NFATc1/A: The other face of NFAT factors in lymphocytes

Cell Communication and Signaling

Volumn 10, Issue , 2012, Pages

  Serfling, Edgar ^a   Avots, Andris ^a   Klein Hessling, Stefan ^a   Rudolf, Ronald ^a   Vaeth, Martin ^a   Berberich Siebelt, Friederike ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Activation induced cell death AICD; Anergy; Apoptosis; Calcineurin; NF B; NFATc; NFATc1 A; Proliferation

Indexed keywords

TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFATC1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; AUTOREGULATION; B LYMPHOCYTE; BINDING AFFINITY; CALCIUM TRANSPORT; CD4+ T LYMPHOCYTE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL DEATH; CELL SURVIVAL; CYTOKINE PRODUCTION; GENE; HUMAN; IMMUNE RESPONSE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; NFATC1 GENE; NFATC2 GENE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE;

EID: 84865267868     PISSN: None     EISSN: 1478811X     Source Type: Journal    
DOI: 10.1186/1478-811X-10-16     Document Type: Article

References (98)

1. Transcriptional regulation by calcium, calcineurin, and NFAT. Hogan PG, Chen L, Nardone J, Rao A, Genes Dev 2003 17 2205 2232 10.1101/gad.1102703 12975316 (Pubitemid 37128637)
2. NFAT signaling: choreographing the social lives of cells. Crabtree GR, Olson EN, Cell 2002 109 Suppl 67 S79 11983154
3. The role of NF-AT transcription factors in T cell activation and differentiation. Serfling E, Berberich-Siebelt F, Chuvpilo S, Jankevics E, Klein-Hessling S, Twardzik T, Avots A, Biochim Biophys Acta 2000 1498 1 18 10.1016/S0167-4889(00)00082-3 11042346
4. NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun. Lopez-Rodriguez C, Aramburu J, Rakeman AS, Rao A, Proc Natl Acad Sci USA 1999 96 7214 7219 10.1073/pnas.96.13.7214 10377394 (Pubitemid 29299641)
5. A T cell nuclear factor resembling NF-AT binds to an NF-kappa B site and to the conserved lymphokine promoter sequence "cytokine-1". McCaffrey PG, Jain J, Jamieson C, Sen R, Rao A, J Biol Chem 1992 267 1864 1871 1730723
6. NFAT and NF-kappaB factors-the distant relatives. Serfling E, Berberich-Siebelt F, Avots A, Chuvpilo S, Klein-Hessling S, Jha MK, Kondo E, Pagel P, Schulze-Luehrmann J, Palmetshofer A, Int J Biochem Cell Biol 2004 36 1166 1170 10.1016/j.biocel.2003.07.002 15109564 (Pubitemid 38515658)
7. Structure of NFAT1 bound as a dimer to the HIV-1 LTR kappa B element. Giffin MJ, Stroud JC, Bates DL, von Koenig KD, Hardin J, Chen L, Nat Struct Biol 2003 10 800 806 10.1038/nsb981 12949493 (Pubitemid 37187650)
8. An asymmetric NFAT1 dimer on a pseudo-palindromic kappa B-like DNA site. Jin L, Sliz P, Chen L, Macian F, Rao A, Hogan PG, Harrison SC, Nat Struct Biol 2003 10 807 811 10.1038/nsb975 12949491 (Pubitemid 37187651)
9. Identification of a putative regulator of early T cell activation genes. Shaw JP, Utz PJ, Durand DB, Toole JJ, Emmel EA, Crabtree GR, Science 1988 241 202 205 10.1126/science.3260404 3260404
10. Ubiquitous and lymphocyte-specific factors are involved in the induction of the mouse interleukin 2 gene in T lymphocytes. Serfling E, Barthelmas R, Pfeuffer I, Schenk B, Zarius S, Swoboda R, Mercurio F, Karin M, EMBO J 1989 8 465 473 2542017 (Pubitemid 19274965)
11. Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum. de la Pompa JL, Timmerman LA, Takimoto H, Yoshida H, Elia AJ, Samper E, Potter J, Wakeham A, Marengere L, Langille BL, et al. Nature 1998 392 182 186 10.1038/32419 9515963 (Pubitemid 28162791)
12. The transcription factor NF-ATc is essential for cardiac valve formation. Ranger AM, Grusby MJ, Hodge MR, Gravallese EM, de la Brousse FC, Hoey T, Mickanin C, Baldwin HS, Glimcher LH, Nature 1998 392 186 190 10.1038/32426 9515964 (Pubitemid 28162792)
13. An enhanced immune response in mice lacking the transcription factor NFAT1. Xanthoudakis S, Viola JP, Shaw KT, Luo C, Wallace JD, Bozza PT, Luk DC, Curran T, Rao A, Science 1996 272 892 895 10.1126/science.272.5263.892 8629027
14. Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice. Hodge MR, Ranger AM, Charles De La Brousse F, Hoey T, Grusby MJ, Glimcher LH, Immunity 1996 4 397 405 10.1016/S1074-7613(00)80253-8 8612134 (Pubitemid 26174981)
15. NF-ATp plays a prominent role in the transcriptional induction of Th2-type lymphokines. Schuh K, Kneitz B, Heyer J, Siebelt F, Fischer C, Jankevics E, Rude E, Schmitt E, Schimpl A, Serfling E, Immunol Lett 1997 57 171 175 10.1016/S0165-2478(97)00068-0 9232447 (Pubitemid 27319334)
16. The interleukin 2 receptor alpha chain/CD25 promoter is a target for nuclear factor of activated T cells. Schuh K, Twardzik T, Kneitz B, Heyer J, Schimpl A, Serfling E, J Exp Med 1998 188 1369 1373 10.1084/jem.188.7.1369 9763616 (Pubitemid 28478025)
17. Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development. Ranger AM, Oukka M, Rengarajan J, Glimcher LH, Immunity 1998 9 627 635 10.1016/S1074-7613(00)80660-3 9846484 (Pubitemid 28557591)
18. NFATc2 and NFATc3 regulate T(H)2 differentiation and modulate TCR-responsiveness of naive T(H)cells. Rengarajan J, Tang B, Glimcher LH, Nat Immunol 2002 3 48 54 10.1038/ni744 11740499 (Pubitemid 34065617)
19. Sequential involvement of NFAT and Egr transcription factors in FasL regulation. Rengarajan J, Mittelstadt PR, Mages HW, Gerth AJ, Kroczek RA, Ashwell JD, Glimcher LH, Immunity 2000 12 293 300 10.1016/S1074-7613(00)80182-X 10755616
20. The transcription factor NFAT4 is involved in the generation and survival of T cells. Oukka M, Ho IC, de la Brousse FC, Hoey T, Grusby MJ, Glimcher LH, Immunity 1998 9 295 304 10.1016/S1074-7613(00)80612-3 9768749 (Pubitemid 28462750)
21. Selective role of NFATc3 in positive selection of thymocytes. Cante-Barrett K, Winslow MM, Crabtree GR, J Immunol 2007 179 103 110 17579027 (Pubitemid 46986523)
22. The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production. Yoshida H, Nishina H, Takimoto H, Marengere LE, Wakeham AC, Bouchard D, Kong YY, Ohteki T, Shahinian A, Bachmann M, et al. Immunity 1998 8 115 124 10.1016/S1074-7613(00)80464-1 9462517 (Pubitemid 28097829)
23. Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc. Ranger AM, Hodge MR, Gravallese EM, Oukka M, Davidson L, Alt FW, de la Brousse FC, Hoey T, Grusby M, Glimcher LH, Immunity 1998 8 125 134 10.1016/S1074-7613(00)80465-3 9462518 (Pubitemid 28097830)
24. NFATc1 affects mouse splenic B cell function by controlling the calcineurin - NFAT signaling network. Bhattacharyya S, Deb J, Patra AK, Thuy Pham DA, Chen W, Vaeth M, Berberich-Siebelt F, Klein-Hessling S, Lamperti ED, Reifenberg K, et al. J Exp Med 2011 208 823 839 10.1084/jem.20100945 21464221
25. Normal B-1a cell development requires B cell-intrinsic NFATc1 activity. Berland R, Wortis HH, Proc Natl Acad Sci USA 2003 100 13459 13464 10.1073/pnas.2233620100 14595020 (Pubitemid 37444764)
26. Inhibition of calcineurin-NFAT signaling by the pyrazolopyrimidine compound NCI3. Sieber M, Karanik M, Brandt C, Blex C, Podtschaske M, Erdmann F, Rost R, Serfling E, Liebscher J, Patzel M, et al. Eur J Immunol 2007 37 2617 2626 10.1002/eji.200737087 17694572 (Pubitemid 47423629)
27. The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease. Liu Z, Lee J, Krummey S, Lu W, Cai H, Lenardo MJ, Nat Immunol 2011 12 1063 1070 10.1038/ni.2113 21983832
28. A strategy for probing the function of noncoding RNAs finds a repressor of NFAT. Willingham AT, Orth AP, Batalov S, Peters EC, Wen BG, Aza-Blanc P, Hogenesch JB, Schultz PG, Science 2005 309 1570 1573 10.1126/science.1115901 16141075 (Pubitemid 41266484)
29. Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex. Sharma S, Findlay GM, Bandukwala HS, Oberdoerffer S, Baust B, Li Z, Schmidt V, Hogan PG, Sacks DB, Rao A, Proc Natl Acad Sci USA 2011 108 11381 11386 10.1073/pnas.1019711108 21709260
30. Calcium signalling in lymphocyte activation and disease. Feske S, Nat Rev Immunol 2007 7 690 702 10.1038/nri2152 17703229 (Pubitemid 47327393)
31. Molecular basis of calcium signaling in lymphocytes: STIM and ORAI. Hogan PG, Lewis RS, Rao A, Annu Rev Immunol 2010 28 491 533 10.1146/annurev.immunol. 021908.132550 20307213
32. Interaction of calcineurin with substrates and targeting proteins. Li H, Rao A, Hogan PG, Trends Cell Biol 2011 21 91 103 10.1016/j.tcb.2010.09.011 21115349
33. A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants. Rodriguez A, Roy J, Martinez-Martinez S, Lopez-Maderuelo MD, Nino-Moreno P, Orti L, Pantoja-Uceda D, Pineda-Lucena A, Cyert MS, Redondo JM, Mol Cell 2009 33 616 626 10.1016/j.molcel.2009.01.030 19285944
34. Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity. Okamura H, Aramburu J, Garcia-Rodriguez C, Viola JP, Raghavan A, Tahiliani M, Zhang X, Qin J, Hogan PG, Rao A, Mol Cell 2000 6 539 550 10.1016/S1097-2765(00)00053-8 11030334
35. Autoregulation of NFATc1/A expression facilitates effector T cells to escape from rapid apoptosis. Chuvpilo S, Jankevics E, Tyrsin D, Akimzhanov A, Moroz D, Jha MK, Schulze-Luehrmann J, Santner-Nanan B, Feoktistova E, Konig T, et al. Immunity 2002 16 881 895 10.1016/S1074-7613(02)00329-1 12121669 (Pubitemid 34786486)
36. Multiple NF-ATc isoforms with individual transcriptional properties are synthesized in T lymphocytes. Chuvpilo S, Avots A, Berberich-Siebelt F, Glockner J, Fischer C, Kerstan A, Escher C, Inashkina I, Hlubek F, Jankevics E, et al. J Immunol 1999 162 7294 7301 10358178 (Pubitemid 29277703)
37. Mechanisms of transactivation by nuclear factor of activated T cells-1. Luo C, Burgeon E, Rao A, J Exp Med 1996 184 141 147 10.1084/jem.184.1.141 8691127 (Pubitemid 26247223)
38. Sumoylation of the transcription factor NFATc1 leads to its subnuclear relocalization and interleukin-2 repression by histone deacetylase. Nayak A, Glöckner-Pagel J, Vaeth M, Schumann JE, Buttmann M, Bopp T, Schmitt E, Serfling E, Berberich-Siebelt F, J Biol Chem 2009 284 10935 10946 10.1074/jbc.M900465200 19218564
39. Hock M, Vaeth M, Muhammad K, Rudolf R, Pusch T, Berberich-Siebelt F, Tyrsin D, Chuvpilo S, Avots A, Serfling E, Klein-Hessling S, The induction of NFATc1 in peripheral T and B lymphocytes, 2012 Submitted for publication
40. A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Fontenot JD, Rudensky AY, Nat Immunol 2005 6 331 337 10.1038/ni1179 15785758 (Pubitemid 41716769)
41. FOXP3 inhibits activation-induced NFAT2 expression in T cells thereby limiting effector cytokine expression. Torgerson TR, Genin A, Chen C, Zhang M, Zhou B, Anover-Sombke S, Frank MB, Dozmorov I, Ocheltree E, Kulmala P, et al. J Immunol 2009 183 907 915 10.4049/jimmunol.0800216 19564342
42. Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression. Bopp T, Becker C, Klein M, Klein-Hessling S, Palmetshofer A, Serfling E, Heib V, Becker M, Kubach J, Schmitt S, et al. J Exp Med 2007 204 1303 1310 10.1084/jem.20062129 17502663 (Pubitemid 46919868)
43. Regulatory T cells facilitate the nuclear accumulation of inducible cAMP early repressor (ICER) and suppress nuclear factor of activated T cell c1 (NFATc1). Vaeth M, Gogishvili T, Bopp T, Klein M, Berberich-Siebelt F, Gattenloehner S, Avots A, Sparwasser T, Grebe N, Schmitt E, et al. Proc Natl Acad Sci USA 2011 108 2480 2485 10.1073/pnas.1009463108 21262800
44. Alternative polyadenylation events contribute to the induction of NF-ATc in effector T cells. Chuvpilo S, Zimmer M, Kerstan A, Glockner J, Avots A, Escher C, Fischer C, Inashkina I, Jankevics E, Berberich-Siebelt F, et al. Immunity 1999 10 261 269 10.1016/S1074-7613(00)80026-6 10072078 (Pubitemid 29115631)
45. A Costimulation-Initiated Signaling Pathway Regulates NFATc1 Transcription in T Lymphocytes. Nurieva RI, Chuvpilo S, Wieder ED, Elkon KB, Locksley R, Serfling E, Dong C, J Immunol 2007 179 1096 1103 17617602
46. Regulation of the murine Nfatc1 gene by NFATc2. Zhou B, Cron RQ, Wu B, Genin A, Wang Z, Liu S, Robson P, Baldwin HS, J Biol Chem 2002 277 10704 10711 10.1074/jbc.M107068200 11786533 (Pubitemid 34968198)
47. Alternative splicing and expression of human and mouse NFAT genes. Vihma H, Pruunsild P, Timmusk T, Genomics 2008 92 279 291 10.1016/j.ygeno.2008.06.011 18675896
48. Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. Wei G, Wei L, Zhu J, Zang C, Hu-Li J, Yao Z, Cui K, Kanno Y, Roh TY, Watford WT, et al. Immunity 2009 30 155 167 10.1016/j.immuni.2008.12.009 19144320
49. Epigenetic Changes and Suppression of the Nuclear Factor of Activated T Cell 1 (NFATC1) Promoter in Human Lymphomas with Defects in Immunoreceptor Signaling. Akimzhanov A, Krenacs L, Schlegel T, Klein-Hessling S, Bagdi E, Stelkovics E, Kondo E, Chuvpilo S, Wilke P, Avots A, et al. Am J Pathol 2008 172 215 224 10.2353/ajpath.2008.070294 18156209 (Pubitemid 351186382)
50. NFATc1 autoregulation: a crucial step for cell-fate determination. Serfling E, Chuvpilo S, Liu J, Hofer T, Palmetshofer A, Trends Immunol 2006 27 461 469 10.1016/j.it.2006.08.005 16931157 (Pubitemid 44354312)
51. The NIH Roadmap Epigenomics Mapping Consortium. Bernstein BE, Stamatoyannopoulos JA, Costello JF, Ren B, Milosavljevic A, Meissner A, Kellis M, Marra MA, Beaudet AL, Ecker JR, et al. Nat Biotechnol 2010 28 1045 1048 10.1038/nbt1010-1045 20944595
52. Alternative poly(A) site selection in complex transcription units: means to an end? Edwalds-Gilbert G, Veraldi KL, Milcarek C, Nucleic Acids Res 1997 25 2547 2561 10.1093/nar/25.13.2547 9185563 (Pubitemid 27298148)
53. A central role for central tolerance. Kyewski B, Klein L, Annu Rev Immunol 2006 24 571 606 10.1146/annurev.immunol.23.021704.115601 16551260
54. T cell anergy. Schwartz RH, Annu Rev Immunol 2003 21 305 334 10.1146/annurev.immunol.21.120601.141110 12471050 (Pubitemid 37174534)
55. NFAT transcription factors in control of peripheral T cell tolerance. Serfling E, Klein-Hessling S, Palmetshofer A, Bopp T, Stassen M, Schmitt E, Eur J Immunol 2006 36 2837 2843 10.1002/eji.200536618 17039563 (Pubitemid 44782556)
56. Transcriptional mechanisms underlying lymphocyte tolerance. Macian F, Garcia-Cozar F, Im SH, Horton HF, Byrne MC, Rao A, Cell 2002 109 719 731 10.1016/S0092-8674(02)00767-5 12086671 (Pubitemid 34722268)
57. Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Heissmeyer V, Macian F, Im SH, Varma R, Feske S, Venuprasad K, Gu H, Liu YC, Dustin ML, Rao A, Nat Immunol 2004 5 255 265 14973438 (Pubitemid 38332122)
58. Transcriptional complexes formed by NFAT dimers regulate the induction of T cell tolerance. Soto-Nieves N, Puga I, Abe BT, Bandyopadhyay S, Baine I, Rao A, Macian F, J Exp Med 2009 206 867 876 10.1084/jem.20082731 19307325
59. Involvement of NFAT1 in B cell self-tolerance. Barrington RA, Borde M, Rao A, Carroll MC, J Immunol 2006 177 1510 1515 16849457 (Pubitemid 44092484)
60. Different nuclear signals are activated by the B cell receptor during positive versus negative signaling. Healy JI, Dolmetsch RE, Timmerman LA, Cyster JG, Thomas ML, Crabtree GR, Lewis RS, Goodnow CC, Immunity 1997 6 419 428 10.1016/S1074-7613(00)80285-X 9133421 (Pubitemid 27208197)
61. Behind the scenes of anergy: a tale of three E3s. Davis M, Ben-Neriah Y, Nat Immunol 2004 5 238 240 14985708 (Pubitemid 38332118)
62. The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation. Nurieva RI, Zheng S, Jin W, Chung Y, Zhang Y, Martinez GJ, Reynolds JM, Wang SL, Lin X, Sun SC, et al. Immunity 2010 32 670 680 10.1016/j.immuni.2010.05.002 20493730
63. T cell hyporesponsiveness induced by oral administration of ovalbumin is associated with impaired NFAT nuclear translocation and p27kip1 degradation. Asai K, Hachimura S, Kimura M, Toraya T, Yamashita M, Nakayama T, Kaminogawa S, J Immunol 2002 169 4723 4731 12391180 (Pubitemid 35217133)
64. Thymus and autoimmunity. Transplantation of the thymus from cyclosporin A-treated mice causes organ-specific autoimmune disease in athymic nude mice. Sakaguchi S, Sakaguchi N, J Exp Med 1988 167 1479 1485 10.1084/jem.167.4.1479 2965739
65. FOXP3: of mice and men. Ziegler SF, Annu Rev Immunol 2006 24 209 226 10.1146/annurev.immunol.24.021605.090547 16551248
66. FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT. Wu Y, Borde M, Heissmeyer V, Feuerer M, Lapan AD, Stroud JC, Bates DL, Guo L, Han A, Ziegler SF, et al. Cell 2006 126 375 387 10.1016/j.cell.2006.05.042 16873067 (Pubitemid 44092960)
67. Structure of a domain-swapped FOXP3 dimer on DNA and its function in regulatory T cells. Bandukwala HS, Wu Y, Feuerer M, Chen Y, Barboza B, Ghosh S, Stroud JC, Benoist C, Mathis D, Rao A, Chen L, Immunity 2011 34 479 491 10.1016/j.immuni.2011.02.017 21458306
68. T helper cell subsets in insulin-dependent diabetes. Katz JD, Benoist C, Mathis D, Science 1995 268 1185 1188 10.1126/science.7761837 7761837
69. NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4+ T lymphocytes by CD4+ CD25+ regulatory T cells. Bopp T, Palmetshofer A, Serfling E, Heib V, Schmitt S, Richter C, Klein M, Schild H, Schmitt E, Stassen M, J Exp Med 2005 201 181 187 10.1084/jem.20041538 15657288 (Pubitemid 40189426)
70. The dependence on NFAT levelsdiscriminates conventional T cells from Foxp3+ regulatory T cells. Vaeth M, Schlieer U, Reiig S, Satoh K, Jonuleit H, Waisman A, Müller MR, Serfling E, Sawitzki B, Berberich-Siebelt F, In revision 2012
71. Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation. Izcue A, Coombes JL, Powrie F, Immunol Rev 2006 212 256 271 10.1111/j.0105-2896.2006.00423.x 16903919 (Pubitemid 44116713)
72. Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer. Tone Y, Furuuchi K, Kojima Y, Tykocinski ML, Greene MI, Tone M, Nat Immunol 2008 9 194 202 10.1038/ni1549 18157133
73. Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivo. Gavin MA, Clarke SR, Negrou E, Gallegos A, Rudensky A, Nat Immunol 2002 3 33 41 11740498 (Pubitemid 34065615)
74. Regulation of the NFAT pathway discriminates CD4 + CD25+ regulatory T cells from CD4 + CD25- helper T cells. Sumpter TL, Payne KK, Wilkes DS, J Leukoc Biol 2008 83 708 717 18032693 (Pubitemid 351966881)
75. The hallmarks of cancer. Hanahan D, Weinberg RA, Cell 2000 100 57 70 10.1016/S0092-8674(00)81683-9 10647931 (Pubitemid 30046295)
76. NF-ATc2 induces apoptosis in Burkitt's lymphoma cells through signaling via the B cell antigen receptor. Kondo E, Harashima A, Takabatake T, Takahashi H, Matsuo Y, Yoshino T, Orita K, Akagi T, Eur J Immunol 2003 33 1 11 10.1002/immu.200390000 12594826 (Pubitemid 36157637)
77. Two NFAT transcription factor binding sites participate in the regulation of CD95 (Fas) ligand expression in activated human T cells. Latinis KM, Norian LA, Eliason SL, Koretzky GA, J Biol Chem 1997 272 31427 31434 10.1074/jbc.272.50.31427 9395475 (Pubitemid 28013280)
78. Novel Egr/NF-AT composite sites mediate activation of the CD95 (APO-1/Fas) ligand promoter in response to T cell stimulation. Li-Weber M, Laur O, Krammer PH, Eur J Immunol 1999 29 3017 3027 10.1002/(SICI)1521-4141(199909) 29:09<3017::AID-IMMU3017>3.0.CO;2-R 10508276 (Pubitemid 30099026)
79. FasL promoter activation by IL-2 through SP1 and NFAT but not Egr-2 and Egr-3. Xiao S, Matsui K, Fine A, Zhu B, Marshak-Rothstein A, Widom RL, Ju ST, Eur J Immunol 1999 29 3456 3465 10.1002/(SICI)1521-4141(199911)29:11<3456:: AID-IMMU3456>3.0.CO;2-B 10556800 (Pubitemid 29527793)
80. The human gp39 promoter. Two distinct nuclear factors of activated T cell protein-binding elements contribute independently to transcriptional activation. Schubert LA, King G, Cron RQ, Lewis DB, Aruffo A, Hollenbaugh D, J Biol Chem 1995 270 29624 29627 10.1074/jbc.270.50.29624 8530342 (Pubitemid 26002152)
81. A T-cell-specific CD154 transcriptional enhancer located just upstream of the promoter. Brunner M, Zhang M, Genin A, Ho IC, Cron RQ, Genes Immun 2008 9 640 649 10.1038/gene.2008.67 18719603
82. Up-regulation of c-FLIP short by NFAT contributes to apoptosis resistance of short-term activated T cells. Ueffing N, Schuster M, Keil E, Schulze-Osthoff K, Schmitz I, Blood 2008 112 690 698 10.1182/blood-2008-02-141382 18509086
83. Nfatc-genes as target of insertional mutagenesis in retrovirus- induclymphomas. Jessen R, PhD Thesis Aarhus University 2011
84. A tumor-suppressor function for NFATc3 in T-cell lymphomagenesis by murine leukemia virus. Glud SZ, Sorensen AB, Andrulis M, Wang B, Kondo E, Jessen R, Krenacs L, Stelkovics E, Wabl M, Serfling E, et al. Blood 2005 106 3546 3552 10.1182/blood-2005-02-0493 16051745 (Pubitemid 41609192)
85. Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks. Uren AG, Kool J, Matentzoglu K, de Ridder J, Mattison J, van Uitert M, Lagcher W, Sie D, Tanger E, Cox T, et al. Cell 2008 133 727 741 10.1016/j.cell.2008.03.021 18485879 (Pubitemid 351637624)
86. Genetic profile of insertion mutations in mouse leukemias and lymphomas. Hansen GM, Skapura D, Justice MJ, Genome Res 2000 10 237 243 10.1101/gr.10.2.237 10673281 (Pubitemid 30119592)
87. New genes involved in cancer identified by retroviral tagging. Suzuki T, Shen H, Akagi K, Morse HC, Malley JD, Naiman DQ, Jenkins NA, Copeland NG, Nat Genet 2002 32 166 174 10.1038/ng949 12185365 (Pubitemid 34977213)
88. RTCGD, 2011 Online: http://rtcdg.ncifcrf.gov/
89. The nuclear factor of activated T cells (NFAT) transcription factor NFATp (NFATc2) is a repressor of chondrogenesis. Ranger AM, Gerstenfeld LC, Wang J, Kon T, Bae H, Gravallese EM, Glimcher MJ, Glimcher LH, J Exp Med 2000 191 9 22 10.1084/jem.191.1.9 10620601 (Pubitemid 30043644)
90. Dual roles for NFAT transcription factor genes as oncogenes and tumor suppressors. Robbs BK, Cruz AL, Werneck MB, Mognol GP, Viola JP, Mol Cell Biol 2008 28 7168 7181 10.1128/MCB.00256-08 18809576
91. NFAT proteins: emerging roles in cancer progression. Mancini M, Toker A, Nat Rev Cancer 2009 9 810 820 10.1038/nrc2735 19851316
92. NFAT, immunity and cancer: a transcription factor comes of age. Muller MR, Rao A, Nat Rev Immunol 2010 10 645 656 10.1038/nri2818 20725108
93. An epigenetic chromatin remodeling role for NFATc1 in transcriptional regulation of growth and survival genes in diffuse large B-cell lymphomas. Pham LV, Tamayo AT, Li C, Bueso-Ramos C, Ford RJ, Blood 2010 116 3899 3906 10.1182/blood-2009-12-257378 20664054
94. Overexpression of c-myc in pancreatic cancer caused by ectopic activation of NFATc1 and the Ca2+/calcineurin signaling pathway. Buchholz M, Schatz A, Wagner M, Michl P, Linhart T, Adler G, Gress TM, Ellenrieder V, EMBO J 2006 25 3714 3724 10.1038/sj.emboj.7601246 16874304 (Pubitemid 44264881)
95. NFAT-induced histone acetylation relay switch promotes c-Myc-dependent growth in pancreatic cancer cells. Koenig A, Linhart T, Schlengemann K, Reutlinger K, Wegele J, Adler G, Singh G, Hofmann L, Kunsch S, Buch T, et al. Gastroenterology 2010 138 1181 1182
96. CBP/p300 integrates Raf/Rac-signaling pathways in the transcriptional induction of NF-ATc during T cell activation. Avots A, Buttmann M, Chuvpilo S, Escher C, Smola U, Bannister AJ, Rapp UR, Kouzarides T, Serfling E, Immunity 1999 10 515 524 10.1016/S1074-7613(00)80051-5 10367897 (Pubitemid 29262654)
97. Dual role of sumoylation in the nuclear localization and transcriptional activation of NFAT1. Terui Y, Saad N, Jia S, McKeon F, Yuan J, J Biol Chem 2004 279 28257 28265 10.1074/jbc.M403153200 15117942 (Pubitemid 38900103)
98. B cell hyperresponsiveness and expansion of mature follicular B cells but not of marginal zone B cells in NFATc2/c3 double-deficient mice. Samanta DN, Palmetshofer A, Marinkovic D, Wirth T, Serfling E, Nitschke L, J Immunol 2005 174 4797 4802 15814705