Sodium/iodide symporter (NIS) gene expression is the limiting step for the onset of thyroid function in the human fetus

Journal of Clinical Endocrinology and Metabolism

Volumn 92, Issue 1, 2007, Pages 70-76

  Szinnai, Gabor ^a   Lacroix, Ludovic ^b   Carré, Aurore ^a   Guimiot, Fabien ^c   Talbot, Monique ^b   Martinovic, Jelena ^a   Delezoide, Anne Lise ^c   Vekemans, Michel ^a   Michiels, Stefan ^b   Caillou, Bernard ^b   Schlumberger, Martin ^b   Bidart, Jean Michel ^b   Polak, Michel ^a,d  

^a HÔPITAL NECKER ENFANTS MALADES   (France)

^b INSTITUT GUSTAVE ROUSSY   (France)

^c HÔPITAL ROBERT DEBRÉ   (France)

^d ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

FORKHEAD TRANSCRIPTION FACTOR; MESSENGER RNA; PENDRIN; SODIUM IODIDE SYMPORTER; THYROGLOBULIN; THYROID PEROXIDASE; THYROID TRANSCRIPTION FACTOR 1; THYROTROPIN RECEPTOR; TRANSCRIPTION FACTOR PAX8;

ARTICLE; CELLULAR DISTRIBUTION; EMBRYO; FETUS; GENE EXPRESSION; GESTATIONAL AGE; HORMONE SYNTHESIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; ONTOGENY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REGRESSION ANALYSIS; THYROID CELL; THYROID FUNCTION;

EID: 33846093170     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2006-1450     Document Type: Article

References (33)

1. Shepard TH, Andersen H, Andersen HJ 1964 Histochemical studies of the human fetal thyroid during the first half of fetal life. Anat Rec 149:363-380
2. Shepard TH 1967 Onset of function in the human fetal thyroid: biochemical and radioautographic studies from organ culture. J Clin Endocrinol Metab 27:945-958
3. De Felice M, Di Lauro R 2004 Thyroid development and its disorders: genetics and molecular mechanisms. Endocr Rev 25:722-746
4. Plachov D, Chowdhury K, Walther C, Simon D, Guenet JL, Gruss P 1990 Pax8, a murine paired box gene expressed in the developing excretory system and thyroid gland. Development 110:643-651
5. Lazzaro D, Price M, De Felice M, Di Lauro R 1991 Transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain. Development 113:231-238
6. Zannini M, Avantaggiato V, Biffali E, Arnone M, Sato K, Pischetola M, Taylor BA, Phillips SJ, Simeone A, Di Lauro R 1997 TTF-2, a new forkhead protein, shows a temporal expression in the developing thyroid which is consistent with a role in controlling the onset of differentiation. EMBO J 16:3185-3197
7. Rodriguez M, Santisteban P, Acebron A, Hernandez LC, Del Valle M, Jolin T 1992 Expression of thyroglobulin gene in maternal and fetal thyroid in rats. Endocrinology 131:415-422
8. Brown RS, Shalhoub V, Coulter S, Alex S, Joris I, De Vito W, Lian J, Stein GS 2000 Developmental regulation of thyrotropin receptor gene expression in the fetal and neonatal rat thyroid: relation to thyroid morphology and to thyroid-specific gene expression. Endocrinology 141:340-345
9. Postiglione MP, Parlato R, Rodriguez-Mallon A, Rosica A, Mithbaokar P, Maresca M, Marians RC, Davies TF, Zannini MS, De Felice M, Di Lauro R 2002 Role of the thyroid-stimulating hormone receptor signalling in development and differentiation of the thyroid gland. Proc Natl Acad Sci USA 99: 15462-15467
10. Meunier D, Aubin J, Jeanotte L 2003 Perturbed thyroid morphology and transient hypothyroidism symptoms in Hoxa5 mutant mice. Dev Dyn 227: 367-378
11. Trueba S, Auge J, Mattei G, Etchervers H, Martinovic J, Czernichow P, Vekemans M, Polak M, Attie-Bitach T 2005 PAX8, TITF1 and FOXE1 gene expression patterns during human development: new insights into human thyroid development and thyroid dysgenesis associated malformations. J Clin Endocrinol Metab 90:455-462
12. Drumm JE, O'Rahilly R 1977 The assessment of prenatal age from crown to rump length determined ultrasonically. Am J Anat 148:555-560
13. Guihard-Costa AM, Larroche JC 1995 Fetal biometry. In: Droulle P, Guihard-Costa AM, Larroche JC, Narcy F, eds. Fetal diagnosis and therapy. Basel, Switzerland: Karger; 212-278
14. Moore KL, Persaud TVN, Shiota K 1994 Color atlas of clinical embryology. Philadelphia: WB Saunders Co; 153-163
15. O'Rahilly R, Müller F 1987 Developmental stages in human embryos. Carnegie Institution of Washington, Publication 637. Washington DC: Carnegie Institute
16. Munsick R 1984 Human fetal extremity lengths in the interval from 9 to 21 menstrual weeks of pregnancy. Am J Obstet Gynecol 8:883-886
17. Lazar V, Bidart JM, Caillou B, Mahé C, Lacroix L, Filetti S, Schlumberger M 1999 Expression of the Na+/I- symporter gene in human thyroid tumors: a comparison study with other thyroid specific genes. J Clin Endocrinol Metab 84:3228-3234
18. Bidart JM, Mian C, Lazar V, Russo D, Filetti S, Caillou B, Schlumberger M 2000 Expression of Pendrin and the Pendred Syndrome (PDS) gene in human thyroid tissues. J Clin Endocrinol Metab 85:2028-2033
19. Caillou B, Dupuy C, Lacroix L, Nocera M, Talbot M, Ohayon R, De'me D, Bidart JM, Schlumberger M, Virion A 2001 Expression of reduced nicotinamide adenine dinucleotide phosphate oxidase (ThoX, LNOX, Duox) genes and proteins in human thyroid tissues. J Clin Endocrinol Metab 86:3351-3358
20. Lacroix L, Michiels S, Mian C, Arturi F, Caillou B, Filetti S, Schlumberger M, Bidart JM 2006 HEX, PAX-8 and TTF-1 gene expression in human thyroid tissues: a comparative analysis with other genes involved in iodide metabolism. Clin Endocrinol (Oxf) 64:398-404
21. Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, Speleman F 2002 Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 3:1-11
22. Sen AK, Srivastava M 1997 Regression analysis: theory, methods and applications. New York: Springer-Verlag; 45
23. Olin P, Ekholm R, Almquist S 1970 Biosynthesis of thyroglobulin related to the ultrastructure of the human fetal thyroid gland. Endocrinology 87:1000-1014
24. Dohan O, De la Vieja A, Paroder V, Riedel C, Artani M, Reed M, Ginter CS, Carrasco N 2003 The sodium/iodide symporter (NIS): characterization, regulation, and medical significance. Endocr Rev 24:48-77
25. Dentice M, Luongo C, Elefante A, Ambrosio R, Salzano S, Zannini M, Nitsch R, Di Lauro R, Rossi G, Fenzi G, Salvatore D 2005 Pendrin is a novel in vivo downstream target gene of the TTF-1/Nkx-2.1 homeodomain transcription factor in differentiated thyroid cells. Mol Cell Biol 25:10171-10182
26. Pasca di Maglio M, Di Lauro R, Zannini MS 2000 Pax8 has a key role in thyroid cell differentiation. Proc Natl Acad Sci USA 97:13144-13149
27. Di Palma T, Nitsch R, Mascia A, Nitsch L, Di Lauro R 2003 The paired domain-containing factor PAX8 and the homeodomain-containing factor TTF-1 directly interact and synergistically activate transcription. J Biol Chem 278:3395-3402
28. Bernier-Valentin F, Trouttet-Masson S, Rabilloud R, Selmi-Ruby S, Rousset B 2006 Three-dimensional organization of thyroid cells into follicle structures is a pivotal factor in the control of sodium/iodide symporter expression. Endocrinology 147:2035-2042
29. Hodges RE, Evans TC, Bradbury JT, Keettel WC 1955 The accumulation of radioactive iodine by human fetal thyroids. J Clin Endocrinol Metab 15:661-667
30. Greenberg AH, Czernichow P, Reba RC, Tyson J, Blizzard RM 1970 Observations on the maturation of thyroid function in early fetal life. J Clin Invest 49:1790-1803
31. Thorpe-Beeston GJ, Nicolaides KH, Felton CV, Butler J, McGregor AM 1991 Maturation of the secretion of thyroid hormone and thyroid-stimulating hormone in the fetus. N Engl J Med 324:532-536
32. Calvo RM, Jauniaux E, Gulbis B, Asuncion M, Gervy C, Contempré B, Morreale de Escobar G 2002 Fetal tissues are exposed to biologically relevant free thyroxine concentrations during early phases of development. J Clin Endocrinol Metab 87:1768-1777
33. Szinnai G, Kosugi S, Derrien C, David V, Czernichow P, Polak M 2006 Extending the clinical heterogeneity of iodide transport defect (ITD): a novel mutation R124H of the sodium/iodide symporter (NIS) gene and review of genotype-phenotype correlations in ITD. J Clin Endocrinol Metab 91:1199-1204