Oxidative Transformation of Demethoxy- and Bisdemethoxycurcumin: Products, Mechanism of Formation, and Poisoning of Human Topoisomerase IIα

Chemical Research in Toxicology

Volumn 28, Issue 5, 2015, Pages 989-996

  Gordon, Odaine N ^a,b   Luis, Paula B ^a   Ashley, Rachel E ^a   Osheroff, Neil ^a   Schneider, Claus ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b 206 Carnegie Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CURCUMIN; DEMETHOXYCURCUMIN; DIDEMETHOXYCURCUMIN; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE IIALPHA; HORSERADISH PEROXIDASE; HYDROGEN PEROXIDE; POTASSIUM FERRICYANIDE; TURMERIC; UNCLASSIFIED DRUG; BIS(4-HYDROXYCINNAMOYL)METHANE; DNA BINDING PROTEIN; DNA TOPOISOMERASE II ALPHA; EPOXIDE; PLANT EXTRACT; TUMOR ANTIGEN; TURMERIC EXTRACT;

ARTICLE; AUTOOXIDATION; CATALYSIS; CYCLIZATION; DIASTEREOISOMER; DNA CLEAVAGE; ELECTROSPRAY MASS SPECTROMETRY; HETERONUCLEAR MULTIPLE BOND CORRELATION; HETERONUCLEAR NUCLEAR MAGNETIC RESONANCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; MOLECULAR STABILITY; OXIDATION; PH; REACTION TIME; TANDEM MASS SPECTROMETRY; ANALOGS AND DERIVATIVES; CHEMISTRY; CURCUMA; DRUG EFFECTS; HUMAN; METABOLISM; OXIDATION REDUCTION REACTION; TOXICITY;

ARMORACIA RUSTICANA; CURCUMA LONGA;

ANTIGENS, NEOPLASM; CURCUMA; CURCUMIN; DNA CLEAVAGE; DNA TOPOISOMERASES, TYPE II; DNA-BINDING PROTEINS; EPOXY COMPOUNDS; HUMANS; OXIDATION-REDUCTION; PLANT EXTRACTS;

EID: 84929590403     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/acs.chemrestox.5b00009     Document Type: Article

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