α-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling

Nature

Volumn 553, Issue 7689, 2018, Pages 461-466

  Chen, Gaozhi ^a,b   Liu, Yang ^b   Goetz, Regina ^b   Fu, Lili ^a,b   Jayaraman, Seetharaman ^c   Hu, Ming Chang ^d   Moe, Orson W ^d   Liang, Guang ^a   Li, Xiaokun ^a   Mohammadi, Moosa ^b  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NEW YORK STRUCTURAL BIOLOGY CENTER   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA KLOTHO PROTEIN; FIBROBLAST GROWTH FACTOR 23; FIBROBLAST GROWTH FACTOR RECEPTOR 1; GLYCOSIDASE; HEPARAN SULFATE; KLOTHO PROTEIN; MOLECULAR SCAFFOLD; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG; BETA GLUCURONIDASE; FGFR1 PROTEIN, HUMAN; FIBROBLAST GROWTH FACTOR; LIGAND; MULTIPROTEIN COMPLEX; PROTEIN BINDING;

COMPLEXITY; ENZYME; ENZYME ACTIVITY; HOMEOSTASIS; HORMONE; ION; PROTEIN; VITAMIN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIMERIZATION; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; ANIMAL; BINDING SITE; BODY FLUID; CHEMISTRY; FEMALE; GENETICS; HUMAN; MALE; METABOLISM; MOLECULAR MODEL; MOUSE; MUTATION; PROTEIN MULTIMERIZATION; SOLUBILITY;

ANIMALS; BINDING SITES; BODY FLUIDS; FEMALE; FIBROBLAST GROWTH FACTORS; GLUCURONIDASE; HEPARITIN SULFATE; HUMANS; LIGANDS; MALE; MICE; MODELS, MOLECULAR; MULTIPROTEIN COMPLEXES; MUTATION; PARACRINE COMMUNICATION; PROTEIN BINDING; PROTEIN DOMAINS; PROTEIN MULTIMERIZATION; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; SIGNAL TRANSDUCTION; SOLUBILITY;

EID: 85041051833     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature25451     Document Type: Article

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