The OC43 human coronavirus envelope protein is critical for infectious virus production and propagation in neuronal cells and is a determinant of neurovirulence and CNS pathology

Virology

Volumn 515, Issue , 2018, Pages 134-149

  Stodola, Jenny K ^a   Dubois, Guillaume ^a   Le Coupanec, Alain ^a   Desforges, Marc ^a   Talbot, Pierre J ^a  

^a INRS INSTITUT ARMAND FRAPPIER   (Canada)

Author keywords

Coronavirus; E protein; HCoV OC43; Pathogenesis; PDZ binding motif; Transmembrane domain; Virus production

Indexed keywords

ION CHANNEL; PDZ PROTEIN; VIRUS ENVELOPE PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CENTRAL NERVOUS SYSTEM INFECTION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN CORONAVIRUS OC43; MALE; MOUSE; NEURONAL CELL LINE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; VIRION; VIRUS INFECTIVITY; VIRUS RECOMBINANT; VIRUS REPLICATION; VIRUS STRAIN; VIRUS VIRULENCE; ANIMAL; C57BL MOUSE; CELL LINE; CENTRAL NERVOUS SYSTEM; CORONAVIRUS INFECTION; GENETICS; METABOLISM; NERVE CELL; PATHOGENICITY; PATHOLOGY; PHYSIOLOGY; VIROLOGY; VIRULENCE;

ANIMALS; CELL LINE; CENTRAL NERVOUS SYSTEM; CORONAVIRUS INFECTIONS; CORONAVIRUS OC43, HUMAN; FEMALE; HUMANS; MALE; MICE; MICE, INBRED C57BL; NEURONS; VIRAL ENVELOPE PROTEINS; VIRULENCE;

EID: 85039147968     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2017.12.023     Document Type: Article

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