Serum iodothyronines in the human fetus and the newborn: Evidence for an important role of placenta in fetal thyroid hormone homeostasis

Journal of Clinical Endocrinology and Metabolism

Volumn 84, Issue 2, 1999, Pages 493-498

  Santini, Ferruccio ^a   Chiovato, Luca ^a   Ghirri, Paolo ^a   Lapi, Paola ^a   Mammoli, Claudia ^a   Montanelli, Lucia ^a   Scartabelli, Giovanna ^a   Ceccarini, Giovanni ^a   Coccoli, Luca ^a   Chopra, Inder J ^b   Boldrini, Antonio ^a   Pinchera, Aldo ^a  

^a UNIVERSITY OF PISA   (Italy)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,3',5' TRIIODOTHYRONINE; IODOTHYRONINE; LIOTHYRONINE; LIOTHYRONINE SULFATE; THYROXINE DEIODINASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; FETUS; HOMEOSTASIS; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; NEWBORN; PRIORITY JOURNAL; THYROID HORMONE BLOOD LEVEL; THYROID HORMONE METABOLISM;

FEMALE; FETAL BLOOD; GESTATIONAL AGE; HOMEOSTASIS; HUMANS; INFANT, NEWBORN; IODIDE PEROXIDASE; PLACENTA; PREGNANCY; THYROID HORMONES; TRIIODOTHYRONINE; TRIIODOTHYRONINE, REVERSE;

AVES; PASSER DOMESTICUS; PASSERIDAE; PASSERIFORMES;

EID: 0033016976     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.84.2.493     Document Type: Article

References (39)

1. 1. Morreale de Escobar G, Obregon MJ, Escobar del Rey F. 1987 Fetal and maternal thyroid hormones. Horm Res. 26:12-27.
2. 2. Porterfield SP, Hendrich CE. 1993 The role of thyroid hormones in prenatal and neonatal neurological development - current perspectives. Endocr Rev. 14:94-106.
3. 3. Burrow GN, Fisher DA, Larsen PR. 1994 Maternal and fetal thyroid function. N Engl J Med. 331:1072-1078.
4. 4. Polk DH, Fisher DA, Wu SY. Alternate pathways of thyroid hormone metabolism in developing mammals. In: Wu SY, Visser TJ, eds. Thyroid hormone metabolism. Molecular biology and alternate pathways. Boca Raton, FL: CRC Press Inc; 223-243.
5. 4 5'-monodeiodinase vs. tissue sulfhydryl content - a clarification. J Dev Physiol. 8:43-47.
6. 6. Wu SY, Klein AH, Chopra IJ, Fisher DA. 1978 Alterations in tissue thyroxine-5'-monodeiodinating activity in perinatal period. Endocrinology. 103:235-239.
7. 7. Harris ARC, Fang SL, Prosky J, Braverman LE, Vagenakis AG. 1978 Decreased outer ring monodeiodination of thyroxine and reverse triiodothyronine in the fetal and neonatal rat. Endocrinology. 103:2216-2222.
8. 8. Santini F, Chopra IJ. 1992 A radioimmunoassay of rat type I iodothyronine 5'-monodeiodinase. Endocrinology. 131:2521-2526.
9. 3). J Clin Invest. 54:583-592.
10. 10. Santini F, Cortelazzi D, Baggiani AM, Marconi AM, Beck-Peccoz P, Chopra IJ. 1993 A study of the serum 3,5,3'-triiodothyronine sulfate concentration in normal and hypothyroid fetuses at various gestational stages. J Clin Endocrinol Metab. 76:1583-1587.
11. 11. Huang T, Chopra IJ, Boado R, Solomon DH, Chua Teco GN. 1988 Thyroxine inner ring monodeiodinating activity in fetal tissues of the rat. Pediatr Res. 23:196-199.
12. 12. Roti E, Fang SL, Green K, Emerson CH, Braverman LE. 1981 Human placenta is an active site of thyroxine and 3,3'5-triiodothyronine tyrosil ring deiodination. J Clin Endocrinol Metab. 53:498-501.
13. 13. Koopdonk-Kool JM, De Vijlder JJM, Veenboer GJM, et al. 1996 Type II and type III deiodinase activity in human placenta as a function of gestational age. J Clin Endocrinol Metab. 81:2154-2158.
14. 14. Dubowitz LM, Dubowitz V. 1997 Clinical assessment for gestational age in newborn infants. J Pediatr. 77:1-10.
15. 15. Chopra IJ, Wu S-Y, Chua GN, Santini F. 1992 A radioimmunoassay for measurement of 3,5,3'-triiodothyronine sulfate: studies in thyroidal and nonthyroidal diseases, pregnancy and neonatal life. J Clin Endocrinol Metab. 75:189-194.
16. 16. Fisher DA, Dussault JH, Sack J, Chopra IJ. 1977 Ontogenesis of hypothalamic-pituitary-thyroid function and metabolism in man, sheep and rat. Recent Prog Horm Res. 33:59-116.
17. 17. Thorpe-Beeston JC, Nicolaides KH, Felton CV, Butler J, McGregor AM. 1991 Maturation of the secretion of thyroid hormone and thyroid-stimulating hormone in the fetus. N Engl J Med. 324:532-536.
18. 18. Wu SY, Huang WS, Polk DH, et al. 1993 The development of a radioimmunoassay for reverse triiodothyronine sulfate in human serum and amniotic fluid. J Clin Endocrinol Metab. 76:1625-1630.
19. 19. Chopra IJ, Santini F, Hurd RE, Chua Teco GN. 1993 A radioimmunoassay for measurement of thyroxine sulfate. J Clin Endocrinol Metab. 76:145-150.
20. 20. Fuse Y. 1996 Development of the hypothalamic-pituitary-thyroid axis in humans. Reprod Fertil Dev. 8:1-21.
21. 21. Otten MH, Mol JA, Visser TJ. 1983 Sulfation preceding deiodination of iodothyronines in rat hepatocytes. Science. 221:81-83.
22. 3 metabolism in man. J Clin Endocrinol Metab. 78:688-692.
23. 23. Abuid J, Stinson DA, Larsen PR. 1973 Serum triiodothyronine and thyroxine in the neonate and the acute increases in these hormones following delivery. J Clin Invest. 52:1195-1199.
24. 24. Anderson RJ. 1994 Biochemical characterization of triiodothyronine sulfotransferase. In: Wu SY, Visser TJ, eds. Thyroid hormone metabolism. Molecular biology and alternate pathways. Boca Raton, FL: CRC Press Inc; 85-117.
25. 25. Eelkman-Rooda SJ, Rutgers M, Kaptein E, Visser TJ. 1988 Increased plasma triiodothyronine sulfate in rats with inhibited type I iodothyronine deiodinase activity as measured by radioimmunoassay. Endocrinology. 124:740-745.
26. 26. Santini F, Chiovato L, Bartalena L, et al. 1996 Study of serum 3,5,3'-triiodothyronine sulfate concentration in patients with systemic non-thyroidal illness. Eur J Endocrinol. 134:45-49.
27. 27. van Wassenaer AG, Kok JH, Endert E, Vulsma T, de Vijlder JJM. 1993 Thyroxine administration to infants of less than 30 weeks' gestational age does not increase plasma triiodothyronine concentrations. Acta Endocrinol (Copenh). 129:139-146.
28. 28. Chiovato L, Giusti L, Tonacchera M, et al. 1991 Evaluation of L-thyroxine replacement therapy in children with congenital hypothyroidism. J Endocrinol Invest. 14:957-964.
29. 29. Santini F, Hurd RE, Chopra IJ. 1992 A study of metabolism of deaminated and sulfoconjugated iodothyronines by rat placental iodothyronine 5-monodeiodinase. Endocrinology. 131:1689-1694.
30. 30. Santini F, Chopra IJ, Solomon DH, Chua-Teco GN. 1992 Evidence that the human placental 5-monodeiodinase is a phospholipid-requiring enzyme. J Clin Endocrinol Metab. 74:1366-1371.
31. 31. Mortimer RH, Galligan JP, Cannell GR, Addison RS, Roberts MS. 1996 Maternal to fetal thyroxine transmission in the human term placenta is limited by inner ring deiodination. J Clin Endocrinol Metab. 81:2247-2249.
32. 32. Contemprè B, Jauniaux E, Calvo R, Jurkovic D, Campbell S, Morreale de Escobar G. 1993 Detection of thyroid hormones in human embryonic cavities during the first trimester of pregnancy. J Clin Endocrinol Metab. 77:1719-1722.
33. 33. Polk DH, Wu SY, Fisher DA. 1986 Serum thyroid hormones and tissue 5'-monodeiodinase activity in acutely thyroidectomized newborn lambs. Am J Physiol. 251:151-155.
34. 34. Sack J, Beaudry M, DeLamater PV, Oh W, Fisher DA. 1976 Umbilical cord cutting triggers hypertriiodothyroninemia and nonshivering thermogenesis in the newborn lamb. Pediatr Res. 10:169-175.
35. 35. Fisher DA. 1986 Neonatal thyroid disease in the offspring of women with autoimmune thyroid disease. Thyroid Today. 9:1-7.
36. 36. Fisher DA, Odell WD. 1969 Acute release of thyrotropin in the newborn. J Clin Invest. 48:1670.
37. 37. Polk DH, Reviczky A, Wu SY, Huang WS, Fisher DA. 1994 Metabolism of sulfoconjugated thyroid hormone derivatives in developing sheep. Am J Physiol. 266: E892-E895.
38. 38 Richard K, Hume R, Kaptein E, et al. Ontogeny of type I and type III iodothyronine deiodinases in human liver. Proc of the 70th Annual Meeting of The American Thyroid Association, Colorado Springs, CO, 1997, p S-117 (Abstract).
39. 39. Salvatore D, Tu H, Harney JW, Larsen PR. 1996 Type 2 iodothyronine deiodinase is highly expressed in human thyroid. J Clin Invest. 98:692-698.