Graded regulation of the Kv2.1 potassium channel by variable phosphorylation

Science

Volumn 313, Issue 5789, 2006, Pages 976-979

  Park, Kang Sik ^a   Mohapatra, Durga P ^a   Misonou, Hiroaki ^a   Trimmer, James S ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ELECTRIC POTENTIAL; ISOTOPES; MASS SPECTROMETRY; POLARIZATION; POTASSIUM;

CALCINEURIN; NEURONAL FIRING PROPERTIES; NEURONAL PLASTICITY; VARIABLE PHOSPHORYLATION;

NEUROLOGY;

ALANINE; AMINO ACID; ASPARTIC ACID; CALCINEURIN; POTASSIUM CHANNEL; POTASSIUM CHANNEL KV2.1; UNCLASSIFIED DRUG;

BIOCHEMISTRY; ENZYME ACTIVITY; MAMMAL; MASS SPECTROMETRY; MUTATION; POTASSIUM; RESPIRATION;

ANIMAL CELL; ARTICLE; CELL CULTURE; CHANNEL GATING; CONTROLLED STUDY; DEPHOSPHORYLATION; HUMAN; HUMAN CELL; HYPERPOLARIZATION; ISOTOPE LABELING; MASS SPECTROMETRY; MUTATION; NERVE CELL EXCITABILITY; NERVE CELL PLASTICITY; NERVE CONDUCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; REGULATORY MECHANISM;

ALANINE; ALKALINE PHOSPHATASE; ANIMALS; ASPARTIC ACID; BRAIN; CALCINEURIN; CALCIUM; CELL LINE; CHROMATOGRAPHY, LIQUID; HUMANS; ION CHANNEL GATING; IONOMYCIN; MASS SPECTROMETRY; MUTATION; NEURONS; PATCH-CLAMP TECHNIQUES; PHOSPHORYLATION; PHOSPHOSERINE; PHOSPHOTHREONINE; POINT MUTATION; RATS; RECOMBINANT PROTEINS; SERINE; SHAB POTASSIUM CHANNELS; TRANSFECTION;

MAMMALIA;

EID: 33747592823     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1124254     Document Type: Article

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19. We thank R. W. Aldrich, J. Engebrecht, W. Li, C. Miller, J. Sack, and M. E. Wright for helpful suggestions and/or critical readings of the manuscript; Y. M. Lee, Y. J. Lee, and M. R. Salemi for initial technical advice in mass spectrometric studies; and L. Guy and D. Siino for technical assistance. Mass spectrometry was performed at the UC Davis Proteomics Facility. This work was supported by NIH grant NS42225 to J.S.T. K.-S.P. was supported in part by the postdoctoral fellowship program of Korea Science and Engineering Foundation, and H.W. by the American Heart Association. D.P.M. acknowledges postdoctoral fellowship support from the Epilepsy Foundation through the support of the American Epilepsy Society and the Milken Family Foundation.