Activation of KGFR-Akt-mTOR-Nrf2 signaling protects human retinal pigment epithelium cells from Ultra-violet

Biochemical and Biophysical Research Communications

Volumn 495, Issue 3, 2018, Pages 2171-2177

  Hu, Haitao ^a,b   Hao, Lanxiang ^b   Tang, Chunzhou ^a   Zhu, Yunxi ^a   Jiang, Qin ^a   Yao, Jin ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b Yancheng City No1 People's Hospital   (China)

Author keywords

Akt mTORC1; Keratinocyte growth factor (KGF); Nrf2; Retinal pigment epithelium (RPE) cells; Ultra violet (UV)

Indexed keywords

KERATINOCYTE GROWTH FACTOR; KERATINOCYTE GROWTH FACTOR RECEPTOR; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SERINE; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR NRF2; FGF7 PROTEIN, HUMAN; FIBROBLAST GROWTH FACTOR RECEPTOR 2; MTOR PROTEIN, HUMAN; NFE2L2 PROTEIN, HUMAN; ONCOPROTEIN; TARGET OF RAPAMYCIN KINASE;

APOPTOSIS; ARPE-19 CELL LINE; ARTICLE; CELL DEATH; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; GCLC GENE; GENE; HO1 GENE; HUMAN; HUMAN CELL; NOQ1 GENE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; RETINAL PIGMENT EPITHELIUM; SIGNAL TRANSDUCTION; ULTRAVIOLET RADIATION; CELL CULTURE; DIAGNOSTIC IMAGING; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; PHYSIOLOGY; RADIATION DOSE; RADIATION RESPONSE; TREATMENT OUTCOME;

CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLAST GROWTH FACTOR 7; HUMANS; NF-E2-RELATED FACTOR 2; ONCOGENE PROTEIN V-AKT; RADIATION DOSAGE; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 2; RETINAL PIGMENT EPITHELIUM; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TREATMENT OUTCOME; ULTRAVIOLET RAYS;

EID: 85038966181     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2017.12.078     Document Type: Article

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