Steroid hormone biosynthesis and actions in the maternofeto-placental unit

Clinics in Perinatology

Volumn 25, Issue 4, 1998, Pages 799-817

  Miller, W L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENAL GLAND; BRAIN; CHOLESTEROL TRANSPORT; CORPUS LUTEUM FUNCTION; FEMALE; FETOPLACENTAL UNIT; FETUS DEVELOPMENT; GENETIC ANALYSIS; GONAD; HUMAN; PREGNANCY; PRIORITY JOURNAL; REVIEW; STEROID METABOLISM; STEROIDOGENESIS;

EID: 0031794582     PISSN: 00955108     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0095-5108(18)30084-8     Document Type: Review

References (105)

1. Allen J.P. Greer M.A. McGilvra R. Endocrine function in an anencephalic infant 1 Clin Endocrinol Metab 38 1974 94 98
2. 5 augments the 17,20 lyase activity of human P450cl7 without direct electron transfer J Biol Chem 273 1998 3158 3165
3. Bamberger C.M. Heinrich M.S. Chrousos G.P. Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids Endocr Rev 17 1996 245 261
4. Beitens I.Z. Bayard F. Ances I.G. The metabolic clearance rate, blood production, interconversion and transplacental passage of cortisol and cortisone in pregnancy near term Pediatr Res 7 1973 509 519
5. Benirschke K. Adrenals in anencephaly and hydrocephaly Obstet Gynecol 8 1956 412 425
6. Berube D. Luu-The V. Lachance Y. Assignment of the human 3β-hydroxysteroid dehydrogenase gene (HSDB3) to the pl3 band of chromosome 1 Cyteogenet Cell Genet 52 1989 199 200
7. Bose H.S. Pescovitz O.H. Miller W. Spontaneous feminization in a 46,XX female patient with congenital lipoid adrenal hyperplasia caused by a homozygous frame-shift mutation in the steroidogenic acute regulatory protein J Clin Endocrinol Metab 82 1997 1511 1515
8. Bose H.S. Sugawara T. Strauss J.F. III The pathophysiology and genetics of congenital lipoid adrenal hyperplasia N Engl J Med 335 1996 1870 1878
9. Casey M.L. MacDonald P.C. Extra-adrenal formation of a mineralocorticoid: Deoxycorticosterone and deoxycorticosterone sulfate biosynthesis and metabolism Endocr Rev 3 1982 396 403
10. Casey M.L. Winkel C.A. MacDonald P. Conversion of progesterone to deoxycorticosterone in the human fetus: Steroid 21-hydroxylase activity in fetal tissues J Steroid Biochem Mol Biol 18 1983 449 452
11. Chang C.-Y. Wu D.-A. Lai C.-C. Cloning and structure of the human adrenodoxin gene DNA 7 1988 609 615
12. Cole T.J. Blendy J.A. Monaghan A.P. Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severly retards lung maturation Genes Dev 9 1995 1608 1621
13. Compagnone N.A. Bulfone A. Rubenstein J.L.R. Expression of the steroidogenic enzyme P450scc in the central and peripheral nervous systems during rodent embryogenesis Endocrinology 136 1995 2689 2696
14. Compagnone N.A. Bulfone A. Rubenstein J.L.R. Steroidogenic enzyme P450cl7 is expressed in the embryonic central nervous system Endocrinology 136 1995 5212 5223
15. Compagnone N.A. Mellon S.H. Dehydroepiandrosterone: A signalling molecule for neocortical organization during development Proc Natl Acad Sei USA 95 1998 4678 4683
16. Compagnone N.A. Salido E. Shapiro L.J. Expression of steroid sulfatase during embryogenesis Endocrinology 138 1997 4768 4773
17. Conte F.A. Grumbach M.M. Ito Y. A syndrome of female pseudohermaphrodism, hypergonadotropic hypogonadism, and multicystic ovaries associated with missense mutations in the gene encoding aromatase (P450arom) J Clin Endocrinol Metab 78 1994 1287 1292
18. Corpechot C. Robel P. Axelson M. Characterization and measurement of dehydroepiandrosterone sulfate in rat brain Proc Natl Acad Sei USA 78 1981 4704 4707
19. Csapo A.I. Pulkkinen M.O. Indispensibility of the human corpus luteum in the maintenance of early pregnancy: Luteectomy evidence Obstet Gynecol Surv 83 1978 69 81
20. Dibbelt L. Kuss E. Human placental sterylsulfatase: Interaction of the isolated enzyme with substrates, products, transition-state analogues, amino-acid modifiers and anion transport inhibitors Biol Chem 372 1991 173 185
21. El-Etr M. Akwa Y. Fiddes R.J. A progesterone metabolite stimulates the release of gonadotropin-releasing hormone from GT1-1 hypothalamic neurons via the y-aminobutyric acid type A receptor Proc Natl Acad Sei USA 92 1995 3769 3773
22. Fardella C.E. Miller W.L. Molecular biology of mineralocorticoid metabolism Annu Rev Nutr 16 1996 443 470
23. Fu G.K. Portale A.A. Miller W.L. Complete structure of the human gene for the vitamin D la-hydroxyase, P450cla DNA Cell Biol 16 1997 1499 1507
24. Fujieda K. Tajima T. Nakae J. Spontaneous puberty in 46,XX subjects with congenital lipoid adrenal hyperplasia J Clin Invest 99 1997 1265 1271
25. Gee K.W. Bolger M.B. Brinton R.E. Steroid modulation of the chloride ionophore in rat brain: Structure-activity requirements, regional dependence and mechanism of action J Pharmacol Exp Ther 246 1988 803 812
26. Geissler W.M. Davis D.L. Wu L. Male pseudohermaphroiditism caused by mutations of testicular 17β-hydroxysteroid dehydrogenase 3 Nat Genet 7 1994 34 39
27. George F.W. Wilson J.D. Conversion of androgen to estrogen by the human fetal ovary J Clin Endocrinol Metab 47 1978 550 555
28. Gomez-Sanchez C.E. Zhou M.Y. Cozza E.N. Aldosterone biosynthesis in the rat brain Endocrinology 138 1997 3369 3373
29. Gray E.S. Abramovitch D.R. Morphologic features of the anencephalic adrenal gland in early pregnancy Am J Obstet Gynecol 137 1980 491 495
30. Harada N. Ogawa H. Shozu M. Biochemical and molecular genetic analyses on placental aromatase (P450arom) deficiency J Biol Chem 267 1992 4781 4785
31. Harkness R.A. Current clinical problems in placental steroid or arylsulphatase C deficiency and the related “cervical dystocia” and X-linked ichthyosis J Inherit Metab Dis 5 1982 142 144
32. Huhtaniemi I.T. Korenbrot C.C. Jaffe R.B. hCG binding and stimulation of testosterone biosynthesis in the human fetal testis J Clin Endocrinol Metab 44 1977 963 967
33. Hum D.W. Miller W.L. Transcriptional regulation of human genes for steroidogenic enzymes Clin Chem 39 1993 333 340
34. Ito Y. Fisher C.R. Conte F.A. Molecular basis of aromatase deficiency in an adult female with sexual infantilism and polycystic ovaries Proc Natl Acad Sei USA 90 1993 11673 11677
35. Kari M.A. Raivio K.O. Stenman U.-H. Serum cortisol, dehydroepiandrosterone sulfate, and sterol-binding globulins in preterm neonates: Effects of gestational age and dexamethasone therapy Pediatr Res 40 1996 319 324
36. Khanna M. Qin K.N. Wang R.W. Substrate specificity, gene structure and tissue-specific distribution of multiple human 3a-hydroxysteroid dehydrogenases J Biol Chem 270 1995 20162 20168
37. Kiriakidou M. McAllister J.M. Sugawara T. Expression of steroidogenic acute regulatory protein (StAR) in the human ovary J Clin Endocrinol Metab 81 1996 4122 4128
38. Kotelevtsev Y. Holmes M.C. Burchell A. 11β-Hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress Proc Natl Acad Sei USA 94 1997 14924 14929
39. 4-isomerase gene and its expression in mammalian cells J Biol Chem 265 1990 20469 20475
40. 4 isomerase (3β-HSD) gene: Adrenal and gonadal specificity DNA Cell Biol 10 1991 701 711
41. Lauber M.E. Lichtensteiger W. Ontogeny of 5a-reductase (type I) messenger ribonucleic acid expression in rat brain: Early presence in germinal zones Endocrinology 137 1996 2718 2730
42. Lauber M.E. Lichtensteiger W. Pre- and postnatal ontogeny of aromatase cytochrome P450 messenger ribonucleic acid expression in the male rat brain studied by in situ hybridization Endocrinology 135 1994 1661 1668
43. Lieberman S. Prasad V.V.K. Heterodox notions on pathways of steroidogenesis Endocr Rev 11 1990 469 493
44. Lin D. Shi Y. Miller W.L. Cloning and sequence of the human adrenodoxin reductase gene Proc Natl Acad Sei USA 87 1990 8516 8520
45. Lin D. Sugawara T. Strauss J.F. III Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesis Science 267 1995 1828 1831
46. Majewska M.D. Harrison N.L. Schwartz R.D. Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor Science 232 1986 1004 1007
47. Marano R.P.C. Ortiz M.A. Stradtmann O. Ocular findings associated with congenital X-linked ichthyosis Ann Ophthalmol 23 1991 167 172
48. Mellon S.H. Neurosteroids: Biochemistry, modes of action, and clinical relevance J Clin Endocrinol Metab 78 1994 1003 1008
49. Mellon S.H. Deschepper C.F. Neurosteroid biosynthesis: Genes for adrenal steroidogenic enzymes are expressed in the brain Brain Res 629 1993 283 292
50. Mellon S.H. Miller W. Extra-adrenal steroid 21-hydroxylation is not mediated by P450c21 J Clin Invest 84 1989 1497 1502
51. Mesiano S. Coulter C.L. Jaffe R. Localization of cytochrome P450 cholesterol side-chain cleavage, cytochrome P450 17ct-hydroxylase/17,20 lyase, and 3 β-hydroxy steroid dehydrogenase-isomerase steroidogenic enzymes in human and rhesus monkey fetal adrenal glands: Reappraisal of functional zonation J Clin Endocrinol Metab 77 1993 1184 1189
52. Mesiano S. Mellon S.H. Jaffe R.B. Mitogenic action, regulation, and localization of insulin-like growth factors in the human fetal adrenal gland J Clin Endocrinol Metab 76 1993 968 976
53. Miller W.L. Congenital lipoid adrenal hyperplasia: The human gene knockout of the steroidogenic acute regulatory protein J Mol Endocrinol 17 1997 227 240
54. Miller W.L. Congenital adrenal hyperplasia in the adult patient Adv Intern Med 44 1998 155 173
55. Miller W. Genetics, diagnosis, and management of 21-hydroxylase deficiency J Clin Endocrinol Metab 78 1994 241 246
56. Miller W.L. Molecular biology of steroid hormone synthesis Endocr Rev 9 1988 295 318
57. Miller W.L. Why nobody has P450scc (20, 22 desmolase) deficiency J Clin Endocrinol Metab 83 1998 1399 1400 [letter]
58. Miller W.L. Auchus R.J. Geller D. The regulation of 17,20 lyase activity Steroids 62 1997 135 144
59. Mitani F. Suzuhi H. Hata J. A novel cell layer without corticosteroid-synthesizing enzymes in rat adrenal cortex: Histochemical detection and possible physiologic role Endocrinology 135 1994 431 438
60. Miyakawa I. Ikeda I. Maeyama M. Transport of ACTH across human placenta J Clin Endocrinol Metab 39 1974 440 442
61. Molsberry R.L. Carr B.R. Mendelson C.R. Human chorionic gonadotropin binding to human fetal testes as a function of gestational age J Clin Endocrinol Metab 55 1982 791 794
62. Morel Y. Miller W. Clinical and molecular genetics of congenital adrenal hyperplasia due to 21-hydroxylase deficiency Adv Hum Genet 20 1991 1 68
63. Morohashi K. Sogawa K. Omura T. Gene structure of human cytochrome P450(scc), cholesterol desmolase J Biochem 101 1987 879 887
64. Muscatelli F. Strom T.M. Walker A.P. Mutations in the DAX-1 gene give rise to both X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism Nature 372 1994 672 676
65. Nakae J. Tajima T. Kusuda S. Truncation at the C-terminus of the DAX-1 protein impairs its biological actions in patients with X-linked adrenal hypoplasia congenita J Clin Endocrinol Metab 81 1996 3680 3685
66. Nakae J. Tajima T. Sugawara T. Analysis of the steroidogenic acute regulatory protein (StAR) gene in Japanese patients with congenital lipoid adrenal hyperplasia Hum Mol Genet 6 1997 571 576
67. New M.I. White P. Pang S. The adrenal hyperplasias Scriver C.R. Beaudet A. Sly S. Valle D. The Metabolic Basis of Inherited Disease 1989 McGraw-Hill New York 1881 1917
68. Osamura R.Y. Functional prenatal development of anencephalic and normal anterior pituitary glands Acta Pathol Jpn 27 1977 495 509
69. Pang S. Yang X.H. Wang M. Inherited congenital adrenal hyperplasia in the rabbit: Absent cholesterol side-chain cleavage cytochrome P450 gene expression Endocrinology 131 1992 181 186
70. Penning T.M. Molecular endocrinology of hydroxysteroid dehydrogenases Endocr Rev 18 1997 281 305
71. Picado-Leonard J. Miller W. Cloning and sequence of the human gene encoding P450cl7 (steroid 17ct-hydroxylase/17,20 lyase): Similarity to the gene for P450c21 DNA 6 1987 439 448
72. Purdy R.H. Morrow A.L. Moore P.H.J. Stress-induced elevations of y-aminobutyric acid type A receptor-active steroids in the rat brain Proc Natl Acad Sei USA 88 1991 4554 4557
73. 4-isomerase in human adrenals and gonads Mol Endocrinol 5 1991 1147 1157
74. Robei P. Baulieu E. Neurosteroids: Biosynthesis and function Trends Endocrinol Metab 5 1994 1 7
75. Rogier L.E. Pintar J.E. Expression of the P450 side-chain cleavage and adrenodoxin genes begins during early stages of adrenal cortex development Mol Endocrinol 7 1993 453 461
76. Rose K.A. Stapleton G. Dott K. Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7a-hydroxy dehydroepiandrosterone and 7ct-hydroxy pregnenolone Proc Natl Acad Sei USA 94 1997 4925 4930
77. Saenger P. Klonari Z. Black S.M. Prenatal diagnosis of congenital lipoid adrenal hyperplasia J Clin Endocrinol Metab 80 1995 200 205
78. Salido E.C. Yen P.H. Barajas L. Steroid sulfatase expression in human placenta: Immunocytochemistry and in situ hybridization study J Clin Endocrinol Metab 70 1990 1564 1567
79. Sarda I.R. Gorwill R.H. Hormonal studies in pregnancy: I. Total unconjugated estrogens in maternal peripheral vein, cord vein, and cord artery serum at delivery Am J Obstet Gynecol 124 1976 234 238
80. Schwitzgebel V.M. Kaplan S.L. Grumbach M.M. Normal female offspring in mothers with salt-losing form of 21-hydroxylase deficiency Horm Res 48 suppl 2 1997 33 [abstract]
81. Seckl J.R. Miller W.L. How safe is long-term prenatal glucocorticoid treatment? JAMA 277 1997 1077 1079
82. Shozu M. Akasofu K. Harada T. A new cause of female pseudo-hermaphroditism: Placental aromatase deficiency J Clin Endocrinol Metab 72 1991 560 566
83. Simard J. Rheaume E. Sanchez R. Molecular basis of congenital adrenal hyperplasia due to 3β-hydroxysteroid dehydrogenase deficiency Mol Endocrinol 7 1993 716 728
84. Simpson E.R. Mahendroo M.S. Means G.D. Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis Endocr Rev 15 1994 342 355
85. Smith E.P. Boyd J. Frank G.R. Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man N Engl J Med 331 1994 1056 1061
86. Stocco D.M. Clark B.J. Regulation of the acute production of steroids in steroidogenic cells Endocr Rev 17 1996 221 224
87. Strauss J.F. III Gfvels M.E. King B.F. Placental hormones DeGroot Endocrinology 1995 WB Saunders Philadelphia 2171 2206
88. Strauss JF III, Penning TM: Synthesis of the sex steroid hormones: Molecular and structural biology with implications for Clinical Practice. In Fauser BCJM, Rutherford AJ, Strauss JF III, et al (eds): Molecular Biology in Reproductive Medicine. Carnforth, UK, Parthenon Press (in press)
89. Sugawara T. Holt J.A. Driscoll D. Human steroidogenic acute regulatory protein (StAR): Functional activity in COS-1 cells, tissue-specific expression, and mapping of the structural gene to 8pll.2 and an expressed pseudogene to chromosome 13 Proc Natl Acad Sei USA 92 1995 4778 4782
90. Tapanainen J. Kellokumpu-Lehtinen P. Pelliniemi L. Age-related changes in endogenous steroids of human fetal testis during early and midpregnancy J Clin Endocrinol Metab 52 1981 98 102
91. Tremblay Y. Ringler G.E. Morel Y. Regulation of the gene for estrogenic 17-ketosteroid reductase lying on chromosome 17cen→q25 J Biol Chem 264 1989 20458 20462
92. van Grunsven E.G. van Berkel E. Ijlst L. Peroxisomal D-hydroxyacyl-CoA dehydrogenase deficiency: Resolution of the enzyme defect and its molecular basis in bifunctional protein deficiency Proc Natl Acad Sei USA 95 1998 2128 2133
93. Voutilainen R. Ilvesmaki V. Miettinen P. Low expression of 3β-hydroxy-5-ene steroid dehydrogenase gene in human fetal adrenals in vivo. Adrenocorticotropin and protein kinase C-dependent regulation in adrenocortical cultures J Clin Endocrinol Metab 72 1991 761 767
94. Voutilainen R. Miller W.L. Coordinate tropic hormone regulation of mRNAs for insulin-like growth factor II and the cholesterol side-chain cleavage enzyme, P450scc, in human steroidogenic tissues Proc Natl Acad Sei U S A 84 1987 1590 1594
95. Voutilainen R. Miller W.L. Developmental expression of genes for the steroidogenic enzymes P450scc (20,22 desmolase), P450cl7 (17a-hydroxylase/17,20 lyase) and P450c21 (21-hydroxylase) in the human fetus J Clin Endocrinol Metab 63 1986 1145 1150
96. Voutilainen R. Tapanainen J. Chung B. Hormonal regulation of P450scc (20,22- desmolase) and P450cl7 (17a-hydroxylase/17,20-lyase) in cultured human granulosa cells J Clin Endocrinol Metab 63 1986 202 207
97. Watari H. Arakane F. Moog-Lutz C. MLN64 contains a domain with homology to the steroidogenic acute regulatory protein (StAR) that stimulates steroidogenesis Proc Natl Acad Sei U S A 94 1997 8462 8467
98. White P.C. Curnow K.M. Pascoe L. Disorders of steroid 11β-hydroxylase isozymes Endocr Rev 15 1994 421 438
99. White P.C. Mune T. Agarwal A.K. 11β-hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess Endocr Rev 18 1997 135 156
100. Wilson J.D. Griffin J.E. Russell D. Steroid 5a~reductase 2 deficiency Endocr Rev 14 1994 577 593
101. Yalcinkaya T.M. Siiteri P.K. Vigne J.-L. A mechanism for virilization of female spotted hyenas in utero Science 260 1993 1929 1931
102. Yang X. Iwamoto K. Wang M. Inherited congenital adrenal hyperplasia in the rabbit is caused by a deletion in the gene encoding cytochrome P450 cholesterol side-chain cleavage enzyme Endocrinology 132 1993 1977 1982
103. Yen P.H. Marsh B. Allen E. The human X-linked steroid sulfatase gene and a Y-encoded pseudogene: Evidence for an inversion of the Y chromosome during primate evolution Cell 55 1988 1123 1135
104. Zanaria E. Muscatelli F. Bardoni B. An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita Nature 372 1994 635 641
105. Zhang L. Rodriguez H. Ohno S. Serine phosphorylation of human P450cl7 increases 17,20 lyase activity: Implications for adrenarche and for the polycystic ovary syndrome Proc Natl Acad Sei U S A 92 1995 10619 10623