HIF-KDM3A-MMP12 regulatory circuit ensures trophoblast plasticity and placental adaptations to hypoxia

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 46, 2016, Pages E7212-E7221

  Chakraborty, Damayanti ^a,b   Cui, Wei ^a,b,d   Rosario, Gracy X ^a,b,e   Scott, Regan L ^a,b   Dhakal, Pramod ^a,b   Renaud, Stephen J ^a,b,f   Tachibana, Makoto ^c   Karim Rumi, M A ^a,b   Mason, Clifford W ^a   Krieg, Adam J ^a,g   Soares, Michael J ^a,b  

^a UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TOKUSHIMA   (Japan)

^d UNIVERSITY OF MASSACHUSETTS   (United States)

^e Global Pathways Institute   (India)

^f UNIVERSITY OF WESTERN ONTARIO   (Canada)

^g OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Epigenetics; Hypoxia; Placenta; Plasticity; Trophoblast invasion

Indexed keywords

HYPOXIA INDUCIBLE FACTOR; KDM3A PROTEIN; LENTIVIRUS VECTOR; MACROPHAGE ELASTASE; OXYGEN; PROTEIN; UNCLASSIFIED DRUG; HISTONE DEMETHYLASE; HYPOXIA INDUCIBLE FACTOR 1; KDM3A PROTEIN, MOUSE;

ADAPTATION; AMBIENT AIR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL PLASTICITY; CONTROLLED STUDY; DNA MICROARRAY; EMBRYO; FEMALE; GENE SILENCING; GENE TARGETING; HYPOXIA; IN VITRO STUDY; IN VIVO STUDY; METHYLATION; NONHUMAN; PHENOTYPE; PLACENTA; PRIORITY JOURNAL; RAT; TROPHOBLAST; UPREGULATION; VASCULAR REMODELING; VIRAL GENE DELIVERY SYSTEM; ANIMAL; CELL LINE; GENETICS; HUMAN; METABOLISM; MOUSE; MUTANT RAT STRAIN; PHYSIOLOGY; PREGNANCY; SPRAGUE DAWLEY RAT;

ANIMALS; CELL LINE; CELL PLASTICITY; FEMALE; HUMANS; HYPOXIA; HYPOXIA-INDUCIBLE FACTOR 1; JUMONJI DOMAIN-CONTAINING HISTONE DEMETHYLASES; MATRIX METALLOPROTEINASE 12; MICE; PLACENTA; PREGNANCY; RATS; RATS, MUTANT STRAINS; RATS, SPRAGUE-DAWLEY; TROPHOBLASTS;

EID: 84995554927     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1612626113     Document Type: Article

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