A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

Cell

Volumn 172, Issue 1-2, 2018, Pages 373-386.e10

  Sachs, Norman ^a,b,f,i   de Ligt, Joep ^c,f   Kopper, Oded ^a,f   Gogola, Ewa ^d   Bounova, Gergana ^d,f   Weeber, Fleur ^d   Balgobind, Anjali Vanita ^a,b   Wind, Karin ^a   Gracanin, Ana ^a   Begthel, Harry ^a   Korving, Jeroen ^a   van Boxtel, Ruben ^c,f   Duarte, Alexandra Alves ^d   Lelieveld, Daphne ^c   van Hoeck, Arne ^c,f   Ernst, Robert Frans ^c,f   Blokzijl, Francis ^c,f   Nijman, Isaac Johannes ^c,f   Hoogstraat, Marlous ^d   van de Ven, Marieke ^d   Egan, David Anthony ^c   Zinzalla, Vittoria ^g   Moll, Jurgen ^g   Boj, Sylvia Fernandez ^b,f   Voest, Emile Eugene ^d   Wessels, Lodewyk ^d,f,h   van Diest, Paul Joannes ^c   Rottenberg, Sven ^d,e   Vries, Robert Gerhardus Jacob ^b,f   Cuppen, Edwin ^c,f   Clevers, Hans ^a,f   more..

^a HUBRECHT INSTITUTE   (Netherlands)

^b Foundation Hubrecht Organoid Technology (HUB)   (Netherlands)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d NETHERLANDS CANCER INSTITUTE   (Netherlands)

^e UNIVERSITY OF BERN   (Switzerland)

^f Oncode Institute Utrecht   (Netherlands)

^g BOEHRINGER INGELHEIM RCV GMBH AND CO KG   (Austria)

^h DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

ⁱ VERTEX PHARMACEUTICALS   (United States)

Author keywords

basal; biobank; breast cancer; luminal; organoids; precision medicine; triple negative

Indexed keywords

AFATINIB; AZD 8055; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EVEROLIMUS; GEFITINIB; HORMONE RECEPTOR; IPATASERTIB; NIRAPARIB; OLAPARIB; PICTILISIB; ANTINEOPLASTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOBANK; BREAST CANCER; BREAST EPITHELIUM; CANCER CLASSIFICATION; CANCER PATIENT; CANCER RESEARCH; CLINICAL PROTOCOL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SEQUENCE; DRUG RESPONSE; DRUG SCREENING; GENE DOSAGE; GENETIC VARIATION; HIGH THROUGHPUT SCREENING; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; METASTASIS POTENTIAL; MORPHOLOGY; MOUSE; NONHUMAN; ORGAN CULTURE; ORGANOID; PATIENT ATTITUDE; PERSONALIZED MEDICINE; PRIMARY TUMOR; PRIORITY JOURNAL; XENOTRANSPLANTATION; ANIMAL; BREAST TUMOR; CELL CULTURE; DRUG EFFECT; FEMALE; GENETIC HETEROGENEITY; GENETICS; NUDE MOUSE; PATHOLOGY; PROCEDURES; TISSUE BANK;

ANIMALS; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELLS, CULTURED; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; GENETIC HETEROGENEITY; HUMANS; MICE; MICE, NUDE; ORGANOIDS; PRECISION MEDICINE; TISSUE BANKS;

EID: 85041124826     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2017.11.010     Document Type: Article

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