Cyclin-dependent kinase 5 modulates the P2X2a receptor channel gating through phosphorylation of C-terminal threonine 372

Pain

Volumn 158, Issue 11, 2017, Pages 2155-2168

  Coddou, Claudio ^a,b   Sandoval, Rodrigo ^c   Castro, Patricio ^a   Lazcano, Pablo ^c   Hevia, Maria José ^a   Rokic, Milos ^b   Hall, Bradford ^d   Terse, Anita ^d   Gonzalez Billault, Christian ^c,e,f   Kulkarni, Ashok B ^d   Stojilkovic, Stanko S ^b   Utreras, Elias ^c  

^a UNIVERSIDAD CATÓLICA DEL NORTE   (Chile)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c UNIVERSITY OF CHILE   (Chile)

^d NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^e Universidad de Chile and Geroscience Center for Brain Health and Metabolism   (Chile)

^f BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

Author keywords

Cdk5 activity; P2X2R; P2XR; Patch clamp current; Phosphorylation; Trigeminal ganglia

Indexed keywords

CALCIUM ION; CYCLIN DEPENDENT KINASE 5; PEPTIDE; PROTEIN P35; PURINERGIC P2X2 RECEPTOR; ROSCOVITINE; THREONINE; ADENOSINE TRIPHOSPHATE; ALPHA,BETA-METHYLENEADENOSINE 5'-TRIPHOSPHATE; CALCIUM; PROTEIN KINASE INHIBITOR; PURINE DERIVATIVE; PURINERGIC P2X3 RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHANNEL GATING; COMPARATIVE STUDY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DESENSITIZATION; ELECTROPHYSIOLOGICAL PROCEDURES; HEK293 CELL LINE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; IN VITRO STUDY; MOUSE; NERVE CELL; NONHUMAN; OOCYTE; PAIN; PC12 CELL LINE; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; RAT; SPINAL GANGLION; TRIGEMINUS GANGLION; WHOLE CELL PATCH CLAMP; XENOPUS; ANALOGS AND DERIVATIVES; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MUTATION; PHYSIOLOGY; SENSORY NERVE CELL;

ADENOSINE TRIPHOSPHATE; ANIMALS; CALCIUM; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE 5; GANGLIA, SPINAL; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; ION CHANNEL GATING; MICE; MUTATION; OOCYTES; PROTEIN KINASE INHIBITORS; PURINES; RATS; RECEPTORS, PURINERGIC P2X2; RECEPTORS, PURINERGIC P2X3; SENSORY RECEPTOR CELLS; THREONINE; XENOPUS;

EID: 85040792787     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1097/j.pain.0000000000001021     Document Type: Article

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