메뉴 건너뛰기




Volumn 233, Issue 3, 2018, Pages 2170-2182

Anti-tumor effects of crocetin and related molecular targets

Author keywords

cancer; crocetin; Crocus sativus; saffron

Indexed keywords

CROCETIN; ANTINEOPLASTIC AGENT; CAROTENOID; NUCLEIC ACID SYNTHESIS INHIBITOR;

EID: 85035040109     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.25953     Document Type: Review
Times cited : (46)

References (97)
  • 2
    • 0028177341 scopus 로고
    • Inhibitory effect of crocetin on intracellular nucleic acid and protein synthesis in malignant cells
    • Abdullaev, F. I. (1994). Inhibitory effect of crocetin on intracellular nucleic acid and protein synthesis in malignant cells. Toxicology Letters, 70(2), 243–251.
    • (1994) Toxicology Letters , vol.70 , Issue.2 , pp. 243-251
    • Abdullaev, F.I.1
  • 3
    • 0036377909 scopus 로고    scopus 로고
    • Cancer chemopreventive and tumoricidal properties of saffron (Crocus sativus L.)
    • Abdullaev, F. I. (2002). Cancer chemopreventive and tumoricidal properties of saffron (Crocus sativus L.). Experimental Biology and Medicine, 227(1), 20–25.
    • (2002) Experimental Biology and Medicine , vol.227 , Issue.1 , pp. 20-25
    • Abdullaev, F.I.1
  • 4
    • 80052033921 scopus 로고    scopus 로고
    • Saffron: A potential candidate for a novel anticancer drug against hepatocellular carcinoma
    • Amin, A., Hamza, A. A., Bajbouj, K., Ashraf, S. S., & Daoud, S. (2011). Saffron: A potential candidate for a novel anticancer drug against hepatocellular carcinoma. Hepatology, 54(3), 857–867.
    • (2011) Hepatology , vol.54 , Issue.3 , pp. 857-867
    • Amin, A.1    Hamza, A.A.2    Bajbouj, K.3    Ashraf, S.S.4    Daoud, S.5
  • 5
    • 25444434647 scopus 로고    scopus 로고
    • Orally administered crocetin and crocins are absorbed into blood plasma as crocetin and its glucuronide conjugates in mice
    • Asai, A., Nakano, T., Takahashi, M., & Nagao, A. (2005). Orally administered crocetin and crocins are absorbed into blood plasma as crocetin and its glucuronide conjugates in mice. Journal of Agricultural and Food Chemistry, 53(18), 7302–7306.
    • (2005) Journal of Agricultural and Food Chemistry , vol.53 , Issue.18 , pp. 7302-7306
    • Asai, A.1    Nakano, T.2    Takahashi, M.3    Nagao, A.4
  • 8
    • 34547916395 scopus 로고    scopus 로고
    • Interaction of saffron carotenoids as anticancer compounds with ctDNA, Oligo (dG. dC) 15, and Oligo (dA. dT) 15
    • Bathaie, S. Z., Bolhasani, A., Hoshyar, R., Ranjbar, B., Sabouni, F., & Moosavi-Movahedi, A.-A. (2007). Interaction of saffron carotenoids as anticancer compounds with ctDNA, Oligo (dG. dC) 15, and Oligo (dA. dT) 15. DNA and Cell Biology, 26(8), 533–540.
    • (2007) DNA and Cell Biology , vol.26 , Issue.8 , pp. 533-540
    • Bathaie, S.Z.1    Bolhasani, A.2    Hoshyar, R.3    Ranjbar, B.4    Sabouni, F.5    Moosavi-Movahedi, A.-A.6
  • 9
    • 84888260574 scopus 로고    scopus 로고
    • Anticancer effects of crocetin in both human adenocarcinoma gastric cancer cells and rat model of gastric cancer
    • Bathaie, S. Z., Hoshyar, R., Miri, H., & Sadeghizadeh, M. (2013). Anticancer effects of crocetin in both human adenocarcinoma gastric cancer cells and rat model of gastric cancer. Biochemistry and Cell Biology, 91(6), 397–403.
    • (2013) Biochemistry and Cell Biology , vol.91 , Issue.6 , pp. 397-403
    • Bathaie, S.Z.1    Hoshyar, R.2    Miri, H.3    Sadeghizadeh, M.4
  • 11
    • 84874031173 scopus 로고    scopus 로고
    • Comparative reverse screening approach to identify potential anti-neoplastic targets of saffron functional components and binding mode
    • Bhattacharjee, B., Vijayasarathy, S., Karunakar, P., & Chatterjee, J. (2012). Comparative reverse screening approach to identify potential anti-neoplastic targets of saffron functional components and binding mode. Asian Pacific Journal of Cancer Prevention, 13(11), 5605–5611.
    • (2012) Asian Pacific Journal of Cancer Prevention , vol.13 , Issue.11 , pp. 5605-5611
    • Bhattacharjee, B.1    Vijayasarathy, S.2    Karunakar, P.3    Chatterjee, J.4
  • 12
    • 33746143206 scopus 로고    scopus 로고
    • HPLC quantification of major active components from 11 different saffron (Crocus sativus L.) sources
    • Caballero-Ortega, H., Pereda-Miranda, R., & Abdullaev, F. I. (2007). HPLC quantification of major active components from 11 different saffron (Crocus sativus L.) sources. Food Chemistry, 100(3), 1126–1131.
    • (2007) Food Chemistry , vol.100 , Issue.3 , pp. 1126-1131
    • Caballero-Ortega, H.1    Pereda-Miranda, R.2    Abdullaev, F.I.3
  • 13
    • 33244463729 scopus 로고    scopus 로고
    • Crocetin esters, picrocrocin and its related compounds present in Crocus sativus stigmas and Gardenia jasminoides fruits. Tentative identification of seven new compounds by LC-ESI-MS
    • Carmona, M., Zalacain, A., Sánchez, A. M., Novella, J. L., & Alonso, G. L. (2006). Crocetin esters, picrocrocin and its related compounds present in Crocus sativus stigmas and Gardenia jasminoides fruits. Tentative identification of seven new compounds by LC-ESI-MS. Journal of Agricultural and Food Chemistry, 54(3), 973–979.
    • (2006) Journal of Agricultural and Food Chemistry , vol.54 , Issue.3 , pp. 973-979
    • Carmona, M.1    Zalacain, A.2    Sánchez, A.M.3    Novella, J.L.4    Alonso, G.L.5
  • 14
    • 84886710872 scopus 로고    scopus 로고
    • Protective effect of saffron extract against doxorubicin cardiotoxicity in isolated rabbit heart
    • Chahine, N., Hanna, J., Makhlouf, H., Duca, L., Martiny, L., & Chahine, R. (2013). Protective effect of saffron extract against doxorubicin cardiotoxicity in isolated rabbit heart. Pharmaceutical Biology, 51(12), 1564–1571.
    • (2013) Pharmaceutical Biology , vol.51 , Issue.12 , pp. 1564-1571
    • Chahine, N.1    Hanna, J.2    Makhlouf, H.3    Duca, L.4    Martiny, L.5    Chahine, R.6
  • 15
    • 84927139006 scopus 로고    scopus 로고
    • Crocetin downregulates the proinflammatory cytokines in methylcholanthrene-induced rodent tumor model and inhibits COX-2 expression in cervical cancer cells
    • Chen, B., Hou, Z.-H., Dong, Z., & Li, C.-D. (2015). Crocetin downregulates the proinflammatory cytokines in methylcholanthrene-induced rodent tumor model and inhibits COX-2 expression in cervical cancer cells. BioMed Research International, Article ID 829513.
    • (2015) BioMed Research International
    • Chen, B.1    Hou, Z.-H.2    Dong, Z.3    Li, C.-D.4
  • 16
    • 78651485607 scopus 로고    scopus 로고
    • Crocetin inhibits invasiveness of MDA-MB-231 Breast cancer cells via downregulation of matrix metalloproteinases
    • Chryssanthi, D. G., Dedes, P. G., Karamanos, N. K., Cordopatis, P., & Lamari, F. N. (2011). Crocetin inhibits invasiveness of MDA-MB-231 Breast cancer cells via downregulation of matrix metalloproteinases. Planta Medica, 77(02), 146–151.
    • (2011) Planta Medica , vol.77 , Issue.2 , pp. 146-151
    • Chryssanthi, D.G.1    Dedes, P.G.2    Karamanos, N.K.3    Cordopatis, P.4    Lamari, F.N.5
  • 17
    • 33847666566 scopus 로고    scopus 로고
    • Inhibition of breast cancer cell proliferation by style constituents of different Crocus species
    • Chryssanthi, D. G., Lamari, F. N., Iatrou, G., Pylara, A., Karamanos, N. K., & Cordopatis, P. (2007). Inhibition of breast cancer cell proliferation by style constituents of different Crocus species. Anticancer Research, 27(1A), 357–362.
    • (2007) Anticancer Research , vol.27 , Issue.1A , pp. 357-362
    • Chryssanthi, D.G.1    Lamari, F.N.2    Iatrou, G.3    Pylara, A.4    Karamanos, N.K.5    Cordopatis, P.6
  • 18
    • 0029990657 scopus 로고    scopus 로고
    • High performance thin layer chromatographic quantitative analysis of picrocrocin and crocetin, active principles of saffron (Crocus sativusL.-Iridaceae): a new method
    • Corti, P., Mazzei, E., Ferri, S., Franchi, G., & Dreassi, E. (1996). High performance thin layer chromatographic quantitative analysis of picrocrocin and crocetin, active principles of saffron (Crocus sativusL.-Iridaceae): a new method. Phytochemical Analysis, 7(4), 201–203.
    • (1996) Phytochemical Analysis , vol.7 , Issue.4 , pp. 201-203
    • Corti, P.1    Mazzei, E.2    Ferri, S.3    Franchi, G.4    Dreassi, E.5
  • 19
    • 84882374709 scopus 로고    scopus 로고
    • Crocus sativus stigma extract and its major constituent crocin possess significant antiproliferative properties against human prostate cancer
    • D'Alessandro, A. M., Mancini, A., Lizzi, A. R., De Simone, A., Marroccella, C. E., Gravina, G. L., … Festuccia, C. (2013). Crocus sativus stigma extract and its major constituent crocin possess significant antiproliferative properties against human prostate cancer. Nutrition and Cancer, 65(6), 930–942.
    • (2013) Nutrition and Cancer , vol.65 , Issue.6 , pp. 930-942
    • D'Alessandro, A.M.1    Mancini, A.2    Lizzi, A.R.3    De Simone, A.4    Marroccella, C.E.5    Gravina, G.L.6    Festuccia, C.7
  • 20
    • 77953536106 scopus 로고    scopus 로고
    • Saffron suppresses oxidative stress in DMBA-induced skin carcinoma: A histopathological study
    • Das, I., Das, S., & Saha, T. (2010). Saffron suppresses oxidative stress in DMBA-induced skin carcinoma: A histopathological study. Acta Histochemica, 112(4), 317–327.
    • (2010) Acta Histochemica , vol.112 , Issue.4 , pp. 317-327
    • Das, I.1    Das, S.2    Saha, T.3
  • 22
    • 79957477202 scopus 로고    scopus 로고
    • The neurologic side effects of chemotherapeutic agents
    • Dropcho, E. J. (2011). The neurologic side effects of chemotherapeutic agents. CONTINUUM: Lifelong Learning in Neurology, 17(1 Neurologic Complications of Systemic Disease), 95–112.
    • (2011) CONTINUUM: Lifelong Learning in Neurology , vol.17 , Issue.1 Neurologic Complications of Systemic Disease , pp. 95-112
    • Dropcho, E.J.1
  • 23
    • 0030901888 scopus 로고    scopus 로고
    • In vitro formation of crocetin glucosyl esters by Crocus sativus callus extract
    • Dufresne, C., Cormier, F., & Dorion, S. (1997). In vitro formation of crocetin glucosyl esters by Crocus sativus callus extract. Planta Medica, 63(02), 150–153.
    • (1997) Planta Medica , vol.63 , Issue.2 , pp. 150-153
    • Dufresne, C.1    Cormier, F.2    Dorion, S.3
  • 24
    • 58149391823 scopus 로고    scopus 로고
    • Cytotoxic effect of saffron stigma aqueous extract on human transitional cell carcinoma and mouse fibroblast
    • Feizzadeh, B., Tavakkol Afshari, J., Rakhshandeh, H., Rahimi, A., Brook, A., & Doosti, H. (2008). Cytotoxic effect of saffron stigma aqueous extract on human transitional cell carcinoma and mouse fibroblast. Urology Journal, 5(3), 161–167.
    • (2008) Urology Journal , vol.5 , Issue.3 , pp. 161-167
    • Feizzadeh, B.1    Tavakkol Afshari, J.2    Rakhshandeh, H.3    Rahimi, A.4    Brook, A.5    Doosti, H.6
  • 26
    • 0017059104 scopus 로고
    • The effect of crocetin on skin papillomas and Rous sarcoma
    • Gainer, J., Wallis, D., & Jones, J. (1976). The effect of crocetin on skin papillomas and Rous sarcoma. Oncology, 33(5–6), 222–224.
    • (1976) Oncology , vol.33 , Issue.5-6 , pp. 222-224
    • Gainer, J.1    Wallis, D.2    Jones, J.3
  • 27
    • 20044370663 scopus 로고    scopus 로고
    • Separation and purification of some components of iranian saffron
    • GHAFFARII, M. (2005). Separation and purification of some components of iranian saffron. Asian Journal of Chemistry, 17(2), 725–729.
    • (2005) Asian Journal of Chemistry , vol.17 , Issue.2 , pp. 725-729
    • Ghaffarii, M.1
  • 28
    • 2942615338 scopus 로고    scopus 로고
    • Crocetin from saffron: An active component of an ancient spice
    • Giaccio, M. (2004). Crocetin from saffron: An active component of an ancient spice. Critical Reviews in Food Science and Nutrition, 44(3), 155–172.
    • (2004) Critical Reviews in Food Science and Nutrition , vol.44 , Issue.3 , pp. 155-172
    • Giaccio, M.1
  • 29
    • 33845294078 scopus 로고    scopus 로고
    • The effects of aqueous extract of garlic (Allium sativum L.) on laryngeal cancer cells (Hep-2) and L929 cells in vitro
    • Hadjzadeh, M., Tavakol Afshari, J., Ghorbani, A., & Shakeri, M. (2006). The effects of aqueous extract of garlic (Allium sativum L.) on laryngeal cancer cells (Hep-2) and L929 cells in vitro. Journal of Medicinal Plants, 2(18), 41–48.
    • (2006) Journal of Medicinal Plants , vol.2 , Issue.18 , pp. 41-48
    • Hadjzadeh, M.1    Tavakol Afshari, J.2    Ghorbani, A.3    Shakeri, M.4
  • 32
    • 33751522597 scopus 로고    scopus 로고
    • Simultaneous determination of five major biologically active ingredients in different parts of Gardenia jasminoides fruits by HPLC with diode-array detection
    • He, M.-L., Cheng, X.-W., Chen, J.-K., & Zhou, T.-S. (2006). Simultaneous determination of five major biologically active ingredients in different parts of Gardenia jasminoides fruits by HPLC with diode-array detection. Chromatographia, 64(11-12), 713–717.
    • (2006) Chromatographia , vol.64 , Issue.11-12 , pp. 713-717
    • He, M.-L.1    Cheng, X.-W.2    Chen, J.-K.3    Zhou, T.-S.4
  • 33
    • 84982970557 scopus 로고    scopus 로고
    • Effect of saffron on liver metastases in patients suffering from cancers with liver metastases: A randomized, double blind, placebo-controlled clinical trial
    • Hosseini, A., Mousavi, S. H., Ghanbari, A., Shandiz, F. H., Raziee, H. R., Rad, M. P., & Mousavi, S. H. (2015). Effect of saffron on liver metastases in patients suffering from cancers with liver metastases: A randomized, double blind, placebo-controlled clinical trial. Avicenna Journal of Phytomedicine, 5(5), 434.
    • (2015) Avicenna Journal of Phytomedicine , vol.5 , Issue.5 , pp. 434
    • Hosseini, A.1    Mousavi, S.H.2    Ghanbari, A.3    Shandiz, F.H.4    Raziee, H.R.5    Rad, M.P.6    Mousavi, S.H.7
  • 34
    • 57149107368 scopus 로고    scopus 로고
    • Protective effect of crocus sativus stigma extract and crocin (trans-crocin 4) on Methyl Methanesulfonate-induced DNA damage in mice organs
    • Hosseinzadeh, H., Abootorabi, A., & Sadeghnia, H. R. (2008). Protective effect of crocus sativus stigma extract and crocin (trans-crocin 4) on Methyl Methanesulfonate-induced DNA damage in mice organs. DNA and Cell Biology, 27(12), 657–664.
    • (2008) DNA and Cell Biology , vol.27 , Issue.12 , pp. 657-664
    • Hosseinzadeh, H.1    Abootorabi, A.2    Sadeghnia, H.R.3
  • 35
    • 84876290925 scopus 로고    scopus 로고
    • Avicenna's (Ibn Sina) the Canon of Medicine and saffron (Crocus sativus): a review
    • Hosseinzadeh, H., & Nassiri-Asl, M. (2013). Avicenna's (Ibn Sina) the Canon of Medicine and saffron (Crocus sativus): a review. Phytotherapy Research: PTR, 27(4), 475–483.
    • (2013) Phytotherapy Research: PTR , vol.27 , Issue.4 , pp. 475-483
    • Hosseinzadeh, H.1    Nassiri-Asl, M.2
  • 40
    • 84898070696 scopus 로고    scopus 로고
    • Proposed cytotoxic mechanisms of the saffron carotenoids crocin and crocetin on cancer cell lines
    • Kim, S. H., Lee, J. M., Kim, S. C., Park, C. B., & Lee, P. C. (2014). Proposed cytotoxic mechanisms of the saffron carotenoids crocin and crocetin on cancer cell lines. Biochemistry and Cell Biology, 92(2), 105–111.
    • (2014) Biochemistry and Cell Biology , vol.92 , Issue.2 , pp. 105-111
    • Kim, S.H.1    Lee, J.M.2    Kim, S.C.3    Park, C.B.4    Lee, P.C.5
  • 42
    • 85017472747 scopus 로고    scopus 로고
    • Intake of saffron reduces gamma-radiation-induced genotoxicity and oxidative stress in mice
    • [E-pub ahead of print]
    • Koul, A., & Abraham, S. K. (2017). Intake of saffron reduces gamma-radiation-induced genotoxicity and oxidative stress in mice. Toxicology Mechanisms and Methods [E-pub ahead of print]. https://doi.org/10.1080/15376516.2017.1307476
    • (2017) Toxicology Mechanisms and Methods
    • Koul, A.1    Abraham, S.K.2
  • 43
    • 84963798144 scopus 로고    scopus 로고
    • Evaluation of the effect of crocetin on antitumor activity of doxorubicin encapsulated in PLGA nanoparticles
    • Langroodi, F., Hafezi Ghahestani, Z., Alibolandi, M., Ebrahimian, M., & Hashemi, M. (2016). Evaluation of the effect of crocetin on antitumor activity of doxorubicin encapsulated in PLGA nanoparticles. Nanomedicine Journal, 3(1), 23–34.
    • (2016) Nanomedicine Journal , vol.3 , Issue.1 , pp. 23-34
    • Langroodi, F.1    Hafezi Ghahestani, Z.2    Alibolandi, M.3    Ebrahimian, M.4    Hashemi, M.5
  • 44
    • 84891670962 scopus 로고    scopus 로고
    • Effective isolation protocol for secondary metabolites from Saffron: Semi-preparative scale preparation of crocin-1 and trans-crocetin
    • Lautenschläger, M., Lechtenberg, M., Sendker, J., & Hensel, A. (2014). Effective isolation protocol for secondary metabolites from Saffron: Semi-preparative scale preparation of crocin-1 and trans-crocetin. Fitoterapia, 92, 290–295.
    • (2014) Fitoterapia , vol.92 , pp. 290-295
    • Lautenschläger, M.1    Lechtenberg, M.2    Sendker, J.3    Hensel, A.4
  • 45
    • 0033064693 scopus 로고    scopus 로고
    • Simultaneous quantification of five major biologically active ingredients of saffron by high-performance liquid chromatography
    • Li, N., Lin, G., Kwan, Y.-W., & Min, Z.-D. (1999). Simultaneous quantification of five major biologically active ingredients of saffron by high-performance liquid chromatography. Journal of Chromatography A, 849(2), 349–355.
    • (1999) Journal of Chromatography A , vol.849 , Issue.2 , pp. 349-355
    • Li, N.1    Lin, G.2    Kwan, Y.-W.3    Min, Z.-D.4
  • 46
    • 84921743232 scopus 로고    scopus 로고
    • Anticancer effects of crocetin in human esophageal squamous cell carcinoma KYSE-150 cells
    • Li, S., Jiang, S., Jiang, W., Zhou, Y., Shen, X. Y., Luo, T., … Wang, H. Q. (2015). Anticancer effects of crocetin in human esophageal squamous cell carcinoma KYSE-150 cells. Oncology Letters, 9(3), 1254–1260.
    • (2015) Oncology Letters , vol.9 , Issue.3 , pp. 1254-1260
    • Li, S.1    Jiang, S.2    Jiang, W.3    Zhou, Y.4    Shen, X.Y.5    Luo, T.6    Wang, H.Q.7
  • 48
    • 84912139884 scopus 로고    scopus 로고
    • Saffron (Crocus sativus) for depression: A systematic review of clinical studies and examination of underlying antidepressant mechanisms of action
    • Lopresti, A. L., & Drummond, P. D. (2014). Saffron (Crocus sativus) for depression: A systematic review of clinical studies and examination of underlying antidepressant mechanisms of action. Human Psychopharmacology, 29(6), 517–527.
    • (2014) Human Psychopharmacology , vol.29 , Issue.6 , pp. 517-527
    • Lopresti, A.L.1    Drummond, P.D.2
  • 49
    • 0032926468 scopus 로고    scopus 로고
    • A quantitative high-performance liquid chromatographic method to analyse commercial saffron (Crocus sativus L.) products
    • Lozano, P., Castellar, M., Simancas, M., & Iborra, J. (1999). A quantitative high-performance liquid chromatographic method to analyse commercial saffron (Crocus sativus L.) products. Journal of Chromatography A, 830(2), 477–483.
    • (1999) Journal of Chromatography A , vol.830 , Issue.2 , pp. 477-483
    • Lozano, P.1    Castellar, M.2    Simancas, M.3    Iborra, J.4
  • 51
    • 64549085416 scopus 로고    scopus 로고
    • In vivo protective effect of crocetin on benzo (a) pyrene-induced lung cancer in Swiss albino mice
    • Magesh, V., DurgaBhavani, K., Senthilnathan, P., Rajendran, P., & Sakthisekaran, D. (2009). In vivo protective effect of crocetin on benzo (a) pyrene-induced lung cancer in Swiss albino mice. Phytotherapy Research, 23(4), 533–539.
    • (2009) Phytotherapy Research , vol.23 , Issue.4 , pp. 533-539
    • Magesh, V.1    DurgaBhavani, K.2    Senthilnathan, P.3    Rajendran, P.4    Sakthisekaran, D.5
  • 52
    • 33745953345 scopus 로고    scopus 로고
    • Antitumour activity of crocetin in accordance to tumor incidence, antioxidant status, drug metabolizing enzymes and histopathological studies
    • Magesh, V., Singh, J. P. V., Selvendiran, K., Ekambaram, G., & Sakthisekaran, D. (2006). Antitumour activity of crocetin in accordance to tumor incidence, antioxidant status, drug metabolizing enzymes and histopathological studies. Molecular and Cellular Biochemistry, 287(1-2), 127–135.
    • (2006) Molecular and Cellular Biochemistry , vol.287 , Issue.1-2 , pp. 127-135
    • Magesh, V.1    Singh, J.P.V.2    Selvendiran, K.3    Ekambaram, G.4    Sakthisekaran, D.5
  • 53
    • 0036285969 scopus 로고    scopus 로고
    • Evaluation of the developmental toxicity of crocetin on Xenopus
    • Martin, G., Goh, E., & Neff, A. (2002). Evaluation of the developmental toxicity of crocetin on Xenopus. Food and Chemical Toxicology, 40(7), 959–964.
    • (2002) Food and Chemical Toxicology , vol.40 , Issue.7 , pp. 959-964
    • Martin, G.1    Goh, E.2    Neff, A.3
  • 54
    • 0019972475 scopus 로고
    • Effect of crocetin on experimental skin tumors in hairless mice
    • Mathews-Roth, M. (1982). Effect of crocetin on experimental skin tumors in hairless mice. Oncology, 39(6), 362–364.
    • (1982) Oncology , vol.39 , Issue.6 , pp. 362-364
    • Mathews-Roth, M.1
  • 56
    • 56549100087 scopus 로고    scopus 로고
    • Safety evaluation of saffron (Crocus sativus) tablets in healthy volunteers
    • Modaghegh, M.-H., Shahabian, M., Esmaeili, H.-A., Rajbai, O., & Hosseinzadeh, H. (2008). Safety evaluation of saffron (Crocus sativus) tablets in healthy volunteers. Phytomedicine, 15(12), 1032–1037.
    • (2008) Phytomedicine , vol.15 , Issue.12 , pp. 1032-1037
    • Modaghegh, M.-H.1    Shahabian, M.2    Esmaeili, H.-A.3    Rajbai, O.4    Hosseinzadeh, H.5
  • 59
    • 0027333293 scopus 로고
    • Protective effects of crocetin on the bladder toxicity induced by cyclophosphamide
    • Nair, S., Panikkar, K., & Parthod, R. (1993). Protective effects of crocetin on the bladder toxicity induced by cyclophosphamide. Cancer Biotherapy & Radiopharmaceuticals, 8(4), 339–343.
    • (1993) Cancer Biotherapy & Radiopharmaceuticals , vol.8 , Issue.4 , pp. 339-343
    • Nair, S.1    Panikkar, K.2    Parthod, R.3
  • 60
    • 0025809643 scopus 로고
    • Antitumour activity of saffron (Crocus sativus)
    • Nair, S., Pannikar, B., & Panikkar, K. (1991). Antitumour activity of saffron (Crocus sativus). Cancer Letters, 57(2), 109–114.
    • (1991) Cancer Letters , vol.57 , Issue.2 , pp. 109-114
    • Nair, S.1    Pannikar, B.2    Panikkar, K.3
  • 61
    • 0028286441 scopus 로고
    • Effects of saffron on Vitamin A levels and its Antitumour activity on the growth of solid tumours in mice
    • Nair, S., Varghese, C. D., Paniker, K., Kurumboor, S., & Parathod, R. (1994). Effects of saffron on Vitamin A levels and its Antitumour activity on the growth of solid tumours in mice. International Journal of Pharmacognosy, 32(2), 105–114.
    • (1994) International Journal of Pharmacognosy , vol.32 , Issue.2 , pp. 105-114
    • Nair, S.1    Varghese, C.D.2    Paniker, K.3    Kurumboor, S.4    Parathod, R.5
  • 64
    • 84885476128 scopus 로고    scopus 로고
    • Effects of aqueous saffron extract on nitric oxide production by two human carcinoma cell lines: Hepatocellular carcinoma (HepG2) and laryngeal carcinoma (Hep2)
    • Parizadeh, M. R., Ghafoori Gharib, F., Abbaspour, A. R., Tavakol Afshar, J., & Ghayour-Mobarhan, M. (2011). Effects of aqueous saffron extract on nitric oxide production by two human carcinoma cell lines: Hepatocellular carcinoma (HepG2) and laryngeal carcinoma (Hep2). Avicenna Journal of Phytomedicine, 1(1), 43–50.
    • (2011) Avicenna Journal of Phytomedicine , vol.1 , Issue.1 , pp. 43-50
    • Parizadeh, M.R.1    Ghafoori Gharib, F.2    Abbaspour, A.R.3    Tavakol Afshar, J.4    Ghayour-Mobarhan, M.5
  • 65
    • 0001306847 scopus 로고
    • Separation of crocetin glycosyl esters by high-performance liquid chromatography
    • Pfander, H., & Rychener, M. (1982). Separation of crocetin glycosyl esters by high-performance liquid chromatography. Journal of Chromatography A, 234(2), 443–447.
    • (1982) Journal of Chromatography A , vol.234 , Issue.2 , pp. 443-447
    • Pfander, H.1    Rychener, M.2
  • 67
    • 0038125510 scopus 로고    scopus 로고
    • Protective effects of saffron (Crocus sativus Linn.) on genotoxins-induced oxidative stress in Swiss albino mice
    • Premkumar, K., Abraham, S. K., Santhiya, S., & Ramesh, A. (2003). Protective effects of saffron (Crocus sativus Linn.) on genotoxins-induced oxidative stress in Swiss albino mice. Phytotherapy Research, 17(6), 614–617.
    • (2003) Phytotherapy Research , vol.17 , Issue.6 , pp. 614-617
    • Premkumar, K.1    Abraham, S.K.2    Santhiya, S.3    Ramesh, A.4
  • 68
    • 33644778804 scopus 로고    scopus 로고
    • Protective effect of saffron (Crocus sativus L.) aqueous extract against genetic damage induced by anti-tumor agents in mice
    • Premkumar, K., Thirunavukkarasu, C., Abraham, S., Santhiya, S., & Ramesh, A. (2006). Protective effect of saffron (Crocus sativus L.) aqueous extract against genetic damage induced by anti-tumor agents in mice. Human & Experimental Toxicology, 25(2), 79–84.
    • (2006) Human & Experimental Toxicology , vol.25 , Issue.2 , pp. 79-84
    • Premkumar, K.1    Thirunavukkarasu, C.2    Abraham, S.3    Santhiya, S.4    Ramesh, A.5
  • 69
  • 70
    • 85035043077 scopus 로고    scopus 로고
    • Therapeutic effects of Crocus sativus: An overview of systematic reviews
    • Rouhi Boroujeni, H., & Kiani, S. (2015). Therapeutic effects of Crocus sativus: An overview of systematic reviews. Advanced Herbal Medicine, 1(3), 48–55.
    • (2015) Advanced Herbal Medicine , vol.1 , Issue.3 , pp. 48-55
    • Rouhi Boroujeni, H.1    Kiani, S.2
  • 72
    • 39149137869 scopus 로고    scopus 로고
    • Plant-derived compounds in clinical trials
    • Saklani, A., & Kutty, S. K. (2008). Plant-derived compounds in clinical trials. Drug Discovery Today, 13(3), 161–171.
    • (2008) Drug Discovery Today , vol.13 , Issue.3 , pp. 161-171
    • Saklani, A.1    Kutty, S.K.2
  • 73
    • 0025774015 scopus 로고
    • Inhibitory effects of Nigella sativa and saffron (Crocus sativus) on chemical carcinogenesis in mice
    • Salomi, M. J., Nair, S. C., & Panikkar, K. R. (1991). Inhibitory effects of Nigella sativa and saffron (Crocus sativus) on chemical carcinogenesis in mice. Nutrition and Cancer, 16(1), 67–72.
    • (1991) Nutrition and Cancer , vol.16 , Issue.1 , pp. 67-72
    • Salomi, M.J.1    Nair, S.C.2    Panikkar, K.R.3
  • 74
    • 79956348262 scopus 로고    scopus 로고
    • Suppression of pulmonary tumor promotion and induction of apoptosis by Crocus sativus L. extraction
    • Samarghandian, S., Afshari, J. T., & Davoodi, S. (2011). Suppression of pulmonary tumor promotion and induction of apoptosis by Crocus sativus L. extraction. Applied Biochemistry and Biotechnology, 164(2), 238–247.
    • (2011) Applied Biochemistry and Biotechnology , vol.164 , Issue.2 , pp. 238-247
    • Samarghandian, S.1    Afshari, J.T.2    Davoodi, S.3
  • 75
    • 84889063132 scopus 로고    scopus 로고
    • Crocus sativus L. (saffron) stigma aqueous extract induces apoptosis in alveolar human lung cancer cells through caspase-dependent pathways activation
    • Samarghandian, S., Borji, A., Farahmand, S. K., Afshari, R., & Davoodi, S. (2013). Crocus sativus L. (saffron) stigma aqueous extract induces apoptosis in alveolar human lung cancer cells through caspase-dependent pathways activation. BioMed Research International, 2013, 417928.
    • (2013) BioMed Research International , vol.2013 , pp. 417928
    • Samarghandian, S.1    Borji, A.2    Farahmand, S.K.3    Afshari, R.4    Davoodi, S.5
  • 76
    • 78149457185 scopus 로고    scopus 로고
    • Use of in vitro assays to assess the potential antiproliferative and cytotoxic effects of saffron (Crocus sativus L.) in human lung cancer cell line
    • Samarghandian, S., Boskabady, M. H., & Davoodi, S. (2010). Use of in vitro assays to assess the potential antiproliferative and cytotoxic effects of saffron (Crocus sativus L.) in human lung cancer cell line. Pharmacognosy Magazine, 6(24), 309.
    • (2010) Pharmacognosy Magazine , vol.6 , Issue.24 , pp. 309
    • Samarghandian, S.1    Boskabady, M.H.2    Davoodi, S.3
  • 77
    • 0242464705 scopus 로고
    • In vitro proliferation of saffron (Crocus sativus L.) stigma. Plant Cell
    • Sano, K., & Himeno, H. (1987). In vitro proliferation of saffron (Crocus sativus L.) stigma. Plant Cell. Tissue and Organ Culture, 11(3), 159–166.
    • (1987) Tissue and Organ Culture , vol.11 , Issue.3 , pp. 159-166
    • Sano, K.1    Himeno, H.2
  • 78
    • 34548445132 scopus 로고    scopus 로고
    • Saffron in phytotherapy: Pharmacology and clinical uses
    • Schmidt, M., Betti, G., & Hensel, A. (2007). Saffron in phytotherapy: Pharmacology and clinical uses. WMW Wiener Medizinische Wochenschrift, 157(13), 315–319.
    • (2007) WMW Wiener Medizinische Wochenschrift , vol.157 , Issue.13 , pp. 315-319
    • Schmidt, M.1    Betti, G.2    Hensel, A.3
  • 79
    • 77957587417 scopus 로고    scopus 로고
    • Phytochemicals: Cancer chemoprevention and suppression of tumor onset and metastasis
    • Shu, L., Cheung, K.-L., Khor, T. O., Chen, C., & Kong, A.-N. (2010). Phytochemicals: Cancer chemoprevention and suppression of tumor onset and metastasis. Cancer and Metastasis Reviews, 29(3), 483–502.
    • (2010) Cancer and Metastasis Reviews , vol.29 , Issue.3 , pp. 483-502
    • Shu, L.1    Cheung, K.-L.2    Khor, T.O.3    Chen, C.4    Kong, A.-N.5
  • 81
    • 0025228499 scopus 로고
    • Inhibition of transformation in cultured rat tracheal epithelial cells by potential chemopreventive agents
    • Steele, V. E., Kelloff, G. J., Wilkinson, B. P., & Arnold, J. T. (1990). Inhibition of transformation in cultured rat tracheal epithelial cells by potential chemopreventive agents. Cancer Research, 50(7), 2068–2074.
    • (1990) Cancer Research , vol.50 , Issue.7 , pp. 2068-2074
    • Steele, V.E.1    Kelloff, G.J.2    Wilkinson, B.P.3    Arnold, J.T.4
  • 82
    • 0027055004 scopus 로고
    • Methods for the analysis of the saffron metabolites crocin, crocetins, picrocrocin and safranal for the determination of the quality of the spice using thin-layer chromatography, high-performance liquid chromatography and gas chromatography
    • Sujata, V., Ravishankar, G., & Venkataraman, L. (1992). Methods for the analysis of the saffron metabolites crocin, crocetins, picrocrocin and safranal for the determination of the quality of the spice using thin-layer chromatography, high-performance liquid chromatography and gas chromatography. Journal of Chromatography A, 624(1-2), 497–502.
    • (1992) Journal of Chromatography A , vol.624 , Issue.1-2 , pp. 497-502
    • Sujata, V.1    Ravishankar, G.2    Venkataraman, L.3
  • 83
    • 79960555687 scopus 로고    scopus 로고
    • Anti-cancer natural products isolated from chinese medicinal herbs
    • Tan, W., Lu, J., Huang, M., Li, Y., Chen, M., Wu, G., … Dang, Y. (2011). Anti-cancer natural products isolated from chinese medicinal herbs. Chinese Medicine, 6(1), 27.
    • (2011) Chinese Medicine , vol.6 , Issue.1 , pp. 27
    • Tan, W.1    Lu, J.2    Huang, M.3    Li, Y.4    Chen, M.5    Wu, G.6    Dang, Y.7
  • 84
    • 0028567256 scopus 로고
    • Inhibition of growth and induction of differentiation of promyelocytic leukemia (HL-60) by carotenoids from Crocus sativus L
    • Tarantilis, P., Morjani, H., Polissiou, M., & Manfait, M. (1993). Inhibition of growth and induction of differentiation of promyelocytic leukemia (HL-60) by carotenoids from Crocus sativus L. Anticancer Research 14(5A), 1913–1918.
    • (1993) Anticancer Research , vol.14 , Issue.5A , pp. 1913-1918
    • Tarantilis, P.1    Morjani, H.2    Polissiou, M.3    Manfait, M.4
  • 85
    • 54449093368 scopus 로고    scopus 로고
    • Study of cytotoxic and apoptogenic properties of saffron extract in human cancer cell lines
    • Tavakkol-Afshari, J., Brook, A., & Mousavi, S. H. (2008). Study of cytotoxic and apoptogenic properties of saffron extract in human cancer cell lines. Food and Chemical Toxicology, 46(11), 3443–3447.
    • (2008) Food and Chemical Toxicology , vol.46 , Issue.11 , pp. 3443-3447
    • Tavakkol-Afshari, J.1    Brook, A.2    Mousavi, S.H.3
  • 86
    • 0028892819 scopus 로고
    • Crocetin protects against oxidative damage in rat primary hepatocytes
    • Tseng, T.-H., Chu, C.-Y., Huang, J.-M., Shiow, S.-J., & Wang, C.-J. (1995). Crocetin protects against oxidative damage in rat primary hepatocytes. Cancer Letters, 97(1), 61–67.
    • (1995) Cancer Letters , vol.97 , Issue.1 , pp. 61-67
    • Tseng, T.-H.1    Chu, C.-Y.2    Huang, J.-M.3    Shiow, S.-J.4    Wang, C.-J.5
  • 87
    • 0001016668 scopus 로고
    • Stability of saffron pigments in aqueous extracts
    • Tsimidou, M., & Tsatsaroni, E. (1993). Stability of saffron pigments in aqueous extracts. Journal of Food Science, 58(5), 1073–1075.
    • (1993) Journal of Food Science , vol.58 , Issue.5 , pp. 1073-1075
    • Tsimidou, M.1    Tsatsaroni, E.2
  • 88
    • 79955683473 scopus 로고    scopus 로고
    • The pharmacokinetic profile of crocetin in healthy adult human volunteers after a single oral administration
    • Umigai, N., Murakami, K., Ulit, M., Antonio, L., Shirotori, M., Morikawa, H., & Nakano, T. (2011). The pharmacokinetic profile of crocetin in healthy adult human volunteers after a single oral administration. Phytomedicine, 18(7), 575–578.
    • (2011) Phytomedicine , vol.18 , Issue.7 , pp. 575-578
    • Umigai, N.1    Murakami, K.2    Ulit, M.3    Antonio, L.4    Shirotori, M.5    Morikawa, H.6    Nakano, T.7
  • 89
    • 0025925380 scopus 로고
    • Suppression of aflatoxin B1-induced hepatotoxic lesions by crocetin (a natural carotenoid)
    • Wang, C.-J., Hsu, J.-D., & Lin, J.-K. (1991). Suppression of aflatoxin B1-induced hepatotoxic lesions by crocetin (a natural carotenoid). Carcinogenesis, 12(10), 1807–1810.
    • (1991) Carcinogenesis , vol.12 , Issue.10 , pp. 1807-1810
    • Wang, C.-J.1    Hsu, J.-D.2    Lin, J.-K.3
  • 90
    • 0028816780 scopus 로고
    • Inhibition of tumor promotion in benzo [a] pyrene-initiated CD-1 mouse skin by crocetin
    • Wang, C.-J., Lee, M.-J., Chang, M.-C., & Lin, J.-K. (1995). Inhibition of tumor promotion in benzo [a] pyrene-initiated CD-1 mouse skin by crocetin. Carcinogenesis, 16(2), 187–191.
    • (1995) Carcinogenesis , vol.16 , Issue.2 , pp. 187-191
    • Wang, C.-J.1    Lee, M.-J.2    Chang, M.-C.3    Lin, J.-K.4
  • 91
    • 0025975959 scopus 로고
    • Modulatory effect of crocetin on aflatoxin B 1 cytotoxicity and DNA adduct formation in C3H10T12 fibroblast cell
    • Wang, C.-J., Shiah, H.-S., & Lin, J.-K. (1991). Modulatory effect of crocetin on aflatoxin B 1 cytotoxicity and DNA adduct formation in C3H10T12 fibroblast cell. Cancer Letters, 56(1), 1–10.
    • (1991) Cancer Letters , vol.56 , Issue.1 , pp. 1-10
    • Wang, C.-J.1    Shiah, H.-S.2    Lin, J.-K.3
  • 92
    • 0025780593 scopus 로고
    • Effects of crocetin on the hepatotoxicity and hepatic DNA binding of aflatoxin B1 in rats
    • Wang, C.-J., Shiow, S.-J., & Lin, J.-K. (1991). Effects of crocetin on the hepatotoxicity and hepatic DNA binding of aflatoxin B1 in rats. Carcinogenesis, 12(3), 459–462.
    • (1991) Carcinogenesis , vol.12 , Issue.3 , pp. 459-462
    • Wang, C.-J.1    Shiow, S.-J.2    Lin, J.-K.3
  • 93
    • 0030450890 scopus 로고    scopus 로고
    • Inhibition of protein kinase C and proto-oncogene expression by crocetin in NIH/3T3 cells
    • Wang, C. J., Cheng, T. C., Liu, J. Y., Chou, F. P., Kuo, M. L., & Lin, J. K. (1996). Inhibition of protein kinase C and proto-oncogene expression by crocetin in NIH/3T3 cells. Molecular Carcinogenesis, 17(4), 235–240.
    • (1996) Molecular Carcinogenesis , vol.17 , Issue.4 , pp. 235-240
    • Wang, C.J.1    Cheng, T.C.2    Liu, J.Y.3    Chou, F.P.4    Kuo, M.L.5    Lin, J.K.6
  • 94
    • 22244475784 scopus 로고    scopus 로고
    • Screening method for the detection of artificial colours in saffron using derivative UV-Vis spectrometry after precipitation of crocetin
    • Zalacain, A., Ordoudi, S., Blazquez, I., Díaz-Plaza, E. M., Carmona, M., Tsimidou, M., & Alonso, G. (2005). Screening method for the detection of artificial colours in saffron using derivative UV-Vis spectrometry after precipitation of crocetin. Food Additives and Contaminants, 22(7), 607–615.
    • (2005) Food Additives and Contaminants , vol.22 , Issue.7 , pp. 607-615
    • Zalacain, A.1    Ordoudi, S.2    Blazquez, I.3    Díaz-Plaza, E.M.4    Carmona, M.5    Tsimidou, M.6    Alonso, G.7
  • 95
    • 34848815648 scopus 로고    scopus 로고
    • Direct process integration of extraction and expanded bed adsorption in the recovery of crocetin derivatives from Fructus gardenia
    • Zhang, M., Hu, P., Liang, Q., Yang, H., Liu, Q., Wang, Y., & Luo, G. (2007). Direct process integration of extraction and expanded bed adsorption in the recovery of crocetin derivatives from Fructus gardenia. Journal of Chromatography B, 858(1), 220–226.
    • (2007) Journal of Chromatography B , vol.858 , Issue.1 , pp. 220-226
    • Zhang, M.1    Hu, P.2    Liang, Q.3    Yang, H.4    Liu, Q.5    Wang, Y.6    Luo, G.7
  • 96
    • 82955201782 scopus 로고    scopus 로고
    • Crocetin induces cytotoxicity and enhances vincristine-induced cancer cell death via p53-dependent and-independent mechanisms
    • Zhong, Y.-, Shi, F., Zheng, X.-, Wang, Q., Yang, L., Sun, H., … Qin, Y. (2011). Crocetin induces cytotoxicity and enhances vincristine-induced cancer cell death via p53-dependent and-independent mechanisms. Acta Pharmacologica Sinica, 32(12), 1529–1536.
    • (2011) Acta Pharmacologica Sinica , vol.32 , Issue.12 , pp. 1529-1536
    • Zhong, Y.1    Shi, F.2    Zheng, X.3    Wang, Q.4    Yang, L.5    Sun, H.6    Qin, Y.7
  • 97
    • 22244460475 scopus 로고    scopus 로고
    • Use of non-aqueous capillary electrophoresis for the quality control of commercial saffron samples
    • Zougagh, M., Simonet, B., Rios, A., & Valcarcel, M. (2005). Use of non-aqueous capillary electrophoresis for the quality control of commercial saffron samples. Journal of Chromatography A, 1085(2), 293–298.
    • (2005) Journal of Chromatography A , vol.1085 , Issue.2 , pp. 293-298
    • Zougagh, M.1    Simonet, B.2    Rios, A.3    Valcarcel, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.