Glutamate excitotoxicity is involved in the induction of paralysis in mice after infection by a human coronavirus with a single point mutation in its spike protein

Journal of Virology

Volumn 85, Issue 23, 2011, Pages 12464-12473

  Brison, Elodie ^a   Jacomy, Hélène ^a   Desforges, Marc ^a   Talbot, Pierre J ^a  

^a INRS INSTITUT ARMAND FRAPPIER   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 AMINOPHENYL) 4 METHYL 7,8 METHYLENEDIOXY 5H 2,3 BENZODIAZEPINE; AMPA RECEPTOR; GLIAL GLUTAMATE TRANSPORTER 1; GLUTAMATE TRANSPORTER; GLUTAMIC ACID; UNCLASSIFIED DRUG; VIRUS SPIKE PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN; CELL ACTIVATION; CONTROLLED STUDY; CORONAVIRUS; CORONAVIRUS INFECTION; DOWN REGULATION; EXCITOTOXICITY; FEMALE; HINDLIMB; HUMAN CORONAVIRUS OC43; MICROGLIA; MOTOR DYSFUNCTION; MOUSE; NERVE CELL; NEUROFILAMENT; NONHUMAN; PARALYSIS; PERSISTENT VIRUS INFECTION; POINT MUTATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SCORING SYSTEM; SPINAL CORD; SURVIVAL RATE; VIRUS MUTANT;

ANIMALS; BENZODIAZEPINES; BLOTTING, WESTERN; CORONAVIRUS INFECTIONS; CORONAVIRUS OC43, HUMAN; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; GLUTAMIC ACID; HUMANS; IMMUNOENZYME TECHNIQUES; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; NEUROGLIA; NEURONS; PARALYSIS; POINT MUTATION; RECEPTORS, AMPA; SURVIVAL RATE; VIRAL ENVELOPE PROTEINS;

CORONAVIRUS; MUS;

EID: 81255184318     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.05576-11     Document Type: Article

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