenfeld, M G ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

BMP; FGF; Morphogenesis; Synergy; Transcription factor

Indexed keywords

TRANSCRIPTION FACTOR;

ANIMAL CELL; APOPTOSIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL TYPE; DROSOPHILA MELANOGASTER; EMBRYO DEVELOPMENT; HORMONAL REGULATION; HYPOPHYSIS; MORPHOGENESIS; NONHUMAN; ORGANOGENESIS; PRIORITY JOURNAL; REVIEW; STEM CELL; TRANSCRIPTION REGULATION;

ANIMALS; CELL DIFFERENTIATION; HUMANS; PITUITARY GLAND; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC;

EID: 0034916432     PISSN: 0147006X     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.neuro.24.1.327     Document Type: Review

References (136)

1. Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins
2. Multifunctional role of the Pitx2 homeodomain protein C-terminal tail
3. The molecular basis of Rieger syndrome: Analysis of Pitx2 homeodomain protein activities
4. The Ames dwarf gene is required for Pit-1 gene activation
5. A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins
6. P-Lim, a LIM homeodomain factor, is expressed during pituitary organ and cell commitment and synergizes with Pit-1
7. DNase I-hypersensitive sites I and II of the human growth hormone locus control region are a major developmental activator of somatotrope gene expression
8. Pax6 is implicated in murine pituitary endocrine function
9. The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein
10. A common pro-opiomelanocortin-binding element mediates leukemia inhibitory factor and corticotropin-releasing hormone transcriptional synergy
11. The Pit-1 homeodomain and beta-domain interact with Ets-1 and modulate synergistic activation of the rat prolactin promoter
12. Interaction of Ets-1 and the POU-homeodomain protein GHF-1/Pit-1 reconstitutes pituitary-specific gene expression
13. Cell-specific expression of the mouse glycoprotein hormone alpha-subunit gene requires multiple interacting DNA elements in transgenic mice and cultured cells
14. Localization of the panhypopituitary dwarf mutation (df) on mouse chromosome 11 in an intersubspecific backcross
15. The Pit-1 transcription factor gene is a candidate for the murine Snell dwarf mutation
16. Mechanisms of left-right determination in vertebrates
17. CREB-independent regulation by CBP is a novel mechanism of human growth hormone gene expression
18. Defective retinoic acid regulation of the Pit-1 gene enhancer: A novel mechanism of combined pituitary hormone deficiency
19. The fate map of the cephalic neural primordium at the presomitic to the 3-somite stage in the avian embryo
20. Cell-specific expression of the prolactin gene in transgenic mice is controlled by synergistic interactions between promoter and enhancer elements
21. Compartment boundaries: At the edge of development
22. Effect of the basal diencephalon on the development of Rathke's pouch in rats: A study in combined organ cultures
23. Cooperation of BMP7 and SHH in the induction of forebrain ventral midline cells by prechordal mesoderm
24. Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient induced determination of pituitary cell types
25. Combinatorial codes in signaling and synergy: Lessons from pituitary development
26. Mutations in the homeobox gene HESX1/Hesx1 associated with septo-optic dysplasia in human and mouse
27. Selective inhibition of prolactin gene transcription by the ETS-2 repressor factor
28. "Hot spot" in the PROP1 gene responsible for combined pituitary hormone deficiency
29. An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signaling during mouse organogenesis
30. The Pit-1 gene is regulated by distinct early and late pituitary-specific enhancers
31. The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors
32. Mapping of the presumptive brain regions in the neural plate of Xenopus laevis
33. Regulation of LEF-1/TCF transcription factors by Wnt and other signals
34. Progression from extrinsic to intrinsic signaling in cell fate specification: A view from the nervous system
35. Retinoids: From hindbrain patterning to Parkinson disease
36. Distinct expression and shared activities of members of the hedgehog gene family of Xenopus laevis
37. Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary
38. Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling
39. The distribution of competence for adenohypophysis development in the ectoderm of chick embryos
40. Experimental study of the factors in cytological differentiation of the adenohypophysis in the chick embryo
41. The Ames dwarf gene, df, is required early in pituitary ontogeny for the extinction of Rpx transcription and initiation of lineage-specific cell proliferation
42. Anterior pituitary cells defective in the cell-autonomous factor, df, undergo cell lineage specification but not expansion
43. Dosage requirement of Pitx2 for development of multiple organs
44. Genomic cloning and characterization of the human homeobox gene SIX6 reveals a cluster of SIX genes in chromosome 14 and associates SIX6 hemizygosity with bilateral anophthalmia and pituitary anomalies
45. Tissue interactions in the induction of anterior pituitary: Role of the ventral diencephalon, mesenchyme, and notochord
46. GHRH receptor of little mice contains a missense mutation in the extracellular domain that disrupts receptor function
47. Pit-1 and GATA-2 interact and functionally cooperate to activate the thyrotropin beta-subunit promoter
48. Mice devoid of all known thyroid hormone receptors are viable but exhibit disorders of the pituitary-thyroid axis, growth, and bone maturation
49. The world according to hedgehog
50. Determinants of thyrotrope-specific thyrotropin beta promoter activation: Cooperation of Pit-1 with another factor
51. Rpx: A novel anterior-restricted homeobox gene progressively activated in the prechordal plate, anterior neural plate and Rathke's pouch of the mouse embryo
52. Bone morphogenetic proteins in development
53. Morphogenesis
54. A composite Ets/Pit-1 binding site in the prolactin gene can mediate transcriptional responses to multiple signal transduction pathways
55. A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype
56. The nuclear receptor steroidogenic factor 1 acts at multiple levels of the reproductive axis
57. Six6 (Optx2) is a novel murine Six3-related homeobox gene that demarcates the presumptive pituitary/hypothalamic axis and the ventral optic stalk
58. A role for A/T-rich sequences and Pit-1/GHF-1 in a distal enhancer located in the human growth hormone locus control region with preferential pituitary activity in culture and transgenic mice
59. Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting protein, is expressed early in neuronal development
60. Comparative synteny cloning of zebrafish you-too: Mutations in the Hedgehog target gli2 affect ventral forebrain patterning
61. Evidence that hypophysis and hypothalamus constitute a single entity from the primary stage of histogenesis
62. Induction from posterior hypothalamus is essential for the development of the pituitary proopiomelacortin (POMC) cells of the toad (Bufo japonicus)
63. Enhancer-mediated high level expression of mouse pituitary glycoprotein hormone alpha-subunit transgene in thyrotropes, gonadotropes, and developing pituitary gland
64. Targeted ablation of pituitary gonadotropes in transgenic mice
65. The T/ebp null mouse thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary
66. Pax6 is essential for establishing ventral-dorsal cell boundaries in pituitary gland development
67. Mouse Pitx2 deficiency leads to anomalies of the ventral body wall, heart, extra and periocular mesoderm and right pulmonary isomerism
68. Ptx1, a bicoid-related homeobox transcription factor involved in transcription of the proopiomelanocortin gene
69. Pituitary homeobox 1 (Ptx1) is differentially expressed during pituitary development
70. The bicoid-related homeoprotein Ptx1 defines the most anterior domain of the embryo and differentiates posterior from anterior lateral mesoderm
71. Hindlimb patterning and mandible development require the Ptx1 gene
72. Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud
73. Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1)
74. Dwarf locus mutants lacking three pituitary cell-types result from mutations in the POU-domain gene pit-1
75. Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis
76. Pituitary ontogeny of the Snell dwarf mouse reveals Pit-1-independent and Pit-1-dependent origins of the thyrotrope
77. Molecular basis of the little mouse phenotype and implications for cell type-specific growth
78. Identification of a novel zinc finger protein binding a conserved element critical for Pit-1-dependent growth hormone gene expression
79. Role of Pitx1 upstream of Tbx4 in specification of hindlimb identity
80. Function of Rieger syndrome gene in left-right asymmetry and craniofacial development
81. The roles of FGFs in the early development of vertebrate limbs
82. BMP-4-responsive regulation of dorsal-ventral patterning by the homeobox protein Mix.1
83. Differences in left-right axis pathways in mouse and chick: Functions of FGF8 and SHH
84. Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless
85. Chip, a widely expressed chromosomal protein required for segmentation and activity of a remote wing margin enhancer in Drosophila
86. Antagonistic interactions between FGF and BMP signaling pathways: A mechanism for positioning the sites of tooth formation
87. Restricted expression and retinoic acid-induced down-regulation of the retinaldehyde dehydrogenase type 2 (RALDH-2) gene during mouse development
88. Role of GHF-1 in the regulation of the rat growth hormone gene promoter by thyroid hormone and retinoic acid receptors
89. Impaired adrenocorticotropin-adrenal axis in combined pituitary hormone deficiency caused by a two-base pair deletion (301-302delAG) in the prophet of Pit-1 gene
90. Teeth: Where and how to make them
91. Requirement for LIM homeobox gene Is11 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation
92. Novel dimeric Nur77 signaling mechanism in endocrine and lymphoid cells
93. DNA binding of the glucocorticoid receptor is not essential for survival
94. Feedback control of glucocorticoid production is established during fetal development
95. A tissue-specific enhancer confers Pit-1-dependent morphogen inducibility and autoregulation on the pit-1 gene
96. Clinical and biochemical phenotype of familial anterior hypopituitarism from mutation of the PROP1 gene
97. Regionalization of the prosencephalic neural plate
98. Gli proteins and Hedgehog signaling: Development and cancer
99. The transcription factor GHF-1, but not the splice variant GHF-2, cooperates with thyroid hormone and retinoic acid receptors to stimulate rat growth hormone gene expression
100. Synergistic activation of the rat growth hormone promoter by Pit-1 and the thyroid hormone receptor
101. Role of estrogen receptor-alpha in the anterior pituitary gland
102. The mouse homeoprotein mLIM-3 is expressed early in cells derived from the neuroepithelium and persists in adult pituitary
103. Fgf10 is essential for limb and lung formation
104. Cloning and characterization of a novel bicoid-related homeobox transcription factor gene, RIEG, involved in Rieger syndrome
105. LIM homeodomain factors Lhx3 and Lhx4 assign subtype identities for motor neurons
106. Multistep control of pituitary organogenesis
107. Early steps in pituitary organogenesis
108. Specification of pituitary cell lineages by the LIM homeobox gene Lhx3
109. Pit-1 binding sites at the somatotrope-specific DNase I hypersensitive sites I, II of the human growth hormone locus control region are essential for in vivo hGH-N gene activation
110. Context-dependent transcriptional cooperation mediated by cardiac transcription factors Csx/Nkx-2.5 and GATA-4
111. Pituitary cell phenotypes involve cell-specific Pit-1 mRNA translation and synergistic interactions with other classes of transcription factors
112. A conserved region of engrailed, shared among all en-, gsc-, Nk1-, Nk2- and msh-class homeoproteins, mediates active transcriptional repression in vivo
113. Expression of Hox-7.1 in myoblasts inhibits terminal differentiation and induces cell transformation
114. Pituitary lineage determination by the prophet of Pit-1 homeodomain factor defective in Ames dwarfism
115. GATA-binding proteins regulate the human gonadotropin alpha-subunit gene in the placenta and pituitary gland
116. Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development
117. P-OTX: A PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development
118. Formation of Rathke's pouch requires dual induction from the diencephalon
119. Molecular determinants for cell specificity and glucocorticoid repression of the proopiomelanocortin gene
120. HES-1, a novel homeobox gene expressed by murine embryonic stem cells, identifies a new class of homeobox genes
121. Multiple pituitary and ovarian defects in Krox-24 (NGFI-A, Egr-1)-targeted mice
122. Multistep signaling requirements for pituitary organogenesis in vivo
123. Egr-1 is a downstream effector of GnRH and synergizes by direct interaction with Ptx1 and SF-1 to enhance luteinizing hormone beta gene transcription
124. The pan-pituitary activator of transcription, Ptx1 (pituitary homeobox 1), acts in synergy with SF-1 and Pit1 and is an upstream regulator of the Lim-homeodomain gene Lim3/Lhx3
125. An early haematopoietic defect in mice lacking the transcription factor GATA-2
126. An organ culture study on the site of determination of ACTH and LH cells in the rat adenohypophysis
127. Effects of brain and mesenchyme upon the cytogenesis of rat adenohypophysis in vitro. I. Differentiation of adrenocorticotropes
128. How many homeobox genes does it take to make a pituitary gland?
129. Construction of a 3-Mb contig and partial transcript map of the central region of mouse chromosome 11
130. Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse
131. An upstream regulator of the glycoprotein hormone alpha-subunit gene mediates pituitary cell type activation and repression by different mechanisms
132. Mutations in PROP1 cause familial combined pituitary hormone deficiency
133. Signal-specific coactivator domain requirements for Pit-1 activation
134. Pituitary-directed leukemia inhibitory factor transgene causes Cushing's syndrome: Neuro-immune-endocrine modulation of pituitary development
135. A novel mechanism for cyclic adenosine 3′,5′-monophosphate regulation of gene expression by CREB-binding protein
136. Expression pattern of the murine LIM class homeobox gene Lhx3 in subsets of neural and neuroendocrine tissues