메뉴 건너뛰기




Volumn 236, Issue 1, 2018, Pages R43-R56

Trophoblast lineage specification, differentiation and their regulation by oxygen tension

Author keywords

Cytotrophoblast; Extravillous trophoblast; Hypoxia; Hypoxia inducible factor; Placenta; Syncytiotrophoblast

Indexed keywords

HYPOXIA INDUCIBLE FACTOR; MAMMALIAN TARGET OF RAPAMYCIN; OXYGEN;

EID: 85039990612     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1530/JOE-17-0402     Document Type: Review
Times cited : (120)

References (95)
  • 1
    • 0034671706 scopus 로고    scopus 로고
    • Placental cell fates are regulated in vivo by HIF-mediated hypoxia responses
    • Adelman DM, Gertsenstein M, Nagy A, Simon MC & Maltepe E 2000 Placental cell fates are regulated in vivo by HIF-mediated hypoxia responses. Genes and Development 14 3191-3203. (https://doi.org/10.1101/gad.853700)
    • (2000) Genes and Development , vol.14 , pp. 3191-3203
    • Adelman, D.M.1    Gertsenstein, M.2    Nagy, A.3    Simon, M.C.4    Maltepe, E.5
  • 3
    • 0042031047 scopus 로고    scopus 로고
    • A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets
    • Arsham AM, Howell JJ & Simon MC 2003 A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets. Journal of Biological Chemistry 278 29655-29660. (https://doi.org/10.1074/jbc.M212770200)
    • (2003) Journal of Biological Chemistry , vol.278 , pp. 29655-29660
    • Arsham, A.M.1    Howell, J.J.2    Simon, M.C.3
  • 4
    • 33645085593 scopus 로고    scopus 로고
    • Bi-potential behaviour of cytotrophoblasts in first trimester chorionic villi
    • Baczyk D, Dunk C, Huppertz B, Maxwell C, Reister F, Giannoulias D & Kingdom JC 2006 Bi-potential behaviour of cytotrophoblasts in first trimester chorionic villi. Placenta 27 367-374. (https://doi.org/10.1016/j.placenta.2005.03.006)
    • (2006) Placenta , vol.27 , pp. 367-374
    • Baczyk, D.1    Dunk, C.2    Huppertz, B.3    Maxwell, C.4    Reister, F.5    Giannoulias, D.6    Kingdom, J.C.7
  • 5
    • 67349255287 scopus 로고    scopus 로고
    • Glial cell missing-1 transcription factor is required for the differentiation of the human trophoblast
    • Baczyk D, Drewlo S, Proctor L, Dunk C, Lye S & Kingdom J 2009 Glial cell missing-1 transcription factor is required for the differentiation of the human trophoblast. Cell Death Differentiation 16 719-727. (https://doi.org/10.1038/cdd.2009.1)
    • (2009) Cell Death Differentiation , vol.16 , pp. 719-727
    • Baczyk, D.1    Drewlo, S.2    Proctor, L.3    Dunk, C.4    Lye, S.5    Kingdom, J.6
  • 6
    • 59649093035 scopus 로고    scopus 로고
    • Identification of novel trophoblast invasion-related genes: heme oxygenase-1 controls motility via peroxisome proliferator-activated receptor gamma
    • Bilban M, Haslinger P, Prast J, Klinglmüller F, Woelfel T, Haider S, Sachs A, Otterbein LE, Desoye G & Hiden U, et al. 2009 Identification of novel trophoblast invasion-related genes: heme oxygenase-1 controls motility via peroxisome proliferator-activated receptor gamma. Endocrinology 150 1000-1013. (https://doi.org/10.1210/en.2008-0456)
    • (2009) Endocrinology , vol.150 , pp. 1000-1013
    • Bilban, M.1    Haslinger, P.2    Prast, J.3    Klinglmüller, F.4    Woelfel, T.5    Haider, S.6    Sachs, A.7    Otterbein, L.E.8    Desoye, G.9    Hiden, U.10
  • 12
    • 78751495728 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress in the pathogenesis of early-onset pre-eclampsia
    • Burton GJ & Yung HW 2011 Endoplasmic reticulum stress in the pathogenesis of early-onset pre-eclampsia. Pregnancy Hypertension 1 72-78. (https://doi.org/10.1016/j.preghy.2010.12.002)
    • (2011) Pregnancy Hypertension , vol.1 , pp. 72-78
    • Burton, G.J.1    Yung, H.W.2
  • 13
    • 0032876371 scopus 로고    scopus 로고
    • Maternal arterial connections to the placental intervillous space during the first trimester of human pregnancy: the Boyd collection revisited
    • Burton GJ, Jauniaux E & Watson AL 1999 Maternal arterial connections to the placental intervillous space during the first trimester of human pregnancy: the Boyd collection revisited. American Journal of Obstetrics and Gynecology 181 718-724. (https://doi.org/10.1016/S0002-9378(99)70518-1)
    • (1999) American Journal of Obstetrics and Gynecology , vol.181 , pp. 718-724
    • Burton, G.J.1    Jauniaux, E.2    Watson, A.L.3
  • 14
    • 67349192531 scopus 로고    scopus 로고
    • Rheological and physiological consequences of conversion of the maternal spiral arteries for uteroplacental blood flow during human pregnancy
    • Burton GJ, Woods AW, Jauniaux E & Kingdom JC 2009 Rheological and physiological consequences of conversion of the maternal spiral arteries for uteroplacental blood flow during human pregnancy. Placenta 30 473-482. (https://doi.org/10.1016/j.placenta.2009.02.009)
    • (2009) Placenta , vol.30 , pp. 473-482
    • Burton, G.J.1    Woods, A.W.2    Jauniaux, E.3    Kingdom, J.C.4
  • 15
    • 67349214601 scopus 로고    scopus 로고
    • mTOR mediates human trophoblast invasion through regulation of matrix-remodeling enzymes and is associated with serine phosphorylation of STAT3
    • Busch S, Renaud SJ, Schleussner E, Graham CH & Markert UR 2009 mTOR mediates human trophoblast invasion through regulation of matrix-remodeling enzymes and is associated with serine phosphorylation of STAT3. Experimental Cell Research 315 1724-1733. (https://doi.org/10.1016/j.yexcr.2009.01.026)
    • (2009) Experimental Cell Research , vol.315 , pp. 1724-1733
    • Busch, S.1    Renaud, S.J.2    Schleussner, E.3    Graham, C.H.4    Markert, U.R.5
  • 16
    • 0034100836 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3)
    • Caniggia I, Mostachfi H, Winter J, Gassmann M, Lye SJ, Kuliszewski M & Post M 2000 Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3). Journal of Clinical Investigation 105 577-587. (https://doi.org/10.1172/JCI8316)
    • (2000) Journal of Clinical Investigation , vol.105 , pp. 577-587
    • Caniggia, I.1    Mostachfi, H.2    Winter, J.3    Gassmann, M.4    Lye, S.J.5    Kuliszewski, M.6    Post, M.7
  • 18
    • 85009454867 scopus 로고    scopus 로고
    • Human trophoblast stem cells: real or not real?
    • Chang CW & Parast MM 2017 Human trophoblast stem cells: real or not real? Placenta [epub]. (https://doi.org/10.1016/j.placenta.2017.01.003)
    • (2017) Placenta [epub]
    • Chang, C.W.1    Parast, M.M.2
  • 19
    • 1942539882 scopus 로고    scopus 로고
    • Decreased placental GCM1 (glial cells missing) gene expression in pre-eclampsia
    • Chen CP, Chen CY, Yang YC, Su TH & Chen H 2004 Decreased placental GCM1 (glial cells missing) gene expression in pre-eclampsia. Placenta 25 413-421. (https://doi.org/10.1016/j.placenta.2003.10.014)
    • (2004) Placenta , vol.25 , pp. 413-421
    • Chen, C.P.1    Chen, C.Y.2    Yang, Y.C.3    Su, T.H.4    Chen, H.5
  • 20
    • 75149157036 scopus 로고    scopus 로고
    • Hypoxia and angiogenesis: regulation of hypoxia-inducible factors via novel binding factors
    • Chen L, Endler A & Shibasaki F 2009 Hypoxia and angiogenesis: regulation of hypoxia-inducible factors via novel binding factors. Experimental and Molecular Medicine 41 849-857. (https://doi.org/10.3858/emm.2009.41.12.103)
    • (2009) Experimental and Molecular Medicine , vol.41 , pp. 849-857
    • Chen, L.1    Endler, A.2    Shibasaki, F.3
  • 25
    • 37049037676 scopus 로고    scopus 로고
    • Effects of FGF2 and oxygen in the BMP4-driven differentiation of trophoblast from human embryonic stem cells
    • Das P, Ezashi T, Schulz LC, Westfall SD, Livingston KA & Roberts RM 2007 Effects of FGF2 and oxygen in the BMP4-driven differentiation of trophoblast from human embryonic stem cells. Stem Cell Research 1 61-74. (https://doi.org/10.1016/j.scr.2007.09.004)
    • (2007) Stem Cell Research , vol.1 , pp. 61-74
    • Das, P.1    Ezashi, T.2    Schulz, L.C.3    Westfall, S.D.4    Livingston, K.A.5    Roberts, R.M.6
  • 27
    • 84942614081 scopus 로고    scopus 로고
    • Why is placentation abnormal in preeclampsia
    • Fisher SJ 2015 Why is placentation abnormal in preeclampsia? American Journal of Obstetrics and Gynecology 213 S115-S122. (https://doi.org/10.1016/j.ajog.2015.08.042)
    • (2015) American Journal of Obstetrics and Gynecology , vol.213 , pp. S115-S122
    • Fisher, S.J.1
  • 28
    • 0027756119 scopus 로고
    • Oxygen tension in the oviduct and uterus of rhesus monkeys, hamsters and rabbits
    • Fischer B & Bavister BD 1993 Oxygen tension in the oviduct and uterus of rhesus monkeys, hamsters and rabbits. Journal of Reproduction and Fertility 99 673-679. (https://doi.org/10.1530/jrf.0.0990673)
    • (1993) Journal of Reproduction and Fertility , vol.99 , pp. 673-679
    • Fischer, B.1    Bavister, B.D.2
  • 30
    • 0030026954 scopus 로고    scopus 로고
    • Hypoxia alters early gestation human cytotrophoblast differentiation/invasion in vitro and models the placental defects that occur in preeclampsia
    • Genbacev O, Joslin R, Damsky CH, Polliotti BM & Fisher SJ 1996 Hypoxia alters early gestation human cytotrophoblast differentiation/invasion in vitro and models the placental defects that occur in preeclampsia. Journal of Clinical Investigation 97 540-550. (https://doi.org/10.1172/JCI118447)
    • (1996) Journal of Clinical Investigation , vol.97 , pp. 540-550
    • Genbacev, O.1    Joslin, R.2    Damsky, C.H.3    Polliotti, B.M.4    Fisher, S.J.5
  • 31
    • 0030879909 scopus 로고    scopus 로고
    • Regulation of human placental development by oxygen tension
    • Genbacev O, Zhou Y, Ludlow JW & Fisher SJ 1997 Regulation of human placental development by oxygen tension. Science 277 1669-1672. (https://doi.org/10.1126/science.277.5332.1669)
    • (1997) Science , vol.277 , pp. 1669-1672
    • Genbacev, O.1    Zhou, Y.2    Ludlow, J.W.3    Fisher, S.J.4
  • 32
    • 33751348056 scopus 로고    scopus 로고
    • Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1
    • Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J, Brown M, Fitzgerald KJ & Sabatini DM 2006 Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Developmental Cell 11 859-71. (https://doi.org/10.1016/j.devcel.2006.10.007)
    • (2006) Developmental Cell , vol.11 , pp. 859-871
    • Guertin, D.A.1    Stevens, D.M.2    Thoreen, C.C.3    Burds, A.A.4    Kalaany, N.Y.5    Moffat, J.6    Brown, M.7    Fitzgerald, K.J.8    Sabatini, D.M.9
  • 34
    • 84999264574 scopus 로고    scopus 로고
    • Notch1 controls development of the extravillous trophoblast lineage in the human placenta
    • Haider S, Meinhardt G, Saleh L, Fiala C, Pollheimer J & Knöfler M 2016 Notch1 controls development of the extravillous trophoblast lineage in the human placenta. PNAS 113 E7710-E7719. (https://doi.org/10.1073/pnas.1612335113)
    • (2016) PNAS , vol.113 , pp. E7710-E7719
    • Haider, S.1    Meinhardt, G.2    Saleh, L.3    Fiala, C.4    Pollheimer, J.5    Knöfler, M.6
  • 36
    • 84977499749 scopus 로고    scopus 로고
    • Human pluripotent stem cells as a model of trophoblast differentiation in both normal development and disease
    • Horii M, Li Y, Wakeland AK, Pizzo DP, Nelson KK, Sabatini K, Laurent LC, Liu Y & Parast MM 2016 Human pluripotent stem cells as a model of trophoblast differentiation in both normal development and disease. PNAS 113 E3882-E3891. (https://doi.org/10.1073/pnas.1604747113)
    • (2016) PNAS , vol.113 , pp. E3882-E3891
    • Horii, M.1    Li, Y.2    Wakeland, A.K.3    Pizzo, D.P.4    Nelson, K.K.5    Sabatini, K.6    Laurent, L.C.7    Liu, Y.8    Parast, M.M.9
  • 37
    • 79952104568 scopus 로고    scopus 로고
    • mTOR couples cellular nutrient sensing to organismal metabolic homeostasis
    • Howell JJ & Manning BD 2011 mTOR couples cellular nutrient sensing to organismal metabolic homeostasis. Trends in Endocrinology and Metabolism 22 94-102. (https://doi.org/10.1016/j.tem.2010.12.003)
    • (2011) Trends in Endocrinology and Metabolism , vol.22 , pp. 94-102
    • Howell, J.J.1    Manning, B.D.2
  • 39
    • 70349756962 scopus 로고    scopus 로고
    • Function of IRE1 in the placenta is essential for placental development and embryonic viability
    • Iwawaki T, Akai R, Yamanaka S & Kohno K 2009 Function of IRE1 in the placenta is essential for placental development and embryonic viability. PNAS 106 16657-16662. (https://doi.org/10.1073/pnas.0903775106)
    • (2009) PNAS , vol.106 , pp. 16657-16662
    • Iwawaki, T.1    Akai, R.2    Yamanaka, S.3    Kohno, K.4
  • 41
    • 33749599181 scopus 로고    scopus 로고
    • The effects of oxygen concentration and gestational age on extravillous trophoblast outgrowth in a human first trimester villous explant model
    • James JL, Stone PR & Chamley LW 2006a The effects of oxygen concentration and gestational age on extravillous trophoblast outgrowth in a human first trimester villous explant model. Human Reproduction 21 2699-2705. (https://doi.org/10.1093/humrep/del212)
    • (2006) Human Reproduction , vol.21 , pp. 2699-2705
    • James, J.L.1    Stone, P.R.2    Chamley, L.W.3
  • 42
    • 32544438499 scopus 로고    scopus 로고
    • The regulation of trophoblast differentiation by oxygen in the first trimester of pregnancy
    • James JL, Stone PR & Chamley LW 2006b The regulation of trophoblast differentiation by oxygen in the first trimester of pregnancy. Human Reproduction Update 12 137-144. (https://doi.org/10.1093/humupd/dmi043)
    • (2006) Human Reproduction Update , vol.12 , pp. 137-144
    • James, J.L.1    Stone, P.R.2    Chamley, L.W.3
  • 44
    • 84869094274 scopus 로고    scopus 로고
    • The emerging role of mTORC1 signaling in placental nutrient-sensing
    • Jansson T, Aye IL & Goberdhan DC 2012 The emerging role of mTORC1 signaling in placental nutrient-sensing. Placenta 33 (Supplement 2) e23-e29. (https://doi.org/10.1016/j.placenta.2012.05.010)
    • (2012) Placenta , vol.33
    • Jansson, T.1    Aye, I.L.2    Goberdhan, D.C.3
  • 45
    • 0028266742 scopus 로고
    • Ultrasonographic investigation of placental morphologic characteristics and size during the second trimester of pregnancy
    • Jauniaux E, Ramsay B & Campbell S 1994 Ultrasonographic investigation of placental morphologic characteristics and size during the second trimester of pregnancy. American Journal of Obstetrics and Gynecology 170 130-137. (https://doi.org/10.1016/S0002-9378(13)70293-X)
    • (1994) American Journal of Obstetrics and Gynecology , vol.170 , pp. 130-137
    • Jauniaux, E.1    Ramsay, B.2    Campbell, S.3
  • 48
    • 0033777446 scopus 로고    scopus 로고
    • Hypoxia prevents induction of aro- matase expression in human trophoblast cells in culture: potential inhibitory role of the hypoxia-inducible transcription factor Mash-2 (mammalian acha- ete-schute homologous protein-2)
    • Jiang B, Kamat A & Mendelson CR 2000 Hypoxia prevents induction of aro- matase expression in human trophoblast cells in culture: potential inhibitory role of the hypoxia-inducible transcription factor Mash-2 (mammalian acha- ete-schute homologous protein-2). Molecular Endocrinology 14 1661-1673. (https://doi.org/10.1210/mend.14.10.0539)
    • (2000) Molecular Endocrinology , vol.14 , pp. 1661-1673
    • Jiang, B.1    Kamat, A.2    Mendelson, C.R.3
  • 50
    • 79251497335 scopus 로고    scopus 로고
    • High altitude during pregnancy
    • Julian CG 2011 High altitude during pregnancy. Clinics in Chest Medicine 32 21-31. (https://doi.org/10.1016/j.ccm.2010.10.008)
    • (2011) Clinics in Chest Medicine , vol.32 , pp. 21-31
    • Julian, C.G.1
  • 51
    • 0030846190 scopus 로고    scopus 로고
    • Oxygen and placental villous development: origins of fetal hypoxia
    • Kingdom JC & Kaufmann P 1997 Oxygen and placental villous development: origins of fetal hypoxia. Placenta 18 613-621. (https://doi.org/10.1016/S0143-4004(97)90000-X)
    • (1997) Placenta , vol.18 , pp. 613-621
    • Kingdom, J.C.1    Kaufmann, P.2
  • 53
    • 0037097861 scopus 로고    scopus 로고
    • FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
    • Lando D, Peet DJ, Gorman JJ, Whelan DA, Whitelaw ML & Bruick RK 2002 FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes & Development 16 1466-1471. (https://doi.org/10.1101/gad.991402)
    • (2002) Genes & Development , vol.16 , pp. 1466-1471
    • Lando, D.1    Peet, D.J.2    Gorman, J.J.3    Whelan, D.A.4    Whitelaw, M.L.5    Bruick, R.K.6
  • 54
    • 31044452235 scopus 로고    scopus 로고
    • Low oxygen concentrations inhibit trophoblast cell invasion from early gestation placental explants via alterations in levels of the urokinase plasminogen activator system
    • Lash GE, Otun HA, Innes BA, Bulmer JN, Searle RF & Robson SC 2006 Low oxygen concentrations inhibit trophoblast cell invasion from early gestation placental explants via alterations in levels of the urokinase plasminogen activator system. Biology of Reproduction 74 403-409. (https://doi.org/10.1095/biolreprod.105.047332)
    • (2006) Biology of Reproduction , vol.74 , pp. 403-409
    • Lash, G.E.1    Otun, H.A.2    Innes, B.A.3    Bulmer, J.N.4    Searle, R.F.5    Robson, S.C.6
  • 55
    • 1642387020 scopus 로고    scopus 로고
    • Hypoxia-inducible factor (HIF-1)alpha: its protein stability and biological functions
    • Lee JW, Bae SH, Jeong JW, Kim SH & Kim KW 2004 Hypoxia-inducible factor (HIF-1)alpha: its protein stability and biological functions. Experimental and Molecular Medicine 36 1-12. (https://doi.org/10.1038/emm.2004.1)
    • (2004) Experimental and Molecular Medicine , vol.36 , pp. 1-12
    • Lee, J.W.1    Bae, S.H.2    Jeong, J.W.3    Kim, S.H.4    Kim, K.W.5
  • 56
    • 34250173484 scopus 로고    scopus 로고
    • A unifying concept of trophoblastic differentiation and malignancy defined by biomarker expression
    • Lee Y, Kim KR, McKeon F, Yang A, Boyd TK, Crum CP & Parast MM 2007 A unifying concept of trophoblastic differentiation and malignancy defined by biomarker expression. Human Pathology 38 1003-1013. (https://doi.org/10.1016/j.humpath.2006.12.012)
    • (2007) Human Pathology , vol.38 , pp. 1003-1013
    • Lee, Y.1    Kim, K.R.2    McKeon, F.3    Yang, A.4    Boyd, T.K.5    Crum, C.P.6    Parast, M.M.7
  • 57
    • 84904154186 scopus 로고    scopus 로고
    • BMP4 regulation of human trophoblast development
    • Li Y & Parast MM 2014 BMP4 regulation of human trophoblast development. International Journal of Developmental Biology 58 239-246. (https://doi.org/10.1387/ijdb.130341mp)
    • (2014) International Journal of Developmental Biology , vol.58 , pp. 239-246
    • Li, Y.1    Parast, M.M.2
  • 58
    • 84884246541 scopus 로고    scopus 로고
    • BMP4-directed trophoblast differentiation of human embryonic stem cells is mediated through a ?Np63+ cytotrophoblast stem cell state
    • Li Y, Moretto-Zita M, Soncin F, Wakeland A, Wolfe L, Leon-Garcia S, Pandian R, Pizzo D, Cui L, Nazor K, et al. 2013 BMP4-directed trophoblast differentiation of human embryonic stem cells is mediated through a ?Np63+ cytotrophoblast stem cell state. Development 140 3965-76. (https://doi.org/10.1242/dev.092155)
    • (2013) Development , vol.140 , pp. 3965-3976
    • Li, Y.1    Moretto-Zita, M.2    Soncin, F.3    Wakeland, A.4    Wolfe, L.5    Leon-Garcia, S.6    Pandian, R.7    Pizzo, D.8    Cui, L.9    Nazor, K.10
  • 59
    • 84913594223 scopus 로고    scopus 로고
    • p63 inhibits extravillous trophoblast migration and maintains cells in a cytotrophoblast stem cell-like state
    • Li Y, Moretto-Zita M, Leon-Garcia S & Parast MM 2014 p63 inhibits extravillous trophoblast migration and maintains cells in a cytotrophoblast stem cell-like state. American Journal of Pathology 184 3332-43. (https://doi.org/10.1016/j.ajpath.2014.08.006)
    • (2014) American Journal of Pathology , vol.184 , pp. 3332-3343
    • Li, Y.1    Moretto-Zita, M.2    Leon-Garcia, S.3    Parast, M.M.4
  • 60
    • 0036822271 scopus 로고    scopus 로고
    • Hormones and human trophoblast differentiation: a review
    • Malassine A & Cronier L 2002 Hormones and human trophoblast differentiation: a review. Endocrine 19 3-11. (https://doi.org/10.1385/ENDO:19:1:3)
    • (2002) Endocrine , vol.19 , pp. 3-11
    • Malassine, A.1    Cronier, L.2
  • 61
    • 24344502368 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta
    • Maltepe E, Krampitz GW, Okazaki KM, Red-Horse K, Mak W, Simon MC & Fisher SJ 2005 Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta. Development 132 3393-3403. (https://doi.org/10.1242/dev.01923)
    • (2005) Development , vol.132 , pp. 3393-3403
    • Maltepe, E.1    Krampitz, G.W.2    Okazaki, K.M.3    Red-Horse, K.4    Mak, W.5    Simon, M.C.6    Fisher, S.J.7
  • 62
    • 0037837724 scopus 로고    scopus 로고
    • Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex
    • Maynard MA, Qi H, Chung J, Lee EH, Kondo Y, Hara S, Conaway RC, Conaway JW & Ohh M 2003 Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex. Journal of Biological Chemistry 278 11032-11040. (https://doi.org/10.1074/jbc.M208681200)
    • (2003) Journal of Biological Chemistry , vol.278 , pp. 11032-11040
    • Maynard, M.A.1    Qi, H.2    Chung, J.3    Lee, E.H.4    Kondo, Y.5    Hara, S.6    Conaway, R.C.7    Conaway, J.W.8    Ohh, M.9
  • 63
    • 83155175246 scopus 로고    scopus 로고
    • Evidence implicating peroxisome proliferator-activated receptor-? in the pathogenesis of preeclampsia
    • McCarthy FP, Drewlo S, English FA, Kingdom J, Johns EJ, Kenny LC & Walsh SK 2011a Evidence implicating peroxisome proliferator-activated receptor-? in the pathogenesis of preeclampsia. Hypertension 58 882-887. (https://doi.org/10.1161/HYPERTENSIONAHA.111.179440)
    • (2011) Hypertension , vol.58 , pp. 882-887
    • McCarthy, F.P.1    Drewlo, S.2    English, F.A.3    Kingdom, J.4    Johns, E.J.5    Kenny, L.C.6    Walsh, S.K.7
  • 64
    • 80051471606 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-? as a potential therapeutic target in the treatment of preeclampsia
    • McCarthy FP, Drewlo S, Kingdom J, Johns EJ, Walsh SK & Kenny LC 2011b Peroxisome proliferator-activated receptor-? as a potential therapeutic target in the treatment of preeclampsia. Hypertension 58 280-286. (https://doi.org/10.1161/HYPERTENSIONAHA.111.172627)
    • (2011) Hypertension , vol.58 , pp. 280-286
    • McCarthy, F.P.1    Drewlo, S.2    Kingdom, J.3    Johns, E.J.4    Walsh, S.K.5    Kenny, L.C.6
  • 68
    • 77951251429 scopus 로고    scopus 로고
    • PPARgamma regulates trophoblast proliferation and promotes labyrinthine trilineage differentiation
    • Parast MM, Yu H, Ciric A, Salata MW, Davis V & Milstone DS 2009 PPARgamma regulates trophoblast proliferation and promotes labyrinthine trilineage differentiation. PLoS ONE 4 e8055. (https://doi.org/10.1371/journal.pone.0008055)
    • (2009) PLoS ONE , vol.4
    • Parast, M.M.1    Yu, H.2    Ciric, A.3    Salata, M.W.4    Davis, V.5    Milstone, D.S.6
  • 69
    • 78049283720 scopus 로고    scopus 로고
    • Regulation of hypoxia inducible factors (HIF) in hypoxia and normoxia during placental development
    • Patel J, Landers K, Mortimer RH & Richard K 2010 Regulation of hypoxia inducible factors (HIF) in hypoxia and normoxia during placental development. Placenta 31 951-957. (https://doi.org/10.1016/j.placenta.2010.08.008)
    • (2010) Placenta , vol.31 , pp. 951-957
    • Patel, J.1    Landers, K.2    Mortimer, R.H.3    Richard, K.4
  • 70
    • 1942519383 scopus 로고    scopus 로고
    • Trophoblast oxidative stress, antioxidants and pregnancy outcome--a review
    • Poston L Raijmakers MT 2004 Trophoblast oxidative stress, antioxidants and pregnancy outcome--a review. Placenta 25 (Suppl A) S72-S78.
    • (2004) Placenta , vol.25 , pp. S72-S78
    • Poston, L.1    Raijmakers, M.T.2
  • 71
    • 34247118887 scopus 로고    scopus 로고
    • Signaling to translation: how signal transduction pathways control the protein synthetic machinery
    • Proud CG 2007 Signaling to translation: how signal transduction pathways control the protein synthetic machinery. Biochemical Journal 403 217-234. (https://doi.org/10.1042/BJ20070024)
    • (2007) Biochemical Journal , vol.403 , pp. 217-234
    • Proud, C.G.1
  • 72
    • 4644281668 scopus 로고    scopus 로고
    • Evidence for the functional activity of hypoxia-inducible transcription factors overexpressed in preeclamptic placentae
    • Rajakumar A, Brandon HM, Daftary A, Ness R & Conrad KP 2004 Evidence for the functional activity of hypoxia-inducible transcription factors overexpressed in preeclamptic placentae. Placenta 25 763-769. (https://doi.org/10.1016/j.placenta.2004.02.011)
    • (2004) Placenta , vol.25 , pp. 763-769
    • Rajakumar, A.1    Brandon, H.M.2    Daftary, A.3    Ness, R.4    Conrad, K.P.5
  • 74
    • 0026782588 scopus 로고
    • Oxygen measurements in endometrial and trophoblastic tissues during early pregnancy
    • Rodesch F, Simon P, Donner C & Jauniaux E 1992 Oxygen measurements in endometrial and trophoblastic tissues during early pregnancy. Obstetrics and Gynecology 80 283-285.
    • (1992) Obstetrics and Gynecology , vol.80 , pp. 283-285
    • Rodesch, F.1    Simon, P.2    Donner, C.3    Jauniaux, E.4
  • 75
    • 34347211057 scopus 로고    scopus 로고
    • Mammalian target of rapamycin in the human placenta regulates leucine transport and is down-regulated in restricted fetal growth
    • Roos S, Jansson N, Palmberg I, Säljö K, Powell TL & Jansson T 2007 Mammalian target of rapamycin in the human placenta regulates leucine transport and is down-regulated in restricted fetal growth. Journal of Physiology 582 449-459. (https://doi.org/10.1113/jphysiol.2007.129676)
    • (2007) Journal of Physiology , vol.582 , pp. 449-459
    • Roos, S.1    Jansson, N.2    Palmberg, I.3    Säljö, K.4    Powell, T.L.5    Jansson, T.6
  • 76
    • 39149135857 scopus 로고    scopus 로고
    • Maternal hypoxia activates endovascular trophoblast cell invasion
    • Rosario GX, Konno T & Soares MJ 2008 Maternal hypoxia activates endovascular trophoblast cell invasion. Developmental Biology 314 362-375. (https://doi.org/10.1016/j.ydbio.2007.12.007)
    • (2008) Developmental Biology , vol.314 , pp. 362-375
    • Rosario, G.X.1    Konno, T.2    Soares, M.J.3
  • 78
    • 34047214754 scopus 로고    scopus 로고
    • Diverse subtypes and developmental origins of trophoblast giant cells in the mouse placenta
    • Simmons DG, Fortier AL & Cross JC 2007 Diverse subtypes and developmental origins of trophoblast giant cells in the mouse placenta. Developmental Biology 304 567-78. (https://doi.org/10.1016/j.ydbio.2007.01.009)
    • (2007) Developmental Biology , vol.304 , pp. 567-578
    • Simmons, D.G.1    Fortier, A.L.2    Cross, J.C.3
  • 79
    • 41149115123 scopus 로고    scopus 로고
    • The role of oxygen availability in embryonic development and stem cell function
    • Simon MC & Keith B 2008 The role of oxygen availability in embryonic development and stem cell function. Nature Reviews Molecular and Cellular Biology 9 285-296. (https://doi.org/10.1038/nrm2354)
    • (2008) Nature Reviews Molecular and Cellular Biology , vol.9 , pp. 285-296
    • Simon, M.C.1    Keith, B.2
  • 80
    • 84857373125 scopus 로고    scopus 로고
    • Rat placentation: an experimental model for investigating the hemochorial maternal-fetal interface
    • Soares MJ, Chakraborty D, Karim Rumi MA, Konno T & Renaud SJ 2012 Rat placentation: an experimental model for investigating the hemochorial maternal-fetal interface. Placenta 33 233-243. (https://doi.org/10.1016/j.placenta.2011.11.026)
    • (2012) Placenta , vol.33 , pp. 233-243
    • Soares, M.J.1    Chakraborty, D.2    Karim Rumi, M.A.3    Konno, T.4    Renaud, S.J.5
  • 81
    • 84938328720 scopus 로고    scopus 로고
    • Signaling pathways in mouse and human trophoblast differentiation: a comparative review
    • Soncin F, Natale D & Parast MM 2015 Signaling pathways in mouse and human trophoblast differentiation: a comparative review. Cellular and Molecular Life Sciences 72 1291-1302. (https://doi.org/10.1007/s00018-014-1794-x)
    • (2015) Cellular and Molecular Life Sciences , vol.72 , pp. 1291-1302
    • Soncin, F.1    Natale, D.2    Parast, M.M.3
  • 83
    • 84877666331 scopus 로고    scopus 로고
    • The role of hypoxia and hypoxia-inducible factor-1alpha in preeclampsia pathogenesis
    • Tal R 2012 The role of hypoxia and hypoxia-inducible factor-1alpha in preeclampsia pathogenesis. Biology of Reproduction 87 134. (https://doi.org/10.1093/biolreprod/87.s1.134)
    • (2012) Biology of Reproduction , vol.87 , pp. 134
    • Tal, R.1
  • 84
    • 78650222706 scopus 로고    scopus 로고
    • Effects of hypoxia-inducible factor-1alpha overexpression in pregnant mice: possible implications for preeclampsia and intrauterine growth restriction
    • Tal R, Shaish A, Barshack I, Polak-Charcon S, Afek A, Volkov A, Feldman B, Avivi C & Harats D 2010 Effects of hypoxia-inducible factor-1alpha overexpression in pregnant mice: possible implications for preeclampsia and intrauterine growth restriction. American Journal of Pathology 177 2950-2962. (https://doi.org/10.2353/ajpath.2010.090800)
    • (2010) American Journal of Pathology , vol.177 , pp. 2950-2962
    • Tal, R.1    Shaish, A.2    Barshack, I.3    Polak-Charcon, S.4    Afek, A.5    Volkov, A.6    Feldman, B.7    Avivi, C.8    Harats, D.9
  • 85
    • 0032509321 scopus 로고    scopus 로고
    • Promotion of trophoblast stem cell proliferation by FGF4
    • Tanaka S, Kunath T, Hadjantonakis AK, Nagy A & Rossant J 1998 Promotion of trophoblast stem cell proliferation by FGF4. Science 282 2072-2075. (https://doi.org/10.1126/science.282.5396.2072)
    • (1998) Science , vol.282 , pp. 2072-2075
    • Tanaka, S.1    Kunath, T.2    Hadjantonakis, A.K.3    Nagy, A.4    Rossant, J.5
  • 86
    • 79952008594 scopus 로고    scopus 로고
    • Review: oxygen and trophoblast biology-A source of controversy
    • Tuuli MG, Longtine MS & Nelson DM 2011 Review: oxygen and trophoblast biology-A source of controversy. Placenta 32(Supplement 2) S109-S118. (https://doi.org/10.1016/j.placenta.2010.12.013)
    • (2011) Placenta , vol.32 , pp. S109-S118
    • Tuuli, M.G.1    Longtine, M.S.2    Nelson, D.M.3
  • 88
    • 62849105355 scopus 로고    scopus 로고
    • Syncytin-1 and glial cells missing a: hypoxia-induced deregulated gene expression along with disordered cell fusion in primary term human trophoblasts
    • Wich C, Kausler S, Dotsch J, Rascher W & Knerr I 2009 Syncytin-1 and glial cells missing a: hypoxia-induced deregulated gene expression along with disordered cell fusion in primary term human trophoblasts. Gynecologic and Obstetric Investigation 68 9-18. (https://doi.org/10.1159/000209396)
    • (2009) Gynecologic and Obstetric Investigation , vol.68 , pp. 9-18
    • Wich, C.1    Kausler, S.2    Dotsch, J.3    Rascher, W.4    Knerr, I.5
  • 91
    • 38749144767 scopus 로고    scopus 로고
    • Severe intrauterine growth restriction pregnancies have increased placental endoglin levels: hypoxic regulation via transforming growth factor-beta 3
    • Yinon Y, Nevo O, Xu J, Many A, Rolfo A, Todros T, Post M & Caniggia I 2008 Severe intrauterine growth restriction pregnancies have increased placental endoglin levels: hypoxic regulation via transforming growth factor-beta 3. American Journal of Pathology 172 77-85. (https://doi.org/10.2353/ajpath.2008.070640)
    • (2008) American Journal of Pathology , vol.172 , pp. 77-85
    • Yinon, Y.1    Nevo, O.2    Xu, J.3    Many, A.4    Rolfo, A.5    Todros, T.6    Post, M.7    Caniggia, I.8
  • 92
    • 48749124981 scopus 로고    scopus 로고
    • Evidence of placental translation inhibition and endoplasmic reticulum stress in the etiology of human intrauterine growth restriction
    • Yung HW, Calabrese S, Hynx D, Hemmings BA, Cetin I, Charnock-Jones DS & Burton GJ 2008 Evidence of placental translation inhibition and endoplasmic reticulum stress in the etiology of human intrauterine growth restriction. American Journal of Pathology 173 451-462. (https://doi.org/10.2353/ajpath.2008.071193)
    • (2008) American Journal of Pathology , vol.173 , pp. 451-462
    • Yung, H.W.1    Calabrese, S.2    Hynx, D.3    Hemmings, B.A.4    Cetin, I.5    Charnock-Jones, D.S.6    Burton, G.J.7
  • 94
    • 0041629286 scopus 로고    scopus 로고
    • The placenta at high altitude
    • Zamudio S 2003 The placenta at high altitude. High Altitude Medicine and Biology 4 171-191. (https://doi.org/10.1089/152702903322022785)
    • (2003) High Altitude Medicine and Biology , vol.4 , pp. 171-191
    • Zamudio, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.