Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Journal of Medicinal Food

Volumn 19, Issue 8, 2016, Pages 717-729

  Daily, James W ^a   Yang, Mini ^b   Park, Sunmin ^b  

^a Daily Manufacturing Inc   (United States)

^b Hoseo University   (South Korea)

Author keywords

arthritis; curcuma; osteoarthritis; pain visual analogue score; systematic review; turmeric

Indexed keywords

CHONDROITIN SULFATE; CURCUMIN; DICLOFENAC; DIDEMETHOXYCURCUMIN; GLUCOSAMINE; IBUPROFEN; PLACEBO; TURMERIC; PLANT EXTRACT; TURMERIC EXTRACT;

ABSENCE OF SIDE EFFECTS; ARTHRITIS; BIBLIOGRAPHIC DATABASE; BLURRED VISION; CLINICAL EVALUATION; CLINICAL TRIAL (TOPIC); CNKI DATABASE; COCHRANE LIBRARY; CURCUMA; CURCUMA LONGA; DRUG EFFICACY; DRUG SAFETY; EMBASE; EYE SWELLING; FEVER; GASTROINTESTINAL SYMPTOM; HAIR LOSS; HUMAN; HYPERTENSION; KIDNEY DISEASE; KNEE OSTEOARTHRITIS; MEDLINE; META ANALYSIS; OSTEOARTHRITIS; PAIN VISUAL ANALOG SCORE; PHARYNGITIS; PRIORITY JOURNAL; PRURITUS; PUBLISHING; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RHEUMATOID ARTHRITIS; RISK ASSESSMENT; SYMPTOM; SYSTEMATIC REVIEW; TACHYCARDIA; TONGUE DISEASE; TREATMENT OUTCOME; VISUAL ANALOG SCALE; WANFANG DATABASE; WESTERN ONTARIO AND MCMASTER UNIVERSITIES OSTEOARTHRITIS INDEX; ARTHRITIS, RHEUMATOID; CHEMISTRY; COMPLICATION; PAIN; PHYTOTHERAPY;

ARTHRITIS, RHEUMATOID; CURCUMA; CURCUMIN; HUMANS; OSTEOARTHRITIS; PAIN; PHYTOTHERAPY; PLANT EXTRACTS; TREATMENT OUTCOME;

EID: 84983329153     PISSN: 1096620X     EISSN: 15577600     Source Type: Journal    
DOI: 10.1089/jmf.2016.3705     Document Type: Review

References (49)

1. Johnson VL, Hunter DJ: The epidemiology of osteoarthritis. Best Pract Res Clin Rheumatol 2014;28:5-15.
2. Goldring SR: Pathogenesis of bone and cartilage destruction in rheumatoid arthritis. Rheumatology (Oxford) 2003;42 Suppl 2: ii11-ii16.
3. Vos T, Flaxman AD, Naghavi M, et al.: Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: A systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012;380:2163-2196.
4. Marcu KB, Otero M, Olivotto E, Borzi RM, Goldring MB: NF-kappaB signaling: Multiple angles to target OA. Curr Drug Targets 2010;11:599-613.
5. Suokas AK, Sagar DR, Mapp PI, Chapman V, Walsh DA: Design, study quality and evidence of analgesic efficacy in studies of drugs in models of OA pain: A systematic review and a metaanalysis. Osteoarthritis Cartilage 2014;22:1207-1223.
6. Schnitzer TJ: Update on guidelines for the treatment of chronic musculoskeletal pain. Clin Rheumatol 2006;25 Suppl 1:S22-S29.
7. Funk JL, Frye JB, Oyarzo JN, et al.: Efficacy and mechanism of action of turmeric supplements in the treatment of experimental arthritis. Arthritis Rheum 2006;54:3452-3464.
8. Henrotin Y, Lambert C, Couchourel D, Ripoll C, Chiotelli E: Nutraceuticals: Do they represent a new era in the management of osteoarthritis?-a narrative review from the lessons taken with five products. Osteoarthritis Cartilage 2011;19:1-21.
9. Lakhan SE, Ford CT, Tepper D: Zingiberaceae extracts for pain: A systematic review and meta-analysis. Nutr J 2015;14:50.
10. Goel A, Kunnumakkara AB, Aggarwal BB: Curcumin as ''Curecumin'': From kitchen to clinic. Biochem Pharmacol 2008;75: 787-809.
11. Nurtjahja-Tjendraputra E, Ammit AJ, Roufogalis BD, Tran VH, Duke CC: Effective anti-platelet and COX-1 enzyme inhibitors from pungent constituents of ginger. Thromb Res 2003;111:259-265.
12. Daily JW, Zhang X, Kim DS, Park S: Efficacy of ginger for alleviating the symptoms of primary dysmenorrhea: A systematic review and meta-analysis of randomized clinical trials. Pain Med 2015;16:2243-2255.
13. Peddada KV, Peddada KV, Shukla SK, Mishra A, Verma V: Role of curcumin in common musculoskeletal disorders: A review of current laboratory, translational, and clinical data. Orthop Surg 2015;7:222-231.
14. Appelboom T, Maes N, Albert A: A new curcuma extract (flexofytol(R)) in osteoarthritis: Results from a belgian real-life experience. Open Rheumatol J 2014;8:77-81.
15. Prasad S, Gupta SC, Tyagi AK, Aggarwal BB: Curcumin, a component of golden spice: From bedside to bench and back. Biotechnol Adv 2014;32:1053-1064.
16. Kuptniratsaikul V, Thanakhumtorn S, Chinswangwatanakul P, Wattanamongkonsil L, Thamlikitkul V: Efficacy and safety of Curcuma domestica extracts in patients with knee osteoarthritis. J Altern Complement Med 2009;15:891-897.
17. Panahi Y, Rahimnia AR, Sharafi M, Alishiri G, Saburi A, Sahebkar A: Curcuminoid treatment for knee osteoarthritis: A randomized double-blind placebo-controlled trial. Phytother Res 2014;28:1625-1631.
18. Kuptniratsaikul V, Dajpratham P, Taechaarpornkul W, et al.: Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: A multicenter study. Clin Interv Aging 2014;9:451-458.
19. Belcaro G, Dugall M, Luzzi R, et al.: Meriva(R)+glucosamine versus condroitin+glucosamine in patients with knee osteoarthritis: An observational study. Eur Rev Med Pharmacol Sci 2014; 18:3959-3963.
20. Nakagawa Y, Mukai S, Yamada S, et al.: Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: A randomized, double-blind, placebo-controlled prospective study. J Orthop Sci 2014;19:933-939.
21. Pinsornsak P, Niempoog S: The efficacy of Curcuma longa L. extract as an adjuvant therapy in primary knee osteoarthritis: A randomized control trial. J Med Assoc Thai 2012;95 Suppl 1: S51-S58.
22. Madhu K, Chanda K, Saji MJ: Safety and efficacy of Curcuma longa extract in the treatment of painful knee osteoarthritis: A randomized placebo-controlled trial. Inflammopharmacology 2013; 21:129-136.
23. Belcaro G, Cesarone MR, Dugall M, et al.: Efficacy and safety of Meriva(R), a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients. Altern Med Rev 2010;15:337-344.
24. Chandran B, Goel A: A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytother Res 2012;26:1719-1725.
25. Altman RD: Criteria for the classification of osteoarthritis of the knee and hip. Scand J Rheumatol Suppl 1987;65:31-39.
26. Bellamy N: WOMAC: a 20-year experiential review of a patientcentered self-reported health status questionnaire. J Rheumatol 2002;29:2473-2476.
27. Migliore A, Granata M, Tormenta S, et al.: Hip viscosupplementation under ultra-sound guidance riduces NSAID consumption in symptomatic hip osteoarthritis patients in a long follow-up. Data from Italian registry. Eur Rev Med Pharmacol Sci 2011;15:25-34.
28. Higgins JP, Altman DG, Gotzsche PC, et al.: The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ 2011;343:d5928.
29. Higgins JP, Thompson SG, Deeks JJ, Altman DG: Measuring inconsistency in meta-analyses. BMJ 2003;327:557-560.
30. He Y, Yue Y, Zheng X, Zhang K, Chen S, Du Z: Curcumin, inflammation, and chronic diseases: How are they linked? Molecules 2015;20:9183-9213.
31. Moyer RF, Ratneswaran A, Beier F, Birmingham TB: Osteoarthritis year in review 2014: Mechanics-Basic and clinical studies in osteoarthritis. Osteoarthritis Cartilage 2014;22:1989-2002.
32. Mukherjee D, Nissen SE, Topol EJ: Risk of cardiovascular events associated with selective COX-2 inhibitors. JAMA 2001; 286:954-959.
33. Towheed TE, Maxwell L, Anastassiades TP, et al.: Glucosamine therapy for treating osteoarthritis. Cochrane Database Syst Rev 2005:Cd002946.
34. Rintelen B, Neumann K, Leeb BF: A meta-analysis of controlled clinical studies with diacerein in the treatment of osteoarthritis. Arch Intern Med 2006;166:1899-1906.
35. Pavelka K: A comparison of the therapeutic efficacy of diclofenac in osteoarthritis: A systematic review of randomised controlled trials. Curr Med Res Opin 2012;28:163-178.
36. Fidelix TS, Macedo CR, Maxwell LJ, Fernandes Moca Trevisani V: Diacerein for osteoarthritis. Cochrane Database Syst Rev 2014;2:Cd005117.
37. Dostrovsky NR, Towheed TE, Hudson RW, Anastassiades TP: The effect of glucosamine on glucose metabolism in humans: A systematic review of the literature. Osteoarthritis Cartilage 2011; 19:375-380.
38. Mobasheri A, Henrotin Y, Biesalski HK, Shakibaei M: Scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health. Int J Mol Sci 2012; 13:4202-4232.
39. Clutterbuck AL, Asplin KE, Harris P, Allaway D, Mobasheri A: Targeting matrix metalloproteinases in inflammatory conditions. Curr Drug Targets 2009;10:1245-1254.
40. Shen L, Liu CC, An CY, Ji HF: How does curcumin work with poor bioavailability? Clues from experimental and theoretical studies. Sci Rep 2016;6:20872.
41. Sharma RA, McLelland HR, Hill KA, et al.: Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer. Clin Cancer Res 2001;7:1894-1900.
42. Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB: Bioavailability of curcumin: Problems and promises. Mol Pharm 2007;4:807-818.
43. Lao CD, Ruffin MT 4th, Normolle D, et al.: Dose escalation of a curcuminoid formulation. BMC Complement Altern Med 2006;6:10.
44. Heger M, van Golen RF, Broekgaarden M, Michel MC: The molecular basis for the pharmacokinetics and pharmacodynamics of curcumin and its metabolites in relation to cancer. Pharmacol Rev 2014;66:222-307.
45. Wang YJ, Pan MH, Cheng AL, et al.: Stability of curcumin in buffer solutions and characterization of its degradation products. J Pharm Biomed Anal 1997;15:1867-1876.
46. Gupta SC, Patchva S, Koh W, Aggarwal BB: Discovery of curcumin, a component of golden spice, and its miraculous biological activities. Clin Exp Pharmacol Physiol 2012;39:283-299.
47. Posadzki P, Watson LK, Ernst E: Adverse effects of herbal medicines: An overview of systematic reviews. Clin Med 2013; 13:7-12.
48. Aggarwal BB, Harikumar KB: Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol 2009;41: 40-59.
49. Fan X, Zhang C, Liu DB, Yan J, Liang HP: The clinical applications of curcumin: Current state and the future. Curr Pharm Des 2013;19:2011-2031.