Attenuation of rabies virulence: Takeover by the cytoplasmic domain of its envelope protein

Science Signaling

Volumn 3, Issue 105, 2010, Pages

  Préhaud, Christophe ^a   Wolff, Nicolas ^a,b   Terrien, Elouan ^a,b   Lafage, Mireille ^a,b   Mégret, Françoise ^a   Babault, Nicolas ^a,b   Cordier, Florence ^a,b   Tan, Gene S ^c   Maitrepierre, Elodie ^a,b   Ménager, Pauline ^a   Chopy, Damien ^a   Hoos, Sylviane ^a   England, Patrick ^a   Delepierre, Muriel ^a,b   Schnell, Matthias J ^c   Buc, Henri ^a   Lafon, Monique ^a  

^a INSTITUT PASTEUR   (France)

^b Unité de Résonance Magnétique   (France)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 4; PDZ PROTEIN; PROTEIN MAST1; PROTEIN MAST2; PROTEIN SERINE THREONINE KINASE; THROMBOSPONDIN; UNCLASSIFIED DRUG; PTPN4 PROTEIN, MOUSE; VIRUS ENVELOPE PROTEIN;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL FATE; CELL SURVIVAL; CELLULAR DISTRIBUTION; FEMALE; HUMAN; HUMAN CELL; MICROBIAL ATTENUATION; MOUSE; NERVE CELL; NONHUMAN; PDZ DOMAIN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; RABIES VIRUS; VIRUS STRAIN; VIRUS VIRULENCE; AMINO ACID SUBSTITUTION; ANIMAL; CHEMISTRY; CYTOPLASM; METABOLISM; PATHOGENICITY; PHYSIOLOGY; RABIES; VIROLOGY; VIRULENCE;

RABIES VIRUS;

AMINO ACID SUBSTITUTION; ANIMALS; APOPTOSIS; CYTOPLASM; MICE; NEURONS; PDZ DOMAINS; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 4; PROTEIN-SERINE-THREONINE KINASES; RABIES; RABIES VIRUS; VIRAL ENVELOPE PROTEINS; VIRULENCE;

EID: 77952302814     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2000510     Document Type: Article

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38. This work was supported by grants from Institut Pasteur (IP) and Agence Nationale pour la Recherche (ANR) MIME. E.T., D.C., and N.B. are recipients of Ministère de l'Education et de la Recherche fellowships, and P.M. is a recipient of an ANR fellowship. We thank P. Roux, J. D'Alayer, V. Bondet, E. Frachon, J. Bellalou, and J.-F. Charles from IP core facilities for their help. We thank S. Loh and P. Nicotera for the gift of the SH-SY5Y cells, B. Dietzschold for fruitful discussions, E. Vinolo and B. Ruggiero for help in twohybrid result interpretation, and F. Rey for his support.