Dynamic expression of Erbb pathway members during early mammary gland morphogenesis

Journal of Investigative Dermatology

Volumn 128, Issue 4, 2008, Pages 1009-1021

  Wansbury, Olivia ^a   Panchal, Heena ^a   James, Michelle ^a   Parry, Suzanne ^a   Ashworth, Alan ^a   Howard, Beatrice ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 3; EPIDERMAL GROWTH FACTOR RECEPTOR 4; NEU DIFFERENTIATION FACTOR; NEUREGULIN 2; NEUREGULIN 3; NEUREGULIN 4; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; EMBRYO; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MAMMARY GLAND; MORPHOGENESIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

EID: 40649118293     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/sj.jid.5701118     Document Type: Article

References (76)

1. E.R. Andrechek D. White W.J. Muller Targeted disruption of ErbB2/Neu in the mammary epithelium results in impaired ductal outgrowth Oncogene 24 2005 932 937
2. I. Arnold F.M. Watt c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny Curr Biol 11 2001 558 568
3. B.I. Balinsky On the prenatal growth of the mammary gland rudiment in the mouse J Anat 84 1950 227 235
4. J. Baselga D. Tripathy J. Mendelsohn S. Baughman C.C. Benz L. Dantis Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer J Clin Oncol 14 1996 737 744
5. M.S. Berger G.W. Locher S. Saurer W.J. Gullick M.D. Waterfield B. Groner Correlation of c-erbB-2 gene amplification and protein expression in human breast carcinoma with nodal status and nuclear grading Cancer Res 48 1988 1238 1243
6. C. Blanpain E. Fuchs Epidermal stem cells of the skin Annu Rev Cell Dev Biol 22 2006 339 373
7. K. Boras-Granic H. Chang R. Grosschedl P.A. Hamel Lef1 is required for the transition of Wnt signaling from mesenchymal to epithelial cells in the mouse embryonic mammary gland Dev Biol 295 2006 219 231
8. E.M. Bublil Y. Yarden The EGF receptor family: spearheading a merger of signaling and therapeutics Curr Opin Cell Biol 19 2007 124 134
9. A. Citri Y. Yarden EGF-ERBB signalling: towards the systems level Nat Rev Mol Cell Biol 7 2006 505 516
10. M.A. Cobleigh C.L. Vogel D. Tripathy N.J. Robert S. Scholl L. Fehrenbacher Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease J Clin Oncol 17 1999 2639 2648
11. G.R. Cunha Y.K. Hom Role of mesenchymal-epithelial interactions in mammary gland development J Mammary Gland Biol Neoplasia 1 1996 21 35
12. G.R. Cunha P. Young K. Christov R. Guzman S. Nandi F. Talamantes Mammary phenotypic expression induced in epidermal cells by embryonic mammary mesenchyme Acta Anat (Basel) 152 1995 195 204
13. K.M. Darcy D. Zangani A.L. Wohlhueter R.Y. Huang M.M. Vaughan J.A. Russell Changes in ErbB2 (her-2/neu), ErbB3, and ErbB4 during growth, differentiation, and apoptosis of normal rat mammary epithelial cells J Histochem Cytochem 48 2000 63 80
14. E. de Alava A. Ocana M. Abad J.C. Montero A. Esparis-Ogando C.A. Rodriguez Neuregulin expression modulates clinical response to trastuzumab in patients with metastatic breast cancer J Clin Oncol 25 2007 2656 2663
15. K. Elenius C.J. Choi S. Paul E. Santiestevan E. Nishi M. Klagsbrun Characterization of a naturally occurring ErbB4 isoform that does not bind or activate phosphatidyl inositol 3-kinase Oncogene 18 1999 2607 2615
16. R. Falcioni A. Antonini P. Nistico S. Di Stefano M. Crescenzi P.G. Natali Alpha 6 beta 4 and alpha 6 beta 1 integrins associate with ErbB-2 in human carcinoma cell lines Exp Cell Res 236 1997 76 85
17. D.L. Falls Neuregulins: functions, forms, and signaling strategies Exp Cell Res 284 2003 14 30
18. V. Folgiero R.E. Bachelder G. Bon A. Sacchi R. Falcioni A.M. Mercurio The alpha6beta4 integrin can regulate ErbB-3 expression: implications for alpha6beta4 signaling and function Cancer Res 67 2007 1645 1652
19. M. Frye C. Gardner E.R. Li I. Arnold F.M. Watt Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment Development 130 2003 2793 2808
20. L. Gagnoux-Palacios M. Dans W. van't Hof A. Mariotti A. Pepe G. Meneguzzi Compartmentalization of integrin alpha6beta4 signaling in lipid rafts J Cell Biol 162 2003 1189 1196
21. D. Gambaletta A. Marchetti L. Benedetti A.M. Mercurio A. Sacchi R. Falcioni Cooperative signaling between alpha(6)beta(4) integrin and ErbB-2 receptor is required to promote phosphatidylinositol 3-kinase-dependent invasion J Biol Chem 275 2000 10604 10610
22. J.P. Golding S. Tsoni M. Dixon K.T. Yee T.A. Partridge J.R. Beauchamp Heparin-binding EGF-like growth factor shows transient left-right asymmetrical expression in mouse myotome pairs Gene Expr Patterns 5 2004 3 9
23. W. Guo Y. Pylayeva A. Pepe T. Yoshioka W.J. Muller G. Inghirami Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis Cell 126 2006 489 502
24. M. Harries I. Smith The development and clinical use of trastuzumab (Herceptin) Endocr Relat Cancer 9 2002 75 85
25. N.V. Hayes E. Blackburn L.V. Smart M.M. Boyle G.A. Russell T.M. Frost Identification and characterization of novel spliced variants of Neuregulin 4 in prostate cancer Clin Cancer Res 13 2007 3147 3155
26. S.S. Hobbs S.L. Coffing A.T. Le E.M. Cameron E.E. Williams M. Andrew Neuregulin isoforms exhibit distinct patterns of ErbB family receptor activation Oncogene 21 2002 8442 8452
27. T. Holbro G. Civenni N.E. Hynes The ErbB receptors and their role in cancer progression Exp Cell Res 284 2003 99 110
28. B. Howard H. Panchal A. McCarthy A. Ashworth Identification of the scaramanga gene implicates Neuregulin3 in mammary gland specification Genes Dev 19 2005 2078 2090
29. J.N. Hutchinson W.J. Muller Transgenic mouse models of human breast cancer Oncogene 19 2000 6130 6137
30. R.O. Hynes Integrins: bidirectional, allosteric signaling machines Cell 110 2002 673 687
31. A.J. Jackson-Fisher G. Bellinger R. Ramabhadran J.K. Morris K.F. Lee D.F. Stern ErbB2 is required for ductal morphogenesis of the mammary gland Proc Natl Acad Sci USA 101 2004 17138 17143
32. C. Jamora R. DasGupta P. Kocieniewski E. Fuchs Links between signal transduction, transcription and adhesion in epithelial bud development Nature 422 2003 317 322
33. T. Lechler E. Fuchs Asymmetric cell divisions promote stratification and differentiation of mammalian skin Nature 437 2005 275 280
34. L. Li S. Cleary M.A. Mandarano W. Long C. Birchmeier F.E. Jones The breast proto-oncogene, HRGalpha regulates epithelial proliferation and lobuloalveolar development in the mouse mammary gland Oncogene 21 2002 4900 4907
35. W. Long K.U. Wagner K.C. Lloyd N. Binart J.M. Shillingford L. Hennighausen Impaired differentiation and lactational failure of Erbb4-deficient mammary glands identify ERBB4 as an obligate mediator of STAT5 Development 130 2003 5257 5268
36. N.C. Luetteke T.H. Qiu S.E. Fenton K.L. Troyer R.F. Riedel A. Chang Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development Development 126 1999 2739 2750
37. A.M. Mercurio I. Rabinovitz L.M. Shaw The alpha 6 beta 4 integrin and epithelial cell migration Curr Opin Cell Biol 13 2001 541 545
38. K. Michno K. Boras-Granic P. Mill C.C. Hui P.A. Hamel Shh expression is required for embryonic hair follicle but not mammary gland development Dev Biol 264 2003 153 165
39. M.L. Mikkola S.E. Millar The mammary bud as a skin appendage: unique and shared aspects of development J Mammary Gland Biol Neoplasia 11 2006 187 203
40. C.K. Miranti J.S. Brugge Sensing the environment: a historical perspective on integrin signal transduction Nat Cell Biol 4 2002 E83 E90
41. D. Nanba Y. Nakanishi Y. Hieda Changes in adhesive properties of epithelial cells during early morphogenesis of the mammary gland Dev Growth Differ 43 2001 535 544
42. I. Olivera-Martinez J. Thelu D. Dhouailly Molecular mechanisms controlling dorsal dermis generation from the somitic dermomyotome Int J Dev Biol 48 2004 93 101
43. H. Panchal, O. Sopp, S. Parry, A. Ashworth, B. Howard Neuregulin3 alters cell fato in the epidermis and mammary gland. BMC Dev Biol (in press)
44. A. Propper L. Gomot Tissue interactions during organogenesis of the mammary gland in the rabbit embryo C R Acad Sci Hebd Seances Acad Sci D 264 1967 2573 2575
45. A.Y. Propper Wandering epithelial cells in the rabbit embryo milk line. A preliminary scanning electron microscope study Dev Biol 67 1978 225 231
46. I. Rabinovitz A. Toker A.M. Mercurio Protein kinase C-dependent mobilization of the alpha6beta4 integrin from hemidesmosomes and its association with actin-rich cell protrusions drive the chemotactic migration of carcinoma cells J Cell Biol 146 1999 1147 1160
47. D.J. Riese II D.F. Stern Specificity within the EGF family/ErbB receptor family signaling network Bioessays 20 1998 41 48
48. C. Rio J.D. Buxbaum J.J. Peschon G. Corfas Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4/HER4 J Biol Chem 275 2000 10379 10387
49. T. Sakakura Mammary embryogenesis MCNaCW. Daniel The Mammary Gland Development, Regulation, and Function 1987 Plenum Press New York
50. V.R. Schelfhout E.D. Coene B. Delaey S. Thys D.L. Page C.R. De Potter Pathogenesis of Paget's disease: epidermal heregulin-alpha, motility factor, and the HER receptor family J Natl Cancer Inst 92 2000 622 628
51. V.R. Schelfhout E.D. Coene B. Delaey A.A. Waeytens L. De Rycke M. Deleu The role of heregulin-alpha as a motility factor and amphiregulin as a growth factor in wound healing J Pathol 198 2002 523 533
52. J.A. Schroeder D.C. Lee Dynamic expression and activation of ERBB receptors in the developing mouse mammary gland Cell Growth Differ 9 1998 451 464
53. M. Shackleton F. Vaillant K.J. Simpson J. Stingl G.K. Smyth M.L. Asselin-Labat Generation of a functional mammary gland from a single stem cell Nature 439 2006 84 88
54. P.M. Siegel E.D. Ryan R.D. Cardiff W.J. Muller Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer EMBO J 18 1999 2149 2164
55. D.J. Slamon W. Godolphin L.A. Jones J.A. Holt S.G. Wong D.E. Keith Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer Science 244 1989 707 712
56. I.H. Smart Variation in the plane of cell cleavage during the process of stratification in the mouse epidermis Br J Dermatol 82 1970 276 282
57. I.E. Smith Efficacy and safety of Herceptin in women with metastatic breast cancer: results from pivotal clinical studies Anticancer Drugs 12 Suppl 4 2001 S3 S10
58. A. Sonnenberg J. Calafat H. Janssen H. Daams L.M. van der Raaij-Helmer R. Falcioni Integrin alpha 6/beta 4 complex is located in hemidesmosomes, suggesting a major role in epidermal cell-basement membrane adhesion J Cell Biol 113 1991 907 917
59. D.F. Stern ErbBs in mammary development Exp Cell Res 284 2003 89 98
60. M.D. Sternlicht S.W. Sunnarborg H. Kouros-Mehr Y. Yu D.C. Lee Z. Werb Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin Development 132 2005 3923 3933
61. E. Tagliabue C. Ghirelli P. Squicciarini P. Aiello M.I. Colnaghi S. Menard Prognostic value of alpha 6 beta 4 integrin expression in breast carcinomas is affected by laminin production from tumor cells Clin Cancer Res 4 1998 407 410
62. H. Tidcombe A. Jackson-Fisher K. Mathers D.F. Stern M. Gassmann J.P. Golding Neural and mammary gland defects in ErbB4 knockout mice genetically rescued from embryonic lethality Proc Natl Acad Sci USA 100 2003 8281 8286
63. K.L. Troyer D.C. Lee Regulation of mouse mammary gland development and tumorigenesis by the ERBB signaling network J Mammary Gland Biol Neoplasia 6 2001 7 21
64. J.M. Veltmaat F. Relaix L.T. Le K. Kratochwil F.G. Sala W. van Veelen Gli3-mediated somitic Fgf10 expression gradients are required for the induction and patterning of mammary epithelium along the embryonic axes Development 133 2006 2325 2335
65. C.L. Vogel M.A. Cobleigh D. Tripathy J.C. Gutheil L.N. Harris L. Fehrenbacher Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer J Clin Oncol 20 2002 719 726
66. R.L. Waikel Y. Kawachi P.A. Waikel X.J. Wang D.R. Roop Deregulated expression of c-Myc depletes epidermal stem cells Nat Genet 28 2001 165 168
67. F.M. Watt Role of integrins in regulating epidermal adhesion, growth and differentiation EMBO J 21 2002 3919 3926
68. F.M. Watt C. Lo Celso V. Silva-Vargas Epidermal stem cells: an update Curr Opin Genet Dev 16 2006 518 524
69. J.F. Wiesen P. Young Z. Werb G.R. Cunha Signaling through the stromal epidermal growth factor receptor is necessary for mammary ductal development Development 126 1999 335 344
70. K. Wilhelmsen S.H. Litjens A. Sonnenberg Multiple functions of the integrin alpha6beta4 in epidermal homeostasis and tumorigenesis Mol Cell Biol 26 2006 2877 2886
71. D.G. Wilkinson M.A. Nieto Detection of messenger RNA by in situ hybridization to tissue sections and whole mounts Methods Enzymol 225 1993 361 373
72. Y. Yang E. Spitzer D. Meyer M. Sachs C. Niemann G. Hartmann Sequential requirement of hepatocyte growth factor and Neuregulin in the morphogenesis and differentiation of the mammary gland J Cell Biol 131 1995 215 226
73. Y. Yarden M.X. Sliwkowski Untangling the ErbB signalling network Nat Rev Mol Cell Biol 2 2001 127 137
74. S.O. Yoon S. Shin E.A. Lipscomb A novel mechanism for integrin-mediated ras activation in breast carcinoma cells: the alpha6beta4 integrin regulates ErbB2 translation and transactivates epidermal growth factor receptor/ErbB2 signaling Cancer Res 66 2006 2732 2739
75. S.O. Yoon S. Shin A.M. Mercurio Ras stimulation of E2F activity and a consequent E2F regulation of integrin alpha6beta4 promote the invasion of breast carcinoma cells Cancer Res 66 2006 6288 6295
76. C.A. Zahnow ErbB receptors and their ligands in the breast Expert Rev Mol Med 8 2006 1 21