Thermodynamic properties of leukotriene A4hydrolase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 24, Issue 21, 2016, Pages 5243-5248

  Wittmann, Sandra K ^a   Kalinowsky, Lena ^a   Kramer, Jan S ^a   Bloecher, René ^a   Knapp, Stefan ^a   Steinhilber, Dieter ^a   Pogoryelov, Denys ^a   Proschak, Ewgenij ^a   Heering, Jan ^b  

^a GOETHE UNIVERSITY   (Germany)

^b FRAUNHOFER INSTITUTE FOR MOLECULAR BIOLOGY AND APPLIED ECOLOGY IME   (Germany)

Author keywords

Apo structure; Ligand binding; LTA4H; Water mapping

Indexed keywords

BESTATIN; CAPTOPRIL; LEUKOTRIENE A4 HYDROLASE; LEUKOTRIENE A4 HYDROLASE INHIBITOR; N [3 (4 BENZYLPHENOXY)PROPYL] N METHYL BETA ALANINE; ENZYME INHIBITOR; EPOXIDE HYDROLASE;

ARTICLE; BIOPHYSICS; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG BINDING SITE; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME PURIFICATION; ENZYME STRUCTURE; FLUORESCENCE; HUMAN; MOLECULAR CLONING; PROTEIN EXPRESSION; THERMODYNAMICS; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; METABOLISM; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; EPOXIDE HYDROLASES; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 84991508660     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2016.08.047     Document Type: Article

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