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Volumn 146, Issue 3, 2005, Pages 1498-1505

Intrauterine growth restriction in humans is associated with abnormalities in placental insulin-like growth factor signaling

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 2; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN SHC; RECEPTOR PROTEIN; SOMATOMEDIN; SOMATOMEDIN C RECEPTOR; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN;

EID: 20044376471     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2004-1332     Document Type: Article
Times cited : (137)

References (63)
  • 1
    • 0036186353 scopus 로고    scopus 로고
    • Intrauterine growth restriction
    • Resnik R 2002 Intrauterine growth restriction. Obstet Gynecol 99:490-496
    • (2002) Obstet Gynecol , vol.99 , pp. 490-496
    • Resnik, R.1
  • 2
    • 0021268480 scopus 로고
    • Impaired fetal growth: Definition and clinical diagnosis
    • Seeds JW 1984 Impaired fetal growth: definition and clinical diagnosis. Obstet Gynecol 64:303-310
    • (1984) Obstet Gynecol , vol.64 , pp. 303-310
    • Seeds, J.W.1
  • 3
    • 0033594787 scopus 로고    scopus 로고
    • The fetal insulin hypothesis: An alternative explanation of the association of low birth weight with diabetes and vascular disease
    • Hattersley AT, Tooke JE 1999 The fetal insulin hypothesis: an alternative explanation of the association of low birth weight with diabetes and vascular disease. Lancet 353:1789-1792
    • (1999) Lancet , vol.353 , pp. 1789-1792
    • Hattersley, A.T.1    Tooke, J.E.2
  • 4
    • 0033964819 scopus 로고    scopus 로고
    • Umbilical artery doppler screening for detection of the small fetus in need of antepartum surveillance
    • Baschat AA, Weiner CP 2000 Umbilical artery doppler screening for detection of the small fetus in need of antepartum surveillance. Am J Obstet Gynecol 182:154-158
    • (2000) Am J Obstet Gynecol , vol.182 , pp. 154-158
    • Baschat, A.A.1    Weiner, C.P.2
  • 5
    • 0022514874 scopus 로고
    • Inadequate maternal vascular response to placentation in pregnancies complicated by pre-eclampsia and by small-for-gestational age infants
    • Khong TY, De Wolf F, Robertson WB, Brosens I 1986 Inadequate maternal vascular response to placentation in pregnancies complicated by pre-eclampsia and by small-for-gestational age infants. Br J Obstet Gynaecol 93:1049-1059
    • (1986) Br J Obstet Gynaecol , vol.93 , pp. 1049-1059
    • Khong, T.Y.1    De Wolf, F.2    Robertson, W.B.3    Brosens, I.4
  • 6
    • 0141838042 scopus 로고    scopus 로고
    • The insulin-like growth factors and feto-placental growth
    • Fowden AL 2003 The insulin-like growth factors and feto-placental growth. Placenta 24:803-812
    • (2003) Placenta , vol.24 , pp. 803-812
    • Fowden, A.L.1
  • 7
    • 0028957113 scopus 로고
    • Molecular and cellular aspects of the insulin-like growth factor I receptor
    • LeRoith D, Werner H, Beitner-Johnson D, Roberts C 1995 Molecular and cellular aspects of the insulin-like growth factor I receptor. Endocr Rev 16: 143-163
    • (1995) Endocr Rev , vol.16 , pp. 143-163
    • LeRoith, D.1    Werner, H.2    Beitner-Johnson, D.3    Roberts, C.4
  • 8
    • 0036669037 scopus 로고    scopus 로고
    • Control of cell survival by IGF signaling pathways
    • Vincent AM, Feldman EL 2002 Control of cell survival by IGF signaling pathways. Growth Horm IGF Res 12:193-197
    • (2002) Growth Horm IGF Res , vol.12 , pp. 193-197
    • Vincent, A.M.1    Feldman, E.L.2
  • 9
    • 0032434699 scopus 로고    scopus 로고
    • A prospective study of maternal serum insulin-like growth factor-I in pregnancies with appropriately grown or growth restricted fetuses
    • Holmes RP, Holly JM, Soothill PW 1998 A prospective study of maternal serum insulin-like growth factor-I in pregnancies with appropriately grown or growth restricted fetuses. Br J Obstet Gynaecol 105:1273-1278
    • (1998) Br J Obstet Gynaecol , vol.105 , pp. 1273-1278
    • Holmes, R.P.1    Holly, J.M.2    Soothill, P.W.3
  • 10
    • 0031938241 scopus 로고    scopus 로고
    • Expression of the insulin-like growth factors and their receptors in term placentae: A comparison between normal and IUGR births
    • Abu-Amero SN, Ali Z, Bennett P, Vaughan JI, Moore GE 1998 Expression of the insulin-like growth factors and their receptors in term placentae: a comparison between normal and IUGR births. Mol Reprod Dev 49:229-235
    • (1998) Mol Reprod Dev , vol.49 , pp. 229-235
    • Abu-Amero, S.N.1    Ali, Z.2    Bennett, P.3    Vaughan, J.I.4    Moore, G.E.5
  • 11
    • 0035106193 scopus 로고    scopus 로고
    • Expression of insulin-like growth factor-I and placental growth hormone mRNA in placentae: A comparison between normal and intrauterine growth retardation pregnancies
    • Sheikh S, Satoskar P, Bhartiya D 2001 Expression of insulin-like growth factor-I and placental growth hormone mRNA in placentae: a comparison between normal and intrauterine growth retardation pregnancies. Mol Hum Reprod 7:287-292
    • (2001) Mol Hum Reprod , vol.7 , pp. 287-292
    • Sheikh, S.1    Satoskar, P.2    Bhartiya, D.3
  • 12
    • 0033135205 scopus 로고    scopus 로고
    • An immunohistochemical study of type I insulin-like growth factor receptors in the placentae of pregnancies with appropriately grown or growth restricted fetuses
    • Holmes R, Porter H, Newcomb P, Holly JM, Soothill P 1999 An immunohistochemical study of type I insulin-like growth factor receptors in the placentae of pregnancies with appropriately grown or growth restricted fetuses. Placenta 20:325-330
    • (1999) Placenta , vol.20 , pp. 325-330
    • Holmes, R.1    Porter, H.2    Newcomb, P.3    Holly, J.M.4    Soothill, P.5
  • 13
    • 0037042739 scopus 로고    scopus 로고
    • Placental expression of insulin-like growth factor receptor-1 and insulin receptor in the growth-restricted fetal rat
    • Reid GJ, Flozak AS, Simmons RA 2002 Placental expression of insulin-like growth factor receptor-1 and insulin receptor in the growth-restricted fetal rat. J Soc Gynecol Invest 9:210-214
    • (2002) J Soc Gynecol Invest , vol.9 , pp. 210-214
    • Reid, G.J.1    Flozak, A.S.2    Simmons, R.A.3
  • 15
    • 0023635159 scopus 로고
    • Longitudinal assessment of blood flow velocity waveforms in the healthy human fetus
    • Arduini D, Rizzo G, Mancuso S, Romanini C 1987 Longitudinal assessment of blood flow velocity waveforms in the healthy human fetus. Prenat Diagn 7:613-617
    • (1987) Prenat Diagn , vol.7 , pp. 613-617
    • Arduini, D.1    Rizzo, G.2    Mancuso, S.3    Romanini, C.4
  • 17
    • 0042570843 scopus 로고    scopus 로고
    • Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance
    • Virkamaki A, Ueki K, Kahn CR 1999 Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance. J Clin Invest 103:931-943
    • (1999) J Clin Invest , vol.103 , pp. 931-943
    • Virkamaki, A.1    Ueki, K.2    Kahn, C.R.3
  • 18
    • 0028231105 scopus 로고
    • Involvement of Src-homology/collagen (SHC) proteins in signaling through the insulin receptor and the insulin-like-growth-factor-I-receptor
    • Giorgetti S, Pelicci PG, Pelicci G, Van Obberghen E 1994 Involvement of Src-homology/collagen (SHC) proteins in signaling through the insulin receptor and the insulin-like-growth-factor-I-receptor. Eur J Biochem 223:195-202
    • (1994) Eur J Biochem , vol.223 , pp. 195-202
    • Giorgetti, S.1    Pelicci, P.G.2    Pelicci, G.3    Van Obberghen, E.4
  • 20
    • 0034872441 scopus 로고    scopus 로고
    • The c-Jun N-terminal protein kinase family of mitogen-activated protein kinases (JNK MAPKs)
    • Barr RK, Bogoyevitch MA 2001 The c-Jun N-terminal protein kinase family of mitogen-activated protein kinases (JNK MAPKs). Int J Biochem Cell Biol 33: 1047-1063
    • (2001) Int J Biochem Cell Biol , vol.33 , pp. 1047-1063
    • Barr, R.K.1    Bogoyevitch, M.A.2
  • 22
    • 0027423419 scopus 로고
    • Role of insulin-like growth factors in embryonic and postnatal growth
    • Baker J, Liu JP, Robertson EJ, Efstratiadis A 1993 Role of insulin-like growth factors in embryonic and postnatal growth. Cell 75:73-82
    • (1993) Cell , vol.75 , pp. 73-82
    • Baker, J.1    Liu, J.P.2    Robertson, E.J.3    Efstratiadis, A.4
  • 23
    • 0029805072 scopus 로고    scopus 로고
    • Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene
    • Woods KA, Camacho-Hubner C, Savage MO, Clark AJ 1996 Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene. N Engl J Med 335:1363-1367
    • (1996) N Engl J Med , vol.335 , pp. 1363-1367
    • Woods, K.A.1    Camacho-Hubner, C.2    Savage, M.O.3    Clark, A.J.4
  • 26
    • 0032841435 scopus 로고    scopus 로고
    • IRS-2 coordinates IGF-1 receptor-mediated β-cell development and peripheral insulin signalling
    • Withers DJ, Burks DJ, Towery HH, Altamuro SL, Flint CL, White MF 1999 IRS-2 coordinates IGF-1 receptor-mediated β-cell development and peripheral insulin signalling. Nat Genet 23:32-40
    • (1999) Nat Genet , vol.23 , pp. 32-40
    • Withers, D.J.1    Burks, D.J.2    Towery, H.H.3    Altamuro, S.L.4    Flint, C.L.5    White, M.F.6
  • 27
    • 0035914388 scopus 로고    scopus 로고
    • Akt1/PKBα is required for normal growth but dispensable for maintenance of glucose homeostasis in mice
    • Cho H, Thorvaldsen JL, Chu Q, Feng F, Birnbaum MJ 2001 Akt1/PKBα is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J Biol Chem 276:38349-38352
    • (2001) J Biol Chem , vol.276 , pp. 38349-38352
    • Cho, H.1    Thorvaldsen, J.L.2    Chu, Q.3    Feng, F.4    Birnbaum, M.J.5
  • 28
    • 0037987851 scopus 로고    scopus 로고
    • Chronic pulsatile infusion of growth hormone to growth-restricted fetal sheep increases circulating fetal insulin-like growth factor-I levels but not fetal growth
    • Bauer MK, Breier BB, Bloomfield FH, Jensen EC, Gluckman PD, Harding JE 2003 Chronic pulsatile infusion of growth hormone to growth-restricted fetal sheep increases circulating fetal insulin-like growth factor-I levels but not fetal growth. J Endocrinol 177:83-92
    • (2003) J Endocrinol , vol.177 , pp. 83-92
    • Bauer, M.K.1    Breier, B.B.2    Bloomfield, F.H.3    Jensen, E.C.4    Gluckman, P.D.5    Harding, J.E.6
  • 29
    • 0032885679 scopus 로고    scopus 로고
    • Administration of growth hormone or IGF-I to pregnant rats on a reduced diet throughout pregnancy does not prevent fetal intrauterine growth retardation and elevated blood pressure in adult offspring
    • Woodall SM, Breier BH, Johnston BM, Bassett NS, Barnard R, Gluckman PD 1999 Administration of growth hormone or IGF-I to pregnant rats on a reduced diet throughout pregnancy does not prevent fetal intrauterine growth retardation and elevated blood pressure in adult offspring. J Endocrinol 163:69-77
    • (1999) J Endocrinol , vol.163 , pp. 69-77
    • Woodall, S.M.1    Breier, B.H.2    Johnston, B.M.3    Bassett, N.S.4    Barnard, R.5    Gluckman, P.D.6
  • 30
    • 0033061946 scopus 로고    scopus 로고
    • Islet transplantation restores normal levels of insulin receptor and substrate tyrosine phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle and myocardium of streptozotocin-induced diabetic rats
    • Giorgino F, Logoluso F, Davalli AM, Napoli R, Laviola L, Hirshman MF, Horton ES, Weir GC, Smith RJ 1999 Islet transplantation restores normal levels of insulin receptor and substrate tyrosine phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle and myocardium of streptozotocin-induced diabetic rats. Diabetes 48:801-812
    • (1999) Diabetes , vol.48 , pp. 801-812
    • Giorgino, F.1    Logoluso, F.2    Davalli, A.M.3    Napoli, R.4    Laviola, L.5    Hirshman, M.F.6    Horton, E.S.7    Weir, G.C.8    Smith, R.J.9
  • 31
    • 0035654625 scopus 로고    scopus 로고
    • Effects of streptozotocin diabetes and diabetes treatment by islet transplantation on in vivo insulin signaling in rat heart
    • Laviola L, Belsanti G, Davalli AM, Napoli R, Perrini S, Weir GC, Giorgino R, Giorgino F 2001 Effects of streptozotocin diabetes and diabetes treatment by islet transplantation on in vivo insulin signaling in rat heart. Diabetes 50:2709-2720
    • (2001) Diabetes , vol.50 , pp. 2709-2720
    • Laviola, L.1    Belsanti, G.2    Davalli, A.M.3    Napoli, R.4    Perrini, S.5    Weir, G.C.6    Giorgino, R.7    Giorgino, F.8
  • 32
    • 0030890580 scopus 로고    scopus 로고
    • Insulin receptor substrate (IRS)-1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus
    • Rondinone CM, Wang LM, Lonnroth P, Wesslau C, Pierce JH, Smith U 1997 Insulin receptor substrate (IRS)-1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus. Proc Natl Acad Sci USA 94:4171-4175
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 4171-4175
    • Rondinone, C.M.1    Wang, L.M.2    Lonnroth, P.3    Wesslau, C.4    Pierce, J.H.5    Smith, U.6
  • 33
    • 0031749006 scopus 로고    scopus 로고
    • A specific increased expression of insulin receptor substrate 2 in pancreatic β-cell lines is involved in mediating serum-stimulated β-cell growth
    • Schuppin GT, Pons S, Hugl S, Aiello LP, King GL, White M, Rhodes CJ 1998 A specific increased expression of insulin receptor substrate 2 in pancreatic β-cell lines is involved in mediating serum-stimulated β-cell growth. Diabetes 47:1074-1085
    • (1998) Diabetes , vol.47 , pp. 1074-1085
    • Schuppin, G.T.1    Pons, S.2    Hugl, S.3    Aiello, L.P.4    King, G.L.5    White, M.6    Rhodes, C.J.7
  • 36
    • 0034682780 scopus 로고    scopus 로고
    • Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes
    • Fasshauer M, Klein J, Ueki K, Kriauciunas KM, Benito M, White MF, Kahn CR 2000 Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes. J Biol Chem 275:25494-25501
    • (2000) J Biol Chem , vol.275 , pp. 25494-25501
    • Fasshauer, M.1    Klein, J.2    Ueki, K.3    Kriauciunas, K.M.4    Benito, M.5    White, M.F.6    Kahn, C.R.7
  • 37
    • 0034602675 scopus 로고    scopus 로고
    • Exercise-induced changes in expression and activity of proteins involved in insulin signal transduction in skeletal muscle: Differential effects on insulin-receptor substrates 1 and 2
    • Chibalin AV, Yu M, Ryder JW, Song XM, Galuska D, Krook A, Wallberg-Henriksson H, Zierath JR 2000 Exercise-induced changes in expression and activity of proteins involved in insulin signal transduction in skeletal muscle: differential effects on insulin-receptor substrates 1 and 2. Proc Natl Acad Sci USA 97:38-43
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 38-43
    • Chibalin, A.V.1    Yu, M.2    Ryder, J.W.3    Song, X.M.4    Galuska, D.5    Krook, A.6    Wallberg-Henriksson, H.7    Zierath, J.R.8
  • 38
    • 0040973209 scopus 로고    scopus 로고
    • Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells
    • Bruning JC, Winnay J, Cheatham B, Kahn CR 1997 Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells. Mol Cell Biol 17:1513-1521
    • (1997) Mol Cell Biol , vol.17 , pp. 1513-1521
    • Bruning, J.C.1    Winnay, J.2    Cheatham, B.3    Kahn, C.R.4
  • 42
    • 0036224165 scopus 로고    scopus 로고
    • Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-α or EGF, augments pancreatic β-cell proliferation
    • Lingohr MK, Dickson LM, McCuaig JF, Hugl SR, Twardzik DR, Rhodes CJ 2002 Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-α or EGF, augments pancreatic β-cell proliferation. Diabetes 51:966-976
    • (2002) Diabetes , vol.51 , pp. 966-976
    • Lingohr, M.K.1    Dickson, L.M.2    McCuaig, J.F.3    Hugl, S.R.4    Twardzik, D.R.5    Rhodes, C.J.6
  • 43
    • 4644311421 scopus 로고    scopus 로고
    • Hepatic insulin resistance precedes the development of diabetes in a model of intrauterine growth retardation
    • Vuguin P, Raab E, Liu B, Barzilai N, Simmons R 2004 Hepatic insulin resistance precedes the development of diabetes in a model of intrauterine growth retardation. Diabetes 53:2617-2622
    • (2004) Diabetes , vol.53 , pp. 2617-2622
    • Vuguin, P.1    Raab, E.2    Liu, B.3    Barzilai, N.4    Simmons, R.5
  • 44
    • 0033954382 scopus 로고    scopus 로고
    • To be, or not to be, that is the question. Apoptosis in human trophoblast
    • Levy R, Nelson DM 2000 To be, or not to be, that is the question. Apoptosis in human trophoblast. Placenta 21:1-13
    • (2000) Placenta , vol.21 , pp. 1-13
    • Levy, R.1    Nelson, D.M.2
  • 47
    • 0031447022 scopus 로고    scopus 로고
    • Increased placental apoptosis in intrauterine growth restriction
    • Smith SC, Baker PN, Symonds EM 1997 Increased placental apoptosis in intrauterine growth restriction. Am J Obstet Gynecol 177:1395-1401
    • (1997) Am J Obstet Gynecol , vol.177 , pp. 1395-1401
    • Smith, S.C.1    Baker, P.N.2    Symonds, E.M.3
  • 48
    • 0037331775 scopus 로고    scopus 로고
    • Differences in apoptotic susceptibility of cytotrophoblasts and syncytiotrophoblasts in normal pregnancy to those complicated with preeclampsia and intrauterine growth restriction
    • Crocker IP, Cooper S, Ong SC, Baker PN 2003 Differences in apoptotic susceptibility of cytotrophoblasts and syncytiotrophoblasts in normal pregnancy to those complicated with preeclampsia and intrauterine growth restriction. Am J Pathol 162:637-643
    • (2003) Am J Pathol , vol.162 , pp. 637-643
    • Crocker, I.P.1    Cooper, S.2    Ong, S.C.3    Baker, P.N.4
  • 49
    • 0028572541 scopus 로고
    • Cytotoxicity of tumour necrosis factor-α and γ-interferon against primary human placental trophoblasts
    • Yui J, Garcia-Lloret M, Wegmann TG, Guilbert LJ 1994 Cytotoxicity of tumour necrosis factor-α and γ-interferon against primary human placental trophoblasts. Placenta 15:819-835
    • (1994) Placenta , vol.15 , pp. 819-835
    • Yui, J.1    Garcia-Lloret, M.2    Wegmann, T.G.3    Guilbert, L.J.4
  • 50
    • 0020531291 scopus 로고
    • Morphologic findings in the placenta in intrauterine fetal growth retardation
    • Prinz W, Schuhmann RA, Kalbfleisch W 1983 Morphologic findings in the placenta in intrauterine fetal growth retardation. Zentralbl Gynakol 105:279-286
    • (1983) Zentralbl Gynakol , vol.105 , pp. 279-286
    • Prinz, W.1    Schuhmann, R.A.2    Kalbfleisch, W.3
  • 51
    • 0036583261 scopus 로고    scopus 로고
    • Trophoblast apoptosis from pregnancies complicated by fetal growth restriction is associated with enhanced p53 expression
    • Levy R, Smith SD, Yusuf K, Huettner PC, Kraus FT, Sadovsky Y, Nelson DM 2002 Trophoblast apoptosis from pregnancies complicated by fetal growth restriction is associated with enhanced p53 expression. Am J Obstet Gynecol 186:1056-1061
    • (2002) Am J Obstet Gynecol , vol.186 , pp. 1056-1061
    • Levy, R.1    Smith, S.D.2    Yusuf, K.3    Huettner, P.C.4    Kraus, F.T.5    Sadovsky, Y.6    Nelson, D.M.7
  • 52
    • 0036153117 scopus 로고    scopus 로고
    • Increased apoptosis in the syncytiotrophoblast in human term placentas complicated by either preeclampsia or intrauterine growth retardation
    • Ishihara N, Matsuo H, Murakoshi H, Laoag-Fernandez JB, Samoto T, Maruo T 2002 Increased apoptosis in the syncytiotrophoblast in human term placentas complicated by either preeclampsia or intrauterine growth retardation. Am J Obstet Gynecol 186:158-166
    • (2002) Am J Obstet Gynecol , vol.186 , pp. 158-166
    • Ishihara, N.1    Matsuo, H.2    Murakoshi, H.3    Laoag-Fernandez, J.B.4    Samoto, T.5    Maruo, T.6
  • 53
    • 0034520312 scopus 로고    scopus 로고
    • High insulin-like growth factor 1 (IGF-1) and insulin concentrations trigger apoptosis in the mouseblastocyst via down-regulation of the IGF-1 receptor
    • Chi MM, Schlein AL, Moley KH 2000 High insulin-like growth factor 1 (IGF-1) and insulin concentrations trigger apoptosis in the mouseblastocyst via down-regulation of the IGF-1 receptor. Endocrinology 141:4784-4792
    • (2000) Endocrinology , vol.141 , pp. 4784-4792
    • Chi, M.M.1    Schlein, A.L.2    Moley, K.H.3
  • 54
    • 0034688287 scopus 로고    scopus 로고
    • A central control for cell growth
    • Whitmarsh AJ, Davis RJ 2000 A central control for cell growth. Nature 403: 255-256
    • (2000) Nature , vol.403 , pp. 255-256
    • Whitmarsh, A.J.1    Davis, R.J.2
  • 55
    • 0034881019 scopus 로고    scopus 로고
    • Molecular mechanisms mediating mammalian mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK cell survival signals
    • Ballif BA, Blenis J 2001 Molecular mechanisms mediating mammalian mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK cell survival signals. Cell Growth Differ 12:397-408
    • (2001) Cell Growth Differ , vol.12 , pp. 397-408
    • Ballif, B.A.1    Blenis, J.2
  • 60
    • 0032724021 scopus 로고    scopus 로고
    • Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2
    • Sabapathy K, Jochum W, Hochedlinger K, Chang L, Karin M, Wagner EF 1999 Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2. Mech Dev 89:115-124
    • (1999) Mech Dev , vol.89 , pp. 115-124
    • Sabapathy, K.1    Jochum, W.2    Hochedlinger, K.3    Chang, L.4    Karin, M.5    Wagner, E.F.6
  • 61
    • 0033022990 scopus 로고    scopus 로고
    • Signal transduction and biological function of placenta growth factor in primary human trophoblast
    • 1999
    • Desai J, Holt-Shore V, Tony RJ, Caudle MR, Tony DS 1999 Signal transduction and biological function of placenta growth factor in primary human trophoblast. Biol Reprod 1999 60:887-892
    • (1999) Biol Reprod , vol.60 , pp. 887-892
    • Desai, J.1    Holt-Shore, V.2    Tony, R.J.3    Caudle, M.R.4    Tony, D.S.5


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