Evidence that heparin saccharides promote FGF2 mitogenesis through two distinct mechanisms

Journal of Biological Chemistry

Volumn 283, Issue 19, 2008, Pages 13001-13008

  Goodger, Sarah J ^a   Robinson, Christopher J ^a   Murphy, Kevin J ^b   Gasiunas, Nijole ^a   Harmer, Nicholas J ^c,d   Blundell, Tom L ^c   Pye, David A ^b   Gallagher, John T ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF HUDDERSFIELD   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d UNIVERSITY OF EXETER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOACTIVITY; BIOCATALYSTS; CELL CULTURE; CELL MEMBRANES; GROWTH (MATERIALS); GROWTH KINETICS; PEPTIDES; POLYSACCHARIDES; SUGARS;

ASYMMETRIC MODELS; CELL SURFACES; FIBROBLAST GROWTH FACTORS; GROWTH FACTORS; HEPARAN SULFATES; HEXASACCHARIDES; MITOGENESIS; MITOGENIC; MITOGENIC ACTIVITIES; OCTASACCHARIDE; REDUCING ENDS; SULFATE GROUPS; TERNARY COMPLEX FORMATIONS; TERNARY COMPLEXES; TRANSMEMBRANE SIGNALING; VERY LOW CONCENTRATIONS;

CELL GROWTH;

CELL SURFACE RECEPTOR; DISACCHARIDE; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR 1; HEPARIN; HEPARIN LIKE SACCHARIDE; OLIGOSACCHARIDE; PROTEOHEPARAN SULFATE; UNCLASSIFIED DRUG; SULFATE;

ANIMAL CELL; ARTICLE; CARBOHYDRATE ANALYSIS; CHEMICAL ANALYSIS; COMPLEX FORMATION; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MITOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; CELL LINE; CHEMISTRY; DRUG EFFECT; ISOLATION AND PURIFICATION; METABOLISM; MITOSIS;

TETRA;

ANIMALS; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FIBROBLAST GROWTH FACTOR 2; HEPARIN; MICE; MITOSIS; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; SULFATES;

EID: 45149083078     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M704531200     Document Type: Article

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