Transcription Factor IRF4 Promotes CD8+ T Cell Exhaustion and Limits the Development of Memory-like T Cells during Chronic Infection

Immunity

Volumn 47, Issue 6, 2017, Pages 1129-1141.e5

  Man, Kevin ^a,b,g   Gabriel, Sarah S ^a,b   Liao, Yang ^a,b   Gloury, Renee ^a,b   Preston, Simon ^a,b   Henstridge, Darren C ^c   Pellegrini, Marc ^a,b   Zehn, Dietmar ^d   Berberich Siebelt, Friederike ^e   Febbraio, Mark A ^f   Shi, Wei ^a,b   Kallies, Axel ^a,b  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^e UNIVERSITY OF WÜRZBURG   (Germany)

^f GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^g UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

BATF; CD8+; chronic infection; differentiation; exhaustion; IRF4; memory; metabolic function; NAICE; NFAT; NFAT_AP 1_IRF4 composite element; TCF1; transcription

Indexed keywords

TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR IRF4; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG; BASIC LEUCINE ZIPPER TRANSCRIPTION FACTOR; BATF PROTEIN, MOUSE; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; HNF1A PROTEIN, MOUSE; INTERFERON REGULATORY FACTOR; INTERFERON REGULATORY FACTOR-4; LYMPHOCYTE ANTIGEN RECEPTOR; NFATC1 PROTEIN, MOUSE; PDCD1 PROTEIN, MOUSE; PROGRAMMED DEATH 1 RECEPTOR;

ANIMAL CELL; ANTIGEN SPECIFICITY; ARTICLE; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL METABOLISM; CELL STIMULATION; COMPARATIVE STUDY; CONTROLLED STUDY; GENETIC CODE; GENETIC TRANSCRIPTION; INFECTION; LYMPHOCYTE FUNCTION; MEMORY T LYMPHOCYTE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; ANIMAL; DEFICIENCY; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HEK293 CELL LINE; HUMAN; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; KNOCKOUT MOUSE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DEPLETION; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; SIGNAL TRANSDUCTION; VIROLOGY;

ANIMALS; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; GENE EXPRESSION REGULATION; HEK293 CELLS; HEPATOCYTE NUCLEAR FACTOR 1-ALPHA; HUMANS; IMMUNOLOGIC MEMORY; INTERFERON REGULATORY FACTORS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DEPLETION; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MICE; MICE, KNOCKOUT; NFATC TRANSCRIPTION FACTORS; PROGRAMMED CELL DEATH 1 RECEPTOR; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION;

EID: 85037719884     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2017.11.021     Document Type: Article

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