Extracellular histidine residues identify common structural determinants in the copper/zinc P2X2 receptor modulation

Journal of Neurochemistry

Volumn 95, Issue 2, 2005, Pages 499-512

  Lorca, Ramón A ^a   Coddou, Claudio ^a   Gazitúa, M Consuelo ^a   Bull, Paulina ^a   Arredondo, Cristián ^a   Huidobro Toro, J Pablo ^a  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

Author keywords

Allosteric metal modulation; Extracellular histidines; P2X2 metal coordination complexes; P2X2 receptor; Site directed mutagenesis; Trace metal modulation

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALANINE; CADMIUM; COBALT; COMPLEMENTARY DNA; COORDINATION COMPOUND; COPPER; EXTRACELLULAR HISTIDINE; HISTIDINE; MERCURY; METAL COMPLEX; NICKEL; PALLADIUM; PLATINUM; PURINE P2X2 RECEPTOR; TRANSITION ELEMENT; UNCLASSIFIED DRUG; ZINC;

ALLOSTERISM; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING SITE; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; MEMBRANE CURRENT; METAL BINDING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR AFFINITY; RECEPTOR SENSITIVITY; VOLTAGE CLAMP; XENOPUS LAEVIS;

ADENOSINE TRIPHOSPHATE; ANIMALS; COPPER; DRUG SYNERGISM; ELECTROPHYSIOLOGY; EXTRACELLULAR SPACE; HISTIDINE; HYDROGEN-ION CONCENTRATION; MEMBRANE POTENTIALS; MUTAGENESIS, SITE-DIRECTED; OOCYTES; PATCH-CLAMP TECHNIQUES; RATS; RECEPTORS, PURINERGIC P2; RNA; TRACE ELEMENTS; XENOPUS LAEVIS; ZINC;

XENOPUS LAEVIS;

EID: 26844532207     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2005.03387.x     Document Type: Article

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