Structure-activity relationships of a novel pyranopyridine series of Gram-negative bacterial efflux pump inhibitors

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 9, 2015, Pages 2024-2034

  Nguyen, Son T ^a   Kwasny, Steven M ^a   Ding, Xiaoyuan ^a   Cardinale, Steven C ^a   McCarthy, Courtney T ^a   Kim, Hong Suk ^b   Nikaido, Hiroshi ^b   Peet, Norton P ^a   Williams, John D ^a   Bowlin, Terry L ^a   Opperman, Timothy J ^a  

^a MICROBIOTIX INC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adjunctive therapy; Antibacterial; Efflux pump inhibitor; Enterobacteriaceae; Pyranopyridine

Indexed keywords

ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; MBX2319; PYRAN DERIVATIVE; PYRIDINE DERIVATIVE;

ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; ENTEROBACTERIACEAE; ESCHERICHIA COLI; METABOLISM; MICROBIAL SENSITIVITY TEST; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENTEROBACTERIACEAE; ESCHERICHIA COLI; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PYRANS; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84937761625     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.03.016     Document Type: Article

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