The hydrophobic trap—the Achilles heel of RND efflux pumps

Research in Microbiology

Volumn 169, Issue 7-8, 2018, Pages 393-400

  Aron, Zachary ^a   Opperman, Timothy J ^a  

^a MICROBIOTIX INC   (United States)

Author keywords

Adjunctive therapy; Efflux pump; Efflux pump inhibitor; Hydrophobic trap; RND superfamily

Indexed keywords

ARTICLE; BACTERIAL PHENOMENA AND FUNCTIONS; BINDING AFFINITY; BINDING SITE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; HYDROPHOBICITY; NONHUMAN; PRIORITY JOURNAL; RESISTANCE NODULATION DIVISION EFFLUX PUMP; ANTAGONISTS AND INHIBITORS; CHEMICAL PHENOMENA; CHEMISTRY; DRUG DESIGN; DRUG EFFECT; GENETICS; GRAM NEGATIVE BACTERIUM; METABOLISM; MULTIDRUG RESISTANCE; MULTIGENE FAMILY;

ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; CARRIER PROTEIN;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BINDING SITES; DRUG DESIGN; DRUG RESISTANCE, MULTIPLE, BACTERIAL; GRAM-NEGATIVE BACTERIA; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MEMBRANE TRANSPORT PROTEINS; MULTIGENE FAMILY;

EID: 85035756961     PISSN: 09232508     EISSN: 17697123     Source Type: Journal    
DOI: 10.1016/j.resmic.2017.11.001     Document Type: Article

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