Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB

eLife

Volumn 3, Issue , 2014, Pages

  Eicher, Thomas ^a   Seeger, Markus A ^a   Anselmi, Claudio ^a   Zhou, Wenchang ^a   Brandstätter, Lorenz ^a   Verrey, François ^a   Diederichs, Kay ^a   Faraldo Gómez, José D ^a   Pos, Klaas M ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

antibiotic resistance; biochemistry; biophysics; drug resistance; drug transport; E. coli; efflux pump; H+ transport; mechanistic coupling; structural biology

Indexed keywords

ACRB PROTEIN, E COLI; ESCHERICHIA COLI PROTEIN; MULTIDRUG RESISTANCE PROTEIN; PROTON; WATER;

ANTIBIOTIC RESISTANCE; BINDING SITE; CHEMISTRY; ESCHERICHIA COLI; KINETICS; METABOLISM; MOLECULAR DYNAMICS; PH; PROBABILITY; PROMOTER REGION; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SOFTWARE; X RAY CRYSTALLOGRAPHY; X RAY DIFFRACTION;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HYDROGEN-ION CONCENTRATION; KINETICS; MOLECULAR DYNAMICS SIMULATION; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PROBABILITY; PROMOTER REGIONS, GENETIC; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTONS; SOFTWARE; WATER; X-RAY DIFFRACTION;

EID: 85006314889     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.03145     Document Type: Article

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