Addressing the stability of C-capped dipeptide efflux pump inhibitors that potentiate the activity of levofloxacin in Pseudomonas aeruginosa

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 5, 2001, Pages 663-667

  Renau, Thomas E ^a   Léger, Roger ^a   Flamme, Eric M ^a   She, Miles W ^a   Gannon, Carla L ^a   Mathias, Kristina M ^a   Lomovskaya, Olga ^a   Chamberland, Suzanne ^a   Lee, Ving J ^a   Ohta, Toshiharu ^b   Nakayama, Kiyoshi ^b   Ishida, Yohei ^b  

^a Microcide Pharmaceuticals Inc   (United States)

^b DAIICHI SANKYO CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DIPEPTIDE; LEVO OR; LEVOFLOXACIN; MC 02595; MEXAB OPRM EFFLUX PUMP; ORNITHYLPHENYLALANINE 3 AMINOQUINOLINE; PHENYLALANYLARGININE 2 NAPHTHYLAMIDE; PHENYLALANYLARGININE BETA NAPHTHYLAMINE; PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENTIATION; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TRANSPORT; GRAM NEGATIVE INFECTION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PROTEIN EXPRESSION; PSEUDOMONAS AERUGINOSA; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-INFECTIVE AGENTS; BIOLOGICAL TRANSPORT, ACTIVE; DIPEPTIDES; DRUG DESIGN; DRUG STABILITY; DRUG SYNERGISM; MICE; MICROBIAL SENSITIVITY TESTS; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; OFLOXACIN; PSEUDOMONAS AERUGINOSA; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

PSEUDOMONAS; PSEUDOMONAS AERUGINOSA;

EID: 0035848421     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00033-6     Document Type: Article

References (12)