Identification of the Mechanisms Causing Reversion to Virulence in an Attenuated SARS-CoV for the Design of a Genetically Stable Vaccine

PLoS Pathogens

Volumn 11, Issue 10, 2015, Pages

  Jimenez Guardeño, Jose M ^a   Regla Nava, Jose A ^a   Nieto Torres, Jose L ^a   DeDiego, Marta L ^a,c   Castaño Rodriguez, Carlos ^a   Fernandez Delgado, Raul ^a   Perlman, Stanley ^b   Enjuanes, Luis ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; NUCLEOPORIN; SEVERE ACUTE RESPIRATORY SYNDROME VACCINE; LIVE VACCINE; RECOMBINANT VACCINE; VIRUS VACCINE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; GENE DELETION; GENE EXPRESSION; GENE MUTATION; GENE SEQUENCE; GENETIC STABILITY; HISTOLOGY; MOUSE; NONHUMAN; PHENOTYPE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVERTANT; SARS CORONAVIRUS; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; VIROGENESIS; VIRUS GENOME; VIRUS VIRULENCE; WESTERN BLOTTING; ANIMAL; BAGG ALBINO MOUSE; CELL CULTURE; FEMALE; GROWTH, DEVELOPMENT AND AGING; IMMUNOLOGY; PATHOGENICITY; VIRULENCE;

ANIMALS; CELLS, CULTURED; FEMALE; MICE; MICE, INBRED BALB C; SARS VIRUS; VACCINES, ATTENUATED; VACCINES, SYNTHETIC; VIRAL VACCINES; VIRULENCE;

EID: 84946039010     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1005215     Document Type: Article

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