The anti-inflammatory activity of curcumin is mediated by its oxidative metabolites

Journal of Biological Chemistry

Volumn 292, Issue 52, 2017, Pages 21243-21252

  Edwards, Rebecca L ^a   Luis, Paula B ^a   Varuzza, Paolo V ^a   Joseph, Akil I ^a   Presley, Sai Han ^a   Chaturvedi, Rupesh ^b   Schneider, Claus ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JAWAHARLAL NEHRU UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOMOLECULES; CHEMICAL ACTIVATION; ENZYMES; MEDICAL APPLICATIONS; PEPTIDES; TRANSCRIPTION;

ANTI-INFLAMMATORIES; ANTI-INFLAMMATORY ACTIVITY; CORRELATION COEFFICIENT; GLUTATHIONE ADDUCTS; GLUTATHIONE BIOSYNTHESIS; NUCLEAR FACTOR KAPPAB; OXIDATIVE TRANSFORMATIONS; REACTIVE METABOLITES;

METABOLITES;

4 HYDROXY 3 (PENT 4 YN 1 YLOXY)BENZALDEHYDE; 4 HYDROXY 3 (PENT 4 YN 1 YLOXY)BENZALDEHYDE:3,4 DIHYDROXYBENZALDEHYDE; 4 HYDROXY 3 METHOXY 5 (PENT 4 YN 1 YLOXY)BENZALDEHYDE: 3,4 DIHYDROXY 5 METHOXYBENZALDEHYDE; ALDEHYDE DERIVATIVE; ALKYNYL GROUP; CELL PROTEIN; CURCUMIN; GLUTATHIONE; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; POLYPHENOL DERIVATIVE; SYNAPTOTAGMIN I; SYRINGEALDEHYDE DERIVATIVE; UNCLASSIFIED DRUG; VANILLIN DERIVATIVE; ANTIINFLAMMATORY AGENT; I KAPPA B KINASE; TUMOR NECROSIS FACTOR;

ADDUCTION; ANTIINFLAMMATORY ACTIVITY; ARTICLE; AUTOOXIDATION; BIOTRANSFORMATION; CELL ACTIVATION; CELL CULTURE; CELL PROTECTION; CORRELATION COEFFICIENT; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; IC50; IMMUNOBLOTTING; IN VITRO STUDY; LUCIFERASE ASSAY; METABOLITE; OXIDATION; PRIORITY JOURNAL; STABLE TRANSFECTION; ANIMAL; DRUG EFFECT; HELA CELL LINE; METABOLISM; MOUSE; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; RAW 264.7 CELL LINE; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CURCUMIN; GLUTATHIONE; HELA CELLS; HUMANS; I-KAPPA B KINASE; MICE; NF-KAPPA B; OXIDATION-REDUCTION; OXIDATIVE STRESS; RAW 264.7 CELLS; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 85039778682     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.RA117.000123     Document Type: Article

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