Cdk5 contributes to inflammation-induced thermal hyperalgesia mediated by the p38 MAPK pathway in microglia

Brain Research

Volumn 1619, Issue , 2015, Pages 166-175

  Fang Hu, ^a   Zhang, Hong Hai ^a   Yang, Bin Xia ^b   Huang, Jin Lu ^c   Shun, Jian Liang ^a   Kong, Fei Juan ^a   Peng Xu, ^a   Chen, Zhi Guo ^d   Lu, Jin Miao ^e  

^a NANJING MEDICAL UNIVERSITY   (China)

^b MAYO CLINIC   (United States)

^c SHANGHAI JIAO TONG UNIVERSITY AFFILIATED SIXTH PEOPLE S HOSPITAL   (China)

^d Children's Hospital of Hebei Province   (China)

^e CHILDREN S HOSPITAL OF FUDAN UNIVERSITY   (China)

Author keywords

Cdk5; Hyperalgesia; Inflammatory pain; OX 42; P38; Roscovitine; TNF a

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; GLIAL FIBRILLARY ACIDIC PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; ROSCOVITINE; TUMOR NECROSIS FACTOR ALPHA; CDK5 PROTEIN, RAT; CYCLIN DEPENDENT KINASE 5; FREUND ADJUVANT; IMIDAZOLE DERIVATIVE; PURINE DERIVATIVE; PYRIDINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HYPERALGESIA; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; MICROGLIA; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; SPINAL CORD; SPINAL CORD DORSAL HORN; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICALLY INDUCED; DRUG EFFECTS; METABOLISM; MYELITIS; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; CYCLIN-DEPENDENT KINASE 5; FREUND'S ADJUVANT; HYPERALGESIA; IMIDAZOLES; MALE; MAP KINASE SIGNALING SYSTEM; MICROGLIA; MYELITIS; NEURONS; PURINES; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD DORSAL HORN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84961177137     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2015.01.056     Document Type: Article

References (29)

1. D.L. Boyle, T.L. Jones, D. Hammaker, C.I. Svensson, S. Rosengren, S. Albani, L. Sorkin, and G.S. Firestein Regulation of peripheral inflammation by spinal p38 MAP kinase in rats PLoS Med. 3 2006 e338
2. K.H. Chang, Y. De Pablo, H.p. Lee, H.g. Lee, M.A. Smith, and K. Shah Cdk5 is a major regulator of p38 cascade: relevance to neurotoxicity in Alzheimer's disease J. Neurochem. 113 2010 1221 1229
3. E. Charlton Ethical guidelines for pain research in humans. Committee on ethical issues of the international association for the study of pain Pain 63 1995 277 278
4. J.A. DeLeo, and R.P. Yezierski The role of neuroinflammation and neuroimmune activation in persistent pain Pain 90 2001 1 6
5. K.-Y. Fu, A.R. Light, G.K. Matsushima, and W. Maixner Microglial reactions after subcutaneous formalin injection into the rat hind paw Brain Res. 825 1999 59 67
6. C. Garrison, P. Dougherty, K. Kajander, and S. Carlton Staining of glial fibrillary acidic protein (GFAP) in lumbar spinal cord increases following a sciatic nerve constriction injury Brain Res. 565 1991 1 7
7. H. Han, K.-S. Lee, W. Rong, and G. Zhang Different roles of peripheral mitogen-activated protein kinases in carrageenan-induced arthritic pain and arthritis in rats Anesth. Analg. 115 2012 1221 1227
8. U.K. Hanisch Microglia as a source and target of cytokines Glia 40 2002 140 155
9. K. Hargreaves, R. Dubner, F. Brown, C. Flores, and J. Joris A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia Pain 32 1988 77 88
10. Y. He, H.L. Li, W.Y. Xie, C.Z. Yang, A.C.H. Yu, and Y. Wang The presence of active Cdk5 associated with p35 in astrocytes and its important role in process elongation of scratched astrocyte Glia 55 2007 573 583
11. R.-R. Ji, K. Befort, G.J. Brenner, and C.J. Woolf ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity J. Neurosci. 22 2002 478 485
12. R. Kalla, Z. Liu, and S. Xu Microglia and the early phase of immune surveillance in the axotomized facial motor nucleus: impaired microglial activation and lymphocyte recruitment but no effect on neuronal survival or axonal regeneration in macrophage-colony stimulating factor-deficient mice J. Comp. Neurol. 436 2001 182 201
13. S. Lee, Y.Q. Zhao, A. Ribeiro-da-Silva, and J. Zhang Distinctive response of CNS glial cells in cro-facial pain associated with injury, infection and inflammation Mol Pain 2010
14. S.B. McMahon, W.B. Cafferty, and F. Marchand Immune and glial cell factors as pain mediators and modulators Exp. Neurol. 192 2005 444 462
15. L. Meijer, A. Borgne, O. Mulner, J.P. Chong, J.J. Blow, N. Inagaki, M. Inagaki, J.G. Delcros, and J.P. Moulinoux Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5 Eur. J. Biochem. 243 1997 527 536
16. E.D. Milligan, and L.R. Watkins Pathological and protective roles of glia in chronic Nat. Rev. Neurosci 2009
17. T.K. Pareek, J. Keller, S. Kesavapany, N. Agarwal, R. Kuner, H.C. Pant, M.J. Iadarola, R.O. Brady, and A.B. Kulkarni Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1 Proc. Natl. Acad. Sci. 104 2007 660 665
18. T.K. Pareek, J. Keller, S. Kesavapany, H.C. Pant, M.J. Iadarola, R.O. Brady, and A.B. Kulkarni Cyclin-dependent kinase 5 activity regulates pain signaling Proc. Natl. Acad. Sci. 103 2006 791 796
19. J. Scholz, and C.J. Woolf The neuropathic pain triad: neurons, immune cells and glia Nat. Neurosci. 10 2007 1361 1368
20. C.I. Svensson, M. Marsala, and A. Westerlund Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing J. Neurochem. 86 2003 1534 1544
21. E. Utreras, A. Terse, J. Keller, M.J. Iadarola, and A.B. Kulkarni Resveratrol inhibits Cdk5 activity through regulation of p35 expression Mol. Pain 7 2011 49
22. B.-M. Xing, Y.-R. Yang, J.-X. Du, H.-J. Chen, C. Qi, Z.-H. Huang, Y. Zhang, and Y. Wang Cyclin-dependent kinase 5 controls TRPV1 Membrane Trafficking and the Thermal Sensitivity of Nociceptors through KIF13B J. Neurosci. 32 2012 14709 14721
23. T.L. Yaksh, and T.A. Rudy Chronic catheterization of the spinal subarachnoid space Physiol. Behav. 17 1976 1031 1036
24. Y.-R. Yang, Y. He, Y. Zhang, Y. Li, Y. Li, Y. Han, H. Zhu, and Y. Wang Activation of cyclin-dependent kinase 5 (Cdk5) in primary sensory and dorsal horn neurons by peripheral inflammation contributes to thermal hyperalgesia Pain 127 2007 109 120
25. H.-H. Zhang, X.-Q. Zhang, W.-Y. Wang, Q.-S. Xue, H. Lu, J.-L. Huang, T. Gui, and B.-W. Yu Increased synaptophysin is involved in inflammation-induced thermal hyperalgesia mediated by cyclin-dependent kinase 5 in rats PloS one 7 2012 e46666
26. R. Zhang, Y. Liu, J. Zhang, Y. Zheng, X. Gu, and Z. Ma Intrathecal administration of roscovitine attenuates cancer pain and inhibits the expression of NMDA receptor 2B subunit mRNA Pharmacol. Biochem. Behav. 102 2012 139 145
27. M. Zheng, C.L. Leung, and R.K. Liem Region-specific expression of cyclin-dependent kinase 5 (cdk5) and its activators, p35 and p39, in the developing and adult rat central nervous system J. Neurobiol. 35 1998 141 159
28. Z.-Y. Zhuang, Y. Kawasaki, P.-H. Tan, Y.-R. Wen, J. Huang, and R.-R. Ji Role of the CX3CR1/p38 MAPK pathway in spinal microglia for the development of neuropathic pain following nerve injury-induced cleavage of fractalkine Brain BehavImmun. 21 2007 642 651
29. C.-H. Wang, T.-H. Lee, Y.-J. Tsai, J.-K. Liu, Y.-J. Chen, L.-C. Yang, and C.-Y. Lu Intrathecal cdk5 inhibitor, roscovitine, attenuates morphine antinociceptive tolerance in rats Acta Pharmacol. Sin. 25 8 2004 1027 1030